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[1]王丹輝,張燕,劉麗娟,等.重組人Ⅱ型腫瘤壞死因子受體-抗體融合蛋白 關(guān)節(jié)腔注射聯(lián)合中藥薰洗治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2015,27(07):31-33.
　WANG Danhui,ZHANG Yan,LIU Lijuan,et al.Clinical study on intra-articular injection of TypeⅡrecombinant human tumor necrosis factor receptor-Fc fusion protein combined with Chinese herbal steaming and washing therapy for treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):31-33.
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重組人Ⅱ型腫瘤壞死因子受體-抗體融合蛋白 關(guān)節(jié)腔注射聯(lián)合中藥薰洗治療膝骨關(guān)節(jié)炎的臨床研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第27卷
期數(shù):
2015年07期
頁碼:
31-33
欄目:
膝骨關(guān)節(jié)炎
出版日期:
2015-07-31

文章信息/Info

Title:
Clinical study on intra-articular injection of TypeⅡrecombinant human tumor necrosis factor receptor-Fc fusion protein combined with Chinese herbal steaming and washing therapy for treatment of knee osteoarthritis
作者:
王丹輝; 張燕; 劉麗娟; 田雪秋; 梁一男; 魏鳳娟
吉林省中醫(yī)藥科學(xué)院,吉林 長(zhǎng)春 130021
Author(s):
WANG Danhui; ZHANG Yan; LIU Lijuan; TIAN Xueqiu; LIANG Yinan; WEI Fengjuan
Jilin Academy of Chinese Medical Sciences,Changchun 130021,Jilin,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝;  受體; 腫瘤壞死因子; Ⅱ型;  透明質(zhì)酸;  薰洗;  治療; 臨床研究性
Keywords:
osteoarthritis; knee;  receptors; tumor necrosis factor; typeⅡ;  hyaluronic acid;  steaming washing therapy;  therapies; investigational
摘要:
目的:觀察注射用重組人Ⅱ型腫瘤壞死因子受體-抗體融合蛋白(recombinant human tumor necrosis factor receptor-Fc fusion protein,rhTNFR:Fc)關(guān)節(jié)腔注射聯(lián)合中藥薰洗治療膝骨關(guān)節(jié)炎的臨床療效。方法:將60例膝骨關(guān)節(jié)炎患者隨機(jī)分為2組,每組30例。分別采用關(guān)節(jié)腔注射rhTNFR:Fc聯(lián)合中藥薰洗和關(guān)節(jié)腔注射玻璃酸鈉聯(lián)合中藥薰洗治療。比較治療前后2組膝關(guān)節(jié)疼痛視覺模擬評(píng)分(visual analogue score,VAS)及西安大略和麥克馬斯特大學(xué)(Western Ontario and McMaster Universities,WOMAC)骨關(guān)節(jié)炎評(píng)分,并于治療結(jié)束后3個(gè)月比較2組患者的綜合療效。結(jié)果:治療前2組患者的膝關(guān)節(jié)VAS評(píng)分及WOMAC評(píng)分比較,組間差異均無統(tǒng)計(jì)學(xué)意義[(7.15±1.09)分,(6.90±1.52)分,t=1.045,P=0.309;(54.75±3.23)分,(55.45±3.11)分,t=0.700,P=0.493]。治療結(jié)束后3個(gè)月,2組患者的膝關(guān)節(jié)VAS評(píng)分[(3.05±0.76)分,(4.10±0.97)分]及WOMAC評(píng)分[(16.55±2.65)分,(27.20±3.17)分]均較治療前下降(t=14.173,P=0.000; t=10.101,P=0.000; t=34.451,P=0.000; t=39.161,P=0.000); rhTNFR:Fc組的膝關(guān)節(jié)VAS評(píng)分及WOMAC評(píng)分下降幅度均大于玻璃酸鈉組[(4.10±1.29)分,(2.80±1.31)分,t=3.771,P=0.001;(38.20±4.96)分,(28.25±3.23)分,t=8.132,P=0.000]。治療結(jié)束后3個(gè)月,rhTNFR:Fc組治愈10例、顯效12例、有效7例、無效1例,玻璃酸鈉組治愈6例、顯效8例、有效13例、無效3例,rhTNFR:Fc組療效優(yōu)于玻璃酸鈉組(Z=﹣1.987,P=0.047)。結(jié)論:采用關(guān)節(jié)腔注射rhTNFR:Fc聯(lián)合中藥薰洗治療膝骨關(guān)節(jié)炎,可以有效緩解膝關(guān)節(jié)疼痛,促進(jìn)膝關(guān)節(jié)運(yùn)功功能恢復(fù),療效優(yōu)于關(guān)節(jié)腔注射玻璃酸鈉聯(lián)合中藥薰洗治療,值得臨床推廣應(yīng)用。
Abstract:
Objective:To observe the clinical curative effects of intra-articular injection of TypeⅡrecombinant human tumor necrosis factor receptor-Fc fusion protein(rhTNFR:Fc)combined with Chinese herbal steaming and washing therapy for treatment of knee osteoarthritis(KOA).Methods:Sixty patients with KOA were randomly divided into 2 groups,30 cases in each group.The patients were treated with combination therapy of intra-articular injection of rhTNFR:Fc with Chinese herbal steaming and washing(rhTNFR:Fc group)and combination therapy of intra-articular injection of sodium hyaluronate(SH)with Chinese herbal steaming and washing(SH group)respectively.The knee visual analogue score(VAS)and Western Ontario and McMaster Universities(WOMAC)osteoarthritis score were compared between the 2 groups before and after the treatment,and the total clinical curative effects were also compared between the 2 groups at 3 months after the end of the treatment.Results:There was no statistical difference in the knee VAS scores and WOMAC scores between the 2 groups before the treatment(7.15+/-1.09 vs 6.90+/-1.52 points,t=1.045,P=0.309; 54.75+/-3.23 vs 55.45+/-3.11 points,t=0.700,P=0.493).The knee VAS scores(3.05+/-0.76,4.10+/-0.97 points)and WOMAC scores(16.55+/-2.65,27.20+/-3.17 points)of all patients decreased at 3 months after the end of the treatment(t=14.173,P=0.000; t=10.101,P=0.000; t=34.451,P=0.000; t=39.161,P=0.000).The decreased degree of knee VAS scores and WOMAC scores of rhTNFR:Fc group were greater than those of SH group(4.10+/-1.29 vs 2.80+/-1.31 points,t=3.771,P=0.001; 38.20+/-4.96 vs 28.25+/-3.23 points,t=8.132,P=0.000).At 3 months after the end of the treatment,10 patients were cured,12 got a good result,7 fair and 1 poor in the rhTNFR:Fc group; while 6 patients were cured,8 got a good result,13 fair and 3 poor in the SH group.The rhTNFR:Fc group surpassed the SH group in the curative effect(Z=-1.987,P=0.047).Conclusion:The therapy of intra-articular injection of rhTNFR:Fc combined with Chinese herbal steaming and washing can effectively relieve the knee pain and promote the knee function recovery in the treatment of KOA,and its curative effect is better than that of intra-articular injection of SH combined with Chinese herbal steaming and washing,so it is worthy of popularizing in clinic.

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備注/Memo

備注/Memo:
2015-02-05收稿 2015-03-03修回
基金項(xiàng)目:吉林省中醫(yī)藥研究室資助項(xiàng)目(2011-Y-25)
通訊作者:王丹輝 E-mail:[email protected]
更新日期/Last Update: 2015-07-30