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[1]申震,董瑋,黃雅靜,等.不同中醫(yī)證候膝關(guān)節(jié)自發(fā)性骨壞死患者脂代謝特征的對比研究[J].中醫(yī)正骨,2022,34(09):1-4.
　SHEN Zhen,DONG Wei,HUANG Yajing,et al.Lipid metabolism characteristics of spontaneous knee osteonecrosis patients with different traditional Chinese medicine syndromes:a comparative study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2022,34(09):1-4.
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不同中醫(yī)證候膝關(guān)節(jié)自發(fā)性骨壞死患者脂代謝特征的對比研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第34卷
期數(shù):
2022年09期
頁碼:
1-4
欄目:
臨床研究
出版日期:
2022-09-20

文章信息/Info

Title:
Lipid metabolism characteristics of spontaneous knee osteonecrosis patients with different traditional Chinese medicine syndromes:a comparative study
作者:
申震; 董瑋; 黃雅靜; 雍來清; 郭英; 伍衛(wèi)新
(昆明市中醫(yī)醫(yī)院,云南昆明650051)
Author(s):
SHEN Zhen; DONG Wei; HUANG Yajing; YONG Laiqing; GUO Ying; WU Weixin
Kunming Municipal Hospital of Traditional Chinese Medicine,Kunming 650051,Yunnan,China
關(guān)鍵詞:
骨壞死;  膝關(guān)節(jié);  證候;  脂類代謝;  臨床試驗
Keywords:
osteonecrosis;  knee joint;  syndrome complex;  lipid metabolism;  clinical trial
摘要:
目的:比較不同中醫(yī)證候膝關(guān)節(jié)自發(fā)性骨壞死(spontaneous osteonecrosis of the knee,SONK)患者的脂代謝特征。方法:選取2019年3月至2021年5月收治的56例SONK患者,按照擬定的標(biāo)準(zhǔn)對所有患者進(jìn)行中醫(yī)辨證,并抽取外周靜脈血測定血清總膽固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白膽固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白膽固醇(low density lipoprotein cholesterol,LDL-C)、載脂蛋白A1(apolipoprotein-A1,Apo-A1)、載脂蛋白B(apolipoprotein-B,Apo-B)、脂蛋白a(lipoprotein a,LPA)含量。結(jié)果:56例SONK患者中痰瘀阻絡(luò)證27例、肝腎虧虛證18例、氣滯血瘀證11例。3種中醫(yī)證候SONK患者的血清TC、TG、LDL-C含量比較,組間差異均有統(tǒng)計學(xué)意義[(4.72±0.96)mmol·L-1,(4.49±0.90)mmol·L-1,(3.97±0.99)mmol·L-1,F=6.989,P=0.003;(2.17±1.35)mmol·L-1,(1.44±0.88)mmol·L-1,(1.78±1.16)mmol·L-1,F=2.927,P=0.039;(3.01±0.99)mmol·L-1,(2.98±0.75)mmol·L-1,(2.45±0.94)mmol·L-1,F=3.356,P=0.030]。痰瘀阻絡(luò)證患者的血清TC、TG、LDL-C含量均高于氣滯血瘀證患者(P=0.026,P=0.036,P=0.022); 肝腎虧虛證患者的血清TC、LDL-C含量均低于痰瘀阻絡(luò)證患者(P=0.030,P=0.012),但均高于氣滯血瘀證患者(P=0.018,P=0.011); 肝腎虧虛證患者的血清TG含量低于痰瘀阻絡(luò)證和氣滯血瘀證患者(P=0.027,P=0.040)。3種中醫(yī)證候SONK患者的血清 HDL-C、Apo-A1、Apo-B、LPA含量比較,組間差異均無統(tǒng)計學(xué)意義[(1.04±0.36)mmol·L-1,(1.18±0.35)mmol·L-1,(0.92±0.40)mmol·L-1,F=0.203,P=0.764;(1.20±0.29)g·L-1,(1.18±0.18)g·L-1,(1.03±0.25)g·L-1,F=0.899,P=0.424;(0.86±0.18)g·L-1,(0.83±0.22)g·L-1,(0.75±0.18)g·L-1,F=0.186,P=0.801;(0.33±0.10)g·L-1,(0.30±0.09)g·L-1,(0.29±0.09)g·L-1,F=0.102,P=0.903]。結(jié)論:SONK痰瘀阻絡(luò)證患者與肝腎虧虛證、氣滯血瘀證患者在脂代謝方面存在較大差異,臨床治療SONK痰瘀阻絡(luò)證患者時應(yīng)注意糾正脂代謝異常。
Abstract:
