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[1]梅滿,于波.微重力影響間充質(zhì)干細(xì)胞向軟骨細(xì)胞分化的研究進(jìn)展[J].中醫(yī)正骨,2019,31(01):38-40.
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微重力影響間充質(zhì)干細(xì)胞向軟骨細(xì)胞分化的研究進(jìn)展()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期數(shù):
2019年01期
頁碼:
38-40
欄目:
臨床研究
出版日期:
2019-01-20

文章信息/Info

作者:
梅滿1于波2
(1.山東中醫(yī)藥大學(xué),山東 濟(jì)南 250355; 2.山東中醫(yī)藥大學(xué)附屬醫(yī)院 山東 濟(jì)南 250355)
關(guān)鍵詞:
軟骨 軟骨細(xì)胞 間質(zhì)干細(xì)胞 細(xì)胞分化 組織工程 失重模擬 綜述
摘要:
關(guān)節(jié)軟骨損傷的治療是骨科研究的熱點(diǎn)之一。軟骨組織工程研究致力于通過構(gòu)建細(xì)胞與生物材料的三維復(fù)合體,形成具有生物活性的軟骨組織,在功能及形態(tài)方面完全替代缺損處的軟骨,以醫(yī)治大面積的軟骨缺損。但在重力環(huán)境下,培養(yǎng)出的軟骨細(xì)胞失去原有的細(xì)胞表型及電生理特性,構(gòu)建出的軟骨組織只能在形態(tài)和生化成分上與原缺損處軟骨組織相似。而微重力環(huán)境可影響間充質(zhì)干細(xì)胞的增殖和分化,有促進(jìn)干細(xì)胞向軟骨細(xì)胞分化的作用。本文從微重力環(huán)境的建立和優(yōu)點(diǎn)、微重力對間充質(zhì)干細(xì)胞向軟骨細(xì)胞分化的影響兩大方面,對近年來的研究進(jìn)展進(jìn)行了綜述。

參考文獻(xiàn)/References:

[1] MELLOR LF,STEWARD AJ,NORDBERG RC,et al.Comparison of Simulated Microgravity and Hydrostatic Pressure for Chondrogenesis of hASC[J].Aerosp Med Hum Perform,2017,88(4):377-384.
[2] HINTERMANN B,WAGENER J,KNUPP M,et al.Treatment of extended osteochondral lesions of the talus with a free vascularised bone graft from the medial condyle of the femur[J].Bone Joint J,2015,97-B(9):1242-1249.
[3] RIFF AJ,YANKE AB,SHIN JJ,et al.Midterm results of osteochondral allograft transplantation to the humeral head[J].J Shoulder Elbow Surg,2017,26(7):e207-e215.
[4] SAEED H,AHSAN M,SALEEM Z,et al.Mesenchymal stem cells(MSCs)as skeletal therapeutics-an update[J].J Biomed Sci,2016,23:41.
[5] CHENG T,MADDOX NC,WONG AW,et al.Comparison of gene expression patterns in articular cartilage and dedifferentiated articular chondrocytes[J].J Orthop Res,2012,30(2):234-245.
[6] 周爽,李瑩,詹淵博,等.骨髓間充質(zhì)干細(xì)胞體外有效擴(kuò)增的研究新進(jìn)展[J].現(xiàn)代口腔醫(yī)學(xué)雜志,2017,31(3):154-157.
[7] KANG HJ,LU SB,PENG J,et al.Chondrogenic differentiation of human adipose-derived stem cells using microcarrier and bioreactor combination technique[J].Mol Med Rep,2015,11(2):1195-1199.
[8] WANG N,WANG H,CHEN J,et al.The simulated microgravity enhances multipotential differentiation capacity of bone marrow mesenchymal stem cells[J].Cytotechnology,2014,66(1):119-131.
[9] PAO SI,CHIEN KH,LIN HT,et al.Effect of microgravity on the mesenchymal stem cell characteristics of limbal fibroblasts[J].J Chin Med Assoc,2017,80(9):595-607.
[10] GASPAR DA,GOMIDE V,MONTEIRO FJ.The role of perfusion bioreactors in bone tissue engineering[J].Biomatter,2012,2(4):167-175.
[11] BERENZI A,STEIMBERG N,BONIOTTI JA.MRT letter: 3D culture of isolated cells: a fast and efficient method for optimizing their histochemical and immunocytochemical analyses[J].Microsc Res Tech,2015,78(4):249-254.
[12] 劉天一,周廣東,苗春雷,等.TGF-β1和IGF-Ⅰ和地塞米松誘導(dǎo)BMSCs體外構(gòu)建組織工程化軟骨[J].上海第二醫(yī)科大學(xué)學(xué)報, 2004, 24(4): 262-266.
[13] 林威,陳潔琳,劉威,等.模擬微重力動態(tài)培養(yǎng)構(gòu)建組織工程化軟骨修復(fù)豬關(guān)節(jié)軟骨缺損研究[J].中國運(yùn)動醫(yī)學(xué)雜志,2016,35(5):432-437.
[14] KALE S,BIERMANN S,EDWARDS C,et al.Three-dimensional cellular development is essential for ex vivo formation of human bone[J].Nat Biotechnol,2000,18(9):954-958.
[15] STEWARD AJ,KELLY DJ. Mechanical regulation of mesenchymal stem cell differentiation[J].J Anat,2015,227(6):717-731.
[16] 劉鵬程,劉寬,劉俊峰,等.旋轉(zhuǎn)微重力細(xì)胞培養(yǎng)系統(tǒng)下Indianhedgehogd轉(zhuǎn)染兔BMSCs促進(jìn)成軟骨分化并抑制老化的實(shí)驗(yàn)研究[J].中國修復(fù)重建外科雜志,2016,30(7):892-902.
[17] LEI XH,DENG ZL,ZHANG HS,et al.Rotary suspension culture enhances mesendoderm differentiation of embryonic stem cells through modulation of Wnt/β-catenin pathway[J].Stem Cell Rev,2014,10(4):526-538.
[18] SAMBANDAM Y,TOWNSEND MT,PIERCE JJ,et al.Microgravity control of autophagy modulates osteoclastogenesis[J].Bone,2014,61:125-131.
[19] WU X,LI SH,LOU LM,et al.The effect of the microgravity rotating culture system on the chondrogenic differentiation of bone marrow mesenchymal stem cells[J].Mol Biotechnol,2013,54(2):331-336.
[20] YU B,YU D,CAO L,et al.Simulated microgravity using a rotary cell culture system promotes chondrogenesis of human adipose-derived mesenchymal stem cells via the p38 MAPK pathway[J].Biochem Biophys Res Commun,2011,414(2):412-418.
[21] MAYER-WAGNER S,HAMMERSCHMID F,REDEKER J,et al.Simulated microgravity affects chondrogenesis and hypertrophy of human mesenchymal stem cells[J].Int Orthop,2014,38(12):2615-2621.
[22] GU J,LU Y,LI F,et al.Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation[J].Cell Death Dis,2014,5:e1469.
[23] ZHANG C,LI L,JIANG YD,et al.Space microgravity drives transdifferentiation of human bone marrow-derived mesenchymal stem cells from osteogenesis to adipogenesis[J].FASEB J,2018,32(8):4444-4458.
[24] HUANG Y,DAI ZQ,LING SK,et al.Gravity,a regulation factor in the differentiation of rat bone marrow mesenchymal stem cells[J].J Biomed Sci,2009,16(1):87.

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備注/Memo

備注/Memo:
基金項(xiàng)目:山東省自然科學(xué)基金面上項(xiàng)目(ZR2016HM43),山東省醫(yī)藥衛(wèi)生科技發(fā)展計劃面上項(xiàng)目(2016WS0582),山東省濟(jì)南市科技計劃項(xiàng)目(201602183)
通訊作者:于波 E-mail:[email protected]
更新日期/Last Update: 2019-07-11