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[1]任偉凡,胡勁濤,全仁夫,等.強(qiáng)直性脊柱炎易感基因的相關(guān)研究進(jìn)展[J].中醫(yī)正骨,2019,31(04):48-51.
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強(qiáng)直性脊柱炎易感基因的相關(guān)研究進(jìn)展()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期數(shù):
2019年04期
頁(yè)碼:
48-51
欄目:
綜 述
出版日期:
2019-04-30

文章信息/Info

作者:
任偉凡1胡勁濤1全仁夫2呂建蘭1錢建勝1
(1.浙江中醫(yī)藥大學(xué)第三臨床醫(yī)學(xué)院,浙江 杭州 310053; 2.杭州市蕭山區(qū)中醫(yī)院,浙江 杭州 311201)
關(guān)鍵詞:
脊柱炎強(qiáng)直性 易感基因 遺傳 多態(tài)性單核苷酸 綜述
摘要:
強(qiáng)直性脊柱炎(ankylosing spondylitis,AS)是臨床上常見的一種具有高度遺傳性的慢性炎癥性疾病。HLA-B27基因被認(rèn)為是與AS相關(guān)性最強(qiáng)的易感基因,但越來(lái)越多的研究發(fā)現(xiàn),除HLA-B27基因外,包括內(nèi)質(zhì)網(wǎng)氨基肽酶1基因、白細(xì)胞介素23/白細(xì)胞介素17炎癥軸相關(guān)基因、腫瘤壞死因子α基因、白細(xì)胞介素1基因、殺傷細(xì)胞免疫球蛋白樣受體基因在內(nèi)的多種基因均與AS的易感性有關(guān)。目前所發(fā)現(xiàn)的易感基因與AS關(guān)聯(lián)的機(jī)制尚不十分清楚,仍須開展更多高質(zhì)量、多角度、深層次的研究。

參考文獻(xiàn)/References:

