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[1]周杰,熊小明,何本祥,等.納米微針透皮技術(shù)聯(lián)合鄭氏新傷軟膏貼敷治療急性踝關(guān)節(jié)扭傷的臨床研究[J].中醫(yī)正骨,2021,33(02):20-25.
　ZHOU Jie,XIONG Xiaoming,HE Benxiang,et al.A clinical study of nano-microneedles-assisted transdermal technology combined with external application of Zheng’s Xinshang(鄭氏新傷)ointments for treatment of acute ankle sprain[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2021,33(02):20-25.
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納米微針透皮技術(shù)聯(lián)合鄭氏新傷軟膏貼敷治療急性踝關(guān)節(jié)扭傷的臨床研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第33卷
期數(shù):
2021年02期
頁碼:
20-25
欄目:
臨床研究
出版日期:
2021-02-20

文章信息/Info

Title:
A clinical study of nano-microneedles-assisted transdermal technology combined with external application of Zheng’s Xinshang(鄭氏新傷)ointments for treatment of acute ankle sprain
作者:
周杰1; 熊小明1; 何本祥2; 孫育良1
(1.四川省骨科醫(yī)院,四川 成都 610041; 2.成都體育學(xué)院,四川 成都 610041)
Author(s):
ZHOU Jie1; XIONG Xiaoming1; HE Benxiang2; SUN Yuliang1
1.Sichuan Provincial Orthopedics Hospital,Chengdu 610041,Sichuan,China2.Chengdu Sport University,Chengdu 610041,Sichuan,China
關(guān)鍵詞:
踝關(guān)節(jié);  扭傷和勞損;  投藥; 皮膚;  納米透皮技術(shù);  鄭氏新傷軟膏;  臨床試驗(yàn)
Keywords:
ankle joint;  sprains and strains;  administration; cutaneous;  nanocrystalline transdermal technology;  ZhengShi XinShang ointments;  clinical trial
摘要:
目的:探討納米微針透皮技術(shù)聯(lián)合鄭氏新傷軟膏貼敷治療急性踝關(guān)節(jié)扭傷的臨床療效和安全性。方法:將80例急性踝關(guān)節(jié)扭傷患者隨機(jī)分為2組,每組40例。軟膏貼敷組采用鄭氏新傷軟膏貼敷治療,每晚貼敷8～10 h,共2周; 聯(lián)合治療組在貼敷鄭氏新傷軟膏前先采用納米微針透皮技術(shù)治療,每晚1次,每次3 min,共2周。分別于治療前、治療結(jié)束后記錄并比較2組患者足踝部周徑、踝部疼痛視覺模擬量表(visual analogue scale,VAS)評分及Kofoed踝關(guān)節(jié)評分,并觀察并發(fā)癥發(fā)生情況。結(jié)果:①足踝部周徑。治療前2組患者足踝部周徑比較,差異無統(tǒng)計(jì)學(xué)意義[(35.08±2.39)cm,(34.93±2.44)cm,t=0.278,P=0.782]; 治療結(jié)束后,聯(lián)合治療組患者足踝部周徑小于軟膏貼敷組[(28.63±1.40)cm,(30.18±1.60)cm,t=-4.626,P=0.000],2組患者足踝部周徑均小于治療前(t=17.338,P=0.000; t=14.162,P=0.000)。②踝部疼痛VAS評分。治療前2組患者踝部疼痛VAS評分比較,差異無統(tǒng)計(jì)學(xué)意義[(7.08±1.14)分,(7.05.±1.13)分,t=-0.308,P=0.758]; 治療結(jié)束后,聯(lián)合治療組患者踝部疼痛VAS評分低于軟膏貼敷組[(2.03±0.73)分,(3.10±1.17)分,t=-4.467,P=0.000],2組患者踝部疼痛VAS評分均低于治療前(t=-5.591,P=0.000; t=-5.690,P=0.000)。③Kofoed踝關(guān)節(jié)評分。治療前2組患者Kofoed踝關(guān)節(jié)評分比較,差異無統(tǒng)計(jì)學(xué)意義[(50.18±5.49)分,(50.23±5.26)分,t=-0.042,P=0.967]; 治療結(jié)束后,聯(lián)合治療組患者Kofoed踝關(guān)節(jié)評分高于軟膏貼敷組[(89.95±1.74)分,(82.18±1.88)分,t=19.205,P=0.000],2組患者Kofoed踝關(guān)節(jié)評分均高于治療前(t=-40.124,P=0.000; t=-37.709,P=0.000)。④綜合療效。治療結(jié)束后,聯(lián)合治療組優(yōu)15例、良18例、及格6例、差1例,軟膏貼敷組優(yōu)9例、良16例、及格11例、差4例; 聯(lián)合治療組的綜合療效優(yōu)于軟膏貼敷組(Z=-2.100,P=0.036)。⑤并發(fā)癥發(fā)生情況。2組患者均未出現(xiàn)藥物過敏反應(yīng); 聯(lián)合治療組2例遺留踝關(guān)節(jié)輕微疼痛,軟膏貼敷組7例遺留踝關(guān)節(jié)輕微疼痛,因不影響日常生活,均未給予特殊處理。2組并發(fā)癥發(fā)生率比較,差異無統(tǒng)計(jì)學(xué)意義(χ2=2.003,P=0.157)。結(jié)論:納米微針透皮技術(shù)聯(lián)合鄭氏新傷軟膏貼敷治療急性踝關(guān)節(jié)扭傷,能緩解疼痛、減輕腫脹和改善關(guān)節(jié)功能,其療效優(yōu)于單純鄭氏新傷軟膏貼敷治療,但兩者安全性相當(dāng)。
Abstract:
