84年鼠女哪年财运最旺,857comvvv色九欧美激情|85PO_87国产精品欲av国产av资源

[1]徐文博,汪利合,劉林楓,等.針刀干預(yù)對(duì)膝骨關(guān)節(jié)炎模型兔影響的Meta分析[J].中醫(yī)正骨,2023,35(08):43-50.
　XU Wenbo,WANG Lihe,LIU Linfeng,et al.Effects of acupotomy intervention on model rabbits with knee osteoarthritis:a meta-analysis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(08):43-50.
點(diǎn)擊復(fù)制

針刀干預(yù)對(duì)膝骨關(guān)節(jié)炎模型兔影響的Meta分析()
分享到：

《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期數(shù):
2023年08期
頁碼:
43-50
欄目:
文獻(xiàn)研究
出版日期:
2023-08-20

文章信息/Info

Title:
Effects of acupotomy intervention on model rabbits with knee osteoarthritis:a meta-analysis
作者:
徐文博1; 汪利合2; 劉林楓1; 張文欣1
1.河南中醫(yī)藥大學(xué)骨傷學(xué)院,河南 鄭州 450002; 2.河南中醫(yī)藥大學(xué)第一附屬醫(yī)院,河南 鄭州 450000
Author(s):
XU Wenbo1; WANG Lihe2; LIU Linfeng1; ZHANG Wenxin1
1.College of Orthopaedics and Traumatology of Henan University of Chinese Medicine,Zhengzhou 450002,Henan,China 2.The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝;  針刀療法;  動(dòng)物實(shí)驗(yàn);  兔;  專題Meta分析
Keywords:
osteoarthritis; knee;  acupotomy therapy;  animal experimentation;  rabbits;  meta-analysis as topic
摘要:
目的:系統(tǒng)評(píng)價(jià)針刀干預(yù)對(duì)膝骨關(guān)節(jié)炎(knee osteoarthritis,KOA)模型兔的影響,探討針刀治療KOA的可能的作用機(jī)制。方法:應(yīng)用計(jì)算機(jī)檢索中國知網(wǎng)、萬方數(shù)據(jù)庫、維普網(wǎng)、中國生物醫(yī)學(xué)文獻(xiàn)服務(wù)系統(tǒng)、PubMed、Web of Science、Cochrane Library、Embase,收集針刀干預(yù)KOA模型兔的隨機(jī)對(duì)照動(dòng)物實(shí)驗(yàn),檢索時(shí)限均為建庫至2022年10月21日。實(shí)驗(yàn)組采用針刀療法干預(yù),對(duì)照組不進(jìn)行任何干預(yù)。由2名研究者獨(dú)立篩選文獻(xiàn)、提取數(shù)據(jù)并評(píng)價(jià)納入研究的偏倚風(fēng)險(xiǎn),采用RevMan5.3軟件進(jìn)行Meta 分析。采用STATA14.0軟件進(jìn)行Bgger's檢驗(yàn),評(píng)價(jià)發(fā)表偏倚。結(jié)果:最終納入17項(xiàng)研究,涉及258只KOA模型兔,實(shí)驗(yàn)組和對(duì)照組各129只。Meta分析結(jié)果顯示,針刀干預(yù)后實(shí)驗(yàn)組的Lequesne MG評(píng)分、Mankin評(píng)分、軟骨細(xì)胞凋亡率、關(guān)節(jié)液白細(xì)胞介素(interleukin,IL)-6表達(dá)水平、關(guān)節(jié)液腫瘤壞死因子-α表達(dá)水平均低于對(duì)照組[MD=-3.05,95%CI(-4.05,-2.05),P=0.000; MD=-3.95,95%CI(-4.86,-3.04),P=0.000; SMD=-3.81,95%CI(-5.79,-1.84),P=0.000; SMD=-1.99,95%CI(-2.83,-1.16),P=0.000; SMD=-4.22,95%CI(-7.43,-1.01),P=0.010],2組關(guān)節(jié)液IL-1表達(dá)水平的差異無統(tǒng)計(jì)學(xué)意義[SMD=-22.98,95%CI(-64.60,18.65),P=0.280]。基于Mankin評(píng)分進(jìn)行發(fā)表偏倚分析,Bgger's檢驗(yàn)顯示不存在發(fā)表偏倚(P=0.074)。結(jié)論:現(xiàn)有的證據(jù)表明,針刀干預(yù)能夠減輕KOA模型兔膝關(guān)節(jié)疼痛與腫脹、改善膝關(guān)節(jié)功能和軟骨組織病理學(xué)形態(tài),其作用可能與減少軟骨細(xì)胞凋亡、抑制相關(guān)促炎癥細(xì)胞因子表達(dá)有關(guān)。
