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[1]劉艷,石麗紅,謝新立,等.18F-FDG PET/CT在未知原發(fā)灶腫瘤骨轉移診斷中的價值[J].中醫(yī)正骨,2020,32(09):39-45.
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18F-FDG PET/CT在未知原發(fā)灶腫瘤骨轉移診斷中的價值()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第32卷
期數(shù):
2020年09期
頁碼:
39-45
欄目:
影像診斷
出版日期:
2020-09-20

文章信息/Info

作者:
劉艷; 石麗紅; 謝新立; 杜彪; 韓星敏
(鄭州大學第一附屬醫(yī)院,河南 鄭州 450052)
關鍵詞:
腫瘤; 未知原發(fā)灶;  腫瘤轉移;  骨腫瘤;  氟脫氧葡萄糖F18;  正電子發(fā)射斷層掃描及電腦斷層掃描
摘要:
目的:探討氟脫氧葡萄糖F18(fluorodeoxyglucose F18,18F-FDG)正電子發(fā)射斷層掃描及電腦斷層掃描(positron emission tomography and computed tomography,PET/CT)在未知原發(fā)灶腫瘤骨轉移(bone metastasis of unknown primary origin,BMUO)診斷中的價值。方法:選擇行18F-FDG PET/CT檢查的223例未確定原發(fā)灶的轉移性骨腫瘤患者的病例資料進行分析。男122例,女101例。年齡40～89歲,中位數(shù)62歲。所有納入研究的患者均在常規(guī)影像檢查發(fā)現(xiàn)腫瘤骨轉移病灶后3 d內行18F-FDG PET/CT檢查,查找原發(fā)腫瘤,并通過穿刺、內鏡檢查、手術等方式取病變組織標本進行組織病理檢查。18F-FDG PET/CT檢查均采用Siemens Biograph Truepoint 64(52環(huán))PET/CT。結果:在223例患者中,203例經(jīng)18F-FDG PET/CT檢查診斷為陽性,其中真陽性199例、假陽性4例; 20例診斷為陰性,其中真陰性14例、假陰性6例。18F-FDG PET/CT確定BMUO原發(fā)腫瘤的靈敏度為97.1%、特異度為77.8%、準確度為91.9%、陽性預測值為98.0%、陰性預測值為70.0%。假陽性共4例,其中結核2例、結節(jié)病1例、POEMS綜合征 1例; 假陰性6例,其中胃印戒細胞癌1例、腎透明細胞癌1例、甲狀腺癌1例、前列腺癌1例、膀胱癌2例。 18F-FDG PET/CT檢查檢測到了所有先前已知的轉移灶,并在173例患者身上發(fā)現(xiàn)了新的轉移灶。最終確診的205例患者中,肺癌109例(53.2%)、結腸癌16例(7.8%)、食管癌13例(6.3%)、前列腺癌9例(4.4%)、乳腺癌9例(4.4%)、胃癌8例(3.9%)、卵巢癌7例(3.4%)、直腸癌7例(3.4%)、鼻咽癌6例(2.9%)、喉癌5例(2.4%)、肝癌4例(2.0%)、胰腺癌4例(2.0%)、腎癌3例(1.5%)、膀胱癌2例(1.0%)、多發(fā)骨髓瘤2例(1.0%)、甲狀腺癌1例(0.5%)。按照腫瘤的組織病理學類型,腺癌共135例,約占65.8%(135/205)。結論:18F-FDG PET/CT是診斷BMUO原發(fā)腫瘤的一種可靠方法,可作為查找BMUO原發(fā)病灶的首選檢查方法。

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備注/Memo

備注/Memo:
通訊作者:韓星敏 E-mail:[email protected]
更新日期/Last Update: 2020-09-20