To explore the clinical curative effects and safety of nano-microneedles-assisted transdermal technology combined with external application of Zheng’s Xinshang(鄭氏新傷)ointments for treatment of acute ankle sprain(AAS).Methods:Eighty AAS patients were randomly divided into monotherapy group and combination therapy group,40 cases in each group.All patients were treated with external application of Zheng’s Xinshang(鄭氏新傷)ointments,8-10 hours every night for consecutive 2 weeks; and the nano-microneedles-assisted transdermal technology was used before external application of Zheng’s Xinshang ointments in combination therapy group,once every night for 3 minutes at a time.The ankle circumferences,ankle pain visual analogue scale(VAS)scores and Kofoed ankle scores were recorded and compared between the 2 groups before the treatment and after the end of the treatment respectively,and the complications were observed.Results:There was no statistical difference in ankle circumferences between the 2 groups before the treatment(35.08±2.39 vs 34.93±2.44 cm,t=0.278,P=0.782).The ankle circumferences were smaller in combination therapy group compared to monotherapy group after the end of the treatment(28.63±1.40 vs 30.18±1.60 cm,t=-4.626,P=0.000).The ankle circumferences were smaller after the end of the treatment compared to pre-treatment(t=17.338,P=0.000; t=14.162,P=0.000).There was no statistical difference in ankle pain VAS scores between the 2 groups before the treatment(7.08±1.14 vs 7.05.±1.13 points,t=-0.308,P=0.758).The ankle pain VAS scores were lower in combination therapy group compared to monotherapy group after the end of the treatment(2.03±0.73 vs 3.10±1.17 points,t=-4.467,P=0.000).The ankle pain VAS scores were lower after the end of the treatment compared to pre-treatment(t=-5.591,P=0.000; t=-5.690,P=0.000).There was no statistical difference in Kofoed ankle scores between the 2 groups before the treatment(50.18±5.49 vs 50.23±5.26 points,t=-0.042,P=0.967).The Kofoed ankle scores were higher in combination therapy group compared to monotherapy group after the end of the treatment(89.95±1.74 vs 82.18±1.88 points,t=19.205,P=0.000).The Kofoed ankle scores were higher after the end of the treatment compared to pre-treatment(t=-40.124,P=0.000; t=-37.709,P=0.000).After the end of the treatment,15 patients obtained an excellent result,18 good,6 fair and 1 poor in combination therapy group; while 9 patients obtained an excellent result,16 good,11 fair and 4 poor in monotherapy group.The combination therapy group surpassed the monotherapy group in the total clinical curative effects(Z=-2.100,P=0.036).No drug hypersensitivity reactions were found in the 2 groups.The residual mild ankle pain was found in 2 patients in combination therapy group and 7 patients in monotherapy group,and no special treatment were performed for noneffects on daily living.There was no statistical difference in complication incidences between the 2 groups(χ2=2.003,P=0.157).Conclusion:The combination therapy of nano-microneedles-assisted transdermal technology and external application of Zheng’s Xinshang(鄭氏新傷)ointments can relieve the ankle pain,reduce the ankle swelling and improve the ankle function in treatment of AAS,and it surpasses the monotherapy of external application of Zheng’s Xinshang(鄭氏新傷)ointments in the clinical curative effects,while they are similar to each other in safety.

