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[1]王笑青,張永紅,侯宏理,等.頑痹清丸聯(lián)合非甾體抗炎藥及改善病情的抗風(fēng)濕藥治療濕熱痹阻型類風(fēng)濕關(guān)節(jié)炎[J].中醫(yī)正骨,2013,25(03):41-43.
　WANG Xiao-qing*,ZHANG Yong-hong,HOU Hong-li,et al.Curative effect and safety of WANBIQING pills combined with nonsteroidal antiinflammatory drugs and disease modifying antirheumatic drugs in the treatment of rheumatoid arthritis of dampness-heat stagnation type[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(03):41-43.
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頑痹清丸聯(lián)合非甾體抗炎藥及改善病情的抗風(fēng)濕藥治療 濕熱痹阻型類風(fēng)濕關(guān)節(jié)炎()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期數(shù):
2013年03期
頁碼:
41-43
欄目:
臨床研究
出版日期:
2013-03-20

文章信息/Info

Title:
Curative effect and safety of WANBIQING pills combined with nonsteroidal antiinflammatory drugs and disease modifying antirheumatic drugs in the treatment of rheumatoid arthritis of dampness-heat stagnation type
作者:
王笑青; 張永紅; 侯宏理; 王玉麗; 許素琴; 曹焱
河南省洛陽正骨醫(yī)院,河南 洛陽 471002
Author(s):
WANG Xiao-qing*; ZHANG Yong-hong; HOU Hong-li; WANG Yu-li; XU Su-qin; CAO Yan.
*Luoyang Orthopedic-Traumatological Hospital,Luoyang 471002,Henan,China
關(guān)鍵詞:
關(guān)節(jié)炎; 類風(fēng)濕 痹證 頑痹清丸 消炎藥; 非甾類 抗風(fēng)濕藥 治療; 臨床研究性
Keywords:
Arthritis; rheumatoid;  Arthralgia syndrome;  WANBIQING PILL;  Anti-inflammatory agents; non-steroidal;  Antirheumatic agents;  Therapies; investigational
摘要:
目的:觀察頑痹清丸聯(lián)合非甾體抗炎藥及改善病情的抗風(fēng)濕藥治療濕熱痹阻型類風(fēng)濕關(guān)節(jié)炎的臨床療效及安全性。方法:將53例濕熱痹阻型類風(fēng)濕關(guān)節(jié)炎患者隨機(jī)分為2組,A組患者(25例)采用口服頑痹清丸聯(lián)合雙氯芬酸鈉緩釋膠囊、甲氨蝶呤片和來氟米特片治療,B組患者(28例)采用口服安慰劑聯(lián)合雙氯芬酸鈉緩釋膠囊、甲氨蝶呤片和來氟米特片治療。治療8周后比較2組患者類風(fēng)濕因子、血沉、C反應(yīng)蛋白、關(guān)節(jié)疼痛評(píng)分變化情況及總體療效。結(jié)果:①2組類風(fēng)濕因子、血沉、C反應(yīng)蛋白、VAS評(píng)分均較治療前降低; 2組類風(fēng)濕因子下降幅度比較,差異無統(tǒng)計(jì)學(xué)意義(t=0.071,P=0.944); A組血沉、C反應(yīng)蛋白、關(guān)節(jié)疼痛評(píng)分下降幅度均大于B組(t=-5.305,P=0.000; t=-2.847,P=0.001; t=-4.807,P=0.000)。②A組臨床療效優(yōu)于B組(Z=-2.600,P=0.009)。③A組1例患者出現(xiàn)白細(xì)胞計(jì)數(shù)降低,1例患者出現(xiàn)轉(zhuǎn)氨酶增高,2例患者出現(xiàn)咽喉疼痛; B組1例患者出現(xiàn)轉(zhuǎn)氨酶增高,3例患者出現(xiàn)咽喉疼痛。經(jīng)對癥處理后,2組患者的不良反應(yīng)均消失。2組患者不良反應(yīng)發(fā)生率比較,差異無統(tǒng)計(jì)學(xué)意義(χ2=0.000,P=1.000)。結(jié)論:采用頑痹清丸聯(lián)合非甾體抗炎藥及改善病情的抗風(fēng)濕藥治療濕熱痹阻型類風(fēng)濕關(guān)節(jié)炎,可以有效地降低急性期反應(yīng)物水平,緩解關(guān)節(jié)疼痛,療效確切,且不良反應(yīng)輕微,值得臨床推廣應(yīng)用。
Abstract:
Objective:To observe the clinical curative effect and safety of WANBIQING pills combined with nonsteroidal antiinflammatory drugs(NASIDs)and disease modifying antirheumatic drugs(DMARDs)in the treatment of rheumatoid arthritis(RA)of dampness-heat stagnation type.Methods:Fifty-three patients with RA of dampness-heat stagnation type were randomly divided into 2 groups,25 patients in group A were administrated with oral application of WANBIQING pills combined with diclofenac sodium sustained release capsules,methotrexate tablets and leflunomide tablets,while the others in group B were administrated with oral application of placebo combined with diclofenac sodium sustained release capsules,methotrexate tablets and leflunomide tablets.After eight-week treatment the 2 groups were compared with each other in such parameters as rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),C-reaction protein(CRP),changes of joint pain scores and total curative effects.Results:The RF,ESR,CRP and VAS of the 2 groups were all decreased compared with those before the treatment,and there was no statistical difference in decreasing degree of RF between the 2 groups(t=0.071,P=0.944),while the decreasing degrees of ESR,CRP and joint pain scores in group A were all greater than those in group B(t=-5.305,P=0.000; t=-2.847,P=0.001; t=-4.807,P=0.000).The clinical curative effect of group A was better than that of group B(Z=-2.600,P=0.009).One case with decreased white blood count,1 case with increased aminopherase and 2 cases with sore throat were found in group A,while 1 case with increased aminopherase and 3 cases with sore throat were found in group B.All of the adverse reactions disappeared after symptomatic treatment.There was no statistical difference in adverse reaction ratio between the 2 groups(χ2=0.000,P=1.000).Conclusion:The therapy of WANBIQING pills combined with NASIDs and DMARDs can effectively lower the acute phase reactant level and relieve the pain in joint when it is used in the treatment of RA of dampness-heat stagnation type,furthermore,it has certain curative effects with mild adverse reactions,so it is worthy of popularizing in clinic.

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基金項(xiàng)目:河南省科技發(fā)展計(jì)劃項(xiàng)目(082102310095)
通訊作者:張永紅 E-mail:[email protected]
更新日期/Last Update: 2013-03-20