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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:

第33卷

期數(shù):

2021年08期

頁(yè)碼:

28-32

欄目:

文獻(xiàn)研究

出版日期:

2021-08-20

文章信息/Info

Title:

Medication rules of external-applied Chinese herbal medicine prescriptions for treatment of lumbar spinal stenosis:a data mining-based analysis

作者:

張亞運(yùn); 許金海; 莫文

(上海中醫(yī)藥大學(xué)附屬龍華醫(yī)院,上海 200032)

Author(s):

ZHANG Yayun; XU Jinhai; MO Wen

Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China

關(guān)鍵詞:

外治法;  椎管狹窄;  腰椎;  方劑分析; 計(jì)算機(jī)輔助;  數(shù)據(jù)挖掘

Keywords:

external therapies;  spinal stenosis;  lumbar vertebrae;  formula anal comput assist;  data mining

摘要:

目的:分析腰椎椎管狹窄癥中藥外用方的用藥規(guī)律。方法:利用計(jì)算機(jī)檢索中國(guó)知網(wǎng)、萬(wàn)方醫(yī)學(xué)網(wǎng)、維普網(wǎng)中關(guān)于中藥外用治療腰椎椎管狹窄癥的文獻(xiàn),檢索時(shí)限均為1990年1月1日至2020年12月31日。提取入選文獻(xiàn)中的外用方劑,統(tǒng)計(jì)方劑的組成藥物(包括加減藥物)及藥物的功效、性、味、歸經(jīng),并對(duì)提取的信息進(jìn)行規(guī)范化處理。將提取的藥物信息錄入Microsoft Excel 2016軟件,建立數(shù)據(jù)庫(kù),統(tǒng)計(jì)各種藥物出現(xiàn)的頻次及藥物的功效、性、味、歸經(jīng)分布情況; 采用SPSS25.0軟件對(duì)篩選出的高頻藥物以Q型聚類(lèi)方法進(jìn)行聚類(lèi)分析; 采用SPSS Modeler18.0軟件對(duì)篩選出的高頻藥物進(jìn)行關(guān)聯(lián)規(guī)則分析。結(jié)果:共檢索到217篇文獻(xiàn),通過(guò)篩選最終納入40篇。40篇文獻(xiàn)包含40首外用方劑,涉及119味中藥。119味中藥累計(jì)出現(xiàn)517次,其中出現(xiàn)頻率>1.00%的中藥共32味。119味中藥按照功效分為12類(lèi),其中理血藥占比居第1位、祛風(fēng)濕藥居第2位、補(bǔ)益藥居第3位; 溫性藥出現(xiàn)的頻次最多(264次),其次為平性藥(105次)和寒性藥(104次); 藥味出現(xiàn)頻次前3位的依次為辛味(315次)、甘味(113次)、苦味(69次); 119味中藥涵蓋了11種不同的歸經(jīng),排在前3位的分別是肝經(jīng)(371次)、脾經(jīng)(200次)和腎經(jīng)(135次)。聚類(lèi)分析結(jié)果顯示,32味高頻中藥可聚為3類(lèi),第1類(lèi)包括莪術(shù)、三棱、艾葉、伸筋草、透骨草、蘇木,第2類(lèi)包括延胡索、白芷、姜黃、木香、羌活、花椒、五加皮,第3類(lèi)包括川芎、當(dāng)歸、木瓜、秦艽、赤芍、杜仲、獨(dú)活、防風(fēng)、大黃、草烏、川烏、桂枝、紅花、沒(méi)藥、乳香、威靈仙、細(xì)辛、海桐皮、大血藤。通過(guò)對(duì)32味高頻中藥進(jìn)行關(guān)聯(lián)規(guī)則分析,共獲得9個(gè)關(guān)聯(lián)規(guī)則,涉及7個(gè)核心藥物組合,分別為伸筋草-透骨草、威靈仙-沒(méi)藥、乳香-沒(méi)藥、草烏-川烏、草烏-紅花、威靈仙-沒(méi)藥-乳香、沒(méi)藥-紅花-乳香。結(jié)論:腰椎椎管狹窄癥中藥外用方多以理血藥為核心,輔以祛風(fēng)濕藥和補(bǔ)益藥,多用性溫,味辛、甘,入肝、脾、腎經(jīng)的中藥; 多以伸筋草、透骨草、乳香、沒(méi)藥、威靈仙、川烏、草烏、紅花為核心進(jìn)行加減組方。