參考文獻(xiàn)/References:

[1] HUBBARD-TURNER T,WIKSTROM E A,GUDERIAN S,et al.An acute lateral ankle sprain significantly decreases physical activity across the lifespan[J].J Sports Sci Med,2015,14(3):556-561.
[2] LIU X F,FANG Y,CAO Z H,et al.Repair of acute injuries of the lateral ligament complex of the ankle by suture anchors[J].Int J Clin Exp Med,2015,8(11):21796-21801.
[3] 向澍,顧健華.青鵬軟膏膏摩法治療陳舊性踝關(guān)節(jié)扭傷的臨床研究[J].中醫(yī)正骨,2017,29(8):33-35.
[4] 馬昕,陳世益.運(yùn)動(dòng)員急性踝關(guān)節(jié)外側(cè)副韌帶損傷[J].中國運(yùn)動(dòng)醫(yī)學(xué)雜志,1999,18(1):62-64.
[5] 王和鳴,黃桂成.中醫(yī)骨傷科學(xué)[M].北京:中國中醫(yī)藥出版社,2012:314.
[6] 國家中醫(yī)藥管理局.中醫(yī)病證診斷療效標(biāo)準(zhǔn)[M].南京:南京大學(xué)出版社,1994:198-199.
[7] 周霖,孫凱,陳彥,等.傷柏膏治療急性踝關(guān)節(jié)外側(cè)副韌帶損傷患者疼痛的臨床效果[J].南方醫(yī)科大學(xué)學(xué)報(bào),2017,37(3):398-401.
[8] KOFOED H,S?RENSEN T S.Ankle arthroplasty for rheumatoid arthritis and osteoarthritis:prospective long-term study of cemented replacements[J].J Bone Joint Surg Br,1998,80(2):328-332.
[9] 龔志兵,莊至坤,張煥堂,等.骨散外敷治療急性踝關(guān)節(jié)扭傷氣滯血瘀證的臨床研究[J].中醫(yī)正骨,2018,30(12):13-17.
[10] 李元貞,鄭永浩,胡翔.消定膏外敷聯(lián)合RICE基礎(chǔ)療法治療急性踝關(guān)節(jié)扭傷37例臨床觀察[J].甘肅中醫(yī)藥大學(xué)學(xué)報(bào),2018,35(2):58-62.
[11] 張?zhí)?芳香性中藥成分透皮吸收促進(jìn)作用的研究進(jìn)展[J].中華中醫(yī)藥雜志,2019,34(6):2589-2592.
[12] 白毅,杜麗娜,馮雪,等.天然藥物經(jīng)皮給藥系統(tǒng)研究進(jìn)展[J].中國藥學(xué)雜志,2014,49(16):1377-1381.
[13] MüNCH S,WOHLRAB J,NEUBERT R H H.Dermal and transdermal delivery of pharmaceutically relevant macromolecules[J].Eur J Pharm Biopharm,2017,119:235-342.
[14] 薛冰心,吳純潔.影響藥物經(jīng)皮吸收的客觀因素[J].中國現(xiàn)代醫(yī)學(xué)雜志,2010,20(16):2479-2483.
[15] 張朵朵,吳艷麗,鞠大宏,等.微針在經(jīng)皮給藥領(lǐng)域中的應(yīng)用研究進(jìn)展[J].中華中醫(yī)藥雜志,2014,29(8):2559-2562.
[16] RZHEVSKIY A S,SINGH T R R,DONNELLY R F,et al.Microneedles as the technique of drug delivery enhancement in diverse organs and tissues[J].J Control Release,2018,270:184-202.
[17] CHEN J,QIU Y,ZHANG S,et al.Dissolving microneedle-based intradermal delivery of interferon-α-2b[J].Drug Dev Ind Pharm,2016,42(6):890-896.
