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[1]王一迪,范利娟,石洋,等.基于數(shù)據(jù)挖掘的中藥內(nèi)服治療腰椎間盤(pán)突出癥術(shù)后殘留癥狀用藥規(guī)律研究[J].中醫(yī)正骨,2023,35(08):37-42.
　WANG Yidi,FAN Lijuan,SHI Yang,et al.A data mining-based analysis of clinical medication rules of oral Chinese herbal medicine prescriptions for treatment of residual symptoms after surgery for lumbar disc herniation[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(08):37-42.
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基于數(shù)據(jù)挖掘的中藥內(nèi)服治療腰椎間盤(pán)突出癥術(shù)后殘留癥狀用藥規(guī)律研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期數(shù):
2023年08期
頁(yè)碼:
37-42
欄目:
文獻(xiàn)研究
出版日期:
2023-08-20

文章信息/Info

Title:
A data mining-based analysis of clinical medication rules of oral Chinese herbal medicine prescriptions for treatment of residual symptoms after surgery for lumbar disc herniation
作者:
王一迪1; 范利娟1; 石洋1; 白超楠1; 崔宏勛2
1.河南中醫(yī)藥大學(xué)研究生院,河南 鄭州 450046; 2.河南省洛陽(yáng)正骨醫(yī)院/河南省骨科醫(yī)院,河南 鄭州 450016
Author(s):
WANG Yidi1; FAN Lijuan1; SHI Yang1; BAI Chaonan1; CUI Hongxun2
1.Postgraduate College of Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China 2.Luoyang Orthopedic-Traumatological Hospital,Zhengzhou 450016,Henan,China
關(guān)鍵詞:
椎間盤(pán)移位;  腰椎;  手術(shù)后并發(fā)癥;  中藥;  方劑分析; 計(jì)算機(jī)輔助;  數(shù)據(jù)挖掘
Keywords:
intervertebral disc displacement;  lumbar vertebrae;  postoperative complications;  Traditional Chinese Drugs;  formula analysis; computer assisted;  data mining
摘要:
目的:探討中藥內(nèi)服治療腰椎間盤(pán)突出癥術(shù)后殘留癥狀的用藥規(guī)律。方法:利用計(jì)算機(jī)檢索中國(guó)知網(wǎng)、萬(wàn)方數(shù)據(jù)庫(kù)、維普網(wǎng)、PubMed、Web of Science中有關(guān)中藥內(nèi)服治療腰椎間盤(pán)突出癥術(shù)后殘留癥狀的文獻(xiàn),檢索時(shí)限均為建庫(kù)至2023年1月31日。提取入選文獻(xiàn)中的內(nèi)服方劑,統(tǒng)計(jì)方劑的主治證型、藥物組成,以及藥物的功效、性、味、歸經(jīng)。采用Microsoft Excel 2021軟件統(tǒng)計(jì)藥物的主治證型、出現(xiàn)頻次,以及藥物的功效、性、味、歸經(jīng)分布情況。采用SPSS Modeler 18.0軟件對(duì)篩選出的高頻藥物進(jìn)行關(guān)聯(lián)規(guī)則分析,采用SPSS Statistics 21.0軟件對(duì)篩選出的高頻藥物進(jìn)行聚類(lèi)分析。結(jié)果:納入研究的文獻(xiàn)共117篇,包含123首內(nèi)服方劑。方劑的主治證型主要有4個(gè),其中氣滯血瘀證(42次)、腎虛血瘀證(35次)、肝腎虧虛證(23次)的出現(xiàn)頻次較高。123首內(nèi)服方劑涉及183味中藥,累計(jì)出現(xiàn)1363次,其中出現(xiàn)頻次≥20的藥物共20味,排在前3位的依次為當(dāng)歸(82次)、甘草(70次)、牛膝(66次)。藥物功效統(tǒng)計(jì)結(jié)果顯示,補(bǔ)虛藥(453次)、活血化瘀藥(378次)、祛風(fēng)濕藥(147次)的出現(xiàn)頻次較高。藥性統(tǒng)計(jì)結(jié)果顯示,溫性藥(664次)、平性藥(397次)的出現(xiàn)頻次較高。藥味統(tǒng)計(jì)結(jié)果顯示,甘味藥(746次)、苦味藥(624次)、辛味藥(592次)的出現(xiàn)頻次較高。藥物歸經(jīng)統(tǒng)計(jì)結(jié)果顯示,歸肝經(jīng)(900次)、脾經(jīng)(599次)、腎經(jīng)(438次)的藥物出現(xiàn)頻次較高。將出現(xiàn)頻次≥20的中藥作為高頻藥物,通過(guò)關(guān)聯(lián)規(guī)則分析得到11條關(guān)聯(lián)規(guī)則,其中前3位依次為川芎→當(dāng)歸、黃芪→當(dāng)歸、紅花→當(dāng)歸; 涉及7個(gè)核心藥物,主要為補(bǔ)虛藥(黃芪、當(dāng)歸、甘草)和活血化瘀藥(紅花、川芎、赤芍、桃仁); 通過(guò)聚類(lèi)分析,得到4類(lèi)藥物組合。結(jié)論:中藥內(nèi)服治療腰椎間盤(pán)突出癥術(shù)后殘留癥狀的用藥規(guī)律為,以補(bǔ)虛藥為主,輔以活血化瘀藥; 多用藥性溫、平,藥味甘、苦、辛,歸肝經(jīng)、脾經(jīng)、腎經(jīng)的藥物; 多以黃芪、當(dāng)歸、甘草、紅花、川芎、赤芍、桃仁為主藥進(jìn)行加減。
Abstract:
Objective:To excavate the clinical medication rules of oral Chinese herbal medicine(CHM)prescriptions in treatment of residual symptoms after surgery for lumbar disc herniation(LDH).Methods:All articles about oral CHM prescriptions for treatment of residual symptoms emerged after surgery for LDH included from database establishing to January 31,2023 were retrieved from the China National Knowledge Internet,Wanfang Database,Vip Database,PubMed and Web of Science through computer.The obtained articles were screened according to the predefined inclusion and exclusion criteria,and the oral CHM prescriptions were extracted from the included articles,followed by statistics on the indications,ingredients contained in the CHM prescriptions as well as the efficacy,medicinal property,medicinal flavor and meridian tropism of each Chinese