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[1]李冠慧,李燦東,李西海,等.雌激素調(diào)控絕經(jīng)后骨質(zhì)疏松癥骨吸收-骨形成 耦聯(lián)失衡的機(jī)制[J].中醫(yī)正骨,2016,28(02):36-40.
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雌激素調(diào)控絕經(jīng)后骨質(zhì)疏松癥骨吸收-骨形成 耦聯(lián)失衡的機(jī)制()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第28卷
期數(shù):
2016年02期
頁碼:
36-40
欄目:
學(xué)術(shù)探討
出版日期:
2016-02-20

文章信息/Info

作者:
李冠慧李燦東李西海梁文娜
福建中醫(yī)藥大學(xué),福建 福州 350122
關(guān)鍵詞:
雌激素類 骨質(zhì)疏松絕經(jīng)后 骨生成 骨質(zhì)吸收 骨代謝
摘要:
絕經(jīng)后骨質(zhì)疏松癥指婦女絕經(jīng)后卵巢功能衰退、內(nèi)分泌失調(diào),引起雌激素水平下降,繼發(fā)甲狀旁腺功能亢進(jìn),降鈣素分泌 不足,從而導(dǎo)致骨吸收大于骨形成的代謝性疾病。骨重建過程的主要功能細(xì)胞是破骨細(xì)胞和成骨細(xì)胞,二者經(jīng)由多種信號通路影 響著對方的分化、聚集和功能活動。雌激素作為免疫細(xì)胞和骨細(xì)胞的共同交叉機(jī)制,通過經(jīng)典激素受體途徑,調(diào)節(jié)T細(xì)胞的活化 和免疫因子的產(chǎn)生表達(dá),影響成骨細(xì)胞、破骨細(xì)胞、免疫細(xì)胞的活性和功能; 通過雌激素受體途徑,調(diào)節(jié)破骨細(xì)胞與成骨細(xì)胞的 增殖、分化、凋亡,參與骨形成與骨吸收的調(diào)控。雌激素對骨重建方向的影響,既有正性調(diào)節(jié)作用,又有負(fù)性調(diào)節(jié)作用。因此,雌 激素通過直接調(diào)節(jié)機(jī)制和旁分泌機(jī)制,影響成骨細(xì)胞、破骨細(xì)胞的活性和功能,在絕經(jīng)后骨質(zhì)疏松癥骨吸收-骨形成耦聯(lián)失衡的 病理過程中發(fā)揮著重要的調(diào)控作用。本文從骨形成-骨吸收與骨量的關(guān)系、雌激素調(diào)控骨形成-骨吸收耦聯(lián)的機(jī)制以及雌二醇調(diào) 控骨代謝的作用機(jī)制3個方面進(jìn)行了闡述。

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備注/Memo

備注/Memo:
基金項目:國家自然科學(xué)基金項目(81202645); 福建省自然科學(xué)基金項目(2015J01339); 福建省衛(wèi)生系統(tǒng)中青年骨干人才培養(yǎng) 項目(2015-ZQN-JC-32); 2015年度福建省高等學(xué)校新世紀(jì)優(yōu)秀人才支持計劃
通訊作者:梁文娜 E-mail:[email protected]
更新日期/Last Update: 2016-04-30