84年鼠女哪年财运最旺,857comvvv色九欧美激情|85PO_87国产精品欲av国产av资源

[1]姚彬,葛騰,李越,等.中藥干預(yù)對(duì)骨質(zhì)疏松癥大鼠骨密度及Wnt/β-catenin信號(hào)通路影響的Meta分析[J].中醫(yī)正骨,2023,35(07):16-29.
　YAO Bin,GE Teng,LI Yue,et al.Effects of traditional Chinese drugs intervention on bone mineral density and Wnt/β-catenin signaling pathway in osteoporosis rats:a meta analysis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(07):16-29.
點(diǎn)擊復(fù)制

中藥干預(yù)對(duì)骨質(zhì)疏松癥大鼠骨密度及Wnt/β-catenin信號(hào)通路影響的Meta分析()
分享到：

《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期數(shù):
2023年07期
頁碼:
16-29
欄目:
文獻(xiàn)研究
出版日期:
2023-07-20

文章信息/Info

Title:
Effects of traditional Chinese drugs intervention on bone mineral density and Wnt/β-catenin signaling pathway in osteoporosis rats:a meta analysis
作者:
姚彬1; 葛騰1; 李越1; 康武林2; 楊鋒2; 袁普衛(wèi)2
(1.陜西中醫(yī)藥大學(xué)第一臨床醫(yī)學(xué)院,陜西 咸陽 712046; 2.陜西中醫(yī)藥大學(xué)附屬醫(yī)院,陜西 咸陽 712046)
Author(s):
YAO Bin1; GE Teng1; LI Yue1; KANG Wulin2; YANG Feng2; YUAN Puwei2
1.The First Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China 2.The Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China
關(guān)鍵詞:
骨質(zhì)疏松;  模型; 動(dòng)物;  大鼠;  中藥;  Wnt信號(hào)通路;  骨密度;  專題Meta分析
Keywords:
osteoporosis;  models; animal;  rats;  traditional Chinese drugs;  Wnt signaling pathway;  bone density;  meta-analysis as topic
摘要:
目的:系統(tǒng)評(píng)價(jià)中藥干預(yù)對(duì)骨質(zhì)疏松癥(osteoporosis,OP)大鼠骨密度及Wnt/β-聯(lián)蛋白(β-catenin)信號(hào)通路的影響。方法:應(yīng)用計(jì)算機(jī)檢索中國(guó)知網(wǎng)、維普網(wǎng)、萬方數(shù)據(jù)庫(kù)、中國(guó)生物醫(yī)學(xué)文獻(xiàn)服務(wù)系統(tǒng)、PubMed、Embase和Cochrane Library中關(guān)于中藥干預(yù)大鼠OP的文獻(xiàn),檢索時(shí)限均為建庫(kù)至2023年2月。實(shí)驗(yàn)組的干預(yù)措施為中藥(包括中藥復(fù)方、單味藥、中藥有效成分)灌胃,對(duì)照組的干預(yù)措施為生理鹽水或蒸餾水灌胃。依據(jù)文獻(xiàn)檢索及篩選方案篩選出符合要求的文獻(xiàn)后,由2名研究人員分別獨(dú)立進(jìn)行數(shù)據(jù)提取和質(zhì)量評(píng)價(jià)。采用Stata13.0軟件進(jìn)行Meta分析。結(jié)果:共檢索到210篇文獻(xiàn),最終納入30篇文獻(xiàn),共涉及1105只大鼠,其中實(shí)驗(yàn)組750只,對(duì)照組355只。Meta分析結(jié)果顯示,實(shí)驗(yàn)組大鼠股骨骨密度、腰椎骨密度及骨組織Wnt、β-catenin、Runt相關(guān)轉(zhuǎn)錄因子2、低密度脂蛋白受體相關(guān)蛋白5的mRNA和蛋白表達(dá)水平均高于對(duì)照組[SMD=1.75,95%CI(1.54,1.95),P=0.000; SMD=1.35,95%CI(1.07,1.64),P=0.000; SMD=3.82,95%CI(2.31,5.32),P=0.000; SMD=2.36,95%CI(2.00,2.72),P=0.000; SMD=3.07,95%CI(2.55,3.60),P=0.000; SMD=1.77,95%CI(1.40,2.14),P=0.000; SMD=5.11,95%CI(3.99,6.22),P=0.000; SMD=5.42,95%CI(4.04,6.81),P=0.000; SMD=1.74,95%CI(1.06,2.42),P=0.000; SMD=2.44,95%CI(1.47,3.41),P=0.000]。結(jié)論:中藥干預(yù)能夠提高OP大鼠的骨密度,其作用機(jī)制可能與其能夠上調(diào)Wnt/β-catenin信號(hào)通路相關(guān)蛋白的表達(dá)有關(guān)。
Abstract:
Objective:To systematically review the effects of traditional Chinese drugs(TCDs)intervention on bone mineral density(BMD)and Wnt/β-catenin signaling pathway in osteoporosis(OP)rats.Methods:All the articles about intervention on OP rats with TCDs included from database establishing to February 2023 were retrieved from China National Knowledge Internet,Vip Database,Wanfang Database,Chinese Biomedical Literature Service System,PubMed,Embase and Cochrane Library through computer.The rats in experiment group were intervened by intragastric administration with TCDs including compounds(TCD),simplex drug and Chinese medicine effective constituents,while the ones in control group with normal saline or distilled water.The articles were screened according to the retrieval and screening scheme.The information was extracted and the methodological quality of researches in the articles was evaluated independently by two researchers,and if any disagreement was found between them,discussion was conducted or another researcher was invited for making a final decision,and then a Meta-analysis was conducted by using Stata13.0 software.Results:Two hundred and ten articles were searched out.After screening,30 articles(1105 rats)were included in the final analysis,750 rats in experiment group and 355 ones in control group.The results of Meta-analysis revealed that the BMDs of femur and lumbar vertebrae as well as the mRNA and protein expression levels of Wnt,β-catenin,Runt-related transcription factor 2(RUNX2)and low-density lipoprotein receptor-related protein 5(LRP5)in bone tissues were higher in experiment group compared to control group(SMD=1.75,95%CI(1.54,1.95),P=0.000; SMD=1.35,95%CI(1.07,1.64),P=0.000; SMD=3.82,95%CI(2.31,5.32),P=0.000; SMD=2.36,95%CI(2.00,2.72),P=0.000; SMD=3.07,95%CI(2.55,3.60),P=0.000; SMD=1.77,95%CI(1.40,2.14),P=0.000; SMD=5.11,95%CI(3.99,6.22),P=0.000; SMD=5.42,95%CI(4.04,6.81),P=0.000; SMD=1.74,95%CI(1.06,2.42),P=0.000; SMD=2.44,95%CI(1.47,3.41),P=0.000).Conclusion:TCDs intervention can improve the BMD of OP rats,and its mechanism of action may be that it can up-regulate the expression of Wnt/β-catenin signaling pathway-related proteins in OP rats.

