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[1]李兆勇,楊少鋒,張晨陽.補(bǔ)腎活血方聯(lián)合經(jīng)皮椎體強(qiáng)化術(shù)治療骨質(zhì)疏松性椎體壓縮骨折的系統(tǒng)評價(jià)[J].中醫(yī)正骨,2019,31(03):28-32.
　LI Zhaoyong,YANG Shaofeng,ZHANG Chenyang.Oral application of Bushen Huoxue Fang(補(bǔ)腎活血方)combined with percutaneous vertebral augmentation for treatment of osteoporotic vertebral compression fractures:a systematic review[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(03):28-32.
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補(bǔ)腎活血方聯(lián)合經(jīng)皮椎體強(qiáng)化術(shù)治療骨質(zhì)疏松性椎體壓縮骨折 的系統(tǒng)評價(jià)()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期數(shù):
2019年03期
頁碼:
28-32
欄目:
文獻(xiàn)研究
出版日期:
2019-03-20

文章信息/Info

Title:
Oral application of Bushen Huoxue Fang(補(bǔ)腎活血方)combined with percutaneous vertebral augmentation for treatment of osteoporotic vertebral compression fractures:a systematic review
作者:
李兆勇1; 楊少鋒1; 張晨陽2
(1.湖南中醫(yī)藥大學(xué)第一附屬醫(yī)院,湖南 長沙 410007; 2.湖南中醫(yī)藥大學(xué),湖南 長沙 410208)
Author(s):
LI Zhaoyong1; YANG Shaofeng1; ZHANG Chenyang2
1.The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410007,Hunan,China 2. Hunan University of Traditional Chinese Medicine,Changsha 410208,Hunan,China
關(guān)鍵詞:
骨質(zhì)疏松性骨折;  脊柱骨折;  補(bǔ)腎活血方;  椎體成形術(shù);  椎體后凸成形術(shù);  Meta分析;  系統(tǒng)評價(jià)
Keywords:
osteoporotic fractures;  spinal fractures;  Bushen Huoxue Fang;  vertebroplasty;  kyphoplasty;  meta-analysis;  systematic review
摘要:
目的:評價(jià)補(bǔ)腎活血方聯(lián)合經(jīng)皮椎體強(qiáng)化術(shù)治療骨質(zhì)疏松性椎體壓縮骨折(osteoporotic vertebral compression fracture,OVCF)的臨床療效和安全性。方法:應(yīng)用計(jì)算機(jī)檢索中國知網(wǎng)、維普網(wǎng)、萬方數(shù)據(jù)庫2010年1月1日至2018年10月12日收錄的有關(guān)補(bǔ)腎活血方聯(lián)合經(jīng)皮椎體強(qiáng)化術(shù)(治療組)和單純經(jīng)皮椎體強(qiáng)化術(shù)(對照組)治療OVCF的隨機(jī)對照臨床研究文獻(xiàn)。由2位研究者獨(dú)立篩選文獻(xiàn)、提取資料,依據(jù)Jadad量表進(jìn)行文獻(xiàn)方法學(xué)質(zhì)量評價(jià)后,采用RevMan4.2.7軟件進(jìn)行Meta分析。結(jié)果:最初共檢索到136篇文獻(xiàn),經(jīng)篩選后最終納入14篇文獻(xiàn),均為中文文獻(xiàn)。Meta分析結(jié)果顯示,與對照組相比,治療組的治療有效率更高[OR=4.06,95% CI(2.26,7.30)]、治療后的疼痛視覺模擬量表評分更低[WMD=-0.97,95% CI(-1.50,-0.44)]; 2組治療后的骨密度比較,差異無統(tǒng)計(jì)學(xué)意義[WMD=0.05,95% CI(-0.01,0.11)]; 僅有1篇文獻(xiàn)比較了2組的并發(fā)癥,且2組均未出現(xiàn)并發(fā)癥,故無法進(jìn)行合并分析。利用治療后疼痛視覺模擬量表評分進(jìn)行發(fā)表偏倚分析,漏斗圖顯示分布不對稱,提示可能存在潛在的發(fā)表偏倚。結(jié)論:補(bǔ)腎活血方聯(lián)合經(jīng)皮椎體強(qiáng)化術(shù)是治療OVCF的有效方法,其療效優(yōu)于單純經(jīng)皮椎體強(qiáng)化術(shù)。
Abstract:
Objective:To evaluate the clinical curative effects and safety of oral application of Bushen Huoxue Fang(補(bǔ)腎活血方,BSHXF)combined with percutaneous vertebral augmentation for treatment of osteoporotic vertebral compression fractures(OVCF).Methods:All the randomized controlled trial(RCT)articles about combination therapy of oral application of BSHXF and percutaneous vertebral augmentation(treatment group)versus monotherapy of percutaneous vertebral augmentation(control group)for treatment of OVCF included from January 1,2010 to October 12,2018 were retrieved from China national knowledge internet,VIP Database and WanFang Database through computer.The articles were screened and the information was extracted independently by two searchers.The methodological quality of research in the articles was evaluated by using Jadad scale and a Meta-analysis was conducted by using RevMan4.2.7 software.Results:One hundred and thirty-six articles were searched out in the initial stage.After screening,14 Chinese articles were included in the final analysis.The results of Meta-analysis demonstrated that the effective rates were higher and the posttreatment pain visual analogue scale(VAS)scores were lower in treatment group compared to control group(OR=4.06,95% CI(2.26,7.30); WMD=-0.97,95% CI(-1.50,-0.44)).There was no statistical difference in posttreatment bone mineral density between the 2 groups(WMD=0.05,95% CI(-0.01,0.110)).The complication rates were compared between the 2 groups in 1 article and no complications were found in the 2 groups,so merged analysis could not be conducted.Publication bias was analyzed according to posttreatment pain VAS scores,and the asymmetrical funnel plot demonstrated that there was potential publication bias.Conclusion:The combination therapy of oral application of BSHXF and percutaneous vertebral augmentation is an effective method for treatment of OVCF,and it surpasses the monotherapy of percutaneous vertebral augmentation in the clinical curative effect.

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備注/Memo

備注/Memo:
基金項(xiàng)目:湖南省自然科學(xué)基金項(xiàng)目(2017JJ2208) 通訊作者:楊少鋒 E-mail:[email protected](收稿日期:2018-11-13 本文編輯:李曉樂)
更新日期/Last Update: 2019-03-30