Abstract:
Objective:To systematically review the effects of acupotomy intervention on model rabbits with knee osteoarthritis(KOA),and to explore the possible mechanisms of acupotomy in treatment of KOA.Methods:All the articles about intervention on KOA model rabbits with acupotomy included from database establishing to October 21,2022 were retrieved from China National Knowledge Internet,Wanfang Database,Vip Database,Chinese Biomedical Literature Service System,PubMed,Web of Science,Cochrane Library and Embase through computer.The rabbits in experiment group were intervened by acupotomy therapy,while the ones in control group were not given any intervention.The articles were screened and the information was extracted independently by two researchers.The risk of bias of included researches was assessed and a Meta-analysis was conducted by using RevMan5.3 software.Furthermore,the Bgger's test was performed by using STATA14.0 software,and the publication bias was evaluated.Results:Seventeen articles(258 KOA model rabbits)were included in the final analysis,129 KOA model rabbits in each group.The results of Meta-analysis revealed that the Lequesne MG score,Mankin score,chondrocyte apoptosis rate,the expression levels of interleukin(IL)-6 and tumor necrosis factor-α in knee synovial fluid were all lower in experiment group compared to control group after acupotomy intervention(MD=-3.05,95%CI(-4.05,-2.05),P=0.000; MD=-3.95,95%CI(-4.86,-3.04),P=0.000; SMD=-3.81,95%CI(-5.79,-1.84),P=0.000; SMD=-1.99,95%CI(-2.83,-1.16),P=0.000; SMD=-4.22,95%CI(-7.43,-1.01),P=0.010),however,there was no statistical difference in the expression level of IL-1 in knee synovial fluid between the 2 groups(SMD=-22.98,95%CI(-64.60,18.65),P=0.280).Publication bias was analyzed based on the Mankin scores,and the results of Bgger's test showed that there was no publication bias in the included articles(P=0.074).Conclusion:Available evidences suggest that the acupotomy intervention can reduce knee pain and swelling,improve knee function and histopathologic form of cartilage tissues in model rabbits with KOA possibly by reducing the apoptosis of chondrocytes and inhibiting the expression of related pro-inflammatory cytokines.

