84年鼠女哪年财运最旺,857comvvv色九欧美激情|85PO_87国产精品欲av国产av资源

[1]王潔,王蕭楓.淫羊藿總黃酮的抗骨質(zhì)疏松作用及其對調(diào)控成骨細(xì)胞分化及骨形成關(guān)鍵信號通路的影響[J].中醫(yī)正骨,2017,29(01):45-48.
點(diǎn)擊復(fù)制

淫羊藿總黃酮的抗骨質(zhì)疏松作用及其對調(diào)控成骨細(xì)胞分化及骨形成關(guān)鍵信號通路的影響()
分享到:

《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第29卷
期數(shù):
2017年01期
頁碼:
45-48
欄目:
綜述
出版日期:
2017-01-20

文章信息/Info

作者:
王潔1王蕭楓2
1.安徽中醫(yī)藥大學(xué),安徽 合肥 230012;
2.浙江省溫州市中西醫(yī)結(jié)合醫(yī)院,浙江 溫州 325000
關(guān)鍵詞:
淫羊藿 骨質(zhì)疏松 成骨細(xì)胞 細(xì)胞分化 骨生成 信號傳導(dǎo) Wnt信號通路 綜述
摘要:
淫羊藿總黃酮(total flavonoids of epimedium,TFE)的抗骨質(zhì)疏松作用已被臨床研究證實(shí),但其具體作用機(jī)制尚不完全清楚,可能通過激活與成骨細(xì)胞相關(guān)的信號通路發(fā)揮作用。調(diào)控成骨細(xì)胞分化及骨形成的關(guān)鍵信號通路主要包括骨形態(tài)發(fā)生蛋白(bone morphogenetic protein,BMP)/Smads信號通路、Wnt/β-連環(huán)蛋白信號通路、Notch信號通路、Hedgehog信號通路及成纖維細(xì)胞生長因子(fibroblast growth factor,FGF)信號通路等。本文就TFE的抗骨質(zhì)疏松作用和TFE對調(diào)控成骨細(xì)胞分化及骨形成的關(guān)鍵信號通路的影響進(jìn)行了綜述。

參考文獻(xiàn)/References:

[1] 黃宏興,陳彥東.中西醫(yī)結(jié)合防治骨質(zhì)疏松癥的研究思路與方法[J].中醫(yī)正骨,2008,20(3):74-75.
[2] 李新建,于蘭英,鄧偉,等.淫羊藿防治激素性股骨頭壞死的作用機(jī)制研究[J].中醫(yī)正骨,2013,25(11):3-7.
[3] 鐘瑜,李曉清,徐曉玉,等.淫羊藿苷對腎陽虛細(xì)胞糖皮質(zhì)激素受體表達(dá)影響的研究[J].中國藥房,2007,18(36):2801-2803.
[4] HUANG J,YUAN L,WANG X,et al.Icaritin and its glycosides enhance osteoblastic,but suppress osteoclastic,differentiation and activity in vitro[J].Life Sci,2007,81(10):832-840.
[5] 濮祖茂,李勇,李晶晶,等.淫羊藿總黃酮對去除卵巢大鼠股骨頭作用的掃描電鏡觀察與圖像分析[J].中國骨質(zhì)疏松雜志,2005,11(2):246-250.
[6] 張玉萱,徐玲玲.淫羊藿總黃酮的藥理作用研究進(jìn)展[J].實(shí)用臨床醫(yī)藥雜志,2012,16(9):125-128.
[7] 宋敏,羅曉,李寧,等.淫羊藿總黃酮含藥血清對成骨細(xì)胞OPG/OPGL基因表達(dá)的影響[J].時珍國醫(yī)國藥,2012,23(4):883-886.
[8] SOLTANOFF CS,YANG S,CHEN W,et al.Signaling networks that control the lineage commitment and differentiation of bone cells[J].Crit Rev Eukaryot Gene Expr,2009,19(1):1-46.
[9] SAITO T,OGAWA M,HATA Y,et al.Acceleration effect of human recombinant bone morphogenetic protein-2 on differentiation of human pulp cells into odontoblasts[J].J Endod,2004,30(4):205-208.
[10] CHEN G,DENG C,LI YP.TGF-β and BMP signaling in osteoblast differentiation and bone formation[J].Int J Biol Sci,2012,8(2):272-288.
[11] 周樂,吳鐵,崔燎.淫羊藿調(diào)節(jié)BMP-7預(yù)防糖皮質(zhì)激素致大鼠骨損害的研究[J].中國骨質(zhì)疏松雜志,2014,20(3):234-237.
[12] 尹宏,錢衛(wèi)慶.淫羊藿對骨質(zhì)疏松型骨折局部骨形成蛋白mRNA表達(dá)的影響[J].中國骨質(zhì)疏松雜志,2012,18(8):717-720.
[13] 笪巍偉,趙永見,王擁軍,等.淫羊藿苷對前成骨細(xì)胞株OCT1細(xì)胞BMP-2 mRNA、Runx-2 mRNA表達(dá)的影響[J].上海中醫(yī)藥雜志,2015,49(5):90-94.
[14] 何偉,李自力,崔元璐,等.淫羊藿苷對大鼠成骨細(xì)胞核結(jié)合因子α1、骨形成蛋白-2、骨形成蛋白-4 mRNA表達(dá)的影響[J].北京大學(xué)學(xué)報(醫(yī)學(xué)版),2009,41(6):669-673.
[15] ZHAO J,OHBA S,SHINKAI M,et al.Icariin induces osteogenic differentiation in vitro in a BMP-and Runx2-dependent manner[J].Biochem Biophys Res Commun,2008,369(2):444-448.
[16] 雪原,王沛,齊清會,等.淫羊藿甙對成骨細(xì)胞Smad4 mRNA作用的實(shí)驗(yàn)研究[J].中華骨科雜志,2005,25(2):119-123.
[17] 雪原,齊清會,王沛,等.淫羊藿甙對OVX大鼠成骨細(xì)胞Smad4 mRNA的作用[J].天津醫(yī)藥,2006,34(4):256-258.
[18] 李子龍.淫羊藿甙對MC3T3-E1細(xì)胞Smad1,4,5作用的實(shí)驗(yàn)研究[D].天津:天津醫(yī)科大學(xué),2012.
[19] 牛銀波,梅其炳,張蓉.Wnt/β-catenin信號通路與骨質(zhì)疏松關(guān)系的研究進(jìn)展[J].中華骨科雜志,2009,29(8):775-778.
[20] 許兵,劉彗,許應(yīng)星,等.成骨細(xì)胞中經(jīng)典Wnt/β-catenin通路研究進(jìn)展[J].生命科學(xué),2011,23(5):477-481.
[21] BENNETT CN,LONGO KA,WRIGHT WS,et al.Regulation of osteoblastogenesis and bone mass by Wnt10b[J].Proc Nati Acad Sci U S A,2005,102(9):3324-3329.
[22] 曾建春,曾意榮,樊粵光,等.淫羊藿甙誘導(dǎo)MSCs向成骨細(xì)胞分化過程中對Wnt信號通路的影響[J].廣州中醫(yī)藥大學(xué)學(xué)報,2014,31(4):607-611.
[23] WANG J,TAO Y,PING Z,et al.Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/β-catenin signaling pathway in vivo and in vitro[J].Sci Rep,2016,6:23827.
[24] 李玲慧,丁道芳,杜國慶,等.淫羊藿苷對大鼠成骨細(xì)胞增殖及堿性磷酸酶、Runx2蛋白表達(dá)的影響[J].中國矯形外科雜志,2013,21(21):2195-2199.
[25] CHEN G,WANG C,WANG J,et al.Antiosteoporotic effect of icariin in ovariectomized rats is mediated via the Wnt/β-catenin pathway[J].Exp Ther Med,2016,12(1):279-287.
[26] LI XF,XU H,ZHAO YJ,et al.Icariin augments bone formation and reverses the phenotypes of osteoprotegerin-deficient mice through the activation of Wnt/β-Catenin-BMP signaling[J].Evid Based Complement Alternat Med,2013,2013:652317.
[27] ZHANG JF,LI G,CHAN CY,et al.Flavonoids of herba epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/β-catenin signaling pathway[J].Mol Cell Endocrinol,2010,314(1):70-74.
[28] ZANOTTI S,CANALIS E.Notch and the skeleton[J].Mol Cell Biol,2010,30(4):886-896.
[29] ZANOTTI S,SMERDEL-RAMOYA A,STADMEYER L,et al.Notch inhibits osteoblast differentiation and causes osteopenia[J].Endocrinology,2008,149(8):3890-3899.
[30] UGARTE F,RYSER M,THIEME S,et al.Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells[J].Exp Hematol,2009,37(7):867-875.
[31] 徐婭.淫羊藿苷在促大鼠MSCs骨向分化過程中對Notch信號通路的影響[D].廣州:暨南大學(xué),2013.
[32] 劉序友,舒建昌.Hedgehog信號通路與肝纖維化發(fā)病相關(guān)機(jī)制研究新進(jìn)展[J].胃腸病學(xué)和肝病學(xué)雜志,2016,25(1):108-111.
[33] 徐練,孔清泉.調(diào)控成骨細(xì)胞分化及骨形成關(guān)鍵信號通路的研究進(jìn)展[J].中國修復(fù)重建外科雜志,2014,28(12):1484-1489.

