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[1]王超逸,楊敬言,趙余煬,等.站立身高與椎間盤退變因果關(guān)系的孟德爾隨機(jī)化分析[J].中醫(yī)正骨,2024,36(04):55-61,65.
　WANG Chaoyi,YANG Jingyan,ZHAO Yuyang,et al.The causal relationship between standing height and intervertebral disc degeneration:a mendelian randomization analysis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2024,36(04):55-61,65.
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站立身高與椎間盤退變因果關(guān)系的孟德爾隨機(jī)化分析()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第36卷
期數(shù):
2024年04期
頁(yè)碼:
55-61,65
欄目:
數(shù)據(jù)庫(kù)研究
出版日期:
2024-04-20

文章信息/Info

Title:
The causal relationship between standing height and intervertebral disc degeneration:a mendelian randomization analysis
作者:
王超逸; 楊敬言; 趙余煬; 黃仁俊; 馬涉; 于棟
北京中醫(yī)藥大學(xué)第三附屬醫(yī)院,北京 100029
Author(s):
WANG Chaoyi; YANG Jingyan; ZHAO Yuyang; HUANG Renjun; MA She; YU Dong
Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China
關(guān)鍵詞:
椎間盤退化;  站立身高;  孟德爾隨機(jī)化分析;  全基因組關(guān)聯(lián)研究
Keywords:
intervertebral disc degeneration;  standing height;  Mendelian randomization analysis;  genome-wide association study
摘要:
目的:探討站立身高和椎間盤退變的因果關(guān)系。方法:從IEU OpenGWAS project數(shù)據(jù)庫(kù)獲取站立身高的全基因組關(guān)聯(lián)研究(genome-wide association study,GWAS)數(shù)據(jù)集,篩選符合要求的單核苷酸多態(tài)性(single nucleotide polymorphism,SNP)位點(diǎn)作為工具變量; 從FINNGEN數(shù)據(jù)庫(kù)中獲取關(guān)于椎間盤退變的GWAS數(shù)據(jù)集,從中篩選與工具變量匹配的SNP位點(diǎn)作為結(jié)局變量。將工具變量與結(jié)局變量導(dǎo)入分析工具R包,采用逆方差加權(quán)法(Inverse variance weighted,IVW)、MR-Egger回歸、簡(jiǎn)單中位數(shù)法(Simple mode,SM)、加權(quán)中值法(Weighted median estimator,WME)、加權(quán)中位數(shù)法(Weighted mode,WM)進(jìn)行孟德爾隨機(jī)化(Mendelian randomization,MR)分析。采用MR-Egger截距檢驗(yàn)、Cochran's Q檢驗(yàn)、留一法進(jìn)行敏感性分析。結(jié)果:MR分析結(jié)果顯示,站立身高與椎間盤退變呈正向因果關(guān)系[MR-Egger:OR=1.148,95%CI(0.942,1.401),P=0.174; WME:OR=1.220,95%CI(1.086,1.371),P=0.000; IVW:OR=1.113,95%CI(1.011,1.226),P=0.030; SM:OR=1.106,95%CI(0.837,1.462),P=0.479; WM:OR=1.234,95%CI(1.004,1.519),P=0.048]。MR-Egger截距檢驗(yàn)結(jié)果表明,MR分析結(jié)果不存在水平多效性(P=0.726); 異質(zhì)性檢驗(yàn)結(jié)果顯示,站立身高SNP位點(diǎn)存在異質(zhì)性(P=0.000); 采用IVW的隨機(jī)效應(yīng)模型再次評(píng)估,結(jié)果顯示站立身高與椎間盤退變呈正向因果關(guān)系(P=0.000),異質(zhì)性存在對(duì)結(jié)果無影響; 留一法檢驗(yàn)結(jié)果顯示,MR分析結(jié)果穩(wěn)定。結(jié)論:站立身高與椎間盤退變呈正向因果關(guān)系。
Abstract:
Objective:To explore the causal relationship between standing height and intervertebral disc degeneration(IVDD).Methods:The genome-wide association study(GWAS)datasets about standing height was extracted from the IEU OpenGWAS project database,and the eligible single nucleotide polymorphism(SNP)loci were screened as instrumental variables; meanwhile,the GWAS datasets on IVDD was retrieved from the FINNGEN database,and the SNP loci matched with the instrumental variables were selected as the outcome variables.The instrumental variables and outcome variables were imported into an R package,and then a mendelian randomization(MR)analysis was conducted by using Inverse variance weighted(IVW),MR-Egger regression,Simple mode(SM),Weighted median estimator(WME)and Weighted mode(WM),and the sensitivity was examined via the MR-Egger intercept test,Cochran's Q test,and the leave-one-out(LOO)test.Results:The results of MR analysis showed a positive causal relationship between standing height and IVDD(MR-Egger:OR=1.148,95%CI(0.942,1.401),P=0.174; WME:OR=1.220,95%CI(1.086,1.371),P=0.000; IVW:OR=1.113,95%CI(1.011,1.226),P=0.030; SM:OR=1.106,95%CI(0.837,1.462),P=0.479; WM:OR=1.234,95%CI(1.004,1.519),P=0.048).The results of MR-Egger intercept test indicated that there was no horizontal pleiotropy in the MR analysis results(P=0.726).The results of heterogeneity test revealed that there was heterogeneity in SNP loci of standing height(P=0.000).A re-evaluation was performed by employing a random-effects model of IVW,and the results showcased that the standing height had a positive causal relationship with IVDD(P=0.000),suggesting heterogeneity in SNP loci of standing height having no impact on the MR analysis results.Furthermore,the LOO test suggested that the results of MR analysis were stable.Conclusion:Standing height exhibits a positive causal relationship with IVDD.

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備注/Memo

備注/Memo:
通訊作者:于棟 E-mail:[email protected]
更新日期/Last Update: 1900-01-01