參考文獻(xiàn)/References:

[1] JANG S,LEE K,JU J H.Recent updates of diagnosis,pathophysiology,and treatment on osteoarthritis of the knee[J].Int J Mol Sci,2021,22(5):2619.
[2] SHARMA L.Osteoarthritis of the knee[J].N Engl J Med,2021,384(1):51-59.
[3] CUI A,LI H,WANG D,et al.Global,regional prevalence,incidence and risk factors of knee osteoarthritis in population-based studies[J].EClinicalMedicine,2020,29-30:100587.
[4] 薛慶云,王坤正,裴福興,等.中國40歲以上人群原發(fā)性骨關(guān)節(jié)炎患病狀況調(diào)查[J].中華骨科雜志,2015,35(12):1206-1212.
[5] ARDEN N K,PERRY T A,BANNURU R R,et al.Non-surgical management of knee osteoarthritis:comparison of ESCEO and OARSI 2019 guidelines[J].Nat Rev Rheumatol,2021,17(1):59-66.
[6] KOLASINSKI S L,NEOGI T,HOCHBERG M C,et al.2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand,hip,and knee[J].Arthritis Rheumatol,2020,72(2):220-233.
[7] WANG H,MA B.Healthcare and scientific treatment of knee osteoarthritis[J].J Healthc Eng,2022:5919686.
[8] 賈易臻,谷福順,王愛國.針刀治療膝骨關(guān)節(jié)炎研究進(jìn)展[J].中國中西醫(yī)結(jié)合外科雜志,2022,28(1):126-129.
[9] FANG T,LI Q,ZHOU F,et al.Effect and safety of acupotomy in treatment of knee osteoarthritis:a systematic review and Meta-analysis[J].J Tradit Chin Med,2020,40(3):355-364.
[10] QU B,WU X,LIU H,et al.Meta-analysis and systematic review of acupotomy combined with puncture and moxibustion in the treatment of knee osteoarthritis[J].Ann Palliat Med,2021,10(6):6637-6649.
[11] 李曉樂,李無陰,曹向陽,等.針刀療法治療膝骨關(guān)節(jié)炎臨床療效的Meta分析[J].中醫(yī)學(xué)報(bào),2022,37(11):2478-2486.
[12] 趙霏,唐曉宇,寇城坤,等.動(dòng)物實(shí)驗(yàn)系統(tǒng)評(píng)價(jià)/Meta分析的質(zhì)量和報(bào)告特征[J].中國循證醫(yī)學(xué)雜志,2018,18(8):871-877.
[13] LEQUESNE M G,SAMSON M.Indices of severity in osteoarthritis for weight bearing joints[J].J Rheumatol Suppl,1991,27(3):16-18.
[14] MANKIN H J,DORFMAN H,LIPPIELLO L,et al.Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips.Ⅱ.Correlation of morphology with biochemical and metabolic data[J].J Bone Joint Surg Am,1971,53(3):523-537.
[15] HOOIJMANS C R,ROVERS M M,DE VRIES R B,et al.SYRCLE's risk of bias tool for animal studies[J].BMC Med Res Methodol,2014,14:43.
[16] 修忠標(biāo),劉洪,張良志,等.針刀干預(yù)對(duì)膝骨關(guān)節(jié)炎兔原代軟骨細(xì)胞活性、凋亡及自噬的影響[J].中國醫(yī)藥導(dǎo)報(bào),2022,19(18):123-127.
[17] 王軍美,秦露雪,陳烯琳,等.針刀干預(yù)對(duì)中期膝骨關(guān)節(jié)炎兔軟骨下骨壓縮力學(xué)性能的影響[J].中國中醫(yī)急癥,2022,31(5):781-784.
[18] QIN L X,GUO C Q,ZHAO R L,et al.Acupotomy inhibits aberrant formation of subchondral bone through regulating osteoprotegerin/receptor activator of nuclear factor-κB li-gand pathway in rabbits with knee osteoarthritis induced by modified Videman method[J].J Tradit Chin Med,2022,42(3):389-399.