Abstract:

Objective:To analyze the medication rules of external-applied Chinese herbal medicine(CHM)prescriptions in treatment of lumbar spinal stenosis(LSS).Methods:The articles concerning external application of CHM for treatment of LSS included from January 1,1990 to December 31,2020 were retrieved from China National Knowledge Internet(CNKI),Wanfang Med Online and VIP Database through computer.The external-applied CHM prescriptions were extracted from the included articles and were normalized,followed by statistics on the specific Chinese herbs(including those in modified prescriptions)as well as their efficacy,property,flavor and meridian tropism.The extracted and normalized Chinese herb information was input into the Microsoft Excel 2016 software for building a database,based on which their occurrence frequency as well as efficacy,property,flavor and meridian tropism were statistically analyzed.The high-frequency Chinese herbs were then subjected to Q-mode cluster analysis and association rule analysis by using SPSS25.0 software and SPSS Modeler18.0 software respectively.Results:Two hundred and seventeen articles were searched out.After screening,40 articles were included in the final analysis,involving 40 external-applied CHM prescriptions and 119 Chinese herbs(appeared 517 times),among which 32 ones displayed a occurrence frequency of >1.00%.The 119 Chinese herbs were classified into 12 categories according to their efficacy,and the top 3 herbs with high proportion included blood-regulating herbs,wind-dampness-dispelling herbs and tonifying herbs in turn.Sorted by property,the most frequently appeared Chinese herbs were those with a warm property(264 times),followed by the ones with a neutral property(105 times)and a cold property(104 times).The Chinese herbs with pungent,sweet and bitter flavors were more preferred,with their usage frequency of being 315,113 and 69 times respectively.The 119 Chinese herbs were categorized into 11 types by meridian tropism,and they mainly acted on the liver meridians(371 times),spleen meridians(200 times)and kidney meridians(135 times).As revealed by the cluster analysis,the 32 high-frequency Chinese herbs were clustered into three classes,with Rhizoma Curcumae,Sparganii Rhizoma,Folium Artemisiae Argyi,Herba Lycopodii,Herba Speranskiae Tuberculatae and Lignum Sappan into Class I; Rhizoma Corydalis,Radix Angelicae Dahuricae,Rhizoma Curcumae Longae,Radix Aucklandiae,Rhizoma et Radix Notopterygii,Pericarpium Zanthoxyli and Cortex Acanthopanacis into ClassⅡ; and Rhizoma Ligustici Chuanxiong,Radix Angelicae Sinensis,Fructus Chaenomelis,Radix Gentianae Macrophyllae,Radix Paeoniae Rubra,Cortex Eucommiae,Radix Angelicae Pubescentis,Radix Saposhnikoviae,Radix et Rhizoma Rhei,Radix Aconiti Kusnezoffii,Radix Aconiti,Ramulus Cinnamomi,Flos Carthami,Myrrha,Olibanum,Radix Clematidis,Herba Asari,Cortex Erythrinae and Caulis Sargentodoxae into ClassⅢ.The association rule analysis of the 32 high-frequency Chinese herbs yielded 9 association rules,involving 7 core herb combinations,namely Herba Lycopodii-Herba Speranskiae Tuberculatae,Radix Clematidis-Myrrha,Olibanum-Myrrha,Radix Aconiti Kusnezoffii-Radix Aconiti,Radix Aconiti Kusnezoffii-Flos Carthami,Radix Clematidis-Myrrha-Olibanum and Myrrha-Flos Carthami-Olibanum.Conclusion:The external-applied Chinese herbal prescriptions for LSS are centred on blood-regulating herbs,supplemented by wind-dampness-dispelling herbs and tonifying herbs,which are often warm in property and pungent and sweet in flavor and acts on the liver meridians,spleen meridians and kidney meridians.Herba Lycopodii,Herba Speranskiae Tuberculatae,Olibanum,Myrrha,Radix Clematidis,Radix Aconiti,Radix Aconiti Kusnezoffii and Flos Carthami are usually used as the core of the Chinese herbal prescriptions.

備注/Memo

備注/Memo:

通訊作者:莫文 E-mail:[email protected]

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更新日期/Last Update: 1900-01-01