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[1]祁建華,明洪,張會擇,等.基于數(shù)據(jù)挖掘法探討《世醫(yī)得效方》中治傷方劑的用藥規(guī)律[J].中醫(yī)正骨,2022,34(03):20-25.
　QI Jianhua,MING Hong,ZHANG Huize,et al.A data mining-based analysis of clinical medication rules of prescriptions for treatment of orthopedic and traumatic diseases in Shiyi Dexiao Fang[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2022,34(03):20-25.
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基于數(shù)據(jù)挖掘法探討《世醫(yī)得效方》中治傷方劑的用藥規(guī)律()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第34卷
期數(shù):
2022年03期
頁碼:
20-25
欄目:
文獻研究
出版日期:
2022-03-20

文章信息/Info

Title:
A data mining-based analysis of clinical medication rules of prescriptions for treatment of orthopedic and traumatic diseases in Shiyi Dexiao Fang
作者:
祁建華; 明洪; 張會擇; 胡友鵬; 戴澤林; 楊斐; 陳日高
(成都中醫(yī)藥大學附屬醫(yī)院,四川 成都 610072)
Author(s):
QI Jianhua; MING Hong; ZHANG Huize; HU Youpeng; DAI Zelin; YANG Fei; CHEN Rigao
Hospital of Chengdu University of TCM,Chengdu 610072,Sichuan,China
關(guān)鍵詞:
《世醫(yī)得效方》;  中醫(yī)骨傷科疾病;  方劑分析; 計算機輔助;  數(shù)據(jù)挖掘
Keywords:
Shiyi Dexiao Fang;  orthopedic traumatologic diseases(TCM);  formula anal; comput assist;  data mining
摘要:
目的:探討《世醫(yī)得效方》中治傷方劑的用藥規(guī)律。方法:收集《世醫(yī)得效方》中第18卷“正骨兼金鏃科”中的治傷方劑,建立標準化方藥數(shù)據(jù)庫。采用中醫(yī)傳承計算平臺(V3.0)統(tǒng)計納入方劑中藥物的使用頻次、功效、藥性、藥味及歸經(jīng),采用SPSS Modeler 18.0軟件對其中的高頻藥物進行關(guān)聯(lián)規(guī)則分析,采用SPSS Statistics 26.0軟件對其中的高頻藥物進行聚類分析。結(jié)果:共收集79首方劑,其中內(nèi)服方劑40首、外用方劑39首,共涉及154味中藥。內(nèi)服中藥115味,累計使用頻次278次,使用頻次≥4的中藥共21味,居于前5位的中藥依次為當歸、川芎、乳香、大黃、甘草; 外用中藥81味,累計使用頻次135次,使用頻次≥3的中藥共15味,居于前5位的中藥依次為鉛丹、白芷、楓香脂、地黃、生姜。《世醫(yī)得效方》治傷方劑中內(nèi)服中藥多采用活血化瘀、補虛、解表類藥物,外用中藥主要以解表、清熱、活血化瘀類藥物為主; 藥物多歸肝、脾、心經(jīng),藥味多辛、苦; 內(nèi)服藥的藥性偏溫、平,外用藥的藥性偏溫、寒。對使用頻次≥4的21味內(nèi)服中藥進行關(guān)聯(lián)規(guī)則分析,得到10條關(guān)聯(lián)規(guī)則,涉及10個核心藥物組合,分別為川芎→當歸、沒藥→乳香、蘇木→當歸、白芍→當歸、自然銅→沒藥、肉桂→當歸、白芷→木香、白芷→川芎、白芷→當歸、白芍+川芎→當歸; 對使用頻次≥3的15味外用中藥進行關(guān)聯(lián)規(guī)則分析,得到10條關(guān)聯(lián)規(guī)則,涉及10個核心藥物組合,分別為川芎→白芷、半夏+生姜→黃柏、半夏+黃柏→生姜、生姜+黃柏→半夏、楓香脂+鉛丹→石膏、楓香脂+石膏→鉛丹、楓香脂+鉛丹→白芷、鉛丹+白芷→楓香脂、楓香脂+石膏→白芷、石膏+白芷→楓香脂。聚類分析結(jié)果顯示,使用頻次≥4的21味內(nèi)服中藥可聚為5類,第1類包括白芷、紫金皮、木香、白芍、地黃、川芎,合用能補血活血、行氣止痛; 第2類包括草烏、川烏、麝香、蘇木、鉛丹、大黃,合用能活血止痛; 第3類包括白術(shù)、沉香、甘草、肉桂、生姜,合用能溫補脾腎、行氣止痛; 第4類僅包括當歸,能補血活血; 第5類包括沒藥、自然銅、乳香,合用能活血止痛、生肌接骨。使用頻次≥3的15味外用中藥可聚為4類,第1類包括牛膝、紫金皮、劉寄奴、黃柏、川芎,合用能活血化瘀; 第2類包括生姜、半夏、地黃,合用能解毒散結(jié); 第3類包括龍骨、水松皮、降真香,合用能降氣收斂; 第4類包括白芷、楓香脂、鉛丹、石膏,合用能收斂生肌。結(jié)論:《世醫(yī)得效方》中治傷方劑多采用辛溫之藥,常從肝、脾、心論治,其中內(nèi)服方劑以活血化瘀、補血活血、行氣止痛為主要治法,而外用方劑以解表清熱、活血消腫、收斂生肌為主要治法。
Abstract:
