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[1]李琰,尹煜輝,劉寧,等.《永類鈐方》中骨傷內(nèi)服藥方的用藥規(guī)律分析[J].中醫(yī)正骨,2024,36(04):47-54.
　LI Yan,YIN Yuhui,LIU Ning,et al.Clinical medication rules of the oral prescriptions for treatment of orthopedic traumatologic diseases(TCM)in Yonglei Qianfang[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2024,36(04):47-54.
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《永類鈐方》中骨傷內(nèi)服藥方的用藥規(guī)律分析()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第36卷
期數(shù):
2024年04期
頁碼:
47-54
欄目:
文獻(xiàn)研究
出版日期:
2024-04-20

文章信息/Info

Title:
Clinical medication rules of the oral prescriptions for treatment of orthopedic traumatologic diseases(TCM)in Yonglei Qianfang
作者:
李琰; 尹煜輝; 劉寧; 魏戌
中國中醫(yī)科學(xué)院望京醫(yī)院,北京 100102
Author(s):
LI Yan; YIN Yuhui; LIU Ning; WEI Xu
Wangjing Hospital of CACMS,Beijing 100102,China
關(guān)鍵詞:
中醫(yī)藥學(xué)文獻(xiàn);  《永類鈐方》;  中醫(yī)骨傷科疾病;  方劑構(gòu)成;  方劑分析; 計算機(jī)輔助;  數(shù)據(jù)挖掘;  聚類分析
Keywords:
medicine pharmacologic literature(TCM);  Yonglei Qianfang;  orthopedic traumatologic diseases(TCM);  constitution of formula;  formula analysis; computer assisted;  data mining;  cluster analysis
摘要:
目的:分析《永類鈐方》中骨傷內(nèi)服藥方的用藥規(guī)律。方法:收集《永類鈐方》中的骨傷內(nèi)服藥方,建立標(biāo)準(zhǔn)化方藥數(shù)據(jù)庫。采用Microsoft Office Excel 2019軟件統(tǒng)計納入方劑中組方藥物的出現(xiàn)頻次、藥性、藥味、歸經(jīng)和功效,采用SPSS Modeler 18.0軟件分析納入方劑中組方藥物的關(guān)聯(lián)規(guī)則,采用SPSS Statistics 26.0軟件對高頻藥物進(jìn)行系統(tǒng)聚類分析。結(jié)果:共收集到47首內(nèi)服藥方,涉及162味中藥。出現(xiàn)頻次≥5的中藥共34味,出現(xiàn)頻次排前6位的中藥依次為當(dāng)歸、川芎、白芷、生川烏、乳香、肉桂。藥性出現(xiàn)頻次最高的為溫,藥味出現(xiàn)頻次較高的依次為辛、苦、甘,歸經(jīng)主要歸肝經(jīng)、脾經(jīng)、心經(jīng),藥物功效出現(xiàn)頻次較高的依次為活血化瘀、補(bǔ)虛和解表。對47首骨傷內(nèi)服藥方中的組方藥物進(jìn)行關(guān)聯(lián)規(guī)則分析,共得到17條關(guān)聯(lián)規(guī)則,增益均>1,支持度最高的關(guān)聯(lián)規(guī)則為當(dāng)歸→川芎,置信度為100%的關(guān)聯(lián)規(guī)則為當(dāng)歸→肉桂+川芎、當(dāng)歸→肉桂+白芷、當(dāng)歸→沒藥+川芎; 關(guān)聯(lián)度較強(qiáng)的藥對為川芎-當(dāng)歸、當(dāng)歸-肉桂、當(dāng)歸-乳香、白芷-當(dāng)歸、沒藥-乳香。聚類分析得到新處方3首,分別為川椒-澤蘭-甘草-當(dāng)歸-川芎-肉桂、白芷-桔梗-陳皮-赤芍-茴香-生姜-生地黃、獨活-生草烏-干姜-羌活-蒼術(shù)-牛膝-細(xì)辛-續(xù)斷-何首烏-生川烏-白芍-骨碎補(bǔ)-木鱉子仁-乳香-沒藥-自然銅。結(jié)論:《永類鈐方》中骨傷內(nèi)服藥方多采用辛溫、苦溫和甘溫之藥,常從肝經(jīng)、脾經(jīng)、心經(jīng)論治,以活血化瘀、補(bǔ)虛并兼顧解表為主要治法,以“發(fā)散寒邪,通氣通血”為主要用藥思想。
Abstract:
Objective:To analyze the clinical medication rules of the oral prescriptions for treatment of orthopedic traumatologic diseases(TCM)in Yonglei Qianfang.Methods:The oral prescriptions aimed at treating orthopedic traumatologic diseases(TCM)were extracted from Yonglei Qianfang and a standard database for the prescriptions was established.The occurrence frequency,medicinal property,medicinal flavor,meridian tropism and efficacy of the normalized Chinese herbs(CHs)in the included prescriptions were statistically analyzed by using the Microsoft Office Excel 2019 software; the association rules of the CHs involved in the included prescriptions were analyzed by employing SPSS Modeler 18.0 software; and the high-frequency CHs were