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[1]趙余煬,楊敬言,王超逸,等.基礎(chǔ)代謝率與椎間盤退變因果關(guān)系的孟德爾隨機化研究[J].中醫(yī)正骨,2024,36(05):32-38.
　ZHAO Yuyang,YANG Jingyan,WANG Chaoyi,et al.The causal relationship between basal metabolic rate and intervertebral disc degeneration:a mendelian randomization study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2024,36(05):32-38.
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基礎(chǔ)代謝率與椎間盤退變因果關(guān)系的孟德爾隨機化研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第36卷
期數(shù):
2024年05期
頁碼:
32-38
欄目:
數(shù)據(jù)庫研究
出版日期:
2024-05-20

文章信息/Info

Title:
The causal relationship between basal metabolic rate and intervertebral disc degeneration:a mendelian randomization study
作者:
趙余煬; 楊敬言; 王超逸; 馬涉; 黃仁俊; 于棟
北京中醫(yī)藥大學(xué)第三附屬醫(yī)院,北京 100029
Author(s):
ZHAO Yuyang; YANG Jingyan; WANG Chaoyi; MA She; HUANG Renjun; YU Dong
Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China
關(guān)鍵詞:
椎間盤退化;  基礎(chǔ)代謝率;  孟德爾隨機化分析;  全基因組關(guān)聯(lián)研究
Keywords:
intervertebral disc degeneration;  basal metabolic rate;  Mendelian randomization analysis;  genome-wide association study
摘要:
目的:探討基礎(chǔ)代謝率與椎間盤退變的因果關(guān)系。方法:分別從IEU OpenGWAS project數(shù)據(jù)庫和FINNGEN數(shù)據(jù)庫中篩選,獲得基礎(chǔ)代謝率的全基因組關(guān)聯(lián)研究(genome-wide association study,GWAS)數(shù)據(jù)集和椎間盤退變的GWAS數(shù)據(jù)集。在分析工具R包中從基礎(chǔ)代謝率的GWAS數(shù)據(jù)集中篩選符合要求的單核苷酸多態(tài)性(single nucleotide polymorphism,SNP)位點作為工具變量,根據(jù)篩選出的工具變量從椎間盤退變數(shù)據(jù)集中匹配相應(yīng)的SNP位點。采用逆方差加權(quán)法(inverse variance weighted,IVW)、MR-Egger回歸、簡單中位數(shù)法(simple mode,SM)、加權(quán)中值法(weighted median estimator,WME)、加權(quán)中位數(shù)法(weighted mode,WM)進行孟德爾隨機化(Mendelian randomization,MR)分析。采用MR-Egger截距檢驗、Cochran's Q檢驗、留一法進行敏感性分析。結(jié)果:納入90個基礎(chǔ)代謝率SNP位點作為工具變量。MR分析結(jié)果顯示,基礎(chǔ)代謝率與椎間盤退變呈負向因果關(guān)系[IVW:OR=0.69,95%CI(0.59,0.80),P=0.000; WME:OR=0.69,95%CI(0.58,0.81),P=0.000; MR-Egger:OR=0.59,95%CI(0.42,0.84),P=0.004; WM:OR=0.59,95%CI(0.44,0.81),P=0.001; SM:OR=0.91,95%CI(0.57,1.47),P=0.710]。MR-Egger截距檢驗結(jié)果表明,MR分析結(jié)果不存在水平多效性(P=0.358)。異質(zhì)性檢驗結(jié)果顯示,基礎(chǔ)代謝率SNP位點存在異質(zhì)性(P=0.000); 采用IVW的隨機效應(yīng)模型再次評估,結(jié)果顯示基礎(chǔ)代謝率與椎間盤退變呈負向因果關(guān)系(P=0.000),異質(zhì)性存在對結(jié)果無影響; 留一法檢驗結(jié)果顯示,無單個SNP位點對基礎(chǔ)代謝率與椎間盤退變呈負向因果關(guān)系造成影響,MR分析結(jié)果穩(wěn)定。結(jié)論:基礎(chǔ)代謝率與椎間盤退變呈負向因果關(guān)系。
Abstract:
Objective:To explore the causal relationship between basal metabolic rate(BMR)and intervertebral disc degeneration(IVDD).Methods:The genome-wide association study(GWAS)datasets about BMR and IVDD were retrieved and extracted from the IEU OpenGWAS project database and FINNGEN database,respectively.Furthermore,the eligible single nucleotide polymorphism(SNP)loci were screened from the BMR GWAS datasets as the instrumental variables,and the SNP loci matched with the instrumental variables were selected from the IVDD GWAS datasets in the analysis tool R package.After that,a mendelian randomization(MR)analysis was conducted by using inverse variance weighted(IVW),MR-Egger regression,simple mode(SM),weighted median estimator(WME)and weighted mode(WM),and the sensitivity was examined via the MR-Egger intercept test,Cochran's Q test,and the leave-one-out(LOO)test.Results:Ninety BMR SNP loci were included and served as the instrumental variables.The results of MR analysis showed an inverse causal relationship between BMR and IVDD(IVW:OR=0.69,95%CI(0.59,0.80),P=0.000; WME:OR=0.69,95%CI(0.58,0.81),P=0.000; MR-Egger:OR=0.59,95%CI(0.42,0.84),P=0.004; WM:OR=0.59,95%CI(0.44,0.81),P=0.001; SM:OR=0.91,95%CI(0.57,1.47),P=0.710).The results of MR-Egger intercept test indicated that there was no horizontal pleiotropy in the MR analysis results(P=0.358).The results of heterogeneity test revealed that there was heterogeneity in SNP loci of BMR(P=0.000).A re-evaluation was performed by employing a random-effects model of IVW,and the results showcased that the BMR had an inverse causal relationship with IVDD(P=0.000),suggesting the heterogeneity in SNP loci of BMR having no impact on the MR analysis results.Furthermore,the LOO test showed that none of the single SNP loci had impact on the inverse causal relationship between BMR and IVDD,suggesting the results of MR analysis were stable.Conclusion:BMR exhibits an inverse causal relationship with IVDD.

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備注/Memo

備注/Memo:
通訊作者:于棟 E-mail:[email protected]
更新日期/Last Update: 1900-01-01