Objective:To explore the clinical medication rules of prescriptions for treatment of orthopedic and traumatic diseases in Shiyi Dexiao Fang.Methods:The prescriptions aimed at treating orthopedic and traumatic diseases were extracted from Volume XVIII of Bonesetting&Battlefield Surgery in Shiyi Dexiao Fang and a standard database for the prescriptions was established.The normalized Chinese herbs(CHs)in the extracted prescriptions were input into the Microsoft Office Excel 2016 software for building a standard database,based on which their usage frequency,efficacy,medicinal property,medicinal flavor and meridian tropism were statistically analyzed by using traditional Chinese medicine inheritance support system(TCMISS)software(V3.0).The high-frequency CHs were then subjected to association rule analysis by using SPSS Modeler 18.0 software and cluster analysis by using SPSS Statistics 26.0 software.Results:Seventy-nine prescriptions(154 CHs)were included in the final analysis,including 40 oral prescriptions(115 CHs)and 39 external-applied prescriptions(81 CHs).Among the 115 oral CHs(appeared 278 times),21 ones displayed a usage frequency of ≥4,and the top 5 ones with high usage frequency included Angelica sinensis,Chuanxiong Rhizoma,Frankincense,Rhei Radix et Rhizoma and Glycyrrhiza Uralensis.Among the 81 external-applied CHs(appeared 135 times),15 ones displayed a usage frequency of ≥3,and the top 5 ones with high usage frequency included Plumbum Rubrum,Angelicae Dahuricae Radix,Liquidambaris Resina,Rehmannia Glutinosa and Zingiberis Rhizoma Recens.The CHs are often the ones presented with pungent flavor and bitter flavor and mainly act on liver meridians,spleen meridians and heart meridians in the prescriptions aimed at treating orthopedic and traumatic diseases in Shiyi Dexiao Fang,among which,the oral CHs are mainly the ones for promoting blood circulation to remove blood stasis,tonifying deficiency as well as relieving superficies with properties mainly as warm and neutral; while the external-applied CHs are mainly the ones for relieving superficies,clearing heat and promoting blood circulation to remove blood stasis with properties mainly as warm and cold.The association rule analysis on the 21 oral CHs with a usage frequency of≥4 yielded 10 association rules,involving 10 core CHs combinations,namely Chuanxiong Rhizoma→Angelica sinensis,Myrrha→Frankincense,Sappan Lignum→Angelica sinensis,Paeoniae Radix Alba→Angelica sinensis,Pyritum→Myrrha,Cinnamomi Cortex→Angelica sinensis,Angelicae Dahuricae Radix→Aucklandiae Radix,Angelicae Dahuricae Radix→Chuanxiong Rhizoma,Angelicae Dahuricae Radix→Angelica sinensis and Paeoniae Radix Alba+Chuanxiong Rhizoma→Angelica sinensis.The association rule analysis on the 15 external-applied CHs with a usage frequency of≥3 yielded 10 association rules,involving 10 core CHs combinations,namely Chuanxiong Rhizoma→Angelicae Dahuricae Radix,Pinelliae Rhizoma+Zingiberis Rhizoma Recens→Phellodendri Chinensis Cortex,Pinelliae Rhizoma+Phellodendri Chinensis Cortex→Zingiberis Rhizoma Recens,Zingiberis Rhizoma Recens+Phellodendri Chinensis Cortex→Pinelliae Rhizoma,Liquidambaris Resina+Plumbum Rubrum→Gypsum Fibrosum,Liquidambaris Resina+Gypsum