[19] 史曉偉,烏云額爾頓,王東峰,等.針刀、電針對(duì)制動(dòng)4周KOA兔模型股直肌-股二頭肌肌肉狀態(tài)及拉伸生物力學(xué)的影響[J].針灸臨床雜志,2021,37(11):69-74.
[20] 曾維銓,劉晶,連曉文,等.基于TRPV4通路探討針刀對(duì)兔膝骨關(guān)節(jié)炎軟骨細(xì)胞凋亡的影響[J].福建中醫(yī)藥,2021,52(3):19-22.
[21] 劉廣宇,張杰,張曉峰,等.針刀松解聯(lián)合丹參注射液關(guān)節(jié)腔注射治療骨性關(guān)節(jié)炎模型兔[J].中國組織工程研究,2020,24(2):209-214.
[22] 趙峰.針刀療法對(duì)膝骨關(guān)節(jié)炎的臨床觀察及分子作用機(jī)制的研究[D].哈爾濱:黑龍江中醫(yī)藥大學(xué),2019.
[23] 張偉.針刀療法對(duì)KOA兔軟骨基質(zhì)降解及AKT-GSK3 β、CyclinD1-CDK4/6通路的影響[D].北京:北京中醫(yī)藥大學(xué),2019.
[24] 烏云額爾敦,郭長青,王彤,等.針刀干預(yù)對(duì)中期膝骨關(guān)節(jié)炎兔模型伸肌-屈肌萎縮狀態(tài)及肌肉拉伸彈性模量的影響[J].湖南中醫(yī)藥大學(xué)學(xué)報(bào),2019,39(10):1248-1253.
[25] 宋寒冰,于英君,姜益常,等.針刀松解術(shù)對(duì)膝骨性關(guān)節(jié)炎軟骨細(xì)胞作用分子機(jī)制實(shí)驗(yàn)研究[J].中醫(yī)藥學(xué)報(bào),2017,45(5):64-67.
[26] DING Y,SHI X,WANG L,et al.Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits[J].J Tradit Chin Med,2017,37(3):404-411.
[27] 于佳妮.針刀“調(diào)筋治骨”法對(duì)KOA兔膝關(guān)節(jié)軟骨FAK-PI3K-AKT通路及股四頭肌力學(xué)性能的影響[D].北京:北京中醫(yī)藥大學(xué),2016.
[28] 吳緒平,胡昭端,陳雙平.針刀整體松解術(shù)對(duì)兔膝骨性關(guān)節(jié)炎關(guān)節(jié)液腫瘤壞死因子-α、白介素-6的影響[J].湖北中醫(yī)藥大學(xué)學(xué)報(bào),2016,18(5):9-12.
[29] 梁楚西.針刀干預(yù)對(duì)KOA兔韌帶膠原相關(guān)因子及軟骨細(xì)胞凋亡因子基因、蛋白表達(dá)的影響[D].北京:北京中醫(yī)藥大學(xué),2015.
[30] 覃蔚嵐,嵇波,秦誼,等.針刀松解法治療兔膝關(guān)節(jié)骨性關(guān)節(jié)炎組織形態(tài)學(xué)的研究[J].中國中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志,2009,15(4):308-309.
[31] 何新芳,明順培,俞杰.針刀療法對(duì)膝骨關(guān)節(jié)炎兔關(guān)節(jié)軟骨細(xì)胞凋亡的影響[J].遼寧中醫(yī)雜志,2006,33(7):894-895.
[32] 童娟,余杰,陳健雄,等.針刀療法治療膝骨關(guān)節(jié)炎實(shí)驗(yàn)研究[J].國際醫(yī)藥衛(wèi)生導(dǎo)報(bào),2003,9(16):4-5.
[33] SEBASTIAN A,MURUGESH D K,MENDEZ M E,et al.Global gene expression analysis identifies age-related differences in knee joint transcriptome during the development of post-traumatic osteoarthritis in mice[J].Int J Mol Sci,2020,21(1):364-367.
[34] KIM M,AHN J,LEE J,et al.Combined mesenchymal stem cells and cartilage acellular matrix injection therapy for osteoarthritis in goats[J].Tissue Eng Regen Med,2022,19(1):177-187.
[35] STAINES K A,POULET B,WENTWORTH D N,et al.The STR/ort mouse model of spontaneous osteoarthritis—an update[J].Osteoarthritis Cartilage,2017,25(6):802-808.
[36] MCCOY A M.Animal models of osteoarthritis:comparisons and key considerations[J].Vet Pathol,2015,52(5):803-818.
[37] DE LANGE-BROKAAR B J,IOAN-FACSINAY A,YUSUF E,et al.Evolution of synovitis in osteoarthritic knees and its association with clinical features[J].Osteoarthritis Cartilage,2016,24(11):1867-1874.