herbs(CHs)in prescriptions.The normalized and standardized CHs in the extracted prescriptions were input into the Microsoft Office Excel 2021 software for building a database,based on which their indications,occurrence frequency,efficacy,medicinal property,medicinal flavor and meridian tropism were statistically analyzed.The high-frequency CHs were then subjected to association rule analysis by using SPSS Modeler 18.0 software and cluster analysis by using SPSS Statistics 21.0 software.Results:One hundred and seventeen articles were included in the final analysis,involving 123 oral CHM prescriptions,and they mainly acted on 4 indications,among which Qi-stagnation and blood-stasis syndrome(42 times),kidney-deficiency and blood-stagnation syndrome(35 times)and liver-kidney deficiency syndrome(23 times)occurred more frequently.One hundred and eighty-three CHs(appeared 1363 times)were involved in the 123 oral CHM prescriptions,among which 20 ones displayed a occurrence frequency of≥20,and the top 3 ones with high occurrence frequency included Angelicae Sinensis Radix(TCD)(82 times),Glycyrrhizae Radix et Rhizoma(TCD)(70 times)and Achyranthes Bidentatae Radix(TCD)(66 times).The results of statistics on efficacy showed that the CHs with high occurrence frequency included reinforcing deficiency herbs(453 times),promoting blood circulation and removing blood stasis herbs(378 times)and dispelling pathogenic wind and dampeness herbs(147 times).The results of statistics on medicinal property showed that the most frequently used CHs were those with a warm property(664 times),followed by the ones with a neutral property(397 times).The results of statistics on medicinal flavor showed that the CHs with sweet,bitter and pungent flavors were more preferred,with their occurrence frequency of being 746,624 and 592 times respectively.The results of statistics on meridian tropism showed that the CHs mainly acted on the liver meridians(900 times),spleen meridians(599 times)and kidney meridians(438 times).The CHs with occurrence frequency of≥20 were considered as the high frequency herbs.Eleven association rules were obtained through association rule analysis,among which the top 3 ones included Chuanxiong Rhizoma→Angelicae Sinensis Radix(TCD),Astmgali Radix(TCD)→Angelicae Sinensis Radix(TCD)and Carthami Flos(TCD)→Angelicae Sinensis Radix(TCD).The association rule analysis on the high frequency herbs involved 7 core herbs,which were mainly the reinforcing deficiency herbs(Astmgali Radix(TCD),Angelicae Sinensis Radix(TCD),Glycyrrhizae Radix et Rhizoma(TCD))as well as the promoting blood circulation and removing blood stasis herbs(Carthami Flos(TCD),Chuanxiong Rhizoma,Paeoniae Radix Rubra,Persicae Semen).Furthermore,4 new herb combinations were obtained by cluster analysis on the high frequency herbs.Conclusion:The oral CHM prescriptions aimed at treating residual symptoms after surgery for LDH are centred on the reinforcing deficiency herbs,supplemented by the promoting blood circulation and removing blood stasis herbs,and the CHs in oral CHM prescriptions are often the ones presented with warm and neutral properties,sweet,bitter and pungent flavors and mainly act on liver,spleen and kidney meridians.Astmgali Radix(TCD),Angelicae Sinensis Radix(TCD),Glycyrrhizae Radix et Rhizoma(TCD),Carthami Flos(TCD),Chuanxiong Rhizoma,Paeoniae Radix Rubra and Persicae Semen are usually used as the core of the oral CHM prescriptions.

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備注/Memo

備注/Memo:
基金項(xiàng)目:全國(guó)中醫(yī)藥創(chuàng)新骨干人才項(xiàng)目(國(guó)中醫(yī)藥人教函〔2019〕128號(hào)); 河南省中醫(yī)藥拔尖人才項(xiàng)目(豫中醫(yī)科教〔2018〕25號(hào)) 通訊作者:崔宏勛 E-mail:[email protected]
更新日期/Last Update: 1900-01-01