Objective:To compare the lipid metabolism characteristics of spontaneous knee osteonecrosis patients with different traditional Chinese medicine(TCM)syndromes.Methods:Fifty-six patients with spontaneous osteonecrosis of the knee(SONK)recruited from March 2019 to May 2021 were selected,and their TCM syndromes were differentiated according to the designed standards.The blood sample was drawn from the peripheral vein,and the serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein-A1(Apo-A1),apolipoprotein-B(Apo-B)and lipoprotein a(LPA)were detected by using enzyme linked immunosorbent assay(ELISA).Results:In the 57 SONK patients,the phlegm and blood-stasis blocking collaterals syndrome was found in 27 patients,liver-kidney deficiency syndrome in 18 cases as well as qi-stagnation and blood-stasis syndrome in 11 cases.There was statistical significance in the serum levels of TC,TG and LDL-C between the SONK patients with 3 types of TCM syndrome(4.72±0.96,4.49±0.90,3.97±0.99 mmol/L,F=6.989,P=0.003; 2.17±1.35,1.44±0.88,1.78±1.16 mmol/L,F=2.927,P=0.039; 3.01±0.99,2.98±0.75,2.45±0.94 mmol/L,F=3.356,P=0.030).The serum levels of TC,TG and LDL-C were higher in SONK patients with phlegm and blood-stasis blocking collaterals syndrome compared to SONK patients with qi-stagnation and blood-stasis syndrome(P=0.026,P=0.036,P=0.022).The serum levels of TC and LDL-C were higher in SONK patients with phlegm and blood-stasis blocking collaterals syndrome,while was lower in SONK patients with qi-stagnation and blood-stasis syndrome compared to SONK patients with liver-kidney deficiency syndrome(P=0.030,P=0.012; P=0.018,P=0.011).The serum level of TG was lower in SONK patients with liver-kidney deficiency syndrome compared to SONK patients with phlegm and blood-stasis blocking collaterals syndrome and those with qi-stagnation and blood-stasis syndrome(P=0.027,P=0.040).There was no statistical significance in the serum levels of HDL-C,Apo-A1,Apo-B and LPA between the SONK patients with 3 types of TCM syndrome(1.04±0.36,1.18±0.35,0.92±0.40 mmol/L,F=0.203,P=0.764; 1.20±0.29,1.18±0.18,1.03±0.25 g/L,F=0.899,P=0.424; 0.86±0.18,0.83±0.22,0.75±0.18 g/L,F=0.186,P=0.801; 0.33±0.10,0.30±0.09,0.29±0.09 g/L,F=0.102,P=0.903).Conclusion:There are great differences in lipid metabolism between SONK patients with phlegm and blood-stasis blocking collaterals syndrome and SONK patients with liver-kidney deficiency syndrome as well as between SONK patients with phlegm and blood-stasis blocking collaterals syndrome and SONK patients with qi-stagnation and blood-stasis syndrome,so attention shall be paid to ameliorate the abnormal lipid metabolism in treatment of SONK with phlegm and blood-stasis blocking collaterals syndrome in clinic.

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備注/Memo

備注/Memo:
基金項目:昆明市衛(wèi)生科技人才培養(yǎng)項目暨“十百千”工程培養(yǎng)計劃項目[2020-SW(后備)-52] 通訊作者:伍衛(wèi)新 E-mail:[email protected]
更新日期/Last Update: 1900-01-01