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[1]李明,徐明雄,馮左基,等.自擬壯骨方治療絕經(jīng)后骨質(zhì)疏松癥的療效及作用機(jī)制研究[J].中醫(yī)正骨,2014,26(09):21-24.
　Li Ming*,Xu Mingxiong,Feng Zuoji,et al.Study on the curative effect and mechanism of action of self-made ZHUANGGU decoction in treatment of postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(09):21-24.
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自擬壯骨方治療絕經(jīng)后骨質(zhì)疏松癥的療效及作用機(jī)制研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第26卷
期數(shù):
2014年09期
頁(yè)碼:
21-24
欄目:
臨床研究
出版日期:
2014-09-30

文章信息/Info

Title:
Study on the curative effect and mechanism of action of self-made ZHUANGGU decoction in treatment of postmenopausal osteoporosis
作者:
李明; 徐明雄; 馮左基; 胡建強(qiáng); 郝濤; 賈舜; 祝海濱; 夏文波; 東光彬
山東省青島市黃島區(qū)中醫(yī)醫(yī)院,山東 青島 266500
Author(s):
Li Ming*; Xu Mingxiong; Feng Zuoji; Hu Jianqiang; Hao Tao; Jia Shun; Zhu Haibin; Xia Wenbo; Dong Guangbin.
*Traditional Chinese Medicine Hospital of Huangdao,Qingdao 266500,Shandong,China
關(guān)鍵詞:
骨質(zhì)疏松; 絕經(jīng)后 壯骨方 骨密度 雌二醇 治療; 臨床研究性
Keywords:
Osteoporosis; postmenopausal;  ZHUANGGU decoction;  Bone density;  Estradiol;  Therapies; investigational
摘要:
目的:探討自擬壯骨方治療絕經(jīng)后骨質(zhì)疏松癥的療效及作用機(jī)制。方法:將納入研究的240例絕經(jīng)后骨質(zhì)疏松癥患者隨機(jī)分為2組,每組120例。治療組采用口服自擬壯骨方治療,對(duì)照組采用口服尼爾雌醇片治療。比較2組患者的骨密度及血清中鈣、磷、堿性磷酸酶、雌二醇的水平,同時(shí)比較2組患者治療后的疼痛改善情況。結(jié)果:①骨密度。治療前2組患者腰椎和股骨頸骨密度比較,組間差異均無(wú)統(tǒng)計(jì)學(xué)意義[(0.73±0.26)g·cm-2,(0.71±0.29)g·cm-2,t=3.296,P=0.110;(0.84±0.03)g·cm-2,(0.85±0.02)g·cm-2,t=3.114,P=0.201]。治療組治療前后腰椎骨密度的差值大于對(duì)照組[(0.20±0.15)g·cm-2,(0.18±0.12)g·cm-2,t=4.012,P=0.021]; 2組患者股骨頸骨密度的差值比較,差異無(wú)統(tǒng)計(jì)學(xué)意義[(0.60±0.24)g·cm-2,(0.16±0.14)g·cm-2,t=1.062,P=0.080]。②血生化指標(biāo)。治療前2組患者血清中鈣、磷、堿性磷酸酶、雌二醇濃度比較,組間差異均無(wú)統(tǒng)計(jì)學(xué)意義[(2.24±0.16)mmol·L-1,(2.22±0.14)mmol·L-1,t=5.659,P=0.431;(1.19±0.21)mmol·L-1,(1.18±0.22)mmol·L-1,t=3.314,P=0.158;(109.50±13.41)U·L-1,(108.71±20.42)U·L-1,t=1.354,P=0.762;(40.86±18.26)pmol·L-1,(41.14±19.04)pmol·L-1,t=1.918,P=0.656]。治療組血清中鈣和磷濃度治療前后的差值均大于對(duì)照組[(1.61±0.46)mmol·L-1,(0.31±0.25)mmol·L-1,t=5.618,P=0.000;(0.60±0.24)mmol·L-1,(0.30±0.14)mmol·L-1,t=7.012,P=0.000]; 堿性磷酸酶和雌二醇濃度治療前后的差值與對(duì)照組比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義[(20.21±12.16)U·L-1,(16.11±10.12)U·L-1,t=1.368,P=0.612;(19.26±10.23)pmol·L-1,(16.76±9.67)pmol·L-1,t=1.386,P=0.748]。③疼痛改善情況。治療組顯效74例、有效35例、無(wú)效11例,對(duì)照組顯效71例、有效34例、無(wú)效15例。治療結(jié)束后2組患者疼痛改善情況比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(Z=-0.547,P=0.584)。結(jié)論:自擬壯骨方具有類雌激素樣作用,可通過(guò)提高雌激素水平,改善骨代謝,增加骨密度,減輕絕經(jīng)后骨質(zhì)疏松癥患者的疼痛癥狀。
Abstract:
Objective:To study the curative effect and mechanism of action of self-made ZHUANGGU decoction in treatment of postmenopausal osteoporosis(PMO).Methods:Two hundred and forty patients with PMO were randomly divided into 2 groups,120 cases in each group.The patients in the treatment group was treated with oral application of self-made ZHUANGGU decoction,while others in the control group was treated with nilestriol tablet.Bone mineral density(BMD)and serum level of Ca,P,alkaline phosphatase(ALP)and estradiol(E2)were compared between the 2 groups.Meanwhile,the posttreatment pain degree was compared between the 2 groups.Results:There was no statistical difference in BMD of lumbar spine and femoral neck between the 2 groups before the treatment(0.73+/-0.26 vs 0.71+/-0.29 g/cm(2),t=3.296,P=0.110; 0.84+/-0.03 vs 0.85+/-0.02 g/cm(2),t=3.114,P=0.201).After the treatment,the lumbar spine BMD change of treatment group was greater than that of control group(0.20+/-0.15 vs 0.18+/-0.12 g/cm(2),t=4.012,P=0.021),and there was no statistical difference in the femoral neck BMD change between the 2 groups(0.60+/-0.24 vs 0.16+/-0.14 g/cm(2),t=1.062,P=0.080).There was no statistical difference in serum level of Ca,P,ALP an E2 between the 2 groups before the treatment(2.24+/-0.16 vs 2.22+/-0.14 mmol/L,t=5.659,P=0.431; 1.19+/-0.21 vs 1.18+/-0.22 mmol/L,t=3.314,P=0.158; 109.50+/-13.41 vs 108.71+/-20.42 U/L,t=1.354,P=0.762; 40.86+/-18.26 vs 41.14+/-19.04 pmol·L-1,t=1.918,P=0.656).After the treatmeng,the change of serum level of Ca and P of treatment group was greater than that of control group(1.61+/-0.46 vs 0.31+/-0.25 mmol/L,t=5.618,P=0.000; 0.60+/-0.24 vs 0.30+/-0.14 mmol/L,t=7.012,P=0.000),while there was no statistical difference in the change of serum level of ALP and E2 between the 2 groups(20.21+/-12.16 vs 16.11+/-10.12 U/L,t=1.368,P=0.612; 19.26+/-10.23 vs 16.76+/-9.67 pmol/L,t=1.386,P=0.748).Seventy-four patients obtained an excellent result,35 good and 11 poor in the treatment group; while 71 patients obtained an excellent result,34 good and 15 poor in the control group.There was no statistical difference in the degree of pain relief between 2 groups after the treatment(Z=-0.547,P=0.584).Conclusion:Self-made ZHUANGGU decoction has estrogen-like effects,so it can effectively reduce the pain symptoms of the patients with PMO through increasing estrogen levels and improving bone metabolism and increasing BMD.

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更新日期/Last Update: 2014-09-30