[1] WU Y,ZHANG G,WANG N,et al.Risk factors of renal involvement based on different manifestations in patients with ankylosing spondylitis[J].Kidney Blood Press Res,2018,43(2):367-377. [2] 吳珊珊,段振華.強(qiáng)直性脊柱炎流行病學(xué)研究進(jìn)展[J].安徽醫(yī)科大學(xué)學(xué)報(bào),2013,48(8):988-992. [3] NURULLAH A,YARKAN H,GÖKÇE K,et al.Ankylosing spondylitis:HLA-B*27-positive versus HLA-B*27-negative disease[J].Curr Rheumatol Rep,2017,19(5):322-328. [4] BREWERTON D A.HLA-B27 and the inheritance of susceptibility to rheumatic disease[J].Arthritis Rheum,2010,19(4):656-668. [5] AKASSOU A,YACOUBI H,JAMIL A,et al.Prevalence of HLA-B27 in Moroccan healthy subjects and patients with ankylosing spondylitis and mapping construction of several factors influencing AS diagnosis by using multiple correspondence analysis[J].Rheumatol Int,2015,35(11):1889-1894. [6] LIN H,GONG Y Z.Association of HLA-B27 with ankylosing spondylitis and clinical features of the HLA-B27-associated ankylosing spondylitis:a meta-analysis[J].Rheumatol Int,2017,37(8):1267-1280. [7] KHAN M A,MATHIEU A,SORRENTINO R A.The pathogenetic role of HLA-B27 and its subtypes[J].Autoimmun Rev,2007,6(3):183-189. [8] LIU Y,JIANG L,CAI Q,et al.Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients[J].Tissue Antigens,2010,75(1):61-64. [9] TAUROG J D,DORRIS M L,SATUMTIRA N,et al. Spondylarthritis in HLA–B27/human β2-microglobulin–transgenic rats is not prevented by lack of CD8[J].Arthritis Rheum,2009,60(7):1977-1984. [10] LORIES R J.Animal models of spondyloarthritis[J].Curr Opin Rheumatol,2006,18(4):342-346. [11] ZHANG L,ZHANG Y J,CHEN J,et al.The association of HLA-B27 and Klebsiella pneumoniae in ankylosing spondylitis:A systematic review[J].Microb Pathog,2018,117:49-54. [12] KOLLNBERGER S,BIRD L,SUN M Y,et al.Cell-surface expression and immune receptor recognition of HLA-B27 homodimers[J].Arthritis Rheum,2002,46(11):2972-2982. [13] BOWNESS P,RIDLEY A,SHAW J,et al.Th17 cells expressing KIR3DL2+and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis[J].J Immunol,2011,186(4):2672-2680. [14] ZHAI J,RONG J,LI Q,et al.Immunogenetic study in Chinese population with ankylosing spondylitis:are there specific genes recently disclosed?[J/OL].Clin Dev Immunol,2013[2018-12-15].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562651. [15] International Genetics of Ankylosing Spondylitis Consortium.Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci[J].Nat Genet,2013,45(7):730-738. [16] GARCÍA-MEDEL N,SANZ-BRAVO A,VAN NGUYEN D,et al.Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo[J].Mol Cell Proteomics,2012,11(11):1416-1429. 中醫(yī)正骨2019年4月第31卷第4期 J Trad Chin Orthop Trauma,2019,Vol.31,No.4(總291) (總292)中醫(yī)正骨2019年4月第31卷第4期 J Trad Chin Orthop Trauma,2019,Vol.31,No.4 [17] Wellcome Trust Case Control Consortium,Australo-Anglo-American Spondylitis Consortium,BURTON P R,et al.Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants[J].Nat Genet,2007,39(11):1329-1337. [18] MAKSYMOWYCH W P,INMAN R D,GLADMAN D D,et al.Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis[J].Arthritis Rheum,2009,60(5):1317-1323. [19] EVANS D M,SPENCER C C,POINTON J J,et al.Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility[J].Nat Genet,2011,43(8):761-767. [20] 曲哲,錢邦平,邱勇,等.ERAP1基因單核苷酸多態(tài)性與中國(guó)漢族人群強(qiáng)直性脊柱炎的易感性關(guān)聯(lián)分析[J].中國(guó)脊柱脊髓雜志,2015,25(9):832-836. [21] ETHWA H,BOWNESS P.The interleukin(IL)-23/IL-17 axis in ankylosing spondylitis:new advances and potentials for treatment[J].Clin Exp Immunol,2016,183(1):30-36. [22] BABAIE F,HASANKHANI M,MOHAMMADI H A,et al.The role of gut microbiota and IL-23/IL-17 pathway in ankylosing spondylitis immunopathogenesis:New insights and updates[J].Immunol Lett,2018,196:52-62. [23] DANOY P,PRYCE K,HADLER J,et al.Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease[J].PLoS Genet,2010,6(12):e1001195. [24] DI MEGLIO P,DI CESARE A,LAGGNER U,et al.The IL23R R381Q gene variant protects against Immune-Mediated diseases by impairing IL-23-Induced Th17 effector response in humans[J].PLoS One,2011,6(2):e17160. [25] DAVIDSON S I,WU X,LIU Y,et al.Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population[J].Arthritis Rheum,2009,60(11):3263-3268. [26] DAVIDSON S I,JIANG L,CORTES A,et al.High-Throughput sequencing of IL23R reveals a Low-Frequency,nonsynonymous Single-Nucleotide polymorphism that is associated with ankylosing spondylitis in a Han Chinese population[J].Arthritis Rheum,2013,65(7):1747-1752. [27] CHEN C,ZHANG X E,WANG Y.Analysis of JAK2 and STAT3 polymorphisms in patients with ankylosing spondylitis in Chinese Han population[J].Clinical Immunology,2010,136(3):442-446. [28] BROWN M A.Breakthroughs in genetic studies of ankylosing spondylitis[J].Rheumatology,2008,47(2):132-137. [29] LUBRANO E,PERROTTA F M.Secukinumab for ankylosing spondylitis and psoriatic arthritis[J].Ther Clin Risk Manag,2016,12:1587-1592. [30] 蔡慧顏,鐘華.強(qiáng)直性脊柱炎患者外周血TNF-α、IL-17、IL-23的表達(dá)[J].現(xiàn)代診斷與治療,2016,27(18):3340-3342. [31] JIAO Y L,MA C Y,WANG L C,et al.Polymorphisms of KIRs gene and HLA-C alleles in patients with ankylosing spondylitis:Possible association with susceptibility to the disease[J].J Clin Immunol,2008,28(4):343-349. [32] DÍAZ-PEÑA R,VIDAL-CASTIEIRA R J,ALONSO-ARIAS R,et al.Association of the KIR3DS1*013 and KIR3DL1*004 alleles with susceptibility to ankylosing spondylitis[J].Arthritis Rheum,2010,62(4):1000-1006. [33] Australo-Anglo-American Spondyloarthritis Consortium,REVEILLE J D,SIMS A M,et al.Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci[J].Nat Genet,2010,42(2):123-127.

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通訊作者:全仁夫 E-mail:[email protected](收稿日期:2019-01-03 本文編輯:李曉樂)
更新日期/Last Update: 2019-10-08