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[1]張杰,丁權(quán)威,張玉柱,等.基于數(shù)據(jù)挖掘法探討張玉柱教授治療神經(jīng)根型頸椎病的辨證用藥規(guī)律[J].中醫(yī)正骨,2021,33(11):41-44.
　ZHANG Jie,DING Quanwei,ZHANG Yuzhu,et al.Clinical medication rules of Professor ZHANG Yuzhu in treatment of nerve-root type cervical spondylosis based on syndrome differentiation principles:a data mining-based study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2021,33(11):41-44.
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基于數(shù)據(jù)挖掘法探討張玉柱教授治療神經(jīng)根型頸椎病的辨證用藥規(guī)律()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第33卷
期數(shù):
2021年11期
頁(yè)碼:
41-44
欄目:
調(diào)查研究
出版日期:
2021-11-20

文章信息/Info

Title:
Clinical medication rules of Professor ZHANG Yuzhu in treatment of nerve-root type cervical spondylosis based on syndrome differentiation principles:a data mining-based study
作者:
張杰1; 丁權(quán)威1; 張玉柱1; 王人彥2
(1.杭州市富陽(yáng)中醫(yī)骨傷醫(yī)院,浙江 杭州 311400; 2.浙江骨傷醫(yī)院,浙江 杭州 310015)
Author(s):
ZHANG Jie1; DING Quanwei1; ZHANG Yuzhu1; WANG Renyan2
1.Fuyang TCM Orthopedic-Traumatological Hospital,Hangzhou 311400,Zhejiang,China2.Zhejiang Orthopaedics Hospital,Hangzhou 310015,Zhejiang,China
關(guān)鍵詞:
頸椎病;  中藥療法;  方劑分析; 計(jì)算機(jī)輔助;  數(shù)據(jù)挖掘
Keywords:
cervical spondylosis;  drug therapy(TCD);  formula anal; comput assist;  data mining
摘要:
目的:探討張玉柱教授治療神經(jīng)根型頸椎病的用藥規(guī)律。方法:收集2018年6月至2020年12月在張玉柱教授診室就診的神經(jīng)根型頸椎病患者的病例資料,提取患者的診斷信息(包括癥狀、診斷和中醫(yī)證型)、處方信息(包括方劑組成、藥物劑量)。對(duì)原始數(shù)據(jù)進(jìn)行規(guī)范化處理后,建立藥-方-證數(shù)據(jù)庫(kù)。采用Clementine12.0軟件進(jìn)行數(shù)據(jù)挖掘,統(tǒng)計(jì)分析處方中藥物出現(xiàn)的頻次,采用關(guān)聯(lián)規(guī)則分析方劑中的組方規(guī)律,采用因子分析預(yù)測(cè)可能的新方組合。結(jié)果:①用藥頻次分析結(jié)果。共納入1000首方劑,使用頻次≥116的中藥共25味,其中使用頻次居于前10位的藥物依次為當(dāng)歸、川芎、葛根、地龍、片姜黃、黃芪、炒白芍、豨薟草、羌活、澤蘭。②組方規(guī)律分析結(jié)果。對(duì)所有藥物進(jìn)行關(guān)聯(lián)規(guī)則分析,共得到15個(gè)核心藥物組方,分別為當(dāng)歸-地龍-川芎、當(dāng)歸-地龍-川芎-紅花、當(dāng)歸-地龍、川芎-地龍-紅花、當(dāng)歸-地龍-紅花、當(dāng)歸-川芎、紅花-葛根-川芎、當(dāng)歸-川芎-紅花、紅花-葛根-川芎-當(dāng)歸、當(dāng)歸-紅花、當(dāng)歸-葛根-川芎、川芎-地龍、當(dāng)歸-葛根、當(dāng)歸-葛根-紅花、紅花-地龍。③新方預(yù)測(cè)結(jié)果。通過(guò)因子分析,共得到5種證型基礎(chǔ)方,分別為枸杞子-狗脊-片姜黃-羌活-澤蘭-菊花-炒白芍-炒杜仲-天麻-葛根-石斛、淫羊藿-丹參-川芎-豨薟草-水蛭、黃芪-制川烏-桂枝-僵蠶-當(dāng)歸-夏枯草-地龍、桂枝-僵蠶-豨薟草-水蛭-地龍-制川烏、威靈仙-羌活-防風(fēng)-葛根。結(jié)論:張玉柱教授治療神經(jīng)根型頸椎病的用藥特點(diǎn)為補(bǔ)行兼施、通經(jīng)活絡(luò),常用藥物包括補(bǔ)血活血藥、活血通絡(luò)藥、補(bǔ)血通絡(luò)藥、補(bǔ)血活血通絡(luò)藥4類。
Abstract:
Objective:To explore the clinical medication rules of Professor ZHANG Yuzhu in treatment of nerve-root type cervical spondylosis(NT-CS).Methods:The medical records of NT-CS patients who were diagnosed and treated by Professor ZHANG Yuzhu from June 2018 to December 2020 were collected,and the diagnostic information(including symptoms,diagnosis and TCM syndrome types)and prescription information(including prescription