Fibrosum→Plumbum Rubrum,Liquidambaris Resina+Plumbum Rubrum→Angelicae Dahuricae Radix,Plumbum Rubrum+Angelicae Dahuricae Radix→Liquidambaris Resina,Liquidambaris Resina+Gypsum Fibrosum→Angelicae Dahuricae Radix and Gypsum Fibrosum+Angelicae Dahuricae Radix→Liquidambaris Resina.As revealed by the cluster analysis,the 21 oral CHs with a usage frequency of≥4 were clustered into 5 categories,with Angelicae Dahuricae Radix,Glaucousback Threewingnut Root-bark,Aucklandiae Radix,Paeoniae Radix Alba,Rehmannia Glutinosa and Chuanxiong Rhizoma into Category I,which served together can tonify and activate blood and promot qi circulation to relieve pain; Aconiti Kusnezoffii Radix,Aconiti Radix,Moschus,Sappan Lignum,Plumbum Rubrum and Rhei Radix et Rhizoma into CategoryⅡ,which served together can promot blood circulation to arrest pain; Atractmlodis Macrocephalae Rhizoma,Aquilariae Lignum Resinatum,Glycyrrhiza Uralensis,Cinnamomi Cortex and Zingiberis Rhizoma Recens into CategoryⅢ,which served together can warmly tonify the spleen and kidney and promot qi circulation to relieve pain; Angelica sinensis alone into CategoryⅣ,which can tonify and activate blood; and Myrrha,Pyritum and Frankincense into CategoryⅤ,which served together can promot blood circulation to arrest pain,promote granulation and reunite fractured bone.The 15 external-applied CHs with a usage frequency of≥3 were clustered into 4 categories,with Achyranthes Bidentatae Radix(TCD),Glaucousback Threewingnut Root-bark,Herba Artemisia Anomala,Phellodendri Chinensis Cortex and Chuanxiong Rhizoma into Category I,which served together can promot blood circulation to remove blood stasis; Zingiberis Rhizoma Recens,Pinelliae Rhizoma and Rehmannia Glutinosa into CategoryⅡ,which served together can resolve toxin and dissipate binds; Os Draconis,Glyptostrobus pensilis Cortex and Acronychia pedunculata into CategoryⅢ,which served together can descend qi and astringe; and Angelicae Dahuricae Radix,Liquidambaris Resina,Plumbum Rubrum and Gypsum Fibrosum into CategoryⅣ,which served combinedly can astringe and promote granulation.Conclusion:The CHs with pungent flavor and warm property mainly act on liver meridians,spleen meridians and heart meridians are more preferred in the prescriptions aimed at treating orthopedic and traumatic diseases in Shiyi Dexiao Fang,among which,the oral CHs are mainly the ones for promoting blood circulation to remove blood stasis,tonifying and activating blood as well as promoting qi circulation to relieve pain,and the external-applied CHs are mainly the ones for relieving superficies and clearing heat,activating blood and alleviating edema as well as astringency and promoting granulation.

參考文獻/References:

[1] 徐春娟,陳榮,陳建章.對元代名著《世醫(yī)得效方》的研究[J].中國實驗方劑學雜志, 2012,18(14):317-319.
[2] 鄒來勇,涂國卿,湯群珍.《世醫(yī)得效方》傷科證治特色[J].上海中醫(yī)藥雜志,2010,44(3):56-57.
