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[1]王林,徐勤光,蔣鼎,等.膝骨關節(jié)炎風寒濕痹證素評分與膝骨關節(jié)炎病情嚴重程度的關系研究[J].中醫(yī)正骨,2023,35(09):8-11.
　WANG Lin,XU Qinguang,JIANG Ding,et al.Correlation between syndrome element score of wind-cold-dampness arthralgia and severity of knee osteoarthritis:a clinical study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(09):8-11.
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膝骨關節(jié)炎風寒濕痹證素評分與膝骨關節(jié)炎病情嚴重程度的關系研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期數(shù):
2023年09期
頁碼:
8-11
欄目:
臨床研究
出版日期:
2023-09-20

文章信息/Info

Title:
Correlation between syndrome element score of wind-cold-dampness arthralgia and severity of knee osteoarthritis:a clinical study
作者:
王林; 徐勤光; 蔣鼎; 譚則成; 王學宗; 申安平; 陳博; 龐堅; 詹紅生; 曹月龍
上海中醫(yī)藥大學附屬曙光醫(yī)院,上海 201203
Author(s):
WANG Lin; XU Qinguang; JIANG Ding; TAN Zecheng; WANG Xuezong; SHEN Anping; CHEN Bo; PANG Jian; ZHAN Hongsheng; CAO Yuelong
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
關鍵詞:
骨關節(jié)炎; 膝;  痹證;  風寒濕痹;  證候;  因素分析; 統(tǒng)計學
Keywords:
osteoarthritis; knee;  arthromyodynia;  wind-cold-dampness arthralgia;  syndrome complex;  factor analysis; statistical
摘要:
目的:探討膝骨關節(jié)炎(knee osteoarthritis,KOA)風寒濕痹證素評分與膝骨關節(jié)炎病情嚴重程度的關系。方法:從課題組前期風寒濕痹證隊列研究中篩選患者,從病例資料中提取患者的性別、年齡、體質量指數(shù)、中醫(yī)證候、西安大略和麥克馬斯特大學骨關節(jié)炎指數(shù)(Western Ontario and McMaster Universities osteoarthritis index,WOMAC)評分和膝骨關節(jié)炎全器官磁共振成像評分(whole-organ magnetic resonance imaging score,WORMS)。擬定包含25個證候條目的KOA風寒濕痹證素評分量表,并對入選患者進行證素評分。分析KOA風寒濕痹證素評分與WOMAC評分、WORMS的關系。結果:①一般情況。共納入102例KOA患者,男22例、女80例; 年齡47～73歲,中位數(shù)61歲; 體質量指數(shù)17.87～31.14 kg·m-2,中位數(shù)23.43 kg·m-2; KOA風寒濕痹證素評分0～21分,中位數(shù)7分; WOMAC評分0～159.4分,中位數(shù)39.7分; WORMS 6～60分,中位數(shù)18.75分。②相關性分析結果。KOA風寒濕痹證素評分與WOMAC評分、WORMS均呈正相關(r=0.495,P=0.000; r=0.243,P=0.014); 排除年齡、性別、體質量指數(shù)的影響后,KOA風寒濕痹證素評分與WOMAC評分呈正相關(r=0.419,P=0.000),與WORMS不存在相關性(r=0.163,P=0.108)。③回歸分析結果。KOA風寒濕痹證素評分≥12分對WOMAC評分、WORMS均具有正向影響(β=42.86,P=0.000; β=6.89,P=0.018); 排除年齡、性別、體質量指數(shù)的影響后,KOA風寒濕痹證素評分≥12分對WOMAC評分具有正向影響(β=24.13,P=0.016),對WORMS無影響(β=4.87,P=0.120)。結論:KOA風寒濕痹證素評分與KOA的病情嚴重程度呈正相關,KOA風寒濕痹證素評分≥12分可提示KOA患者病情較重。
Abstract:
Objective:To explore the correlation between the syndrome element score of wind-cold-dampness arthralgia and the severity of knee osteoarthritis(KOA).Methods:The medical records of patients were selected from the previous cohort trial of wind-cold-dampness arthralgia conducted by research group; and the information about gender,age,body mass index(BMI),traditional Chinese medicine(TCM)syndrome,Western Ontario and McMaster Universities osteoarthritis index(WOMAC)score and whole-organ magnetic resonance imaging score(WORMS)was extracted from the medical records.A syndrome element scoring scale including 25 TCM syndrome entry of KOA wind-cold-dampness arthralgia was developed,and the syndrome elements of the included patients were scored.The correlations between KOA wind-cold-dampness arthralgia syndrome element score and WOMAC score as well as between KOA wind-cold-dampness arthralgia syndrome element score and WORMS were analyzed.Results:①One hundred and two KOA patients were included in the study,and they consisted of 22 males and 80 females and ranged in age from 47 to 73 years(Median=61 yrs),BMI from 17.87 to 31.14 kg/m(2)(Median=23.43 kg/m(2)),KOA wind-cold-dampness arthralgia syndrome element score from 0 to 21 points(Median=7 points),WOMAC score from 0 to 159.4 points(Median=39.7 points)and WORMS from 6 to 60 points(Median=18.75 points).②The results of correlation analysis revealed that the KOA wind-cold-dampness arthralgia syndrome element score was positively correlated with WOMAC score and WORMS respectively(r=0.495,P=0.000; r=0.243,P=0.014).After excluding the influences of age,gender and BMI,the KOA wind-cold-dampness arthralgia syndrome element score was positively correlated with WOMAC score(r=0.419,P=0.000)and had no correlation with WORMS(r=0.163,P=0.108).③The results of regression analysis showed that the KOA wind-cold-dampness arthralgia syndrome element score of≥12 points had a positive effect on both WOMAC score and WORMS(β=42.86,P=0.000; β=6.89,P=0.018).After excluding the influences of age,gender and BMI,the KOA wind-cold-dampness arthralgia syndrome element score of≥12 points had a positive effect on WOMAC score(β=24.13,P=0.016),but no effect on WORMS(β=4.87,P=0.120).Conclusion:The KOA wind-cold-dampness arthralgia syndrome element score is positively correlated with the severity of KOA,and the KOA wind-cold-dampness arthralgia syndrome element score of≥12 points may indicate a severe condition in KOA patients.

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備注/Memo

備注/Memo:
基金項目:國家自然科學基金項目(81973874,81373665,82274553); 上海市2020年度“科技創(chuàng)新行動計劃”醫(yī)學創(chuàng)新研究專項項目(20MC1920600)
通訊作者:曹月龍 E-mail:[email protected]
更新日期/Last Update: 1900-01-01