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[1]羅淦,湯樣華,康儀,等.骨關(guān)節(jié)炎相關(guān)信號(hào)通路的研究進(jìn)展[J].中醫(yī)正骨,2019,31(05):31-37.
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骨關(guān)節(jié)炎相關(guān)信號(hào)通路的研究進(jìn)展()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期數(shù):
2019年05期
頁(yè)碼:
31-37
欄目:
綜 述
出版日期:
2019-05-20

文章信息/Info

作者:
羅淦; 湯樣華; 康儀; 辛大偉; 熊振飛; 徐燦達(dá); 岳振雙; 曾林如
(浙江中醫(yī)藥大學(xué)附屬江南醫(yī)院,浙江 杭州 311201)
關(guān)鍵詞:
骨關(guān)節(jié)炎;  p38絲裂原活化蛋白激酶類;  c-Jun氨基末端激酶;  Toll樣受體;  蛋白酪氨酸激酶類;  STAT3轉(zhuǎn)錄因子;  趨化因子CXCL12;  受體;  CXCR4;  受體; Notch;  Wnt信號(hào)通路;  轉(zhuǎn)化生長(zhǎng)因子β;  骨保護(hù)素;  核因子κB受體活化因子;  綜述
摘要:
骨關(guān)節(jié)炎是一種嚴(yán)重影響患者生活質(zhì)量的關(guān)節(jié)退行性疾病,其病因及發(fā)病機(jī)制尚不完全清楚。目前,國(guó)內(nèi)外大量研究已證實(shí)骨關(guān)節(jié)炎的病理變化過(guò)程與眾多信號(hào)通路有密切聯(lián)系,其中部分信號(hào)通路與介導(dǎo)骨關(guān)節(jié)炎軟骨破壞及調(diào)控軟骨細(xì)胞凋亡有關(guān),如p38絲裂原活化蛋白激酶、c-Jun氨基末端激酶、Toll樣受體等信號(hào)通路等; 還有部分信號(hào)通路對(duì)骨關(guān)節(jié)炎軟骨細(xì)胞增殖和凋亡具有雙重調(diào)節(jié)作用,如細(xì)胞外調(diào)節(jié)蛋白激酶、Notch、Wnt等信號(hào)通路。本文就骨關(guān)節(jié)炎相關(guān)信號(hào)通路的研究進(jìn)展進(jìn)行了綜述。

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更新日期/Last Update: 2019-05-20