then subjected to systematic cluster analysis by using SPSS Statistics 26 software.Results:Forty-seven oral prescriptions were included in the final analysis,involving 162 CHs,among which 34 ones displayed a occurrence frequency of ≥5,and the top 6 ones with a high occurrence frequency included Angelicae Sinensis Radix(TCD),Chuanxiong Rhizoma,Angelicae Dahuricae Radix,Radix Aconiti Kusenzoffii,Olibanum(TCD)and Cinnamomi Cortex.The CHs in the 47 oral prescriptions are often the ones presented with warm property,pungent,bitter and sweet flavors,and mainly act on liver meridians,spleen meridians and heart meridians with the efficacies mainly as promoting blood circulation to remove blood stasis,tonifying deficiency as well as releasing exterior.The association rule analysis on the 47 oral prescriptions aimed at treating orthopedic traumatologic diseases(TCM)yielded 17 association rules,with the gains of>1.The association rule with the highest support was Angelicae Sinensis Radix(TCD)→Chuanxiong Rhizoma,the ones with a confidence of 100% included Angelicae Sinensis Radix(TCD)→Cinnamomi Cortex+Chuanxiong Rhizoma,Angelicae Sinensis Radix(TCD)→Cinnamomi Cortex+Angelicae Dahuricae Radix and Angelicae Sinensis Radix(TCD)→Myrrha+Chuanxiong Rhizoma.The paired-herbs with strong correlation were Chuanxiong Rhizoma-Angelicae Sinensis Radix(TCD),Angelicae Sinensis Radix(TCD)-Cinnamomi Cortex,Angelicae Sinensis Radix(TCD)-Olibanum(TCD),Angelicae Dahuricae Radix-Angelicae Sinensis Radix(TCD)and Myrrha-Olibanum(TCD).The cluster analysis generated 3 new prescriptions,namely pericarpium zanthoxyli-Lycopi Herba Glycyrrhizae Radix et Rhizoma(TCD)-Angelicae Sinensis Radix(TCD)-Chuanxiong Rhizoma-Cinnamomi Cortex,Angelicae Dahuricae Radix-Platycodonis Radix-Citri Reticulatae Pericarpium-Paeoniae Radix Rubra-Foeniculum Vulgare-Zingiberis Rhizoma Recens-Rehmanniae Radix,and Angelicae Pubescentis Radix(TCD)-Aconiti Kusnezoffii Radix-Zingiberis Rhizoma-Notopterygii Rhizoma et Radix-Atractlodis Rhizoma-Achyranthes Bidentatae Radix(TCD)-Asari Radix et Rhizoma(TCD)-Dipsaci Radix-Polygoni Multiflori Radix(TCD)-Radix Aconiti Kusenzoffii-Paeoniae Radix Alba-Drynariae Rhizoma-Momordica cochinchinensis seed-Olibanum(TCD)-Myrrha-Pyritum.Conclusion:The CHs with pungent,bitter and sweet flavors and warm property mainly act on liver meridians,spleen meridians and heart meridians are more preferred in the oral prescriptions aimed at treating orthopedic traumatologic diseases(TCM)in Yonglei Qianfang,which mainly follow the principle of promoting blood circulation to remove blood stasis,tonifying deficiency as well as releasing exterior.The medication rules conform to the thoughts of dispersing cold-pathogen and promoting the flow of Qi and blood.

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備注/Memo

備注/Memo:
基金項目:中國中醫(yī)科學(xué)院科技創(chuàng)新工程重大攻關(guān)項目(CI2021A02013) 通訊作者:魏戌 E-mail:[email protected]
更新日期/Last Update: 1900-01-01