ingredients and dosages)were extracted and were normalized for building a herb-prescription-syndrome database.The data mining was conducted by using Clementine12.0 software,followed by statistics and analysis on the occurrence frequency of Chinese herbs in prescriptions.The prescription rules were analyzed based on association rules,and the new prescription combinations were predicted by using factor analysis.Results:①One thousand prescriptions were included in the final analysis,among which 25 herbs displayed a usage frequency of≥116,and the top 10 ones with high usage frequency included Angelica sinensis,Chuanxiong Rhizoma,Puerariae Lobamle Radix,Pheretima,Wenyujin Rhizoma Concisum,Astragalus propinquus,parched Paeoniae Radix Alba,Siegesbeckiae Herba,Notopterygii Rhizoma et Radix and Lycopi Herba in turn.②The association rule analysis on all the included herbs generated 15 core herb combinations,namely Angelica sinensis-Pheretima-Chuanxiong Rhizoma,Angelica sinensis-Pheretima-Chuanxiong Rhizoma-Carthamus tinctorius,Angelica sinensis-Pheretima,Chuanxiong Rhizoma-Pheretima-Carthamus tinctorius,Angelica sinensis-Pheretima-Carthamus tinctorius,Angelica sinensis-Chuanxiong Rhizoma,Carthamus tinctorius-Puerariae Lobamle Radix-Chuanxiong Rhizoma,Angelica sinensis-Chuanxiong Rhizoma-Carthamus tinctorius,Carthamus tinctorius-Puerariae Lobamle Radix-Chuanxiong Rhizoma-Angelica sinensis,Angelica sinensis-Carthamus tinctorius,Angelica sinensis-Puerariae Lobamle Radix-Chuanxiong Rhizoma, Chuanxiong Rhizoma-Pheretima,Angelica sinensis-Puerariae Lobamle Radix,Angelica sinensis-Puerariae Lobamle Radix-Carthamus tinctorius and Carthamus tinctorius-Pheretima.③Five new basic prescriptions were dug out through factor analysis,namely Lycii Fructus-Cibotii Rhizoma-Wenyujin Rhizoma Concisum-Notopterygii Rhizoma et Radix-Lycopi Herba-Chrysanthemi Flos-parched Paeoniae Radix Alba-parched Eucommiae Cortex-Gastrodiae Rhizoma-Puerariae Lobamle Radix-Dendrobii Caulis,Epimedii Folium-Salvia miltiorrhiza-Chuanxiong Rhizoma-Siegesbeckiae Herba-Leeches,Astragalus propinquus-Aconiti Radix Cocta-Cmnamomi Mmulus-Bombyx Batryticatus-Angelica sinensis-Prunellae Spica-Pheretima,Cmnamomi Mmulus-Bombyx Batryticatus-Siegesbeckiae Herba-Leeches-Pheretima-Aconiti Radix Cocta and Clematidis Radix et Rhizoma-Notopterygii Rhizoma et Radix-Saposhnikoviae Radix-Puerariae Lobamle Radix.Conclusion:Professor ZHANG Yuzhu mainly focuses on combinat reinforcing-promoting as well as unblocking meridian and activating collaterals in treatment of NT-CS,and his commonly used herbs include the ones for nourishing and activating blood,activating blood and dredging collaterals,nourishing blood and dredging collaterals as well as nourishing blood,activating blood and dredging collaterals.

