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[1]吳鑫杰,譚明生,移平.NOD樣受體蛋白3炎性小體在創(chuàng)傷性脊髓損傷中的作用[J].中醫(yī)正骨,2019,31(02):31-35.
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NOD樣受體蛋白3炎性小體在創(chuàng)傷性脊髓損傷中的作用()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期數(shù):
2019年02期
頁(yè)碼:
31-35
欄目:
綜 述
出版日期:
2019-02-20

文章信息/Info

作者:
吳鑫杰譚明生移平
(中日友好醫(yī)院,北京 100029)
關(guān)鍵詞:
脊髓損傷 NLRP3 焦亡 綜述
摘要:
NOD樣受體蛋白3(NOD-like receptor protein 3,NLRP3)炎性小體是介導(dǎo)固有免疫反應(yīng)的重要蛋白,在創(chuàng)傷性脊髓損傷的第2個(gè)病理階段中發(fā)揮著重要作用。炎性小體的活化被認(rèn)為是半胱氨酸蛋白水解酶-1依賴(lài)的焦亡途徑的一個(gè)關(guān)鍵因素,參與半胱氨酸蛋白水解酶-1的活化并將白細(xì)胞介素18和白細(xì)胞介素1β前體轉(zhuǎn)化為活性形式,導(dǎo)致脊髓神經(jīng)細(xì)胞死亡。本文對(duì)NLRP3炎性小體的結(jié)構(gòu)及NLRP3炎性小體在創(chuàng)傷性脊髓損傷中的作用機(jī)制、激活途徑及其調(diào)節(jié)以及NLRP3炎性小體在創(chuàng)傷性脊髓損傷治療中的作用進(jìn)行了綜述。

參考文獻(xiàn)/References:

[1] DE RIVERO VACCARI J P,LOTOCKI G,MARCILLO A E,et al.A molecular platform in neurons regulates inflammation after spinal cord injury[J].J Neurosci,2008,28(13):3404-3414. [2] LIN W P,XIONG G P,LIN Q,et al.Heme oxygenase-1 promotes neuron survival through down-regulation of neuronal NLRP1 expression after spinal cord injury[J].J Neuroinflammation,2016,13(1):52. [3] ZENDEDEL A,MOENNINK F,HASSANZADEH G A,et al.Estrogen attenuates local inflammasome expression and activation after spinal cord injury[J].Mol Neurobiol,2018,55(2):1364-1375. [4] MARTINON F,BURNS K,TSCHOPP J.The inflammasome:a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta[J].Mol Cell,2002,10(2):417-426. [5] FLESHNER M,FRANK M,MAIER S F.Danger signals and inflammasomes:Stress-Evoked sterile inflammation in mood disorders[J].Neuropsychopharmacology,2017,42(1):36-45. [6] WALLISCH J S,SIMON D W,BAYIR H,et al.Cerebrospinal fluid NLRP3 is increased after severe traumatic brain injury in infants and children[J].Neurocrit Care,2017,27(1):44-50. [7] FANN D Y,LIM Y A,CHENG Y L,et al.Evidence that NF-kappa B and mapk signaling promotes nlrp inflammasome activation in neurons following ischemic stroke[J].Mol Neurobiol,2018,55(2):1082-1096. [8] MARTINON F.Detection of immune danger signals by NALP3[J].J Leukoc Biol,2008,83(3):507-511. [9] FAUSTIN B,LARTIGUE L,BRUEY J M,et al.Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation[J].Mol Cell,2007,25(5):713-724. [10] MIAO E A,LEAF I A,TREUTING P M,et al.Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria[J].Nat Immunol,2010,11(12):1U94-1136. [11] KAWAI T,AKIRA S.The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors[J].Nat Immunol,2010,11(5):373-384. [12] NI H B,JIN W,ZHU T S,et al.Curcumin modulates TLR4/NF-kappa B inflammatory signaling pathway following traumatic spinal cord injury in rats[J].Journal of Spinal Cord Medicine,2015,38(2):199-206. [13] KONG F,YE B,CAO J,et al.Curcumin represses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB and P2X7R signaling in PMA-induced macrophages[J].Front Pharmacol,2016,7:369. [14] LIU H D,LI W,CHEN Z R,et al.Expression of the NLRP3 inflammasome in cerebral cortex after traumatic brain injury in a rat model[J].Neurochem Res,2013,38(10):2072-2083. [15] SIMON D W,MCGEACHY M J,BAYIR H,et al.The far-reaching scope of neuroinflammation after traumatic brain injury[J].Nat Rev Neurol,2017,13(3):171-191. [16] KATSNELSON M A,RUCKER L G,RUSSO H M.K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling[J].Journal of Immunology,2015,194(8):3937. [17] GAO L,DONG Q,SONG Z,et al.NLRP3 inflammasome:a promising target in ischemic stroke[J].Inflamm Res,2017,66(1):17-24. [18] HE Y,ZENG M Y,YANG D H,et al.NEK7 is an essential mediator of NLRP3 activation downstream of Potassium efflux[J].Nature,2016,530(7590):354. [19] PETRILLI V,PAPIN S,DOSTERT C,et al.Activation of the NALP3 inflammasome is triggered by low intracellular Potassium concentration[J].Cell Death Differ,2007,14(9):1583-1589. [20] MURAKAMI T,OCKINGER J,YU J,et al.Critical role for Calcium mobilization in activation of the NLRP3 inflammasome[J].Proc Natl Acad Sci U S A,2012,109(28):11282-11287. [21] NAKAHIRA K,HASPEL J A,RATHINAM V A,et al.Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome[J].Nat Immunol,2011,12(3):222-230. [22] MORTEZAEE K,KHANLARKHANI N,SABBAGHZIARANI F A,et al.Preconditioning with melatonin improves therapeutic outcomes of bone marrow-derived mesenchymal stem cells in targeting liver fibrosis induced by CCl4[J].Cell Tissue Res,2017,369(2):303-312. [23] LANE T,FLAM B,LOCKEY R,et al.TXNIP shuttling: missing Link between oxidative stress and inflannmasome activation[J].Front Physiol,2013,4:50. [24] GUSTIN A,KIRCHMEYER M,KONCINA E,et al.NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes[J].PLoS One,2015,10(6):e130624. [25] DOSTERT C,PÉTRILLI V,VAN BRUGGEN R,et al.Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica[J].Science,2008,320(5876):674-677. [26] HALLE A,HORNUNG V,PETZOLD G C,et al.The NALP3 inflammasome is involved in the innate immune response to amyloid-beta[J].Nat Immunol,2008,9(8):857-865. [27] ZENDEDEL A,JOHANN S,MEHRABI S,et al.Activation and regulation of NLRP3 inflammasome by intrathecal application of SDF-1a in a spinal cord injury model[J].Mol Neurobiol,2016,53(5):3063-3075.

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備注/Memo

備注/Memo:
基金項(xiàng)目:國(guó)家自然科學(xué)基金面上項(xiàng)目(81873141); 北京市科委首都臨床特色應(yīng)用研究專(zhuān)項(xiàng)課題(Z161100000516009) 通訊作者:移平 E-mail:[email protected](收稿日期:2019-01-22 本文編輯:李曉樂(lè))
更新日期/Last Update: 2019-02-20