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[1]雷騰飛,張玉民,熊軼喆,等.復方紫荊消傷巴布膏外用聯合益氣活血方內服治療神經根型頸椎病的臨床研究[J].中醫(yī)正骨,2018,30(03):13-16,21.
 LEI Tengfei,ZHANG Yumin,XIONG Yizhe,et al.A clinical study of external application of Fufang Zijing Xiaoshang Babugao(復方紫荊消傷巴布膏)combined with oral application of Yiqi Huoxue Fang(益氣活血方)for treatment of cervical spondylotic radiculopathy[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(03):13-16,21.
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復方紫荊消傷巴布膏外用聯合益氣活血方內服治療神經根型頸椎病的臨床研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期數:
2018年03期
頁碼:
13-16,21
欄目:
頸椎疾患
出版日期:
2018-03-20

文章信息/Info

Title:
A clinical study of external application of Fufang Zijing Xiaoshang Babugao(復方紫荊消傷巴布膏)combined with oral application of Yiqi Huoxue Fang(益氣活血方)for treatment of cervical spondylotic radiculopathy
作者:
雷騰飛1張玉民1熊軼喆1陳博1胡零三1黃海生2詹紅生1
1.上海中醫(yī)藥大學附屬曙光醫(yī)院,上海市中醫(yī)藥研究院骨傷科研究所,上海 201203; 2.上海市中西醫(yī)結合醫(yī)院,上海 200082
Author(s):
LEI Tengfei1ZHANG Yumin1XIONG Yizhe1CHEN Bo1HU Lingsan1HUANG Haisheng2ZHAN Hongsheng1
1.Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China 2.Shanghai combinational hospital of traditional Chinese medicine and Western medicine,Shanghai 200082,China
關鍵詞:
頸椎病 神經根病 益氣活血方 復方紫荊消傷巴布膏 臨床試驗
Keywords:
Keywords cervical spondylosis radiculopathy Yiqi Huoxue Fang Fufang Zijing Xiaoshang Babugao clinical trial
摘要:
目的:觀察復方紫荊消傷巴布膏外用聯合益氣活血方內服治療神經根型頸椎病的臨床療效。方法:將90例神經根型頸椎病患者隨機分為3組,其中采用復方紫荊消傷巴布膏外用37例(復方紫荊消傷巴布膏組)、采用益氣活血方內服29例(益氣活血方組)、采用復方紫荊消傷巴布膏外用聯合益氣活血方內服24例(復方紫荊消傷巴布膏聯合益氣活血方組)。復方紫荊消傷巴布膏外貼每天1次,每次12 h,連用6周; 益氣活血方內服每日1劑,早晚2次服用,連服6周。分別于治療前及治療開始后2周、4周、6周記錄并比較3組患者頸部疼痛視覺模擬量表(visual analogue scale,VAS)評分和頸椎功能障礙指數(neck disability index,NDI)。結果:①頸部疼痛VAS評分。時間因素和分組因素不存在交互效應(F=2.250,P=0.058); 3組患者頸部疼痛VAS評分比較,組間差異無統(tǒng)計學意義,不存在分組效應(F=1.528,P=0.218); 治療前后不同時間點之間頸部疼痛VAS評分的差異有統(tǒng)計學意義,存在時間效應(F=57.080,P=0.000); 3組頸部疼痛VAS評分隨時間均呈降低趨勢,且3組的降低趨勢完全一致[(4.84±1.68)分,(3.62±1.69)分,(2.54±1.88)分,(1.74±1.24)分,F=85.491,P=0.000;(5.14±1.98)分,(4.17±2.19)分,(2.59±1.80)分,(1.84±1.52)分,F=42.705,P=0.000;(5.42±1.67)分,(3.46±1.96)分,(1.83±1.61)分,(1.06±0.63)分,F=42.863,P=0.000]。②NDI。時間因素和分組因素存在交互效應(F=1.930,P=0.026); 3組患者NDI比較,組間差異有統(tǒng)計學意義,存在分組效應(F=3.782,P=0.017); 治療前后不同時間點之間NDI的差異有統(tǒng)計學意義,存在時間效應(F=40.546,P=0.000); 3組NDI隨時間均呈降低趨勢,但3組的降低趨勢不完全一致; 治療前和治療開始后2周,3組NDI比較,組間差異均無統(tǒng)計學意義[(22.54±8.39)%,(20.70±7.48)%,(24.65±8.45)%,F=1.632,P=0.195;(17.50±6.54)%,(17.60±6.41)%,(13.10±4.23)%,F=1.863,P=0.210]; 治療開始后4周和6周,3組NDI比較,組間差異均有統(tǒng)計學意義[(11.31±3.19)%,(13.56±4.45)%,(7.33±2.56)%,F=2.754,P=0.028;(7.82±4.32)%,(9.58±3.26)%,(4.73±2.10)%,F=7.458,P=0.013]; 復方紫荊消傷巴布膏組、益氣活血方組NDI均高于復方紫荊消傷巴布膏聯合益氣活血方組(P=0.008,P=0.039; P=0.011,P=0.006),復方紫荊消傷巴布膏組NDI與益氣活血方組比較差異均無統(tǒng)計學意義(P=0.148,P=0.174)。結論:復方紫荊消傷巴布膏外用聯合益氣活血方內服治療神經根型頸椎病,能夠緩解頸部疼痛,改善頸椎功能,且在改善頸椎功能方面優(yōu)于單純復方紫荊消傷巴布膏外用和單純益氣活血方內服,值得臨床推廣應用。
Abstract:
ABSTRACT Objective:To observe the clinical curative effects of external application of Fufang Zijing Xiaoshang Babugao(復方紫荊消傷巴布膏,FFZJXSBBG)combined with oral application of Yiqi Huoxue Fang(益氣活血方,YQHXF)for treatment of cervical spondylotic radiculopathy(CSR).Methods:Ninety patients with CSR were randomly divided into 3 groups,37 patients were treated with external application of FFZJXSBBG(FFZJXSBBG group),29 patients were treatd with oral application of YQHXF(YQHXF group),while the others were treated with