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[1]黃建武,黃建華,林愛麗.扶中清痹通絡(luò)湯聯(lián)合益賽普對活動(dòng)期類風(fēng)濕關(guān)節(jié)炎患者腫瘤壞死因子-α及血管內(nèi)皮生長因子血清含量的影響[J].中醫(yī)正骨,2013,25(05):9-11.
　HUANG Jian-wu*,HUANG Jian-hua,LIN Ai-li.*.Effect of FUZHONG QINGBI TONGLUO decoction combined with etanercept on the serum contents of tumor necrosis factor-alpha and vascular endothelial growth factor in patients with active rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(05):9-11.
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扶中清痹通絡(luò)湯聯(lián)合益賽普對活動(dòng)期類風(fēng)濕關(guān)節(jié)炎患者腫 瘤壞死因子-α及血管內(nèi)皮生長因子血清含量的影響()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期數(shù):
2013年05期
頁碼:
9-11
欄目:
基礎(chǔ)研究
出版日期:
2013-05-31

文章信息/Info

Title:
Effect of FUZHONG QINGBI TONGLUO decoction combined with etanercept on the serum contents of tumor necrosis factor-alpha and vascular endothelial growth factor in patients with active rheumatoid arthritis
作者:
黃建武; 黃建華; 林愛麗
溫州醫(yī)學(xué)院附屬第三醫(yī)院,浙江 瑞安 325200
Author(s):
HUANG Jian-wu*; HUANG Jian-hua; LIN Ai-li.*
The Third Affiliated Hospital of Wenzhou Medical College,Rui'an 325200,Zhejiang,China
關(guān)鍵詞:
關(guān)節(jié)炎; 類風(fēng)濕 腫瘤壞死因子α 血管內(nèi)皮生長因子類 扶中清痹通絡(luò)湯 注射用重組人Ⅱ型腫瘤壞死因子受體-抗體融合蛋白 治療; 臨床研究性
Keywords:
Arthritis; rheumatoid;  Tumor necrosis factor-alpha;  Vascular endothelial growth factors;  FUZHONG QINGBI TONGLUO decoction;  Recombinant tumor necrosis factor alpha receptor:Fc fusion protein;  Therapies; investigational
摘要:
目的:觀察扶中清痹通絡(luò)湯聯(lián)合益賽普對活動(dòng)期類風(fēng)濕關(guān)節(jié)炎患者血清腫瘤壞死因子-α及血管內(nèi)皮生長因子含量的影響。方法:將納入研究的69例活動(dòng)期類風(fēng)濕關(guān)節(jié)炎患者隨機(jī)分為2組,治療組35例采用口服扶中清痹通絡(luò)湯聯(lián)合皮下注射益賽普治療,對照組34例采用皮下注射益賽普治療。分別于治療前和治療3個(gè)月后抽取靜脈血測定患者血清中腫瘤壞死因子-α及血管內(nèi)皮生長因子的含量。結(jié)果:①腫瘤壞死因子-α血清含量。治療前2組患者血清腫瘤壞死因子-α含量比較,差異無統(tǒng)計(jì)學(xué)意義(t=0.374,P=0.710); 治療后2組患者血清腫瘤壞死因子-α含量均降低[(97.25±18.73)pg·mL-1,(58.98±12.34)pg·mL-1,t=10.094,P=0.000;(95.61±17.66)pg·mL-1,(65.23±10.37)pg·mL-1,t=8.650,P=0.000]; 治療組的降低值大于對照組[(38.96±10.21)pg·mL-1,(31.15±8.43)pg·mL-1,t=3.459,P=0.001]。②血管內(nèi)皮生長因子血清含量。治療前2組患者血清血管內(nèi)皮生長因子含量比較,差異無統(tǒng)計(jì)學(xué)意義(t=1.006,P=0.318); 治療后2組患者血管內(nèi)皮生長因子含量均降低[(85.12±16.56)pg·mL-1,(57.73±12.27)pg·mL-1,t=7.862,P=0.000;(81.42±13.83)pg·mL-1,(69.42±13.12)pg·mL-1,t=3.671,P=0.001]; 治療組的降低值大于對照組[(29.54±8.78)pg·mL-1,(10.63±6.54)pg·mL-1,t=10.123,P=0.000]。結(jié)論:扶中清痹通絡(luò)湯聯(lián)合益賽普可降低活動(dòng)期類風(fēng)濕關(guān)節(jié)炎患者血清中腫瘤壞死因子-α和血管內(nèi)皮生長因子的含量,其效果優(yōu)于單獨(dú)使用益賽普。
Abstract:
Objective:To observe the effect of FUZHONG QINGBI TONGLUO decoction combined with etanercept on the serum contents of tumor necrosis factor-alpha(TNF-α)and vascular endothelial growth factor(VEGF)in patients with active rheumatoid arthritis(RA).Methods:Sixty-nine patients with active RA enrolled in the study were randomly divided into 2 groups,35 cases in the treatment group were administrated with FUZHONG QINGBI TONGLUO decoction combined with subcutaneous injection of etanercept,while the others in the control group were administrated with subcutaneous injection of etanercept alone.The serum contents of TNF-α and VEGF were respectively detected before the treatment and 3 months after the treatment.Results:There was no statistical difference in serum contents of TNF-α between the 2 groups before the treatment(t=0.374,P=0.710); while the serum contents of TNF-α declined in the 2 groups after the treatment[(97.25±18.73)pg·mL-1,(58.98±12.34)pg·mL-1,t=10.094,P=0.000;(95.61±17.66)pg·mL-1,(65.23±10.37)pg·mL-1,t=8.650,P=0.000],and the treatment group had a more obvious decrease in serum contents of TNF-α than did the control group[(38.96±10.21)pg·mL-1,(31.15±8.43)pg·mL-1,t=3.459,P=0.001].There was no statistical difference in serum contents of VEGF between the 2 groups before the treatment(t=1.006,P=0.318); while the serum contents of VEGF declined in the 2 groups after the treatment[(85.12±16.56)pg·mL-1,(57.73±12.27)pg·mL-1,t=7.862,P=0.000;(81.42±13.83)pg·mL-1,(69.42±13.12)pg·mL-1,t=3.671,P=0.001],and the treatment group had a more obvious decrease in serum contents of VEGF than did the control group[(29.54±8.78)pg·mL-1,(10.63±6.54)pg·mL-1,t=10.123,P=0.000].Conclusion:The therapy of FUZHONG QINGBI TONGLUO decoction combined with etanercept can reduce the serum contents of TNF-α and VEGF in patients with active RA,and its effect is better than that of etanercept alone.

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更新日期/Last Update: 1900-01-01