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[1]陳俊杰,莊汝杰,范續(xù),等.膝骨關(guān)節(jié)炎軟骨下炎癥面積與關(guān)節(jié)液中白細(xì)胞介素-1含量的相關(guān)性研究[J].中醫(yī)正骨,2016,28(04):9-11,15.
 CHEN Junjie,ZHUANG Rujie,FAN Xu,et al.Study on the correlations between subchondral inflammation areas and interleukin-1 contents in joint fluid in patients with knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(04):9-11,15.
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膝骨關(guān)節(jié)炎軟骨下炎癥面積與關(guān)節(jié)液中白細(xì)胞介素-1含量的相關(guān)性研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第28卷
期數(shù):
2016年04期
頁碼:
9-11,15
欄目:
臨床研究
出版日期:
2016-04-20

文章信息/Info

Title:
Study on the correlations between subchondral inflammation areas and interleukin-1 contents in joint fluid in patients with knee osteoarthritis
作者:
陳俊杰1莊汝杰2范續(xù)1張婭1
1.浙江中醫(yī)藥大學(xué),浙江 杭州 310053;
2.浙江省中醫(yī)院,浙江 杭州 310006
Author(s):
CHEN Junjie1ZHUANG Rujie2FAN Xu1ZHANG Ya1
1.Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China
2.Zhejiang Provincial Hospital of TCM,Hangzhou 310006,Zhejiang,China
關(guān)鍵詞:
骨關(guān)節(jié)炎 白細(xì)胞介素-1 滑液 軟骨下炎癥面積 相關(guān)分析 磁共振成像
Keywords:
osteoarthritisknee interleukin-1 synovial fluid subchondral inflammation area correlation analysis magnetic resonance imaging
摘要:
目的:探討膝骨關(guān)節(jié)炎軟骨下炎癥面積與關(guān)節(jié)液中白細(xì)胞介素-1含量的相關(guān)性。方法:2014年6—12月,對30例膝骨關(guān)節(jié)炎患者行患肢膝關(guān)節(jié)矢狀面超短回波時(shí)間(ultrashort echo time,UTE)脈沖序列MRI檢查,測量膝關(guān)節(jié)軟骨下炎癥面積,并對其與關(guān)節(jié)液中白細(xì)胞介素-1含量的相關(guān)性進(jìn)行分析。結(jié)果:本組30例,患肢膝關(guān)節(jié)MRI檢查UTE序列上均可見軟骨下高信號(hào)區(qū),其中髕骨軟骨下高信號(hào)區(qū)16例,股骨軟骨下高信號(hào)區(qū)8例,脛骨軟骨下高信號(hào)區(qū)6例。軟骨下炎癥面積(140.61±61.65)mm2,關(guān)節(jié)液中白細(xì)胞介素-1含量(0.170±0.102)pg·mL-1,兩者呈正相關(guān)(r=0.472,P=0.008)。結(jié)論:膝骨關(guān)節(jié)炎患者膝關(guān)節(jié)軟骨下炎癥面積和關(guān)節(jié)液中白細(xì)胞介素-1含量呈正相關(guān); 膝關(guān)節(jié)軟骨下炎癥面積越大,關(guān)節(jié)液中白細(xì)胞介素-1含量越高。
Abstract:
Objective:To explore the correlations between subchondral inflammation areas and interleukin-1(IL-1)contents in joint fluid in patients with knee osteoarthritis(KOA).Methods:The ultrashort echo time(UTE)pulse train MRI examination in sagittal plane were performed upon the affected limbs of 30 patients with KOA from June 2014 to December 2014,then the subchondral inflammation areas of knee joint were measured and the correlations between subchondral inflammation areas and IL-1 contents in joint fluid were analyzed.Results:The subchondral high-intensity zones were found in UTE pulse train MRI images of knee joints in all of the 30 patients,16 cases in patella,8 in femur and 6 in tibia.The subchondral inflammation areas(140.61+/-61.65 mm(2))were positively correlated with IL-1 contents(0.170+/-0.102 pg/ml)in joint fluid(r=0.472,P=0.008).Conclusion:The knee-joint subchondral inflammation areas are positively correlated with IL-1 contents in joint fluid in patients with KOA.The greater the knee-joint subchondral inflammation areas are,the higher the IL-1 contents in joint fluid are.

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備注/Memo

備注/Memo:
基金項(xiàng)目:浙江省醫(yī)藥衛(wèi)生科技計(jì)劃項(xiàng)目(2013KYB184),浙江省重點(diǎn)科技創(chuàng)新團(tuán)隊(duì)項(xiàng)目(2011R50022-04),浙江省重大科技專項(xiàng)計(jì)劃項(xiàng)目(2014C03038)
通訊作者:莊汝杰 E-mail:[email protected]
更新日期/Last Update: 2016-08-30