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[1]王用玉,陳博,許坤,等.口服補腎活血中藥治療老年橈骨遠端骨折臨床療效的Meta分析[J].中醫(yī)正骨,2021,33(09):25-31.
　WANG Yongyu,CHEN Bo,XU Kun,et al.Clinical efficacy of oral application of Bushen Huoxue(補腎活血)traditional Chinese drugs for treatment of distal radius fractures in the aged:a meta-analysis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2021,33(09):25-31.
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口服補腎活血中藥治療老年橈骨遠端骨折臨床療效的Meta分析()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第33卷
期數(shù):
2021年09期
頁碼:
25-31
欄目:
文獻研究
出版日期:
2021-09-20

文章信息/Info

Title:
Clinical efficacy of oral application of Bushen Huoxue(補腎活血)traditional Chinese drugs for treatment of distal radius fractures in the aged:a meta-analysis
作者:
王用玉1; 2; 陳博1; 2; 許坤1; 2; 田飚1; 2; 張潔帆1; 2; 郭海玲1; 2; 趙詠芳1; 2; 詹紅生1; 2; 陳元川1; 2; 龐堅1; 2
(1.上海中醫(yī)藥大學(xué)附屬曙光醫(yī)院,上海 201203; 2.上海市中醫(yī)藥研究院骨傷科研究所,上海 201203)
Author(s):
WANG Yongyu1; 2; CHEN Bo1; 2; XU Kun1; 2; TIAN Biao1; 2; ZHANG Jiefan1; 2; GUO Hailing1; 2; ZHAO Yongfang1; 2; ZHAN Hongsheng1; 2; CHEN Yuanchuan1; 2; PANG Jian1; 2
1.Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China2.The Institute of Traumatology and Orthopedics Affiliated to Shanghai Academy of Traditional Chinese Medicine,Shanghai 201203,China
關(guān)鍵詞:
橈骨骨折;  腕關(guān)節(jié);  老年人;  補腎活血中藥;  Meta分析;  系統(tǒng)評價
Keywords:
radius fractures;  carpal joints;  aged;  reinforcing kidney and activating blood(TCD);  meta analysis;  systematic review
摘要:
目的:系統(tǒng)評價口服補腎活血中藥治療老年橈骨遠端骨折的臨床療效。方法:應(yīng)用計算機檢索中國知網(wǎng)、萬方數(shù)據(jù)庫、維普網(wǎng)、中國生物醫(yī)學(xué)文獻數(shù)據(jù)庫、PubMed、Cochrane Library、Web of science、EBSCO、EMbase建庫至2020年1月收錄的有關(guān)閉合復(fù)位夾板固定或切開復(fù)位內(nèi)固定術(shù)聯(lián)合口服補腎活血中藥(試驗組)和單純閉合復(fù)位夾板固定或切開復(fù)位內(nèi)固定術(shù)(對照組)治療老年橈骨遠端骨折的隨機對照臨床研究文獻。由2名研究者按照納入、排除標準獨立進行文獻篩選和數(shù)據(jù)提取,采用Cochrane偏倚風險評估工具對納入研究文獻的質(zhì)量進行評價,采用RevMan5.3軟件進行Meta分析。結(jié)果:共檢索出1569篇文獻,最終納入12篇文獻,共涉及1039例老年橈骨遠端骨折患者,其中對照組519例、試驗組520例。Meta分析結(jié)果顯示,試驗組骨折愈合時間短于對照組[I2=0%,P=1.000,MD=-0.77,95%CI(-0.94,-0.59)],Gartland-Werley腕關(guān)節(jié)功能評分低于對照組[I2=26%,P=0.190,MD=-2.21,95%CI(-2.43,-1.98)],腕關(guān)節(jié)患者自評量表評分低于對照組[I2=0%,P=1.000,MD=-3.97,95%CI(-4.85,-3.10)],橈骨骨折愈合評分系統(tǒng)(radius union scoring system,RUSS)評分高于對照組[I2=99%,P=0.000,MD=0.53,95%CI(0.09,0.98)]; 按補腎活血中藥的劑量及藥物組成進行亞組分析,補腎活血湯高、低劑量組RUSS評分均高于對照組[I2=0%,P=0.830,MD=0.50,95%CI(0.41,0.59); I2=60%,P=0.110,MD=1.03,95%CI(0.81,1.24)],其他補腎活血中藥(非補腎活血湯)組RUSS評分高于對照組[I2=0%,P=0.410,MD=0.83,95%CI(0.74,0.93)]。結(jié)論:現(xiàn)有的證據(jù)表明,采用口服補腎活血中藥治療老年橈骨遠端骨折,能促進骨折愈合、改善腕關(guān)節(jié)功能。
Abstract:
Objective:To systematically review the clinical curative effects of oral application of Bushen Huoxue(補腎活血,BSHX)traditional Chinese drugs(TCDs)for treatment of distal radius fractures(DRFs)in the aged.Methods:All the randomized controlled trial(RCT)articles about closed reduction splint fixation combined with oral application of BSHX TCDs or open reduction internal fixation(ORIF)combined with oral application of BSHX TCDs(experimental group)versus closed reduction splint fixation or ORIF alone(control group)for treatment of DRFs in the aged included from database establishing to January 2020 were retrieved from China national knowledge internet,WanFang Database,Vip Database,Chinese biomedical literature database,PubMed,Cochrane Library,Web of science,EBSCO and EMbase through computer.The articles were screened and the information was extracted independently by two researchers according to the inclusion and exclusion criteria.The methodological quality of research in the articles was evaluated by using Cochrane bias risk assessment tools,and a Meta-analysis was conducted by using RevMan 5.3 software.Results:One thousand five hundred and sixty-nine articles were searched out.After screening,12 articles(1039 patients)were included in the final analysis,519 patients in control group and 520 patients in experimental group.The results of Meta-analysis revealed that the fracture healing time was shorter,the Gartland-Werley wrist function scores and Patient-Rated Wrist Evaluation(PRWE)scores were lower and the radius union scoring system(RUSS)scores were higher in experimental group compared to control group(I2=0%,P=1.000,MD=-0.77,95%CI(-0.94,-0.59); I2=26%,P=0.190,MD=-2.21,95%CI(-2.43,-1.98); I2=0%,P=1.000,MD=-3.97,95%CI(-4.85,-3.10); I2=99%,P=0.000,MD=0.53,95%CI(0.09,0.98)).The subgroup analysis was conducted according to the doses and ingredients of BSHX TCDs respectively,and the results showed that the RUSS scores were higher in BSHX Tang(補腎活血湯, BSHXT)high- and low-dose group compared to control group(I2=0%,P=0.830,MD=0.50,95%CI(0.41,0.59); I2=60%,P=0.110,MD=1.03,95%CI(0.81,1.24)),and were higher in other BSHX TCDs group(excluding BSHXT)compared to control group(I2=0%,P=0.410,MD=0.83,95%CI(0.74,0.93)).Conclusion:Available evidences suggest that oral application of BSHX TCDs can promote fracture healing and improve wrist function in treatment of DRFs in the aged.

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備注/Memo

備注/Memo:
基金項目:國家自然科學(xué)基金項目(81674003,81102603); 上海市進一步加快中醫(yī)藥事業(yè)發(fā)展三年行動計劃(2018年-2020年)項目[ZY(2018-2020)-CCCX-2003-05]; 全國中醫(yī)學(xué)術(shù)流派傳承工作室第二輪建設(shè)項目(國中醫(yī)藥人教〔2019〕62號); 上海市臨床重點專科建設(shè)項目(shslczdzk03901); 上海市2020年度“科技創(chuàng)新行動計劃”醫(yī)學(xué)創(chuàng)新研究專項項目(20MC1920600)
通訊作者:龐堅 E-mail:[email protected] 陳博 E-mail:[email protected]
更新日期/Last Update: 1900-01-01