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[1]項(xiàng)旻,楊虹,林愛(ài)菊,等.絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素的關(guān)系研究[J].中醫(yī)正骨,2013,25(12):20-23.
　Xiang Min*,Yang Hong,Lin Aiju,et al.Clinical study on the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(12):20-23.
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絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素的關(guān)系研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期數(shù):
2013年12期
頁(yè)碼:
20-23
欄目:
骨質(zhì)疏松癥
出版日期:
2013-12-30

文章信息/Info

Title:
Clinical study on the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes
作者:
項(xiàng)旻; 楊虹; 林愛(ài)菊; 閆紹榮; 葉成夫; 盧學(xué)勉
溫州醫(yī)科大學(xué)附屬第三醫(yī)院,浙江 瑞安 325200
Author(s):
Xiang Min*; Yang Hong; Lin Aiju; Yan Shaorong; Ye Chengfu; Lu Xuemian.*
The Third Affiliated Hospital of Wenzhou Medical University,Ruian 325200,Zhejiang,China
關(guān)鍵詞:
骨質(zhì)疏松; 絕經(jīng)后 糖尿病; 2型 骨密度 微量元素
Keywords:
Osteoporosis; postmenopausal;  Diabetes mellitus; type 2;  Bone density;  Trace elements
摘要:
目的:探討絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素間的關(guān)系。方法:納入絕經(jīng)后女性168例,年齡48～82歲,中位數(shù) 63.5歲; 其中2型糖尿病患者122例,健康女性46例。所有受檢者均測(cè)定血清鈣、鎂、鋅、銅、鐵含量和糖化血紅蛋白含量,并測(cè) 定身高和體質(zhì)量。絕經(jīng)后2型糖尿病患者同時(shí)測(cè)定腰椎和左側(cè)股骨骨密度。將絕經(jīng)后2型糖尿病患者納入Ⅰ組,絕經(jīng)后健康女性納 入Ⅱ組,比較2組受檢者微量元素的血清含量。根據(jù)骨密度檢測(cè)結(jié)果,將122例絕經(jīng)后2型糖尿病患者中骨密度正常者納入A組、骨 量減少者納入B組、骨質(zhì)疏松者納入C組,比較3組患者微量元素的血清含量; 然后根據(jù)是否骨質(zhì)疏松將122例絕經(jīng)后2型糖尿病患 者分為2組,采用Logistic回歸分析法分析絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素的關(guān)系。結(jié)果:①絕經(jīng)后2型糖尿病與血微 量元素的關(guān)系。Ⅰ組受檢者血液中鋅、鎂含量低于Ⅱ組[(91.42±10.88)μmol·L-1,(98.47±11.06) μmol·L-1,t=15.890,P=0.000;(1.46±0.14)mmol·L-1,(1.69±0.14)mmol·L- 1,t=88.490,P=0.000]; 銅、鈣、鐵含量與Ⅱ組比較,差異無(wú)統(tǒng)計(jì)學(xué)意義[(12.95±2.43)μmol·L-1, (12.54±2.11)μmol·L-1,t=1.053,P=0.306;(1.52±0.13)mmol·L-1,(1.54±0.15) mmol·L-1,t=0.890,P=0.347;(8.07±1.16)mmol·L-1,(8.17±1.40)mmol·L- 1,t=0.968,P=0.323]。②絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素的關(guān)系。A組42例,B組40例,C組40例。3組絕經(jīng)后2 型糖尿病患者血液中鈣、鎂、鐵含量比較,組間差異無(wú)統(tǒng)計(jì)學(xué)意義[(1.53±0.10)mmol·L-1, (1.51±0.17)mmol·L-1,(1.50±0.12)mmol·L-1,F=0.362,P=0.697;(1.47±0.13)mmol ·L-1,(1.45±0.15)mmol·L-1,(1.44±0.14)mmol·L-1,F=0.325,P=0.723; (8.39±1.11)mmol·L-1,(7.94±1.28)mmol·L-1,(7.90±1.04)mmol·L- 1,F=2.324,P=0.102]。銅、鋅含量比較,組間差異有統(tǒng)計(jì)學(xué)意義[(13.99±2.33)μmol·L-1, (12.83±1.89)μmol·L-1,(12.09±2.64)μmol·L-1,F=7.027,P=0.001; (96.80±11.09)μmol·L-1,(91.51±9.64)μmol·L-1,(86.21±9.39)μmol·L- 1,F=11.388,P=0.000]。A組患者血液中銅含量高于B組和C組(P=0.027,P=0.000),B、C組比較,差異無(wú)統(tǒng)計(jì)學(xué)意義 (P=0.149); A組患者血液中鋅含量高于B組和C組(P=0.020,P=0.000),B組高于C組(P=0.018)。對(duì)血液中鋅、銅、鈣、鎂、鐵含量 行二元Logistic回歸分析顯示,血液中銅、鋅含量為絕經(jīng)后2型糖尿病患者骨質(zhì)疏松的保護(hù)因素(OR=0.731,P=0.006; OR=0.843,P=0.046)。結(jié)論:絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血液中鋅、銅缺乏有關(guān)。
Abstract:
Objective:To explore the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes.Methods:One hundred and sixty-eight postmenopausal women were recruited.The subjects consisted of 122 women with type 2 diabetes(groupⅠ)and 46 healthy women(groupⅡ),and ranged in age from 48 to 82 years(Median=63.5 yrs).The serum level of calcium,magnesium,zinc,copper,iron and glycosylated hemoglobin were detected,and the body height and body mass were measured for all the subjects.The serum level of trace elements were compared between the two groups.Meanwhile,the bone mineral density(BMD)of lumbar vertebrae and left femur were detected in groupⅠ.According to the BMD,the women in groupⅠwere divided into 3 subgroups.The women with normal BMD were recruited into group A,lower BMD women were recruited into group B,while the osteoporotic women were recruited into group C.The serum level of trace elements were compared between the three subgroups.Furthermore,the women in groupⅠwere divided into osteoporosis subgroup and non-osteoporosis subgroup,and the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes was analyzed through logistic regression analysis.Results:The serum content of zinc and magnesium of groupⅠwere lower than those of groupⅡ(91.42+/-10.88 vs 98.47+/-11.06 μmol/L,t=15.890,P=0.000; 1.46 +/-0.14 vs 1.69+/-0.14 mmol/L,t=88.490,P=0.000).There were no statistical differences in the serum content of copper,calcium and iron between the 2 groups(12.95+/-2.43 vs 12.54+/-2.11 μmol/L,t=1.053,P=0.306; 1.52+/-0.13 vs 1.54+/-0.15 mmol/L,t=0.890,P=0.347; 8.07+/-1.16 vs 8.17+/-1.40 mmol/L,t=0.968,P=0.323).Among the 122 women with type 2 diabetes,42 cases were included into group A,40 cases in group B,40 cases in group C.There were no statistical differences in the serum content of calcium,magnesium and iron among the 3 subgroups(1.53+/- 0.10,1.51+/-0.17,1.50+/-0.12 mmol/L,F=0.362,P=0.697; 1.47+/-0.13,1.45+/-0.15,1.44+/-0.14 mmol/L,F=0.325,P=0.723; 8.39+/-1.11,7.94+/-1.28,7.90+/-1.04 mmol/L,F=2.324,P=0.102).There were statistical differences in the serum content of copper and zinc among the 3 subgroups(13.99+/-2.33,12.83+/-1.89,12.09+/- 2.64 μmol/L,F=7.027,P=0.001; 96.80+/-11.09,91.51+/-9.64,86.21+/-9.39 μmol/L,F=11.388,P=0.000).The serum copper content of group A was higher than that of group B and group C(P=0.027,P=0.000),and there was no statistical differences between group B and group C(P=0.149).The serum zinc content of group A was higher than that of group B and group C(P=0.020,P=0.000),and group B surpassed group C(P=0.018).The results of logistic regression analysis showed that the serum content of copper and zinc was the protective factor for osteoporosis of postmenopausal women with type 2 diabetes(OR=0.731,P=0.006; OR=0.843,P=0.046).Conclusion:The osteoporosis may be associated with lack of serum zinc and serum copper for postmenopausal women with type 2 diabetes.

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備注/Memo

備注/Memo:
2013-09-06收稿 2013-10-20修回
基金項(xiàng)目:浙江省瑞安市科技局基金項(xiàng)目(201302030)
更新日期/Last Update: 2013-12-30