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[1]林晴,林煒,付長(zhǎng)龍,等.細(xì)胞焦亡與關(guān)節(jié)炎的研究進(jìn)展[J].中醫(yī)正骨,2018,30(11):43-47.
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細(xì)胞焦亡與關(guān)節(jié)炎的研究進(jìn)展()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期數(shù):
2018年11期
頁(yè)碼:
43-47
欄目:
綜 述
出版日期:
2018-11-20

文章信息/Info

作者:
林晴1林煒1付長(zhǎng)龍1王文義1吳廣文1鄭春松1葉錦霞2
(1.福建中醫(yī)藥大學(xué),福建 福州 350122; 2.福建省中西醫(yī)結(jié)合老年性疾病重點(diǎn)實(shí)驗(yàn)室,福建 福州 350122)
關(guān)鍵詞:
骨關(guān)節(jié)炎 關(guān)節(jié)炎類風(fēng)濕 脊柱炎強(qiáng)直性 關(guān)節(jié)炎痛風(fēng)性 半胱氨酸天冬氨酸蛋白酶1 細(xì)胞焦亡 綜述
摘要:
細(xì)胞焦亡是一種新近發(fā)現(xiàn)并已證實(shí)的伴隨炎癥反應(yīng)的程序性細(xì)胞死亡方式,其經(jīng)典炎癥小體途徑由半胱氨酸天冬氨酸蛋白酶1(caspase-1)介導(dǎo),而caspase-1存在于大部分關(guān)節(jié)炎的滑膜組織中。越來(lái)越多的研究發(fā)現(xiàn),細(xì)胞焦亡相關(guān)信號(hào)通路在關(guān)節(jié)炎的發(fā)展過(guò)程中扮演著重要的角色,因而細(xì)胞焦亡可能會(huì)為治療關(guān)節(jié)炎提供全新的藥物靶點(diǎn)。本文就細(xì)胞焦亡的特征和分子機(jī)制及與細(xì)胞焦亡相關(guān)的關(guān)節(jié)炎(骨關(guān)節(jié)炎、類風(fēng)濕關(guān)節(jié)炎、強(qiáng)直性脊柱炎、痛風(fēng)性關(guān)節(jié)炎)的研究進(jìn)展進(jìn)行了綜述,以期為關(guān)節(jié)炎的治療提供理論參考。

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中醫(yī)正骨2018年11月第30卷第11期 J Trad Chin Orthop Trauma,2018,Vol.30,No.11(總847)
(總848)中醫(yī)正骨2018年11月第30卷第11期 J Trad Chin Orthop Trauma,2018,Vol.30,No.11
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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省衛(wèi)生計(jì)生中青年骨干人才培養(yǎng)項(xiàng)目(2016-ZQN-68); 福建省高校杰出青年科研人才培育計(jì)劃(閩教科[2016]23號(hào)):福建中醫(yī)藥大學(xué)校管課題(X2015034)
通訊作者:葉錦霞 E-mail:[email protected]
更新日期/Last Update: 2018-11-30