[18] REJINOLD N S,SHIN J H,SEOK H Y,et al.Biomedical applications ofmicroneedles in the rapeutics: recent advancements and implications in drug delivery[J].Expert Opin Drug Deliv,2016,13(1):109-131.
[19] NALWA H S.A special issue on reviews in nanomedicine,drug delivery and vaccine development[J].J Biomed Nanotechnol,2014,10(9):1635-1640.
[20] 林明慧.糠酸莫米松乳膏聯(lián)合納晶納米微針導(dǎo)入對白癜風(fēng)患者復(fù)色情況的影響[J].實(shí)用醫(yī)技雜志.2020,27(8):1064-1065.
[21] 李彩霞,李偉,李聰穎,等.納米微針對皮膚表面麻醉藥膏的透皮吸收的影響[J].中國醫(yī)療美容,2020,10(11):66-68.
[22] HENRY S,MCALLISTER D V,ALLEN M G,et al.Microfabricated microneedles:a novel approach to transdermal drug delivery[J].J Pharm Sci,1998,87(8):922-925.
[23] DENG Y,CHEN J,ZHAO Y,et al.Transdermal delivery of siRNA through microneedle array[J].Sci Rep,2016,6:21-22.
[24] CAFFAREL-SALVADOR E,DONNELLY R F.Transdermal drug delivery mediated by microneedle arrays:innovations and barriers to success[J].Curr Pharm Des,2016,22(9):1105-1117.
[25] 尹璐,王恩波,富彥財(cái),等.納晶微針的促滲透作用及安全性實(shí)驗(yàn)研究[J].臨床軍醫(yī)雜志,2015,43(4):339-341.
[26] CAULMAN S A,ANSTEY A,CATELEY C,et al.Microneedle mediatesd delivery of nanoparticles into human skin[J].Int J Pharm,2009,366(1/2):190-200.
[27] 陶艷玲,苗穎穎,吳婷妍,等.納米微針對人皮膚屏障功能及紅斑的影響[J].中國中西醫(yī)結(jié)合皮膚性病學(xué)雜志,2017,16(1):11-15.
[28] 張亮.新型納米微針與傳統(tǒng)微針對雙氯芬酸鈉凝膠體外透皮實(shí)驗(yàn)的效果對比研究[D].成都:成都體育學(xué)院,2019.
[29] B?ME K,LIKAR R.Efficacy and tolerability of a new opioid analgesic formulation, buprenorphine transdermal therapeutic system(TDS),in the treatment of patients with chronic pain.A randomised,double-blind,placebocontrolled study[J].Pain Clin,2003,15(2):193-202.
[30] 張瑞雪,張慶瑞,戴逸楠,等.納米晶片促進(jìn)藥物經(jīng)皮滲透作用的研究[J].臨床皮膚科雜志,2017,46(4):247-250.

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[12]張海林,吳越.中醫(yī)藥綜合療法治療急性踝關(guān)節(jié)扭傷150例[J].中醫(yī)正骨,2015,27(04):44.
[13]鄔博來,辛景義.距腓前韌帶和跟腓韌帶解剖重建治療習(xí)慣性踝關(guān)節(jié)扭傷[J].中醫(yī)正骨,2017,29(03):60.
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[16]龔志兵,莊至坤,張煥堂,等.骨散外敷治療急性踝關(guān)節(jié)扭傷氣滯血瘀證的臨床研究[J].中醫(yī)正骨,2018,30(12):13.
　GONG Zhibing,ZHUANG Zhikun,ZHANG Huantang,et al.A clinical study of external application of Gusan(骨散)for treatment of qi-stagnation-blood-stasis-type acute ankle sprain[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(02):13.
[17]陳張,王曉東,寇智君,等.理筋手法聯(lián)合探穴針罐法治療陳舊性踝關(guān)節(jié)扭傷的臨床研究[J].中醫(yī)正骨,2021,33(03):20.
　CHEN Zhang,WANG Xiaodong,KOU Zhijun,et al.A clinical study of sinew adjusting manipulation combined with acupuncture-cupping therapy for treatment of old ankle sprain[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2021,33(02):20.

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通訊作者:熊小明 E-mail:[email protected]
更新日期/Last Update: 2021-02-20