相似文獻(xiàn)/References:

[1]劉磊,萬春友,全先輝,等.鎖定鋼板內(nèi)固定結(jié)合肱骨頭植骨重建治療 肱骨近端Neer三、四部分骨折[J].中醫(yī)正骨,2015,27(10):52.
[2]徐偉鋒,葉健,吳連國.強(qiáng)骨飲對骨質(zhì)疏松性股骨頸骨折患者全髖關(guān)節(jié)置換術(shù)后 血清骨代謝生化指標(biāo)和骨密度的影響[J].中醫(yī)正骨,2015,27(02):12.
 XU Weifeng,YE Jian,WU Lianguo.Effect of Qianggu Yin(強(qiáng)骨飲,QGY)on serum bone metabolism indexes and bone density after total hip arthroplasty in patients with osteoporotic femoral neck fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(01):12.
[3]龔江浩.股骨近端防旋髓內(nèi)釘聯(lián)合抗骨質(zhì)疏松藥物治療 不穩(wěn)定型老年股骨轉(zhuǎn)子間骨折的臨床觀察[J].中醫(yī)正骨,2015,27(04):29.
 GONG Jianghao.A combination therapy of proximal femoral nail antirotation and anti-osteoporotic drugs for the treatment of unstable femoral intertrochanteric fractures in the aged[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(01):29.
[4]李冠慧,李燦東,李西海,等.雌激素調(diào)控絕經(jīng)后骨質(zhì)疏松癥骨吸收-骨形成 耦聯(lián)失衡的機(jī)制[J].中醫(yī)正骨,2016,28(02):36.
[5]費(fèi)國芳,費(fèi)紅良,王金法.兩種內(nèi)固定方法治療老年不穩(wěn)定性股骨轉(zhuǎn)子間骨折的對比研究[J].中醫(yī)正骨,2016,28(05):9.
 FEI Guofang,FEI Hongliang,WANG Jinfa.Comparison of two kinds of internal fixation for treatment of unstable femoral intertrochanteric fractures in the aged[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(01):9.
[6]陳思凱,邢金明.骨水泥強(qiáng)化椎弓根螺釘內(nèi)固定治療老年胸腰椎壓縮性骨折[J].中醫(yī)正骨,2016,28(05):35.
[7]孫鵬,譚磊,閻乾,等.人工肱骨頭置換術(shù)治療老年肱骨近端Neer三、四部分骨折[J].中醫(yī)正骨,2016,28(05):43.
[8]王博,吳鵬,史曉林.強(qiáng)骨飲對去卵巢骨質(zhì)疏松大鼠骨顯微結(jié)構(gòu)的影響[J].中醫(yī)正骨,2016,28(07):6.
 WANG Bo,WU Peng,SHI Xiaolin.A retrospective trial of postural reduction combined with percutaneous vertebroplasty versus percutaneous kyphoplasty for treatment of osteoporotic vertebral compression fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(01):6.
[9]馮建軍,鄒浩,朱海燕,等.槲皮素對去卵巢大鼠血清骨鈣素和股骨Ⅰ型膠原蛋白水平的影響[J].中醫(yī)正骨,2016,28(07):10.
 FENG Jianjun,ZOU Hao,ZHU Haiyan,et al.Leverage bone grafting and pedicle screw internal fixation through posterior approach for treatment of thoracolumbar fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(01):10.
[10]王吉利,萬雷,張志海,等.抑制Dickkopf-1和Sclerostin表達(dá)對人成骨肉瘤細(xì)胞MG63骨代謝調(diào)節(jié)相關(guān)蛋白表達(dá)水平的影響[J].中醫(yī)正骨,2016,28(09):13.
 WANG Jili,WAN Lei,ZHANG Zhihai,et al.Effect of suppression of Dickkopf-1 and Sclerostin expression on bone metabolism regulatory protein expression levels in human osteosarcoma MG63 cells[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(01):13.

備注/Memo

備注/Memo:

通訊作者:王蕭楓 E-mail:[email protected]
更新日期/Last Update: 2017-01-20