[38] VIDEMAN T.Experimental osteoarthritis in the rabbit:comparison of different periods of repeated immobilization[J].Acta Orthop Scand,1982,53(3):339-347.
[39] 何業(yè)文,范磊,張堃,等.改良伸直位制動(dòng)法建立兔膝骨關(guān)節(jié)炎模型的效果評(píng)價(jià)[J].中國中西醫(yī)結(jié)合影像學(xué)雜志,2020,18(2):198-200.
[40] 黃旭東,易志勇,韓清民.經(jīng)筋手法干預(yù)膝骨關(guān)節(jié)炎模型兔骨骼肌收縮力學(xué)的改變[J].中國組織工程研究,2021,25(2):201-204.
[41] 余紹涌,周建飛,龐向華.膝骨關(guān)節(jié)炎誘導(dǎo)性動(dòng)物模型研究進(jìn)展[J].廣西中醫(yī)藥大學(xué)學(xué)報(bào),2022,25(5):50-55.
[42] MCGRORY B,WEBER K,LYNOTT J A,et al.The American academy of orthopaedic surgeons evidence-based clinical practice guideline on surgical management of osteoarthritis of the knee[J].J Bone Joint Surg Am,2016,98(8):688-692.
[43] LEPETSOS P,PAPAVASSILIOU K A,PAPAVASSILIOU A G.Redox and NF-κB signaling in osteoarthritis[J].Free Radic Biol Med,2019,20(132):90-100.
[44] MOLNAR V,MATISIC V,KODVANJ I,et al.Cytokines and chemokines involved in osteoarthritis pathogenesis[J].Int J Mol Sci,2021,22(17):9208-9213.
[45] LIU M,XIE Z,SUN G,et al.Macrophage migration inhibitory factor may play a protective role in osteoarthritis[J].Arthritis Res Ther,2021,23(1):59-65.
[46] WIEGERTJES R,THIELEN N G M,VAN CAAM A P M,et al.Increased IL-6 receptor expression and signaling in ageing cartilage can be explained by loss of TGF-β-medi-ated IL-6 receptor suppression[J].Osteoarthritis Cartilage,2021,29(5):773-782.
[47] CHAI Y P,HAN X Q,CUI J Z.Acupotomy combined with intra-articular injection of sodium hyaluronate in the treatment of knee osteoarthritis[J].Medicine(Baltimore),2022,101(35):e30225.
[48] 劉晶,林巧璇,盧莉銘,等.針刀“解結(jié)法”對(duì)膝骨關(guān)節(jié)炎兔軟骨形態(tài)學(xué)及影像學(xué)的影響[J].針刺研究,2021,46(2):129-135.
[49] LIN M,LI X,LIANG W,et al.Needle-knife therapy improves the clinical symptoms of knee osteoarthritis by in-hibiting the expression of inflammatory cytokines[J].Exp Ther Med,2014,7(4):835-842.
[50] 伍閑,宋小鴿,盧曼,等.基于lncRNA/miRNA/NF-κB通路探討針刀對(duì)膝骨關(guān)節(jié)炎兔的軟骨保護(hù)作用機(jī)制[J].北京中醫(yī)藥大學(xué)學(xué)報(bào),2022,45(6):603-611.
[51] HUANG X S,GENG K,LUO S Y,et al.Mechanism of action of acupotomy in inhibiting chondrocyte apoptosis in rabbits with KOA through the PI3K/Akt signaling pathway[J].Evid Based Complement Alternat Med,2020:4241917.
[52] WANG T,GUO Y,SHI X W,et al.Acupotomy contributes to suppressing subchondral bone resorption in KOA rabbits by regulating the OPG/RANKL signaling pathway[J].Evid Based Complement Alternat Med,2021:8168657.