external application of FFZJXSBBG combined with oral application of YQHXF(combination treatment group).FFZJXSBBG were applied once a day,12 hours at a time for consecutive 6 weeks; while YQHXF were taken one dose a day in the morning and evening respectively for consecutive 6 weeks.Neck pain visual analogue scale(VAS)scores and neck disability index(NDI)were recorded and compared between the 3 groups before treatment and at 2,4 and 6 weeks after the beginning of the treatment respectively.Results:The analytic results of neck pain VAS scores showed that(1)there was no interaction between time factor and group factor(F=2.250,P=0.058);(2)there was no statistical difference in neck pain VAS scores between the 3 groups,in other words,there was no group effect(F=1.528,P=0.218);(3)there was statistical difference in the neck pain VAS scores between different timepoints before and after the treatment,in other words,there was time effect(F=57.080,P=0.000); and(4)the neck pain VAS scores presented a time-dependent decreasing trend in the 3 groups and the 3 groups were consistent with each other in the decreasing trend of neck pain VAS scores(4.84+/-1.68,3.62+/-1.69,2.54+/-1.88,1.74+/-1.24 points,F=85.491,P=0.000; 5.14+/-1.98,4.17+/-2.19,2.59+/-1.80,1.84+/-1.52 points,F=42.705,P=0.000; 5.42+/-1.67,3.46+/-1.96,1.83+/-1.61,1.06+/-0.63 points,F=42.863,P=0.000).The analytic results of NDI showed that(1)there was interaction between time factor and group factor(F=1.930,P=0.026);(2)there was statistical difference in NDI between the 3 groups,in other words,there was group effect(F=3.782,P=0.017);(3)there was statistical difference in NDI between different timepoints before and after the treatment,in other words,there was time effect(F=40.546,P=0.000);(4)the NDI presented a time-dependent decreasing trend in the 3 groups while the 3 groups were inconsistent with each other in the decreasing trend of NDI;(5)there was no statistical difference in NDI between the 3 groups before treatment and at 2 weeks after the beginning of the treatment(22.54+/-8.39,20.70+/-7.48,24.65+/-8.45%,F=1.632,P=0.195; 17.50+/-6.54,17.60+/-6.41,13.10+/-4.23%,F=1.863,P=0.210);(6)there was statistical difference in NDI between the 3 groups at 4 and 6 weeks after the beginning of the treatment(11.31+/-3.19,13.56+/-4.45,7.33+/-2.56%,F=2.754,P=0.028; 7.82+/-4.32,9.58+/-3.26,4.73+/-2.10%,F=7.458,P=0.013); and(7)the NDI were higher in FFZJXSBBG group and YQHXF group compared to combination treatment group(P=0.008,P=0.039; P=0.011,P=0.006)and there was no statistical difference in NDI between FFZJXSBBG group and YQHXF group(P=0.148,P=0.174).Conclusion:Combination of external application of FFZJXSBBG with oral application of YQHXF can relieve neck pain and improve cervical vertebra function in treatment of CSR,and it is superior to the monotherapy of external application of FFZJXSBBG and the monotherapy of oral application of YQHXF in improving cervical vertebra function,so it is worthy of popularizing in clinic.

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備注/Memo

備注/Memo:
基金項目:國家自然科學基金面上項目(81473702); 國家自然科學基金青年科學基金項目(81503596); 上海市科學技術委員會科研計劃項目(14401970402,15401934100); 上海市進一步加快中醫(yī)藥事業(yè)發(fā)展三年行動計劃建設(2014—2016年)項目(ZY3-LCPT-2-1005); 上海市市級醫(yī)院新興前沿技術聯合攻關項目(SHDC12014121) 通訊作者:詹紅生 E-mail:[email protected]
更新日期/Last Update: 2018-08-02