參考文獻(xiàn)/References:

[1] 李建壘,宋永偉.神經(jīng)根型頸椎病的中西醫(yī)治療概況[J].中國(guó)醫(yī)藥導(dǎo)刊,2020,22(6):381-384.
[2] 孫奇,楊力,王人彥,等.基于數(shù)據(jù)挖掘的張玉柱治療老年退行性腰痛的用藥規(guī)律的研究[J].中華中醫(yī)藥學(xué)刊,2016,34(2):277-279.
[3] TZENG Y S,CHEN S G,CHEN T M.Herniation of the cervical disk in plastic surgeons[J].Ann Plast Surg,2012,69(6):672-674.
[4] XIONG W,LI F,GUAN H.Tetraplegia after thyroidectomy in a patient with cervical spondylosis:a case report and literature review[J].Medicine(Baltimore),2015,94(6):e524.
[5] INOUE S,MORIYAMA T,TACHIBANA T,et al.Risk factors for intraoperative lateral mass fracture of lateral mass screw fixation in the subaxial cervical spine[J].J Neurosurg Spine,2014,20(1):11-17.
[6] 曾慶.神經(jīng)根型頸椎病的中醫(yī)藥治療近況[J].中醫(yī)臨床研究,2017,9(16):132-133.
[7] 張宏翔,付小勇.高效用挖掘算法在處方數(shù)據(jù)中的應(yīng)用[J].信息與電腦,2017(18):39-41.
[8] 王東,王益民,張伯禮.方劑“組方配伍網(wǎng)絡(luò)”分析方法研究—以名老中醫(yī)門診處方數(shù)據(jù)為例[J].天津中醫(yī)藥大學(xué)學(xué)報(bào),2019,38(1):1-5.
[9] 白揚(yáng),林江,任素劍,等.數(shù)據(jù)挖掘在方劑學(xué)研究中的應(yīng)用與發(fā)展[J].山東中醫(yī)藥大學(xué)學(xué)報(bào),2019,43(1):24-27.
[10] 毛卓鵬,劉紅寧,熊延熙,等.數(shù)據(jù)挖掘在方劑配伍規(guī)律研究中的應(yīng)用述評(píng)[J].江西中醫(yī)藥大學(xué)學(xué)報(bào),2017,29(6):118-121.
[11] 白揚(yáng),林江,任素劍,等.數(shù)據(jù)挖掘在方劑研究中的應(yīng)用與發(fā)展[J].山東中醫(yī)藥大學(xué)學(xué)報(bào),2019,43(1):24-27.
[12] 蔣志濱.基于數(shù)據(jù)挖掘的方劑配伍規(guī)律研究方法探討[D].南京:南京中醫(yī)藥大學(xué),2015.
[13] 班圓圓,彭欣.數(shù)據(jù)挖掘技術(shù)在方劑學(xué)研究中的應(yīng)用進(jìn)展[J].山東中醫(yī)雜志,2016,35(11):1002-1004.
[14] 毛卓鵬,劉紅寧,熊延熙,等.數(shù)據(jù)挖掘在方劑配伍規(guī)律研究中的應(yīng)用評(píng)述[J].江西中醫(yī)藥大學(xué)學(xué)報(bào),2017,29(6):118-121.
[15] 雷金星.基于大數(shù)據(jù)下的空間數(shù)據(jù)挖掘分析[J].內(nèi)蒙古科技與經(jīng)濟(jì),2016,20(3):156-158.
[16] 曹毅,季聰華.臨床科研設(shè)計(jì)與分析[M].杭州:浙江科學(xué)技術(shù)出版社,2015:189.
[17] 吳磊,李舒.中醫(yī)方劑數(shù)據(jù)庫(kù)文本挖掘數(shù)據(jù)預(yù)處理的嘗試[J].中國(guó)中醫(yī)藥圖書(shū)情報(bào)雜志,2015,39(3):8-11.
[18] 郝懷宇,閆立民,王守利,等.觀察分析神經(jīng)根型頸椎病手術(shù)治療的臨床療效[J].系統(tǒng)醫(yī)學(xué),2017,2(9):45-47.
[19] 孟光強(qiáng).神經(jīng)根型頸椎病手術(shù)治療的療效觀察[J].臨床醫(yī)藥文獻(xiàn)電子雜志,2019,6(31):43.
[20] 胥少汀,葛寶豐,盧世璧.實(shí)用骨科學(xué):第4版修訂本[M].北京:人民軍醫(yī)出版社,2019:1974.
[21] 羅芳.神經(jīng)根型頸椎病的診斷研究進(jìn)展[J].癲癇與神經(jīng)電生理學(xué)雜志,2017,26(2):113-115.
[22] 中華醫(yī)學(xué)會(huì).臨床診療指南:骨科分冊(cè)[M].北京:人民衛(wèi)生出版社,2009:87.
[23] 鐘贛生.中藥學(xué)[M].北京:中國(guó)中醫(yī)藥出版社,2013.
[24] 國(guó)家中醫(yī)藥管理局.中醫(yī)病證診斷療效標(biāo)準(zhǔn)[M].南京:南京大學(xué)出版社,1994:189.
[25] 季聰華,曹毅,張穎,等.基于SPSS Clementine 軟件的關(guān)聯(lián)規(guī)則算法的應(yīng)用[J].中醫(yī)藥管理雜志,2014,22(1):31-33.
[26] 徐雪琪.數(shù)據(jù)挖掘方法與應(yīng)用[M].北京:清華大學(xué)出版社,2020:22.
[27] 郭曙光,李曉艷,張中青.肢體經(jīng)絡(luò)病證的特征與通經(jīng)活絡(luò)法[J].中國(guó)民族民間醫(yī)藥,2010,19(2):54-55.

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　SUN Xianwu,YU Xianglan,SHAO Haiyan,et al.Clinical study on three-dimensional dynamic and static equilibrium rehabilitation modality in the treatment of non-myelopathy type cervical spondylosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(11):8.
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[12]陳 偉.鄧友章教授治療頸椎病的經(jīng)驗(yàn)[J].中醫(yī)正骨,2016,28(06):68.

備注/Memo

備注/Memo:
基金項(xiàng)目:全國(guó)名老中醫(yī)藥專家傳承工作室建設(shè)項(xiàng)目(國(guó)中醫(yī)藥人教發(fā)〔2013〕47號(hào))
通訊作者:張杰 E-mail:[email protected]
更新日期/Last Update: 1900-01-01