相似文獻(xiàn)/References:

[1]樊慶陽,任凱晶.定制3D打印切模輔助全膝關(guān)節(jié)置換術(shù)治療 膝骨關(guān)節(jié)炎合并股骨干骨折畸形愈合[J].中醫(yī)正骨,2015,27(11):37.
[2]劉曉雅,孫永強(qiáng),劉國杰.主動(dòng)快速康復(fù)鍛煉對(duì)全膝關(guān)節(jié)置換術(shù)后關(guān)節(jié)活動(dòng)度的影響[J].中醫(yī)正骨,2015,27(09):73.
[3]鄭春松,葉蕻芝,李西海,等.透骨消痛膠囊中補(bǔ)腎柔肝藥和活血祛風(fēng)藥治療 骨關(guān)節(jié)炎作用方式的計(jì)算機(jī)模擬比較[J].中醫(yī)正骨,2015,27(07):6.
　ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Comparison of the mode of action of Bushen Rougan(補(bǔ)腎柔肝)drugs versus Huoxue Qufeng(活血祛風(fēng))drugs contained in Tougu Xiaotong Jiaonang(透骨消痛膠囊)for the treatment of osteoarthritis:A computer simulation study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(08):6.
[4]宋兵華,孫俊英,倪增良,等.全膝關(guān)節(jié)置換術(shù)前CT測量股骨后髁角的臨床意義[J].中醫(yī)正骨,2015,27(07):38.
[5]鄭春松,葉蕻芝,李西海,等.獨(dú)活寄生湯含藥血清對(duì)白細(xì)胞介素1β誘導(dǎo)的 退變關(guān)節(jié)軟骨細(xì)胞中基質(zhì)金屬蛋白酶 和環(huán)氧化酶2表達(dá)的影響[J].中醫(yī)正骨,2015,27(12):1.
　ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Impact of Duhuo Jisheng Tang(獨(dú)活寄生湯)medicated serum on expression of matrix metalloproteinase and cyclooxygenase 2 in degenerative articular chondrocytes induced by interleukin-1 beta[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(08):1.
[6]王金良,孫京濤,李玲,等.骨水泥聯(lián)合螺釘修復(fù)全膝關(guān)節(jié)置換術(shù)中 脛骨平臺(tái)內(nèi)側(cè)骨缺損[J].中醫(yī)正骨,2015,27(12):55.
[7]馮榮,王平,李炳奇,等.鈹針刺絡(luò)拔罐結(jié)合中藥口服治療膝骨關(guān)節(jié)炎合并 原發(fā)性血小板增多癥1例[J].中醫(yī)正骨,2015,27(12):73.
[8]蔡云仙.圍手術(shù)期耳穴按壓聯(lián)合平衡針療法 在全膝關(guān)節(jié)置換術(shù)后鎮(zhèn)痛中的應(yīng)用[J].中醫(yī)正骨,2015,27(06):41.
[9]張榮,王健.人工全膝關(guān)節(jié)置換術(shù)的圍手術(shù)期心理護(hù)理[J].中醫(yī)正骨,2015,27(05):77.
[10]喻長純,楊明路,王戰(zhàn)朝.不同手術(shù)方式治療脛骨平臺(tái)骨折畸形愈合的體會(huì)[J].中醫(yī)正骨,2015,27(03):37.
[11]孟維娜,明立功,王新德,等.關(guān)節(jié)鏡下清理聯(lián)合腓骨近1/3段截骨治療膝骨關(guān)節(jié)炎[J].中醫(yī)正骨,2015,27(11):40.
[12]明立功,孟維娜,王新德,等.腓骨近端截骨治療內(nèi)側(cè)間室膝骨關(guān)節(jié)炎的近期療效觀察[J].中醫(yī)正骨,2015,27(10):25.
[13]張杰,王人彥,張玉柱.膝骨關(guān)節(jié)炎的治療進(jìn)展[J].中醫(yī)正骨,2015,27(10):68.
[14]梁朝,蔡靜怡,閆立,等.針刀療法改善膝骨關(guān)節(jié)炎早期疼痛癥狀的療效評(píng)價(jià)[J].中醫(yī)正骨,2015,27(09):9.
　LIANG Zhao,CAI Jingyi,YAN Li,et al.Evaluation of the curative effect of needle-knife therapy for relieving knee pain in patients with early knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(08):9.
[15]王建武,黨建軍,李強(qiáng),等.四聯(lián)療法治療膝骨關(guān)節(jié)炎[J].中醫(yī)正骨,2015,27(08):44.
[16]劉紅娟,郭會(huì)利,郭樹農(nóng).云克聯(lián)合中藥治療膝骨關(guān)節(jié)炎的護(hù)理[J].中醫(yī)正骨,2015,27(08):75.
[17]陳衛(wèi)衡.探索建立系統(tǒng)的膝骨關(guān)節(jié)炎中醫(yī)臨床科研范式 和理論體系[J].中醫(yī)正骨,2015,27(07):1.
[18]帥波,沈霖,楊艷萍,等.加味青娥丸治療膝骨關(guān)節(jié)炎的作用機(jī)制研究[J].中醫(yī)正骨,2015,27(07):15.
　SHUAI Bo,SHEN Lin,YANG Yanping,et al.Study on the mechanism of action of Jiawei Qing'e Wan(加味青娥丸)for the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(08):15.
[19]梅其杰,袁長深,段戡,等.壯藥骨痹方燙熨聯(lián)合運(yùn)動(dòng)療法治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2015,27(07):27.
　MEI Qijie,YUAN Changshen,DUAN Kan,et al.Clinical study of the curative effect of hot compressing and rubbing with packet of Gubi Fang(骨痹方)combined with exercise therapy in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(08):27.
[20]王丹輝,張燕,劉麗娟,等.重組人Ⅱ型腫瘤壞死因子受體-抗體融合蛋白 關(guān)節(jié)腔注射聯(lián)合中藥薰洗治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2015,27(07):31.
　WANG Danhui,ZHANG Yan,LIU Lijuan,et al.Clinical study on intra-articular injection of TypeⅡrecombinant human tumor necrosis factor receptor-Fc fusion protein combined with Chinese herbal steaming and washing therapy for treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(08):31.

備注/Memo

備注/Memo:
基金項(xiàng)目:河南省中醫(yī)藥拔尖人才培養(yǎng)項(xiàng)目(豫中醫(yī)科教〔2018〕35號(hào)) 通訊作者:汪利合 E-mail:[email protected]
更新日期/Last Update: 1900-01-01