[3] 國家藥典委員會.中華人民共和國藥典:一部[M].北京:中國醫(yī)藥科技出版社,2020.
[4] 國家中醫(yī)藥管理局.中華本草[M].上海:上海科學技術(shù)出版社,1999.
[5] 南京中醫(yī)藥大學.中藥大辭典[M].上海:上海科學技術(shù)出版社,2006.
[6] 涂鵬程,郭楊,馬勇,等.馬勇以“陰陽為綱,氣血為本,陽氣為先”思想指導骨傷科疾病治療[J].中華中醫(yī)藥雜志, 2020,35(2):732-734.
[7] 陳二林,李喜香,伍珊娜,等.基于活血生物效價的當歸質(zhì)量評價研究[J].中藥材,2019,42(4):818-821.
[8] 蒲忠慧,代敏,彭成,等.川芎生物堿的物質(zhì)基礎(chǔ)及藥理作用研究進展[J].中國藥房,2020,31(8):1020-1024.
[9] 劉志強,王博龍.計算機模擬研究肝素聯(lián)合川芎嗪的協(xié)同抗血栓藥理機制[J].中國醫(yī)院藥學雜志,2019,39(3):247-254.
[10] 劉迪,張冰洋,姚鐵,等.乳香化學成分及藥理作用研究進展[J].中草藥,2020,51(22):5900-5914.
[11] 楊煬,稅丕先,陳滟,等.中藥大黃在臨床應(yīng)用中的功效以及對其藥理作用[J].基因組學與應(yīng)用生物學,2017,36(3):1226-1231.
[12] 鄧桃妹,彭燦,彭代銀,等.甘草化學成分和藥理作用研究進展及質(zhì)量標志物的探討[J].中國中藥雜志,2021,41(11):2660-2676.
[13] 王蕊,劉軍,楊大宇,等.白芷化學成分與藥理作用研究進展[J].中醫(yī)藥信息,2020,37(2):123-128.
[14] 連靖娉,劉溯,王倩.生地黃煎劑對膿毒癥患者血小板及凝血功能的影響[J].實用臨床醫(yī)藥雜志,2016,20(7):166-167.
[15] 莫瓊,郝二偉,覃文慧,等.平性活血化瘀中藥物質(zhì)基礎(chǔ)與藥理作用的研究進展[J].中國實驗方劑學雜志,2020,26(1):205-216.
[16] 高櫻,楊龍飛,翟陽,等.具有活血化瘀功效的中藥藥理作用及機制研究進展[J].中華中醫(yī)藥雜志,2018,33(11):5053-5056.
[17] 周鴻,黃含含,張靜澤,等.川芎-當歸藥對研究進展[J].中成藥,2015,37(1):184-188.
[18] 蔣海峰,宿樹蘭,歐陽臻,等.乳香、沒藥提取物及其配伍對血小板聚集與抗凝血酶活性的影響[J].中國實驗方劑學雜志,2011,17(19):160-165.
[19] 劉陸,安玉芳.中藥川烏與草烏的研究進展[J].黑龍江中醫(yī)藥,2019,48(2):175-177.
[20] 蔣燕萍,甘彥雄,嚴鑫,等.自然銅的研究進展[J].中藥與臨床,2016,7(1):62-64.
[21] 林遠茂,施榮聰,孫誠攻,等.基于網(wǎng)絡(luò)藥理學分析北劉寄奴的活性成分及其藥效作用機制[J].中醫(yī)藥導報,2020,26(10):46-51.
[22] 張曉娟,張燕麗,左冬冬.川芎的化學成分和藥理作用研究進展[J].中醫(yī)藥信息,2020,37(6):128-133.
[23] 林俊濤,劉俊,徐紫丹,等.降真香不同溶劑萃取物對口腔常見菌的抑菌活性研究[J].生物化工,2021,7(1):40-43.
(收稿日期:2021-06-16 本文編輯:時紅磊)

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通訊作者:陳日高 E-mail:[email protected]
更新日期/Last Update: 1900-01-01