參考文獻(xiàn)/References:

[1] LENCHIK L,SARTORIS D J.Current concepts in osteo-porosis[J].AJR Am J Roentgenol,1997,168(4):905-911.
[2] 中華醫(yī)學(xué)會(huì)骨質(zhì)疏松和骨礦鹽疾病分會(huì).原發(fā)性骨質(zhì)疏松癥診療指南(2022)[J].中國(guó)全科醫(yī)學(xué),2023,26(14):1671-1691.
[3] 中華醫(yī)學(xué)會(huì)骨質(zhì)疏松和骨礦鹽疾病分會(huì).中國(guó)骨質(zhì)疏松癥流行病學(xué)調(diào)查及“健康骨骼”專項(xiàng)行動(dòng)結(jié)果發(fā)布[J].中華骨質(zhì)疏松和骨礦鹽疾病雜志,2019,12(4):317-318.
[4] 中國(guó)老年學(xué)和老年醫(yī)學(xué)學(xué)會(huì)骨質(zhì)疏松分會(huì)中醫(yī)藥專家委員會(huì).中醫(yī)藥防治原發(fā)性骨質(zhì)疏松癥專家共識(shí)(2020)[J].中國(guó)骨質(zhì)疏松雜志,2020,26(12):1717-1725.
[5] 尹恒,蘇秋菊,王建偉,等.骨質(zhì)疏松癥中醫(yī)證型現(xiàn)代化研究思路探索[J].中國(guó)骨質(zhì)疏松雜志,2020,26(3):454-457.
[6] 楊彬彬,林適,吳建軍,等.中藥治療脾腎陽虛型原發(fā)性骨質(zhì)疏松癥的Meta分析[J].中國(guó)骨質(zhì)疏松雜志,2023,29(3):313-318.
[7] 王真,王從安,王永泉,等.口服補(bǔ)腎類中成藥治療絕經(jīng)后骨質(zhì)疏松癥有效性與安全性的網(wǎng)狀Meta分析[J].中草藥,2022,53(13):4084-4099.
[8] 馬學(xué)智,馬勇,郭楊.補(bǔ)腎健脾活血法治療絕經(jīng)后骨質(zhì)疏松癥療效的Meta分析[J].中國(guó)骨質(zhì)疏松雜志,2022,28(4):527-535.
[9] 金穎慧,閆國(guó)強(qiáng),張俊艷,等.基于Wnt/β-catenin信號(hào)通路的中醫(yī)藥防治骨質(zhì)疏松癥研究進(jìn)展[J].中國(guó)藥業(yè),2023,32(2):122-127.
[10] 翟柏宇,謝興文,李鼎鵬,等.中醫(yī)藥介導(dǎo)Wnt/β-catenin信號(hào)通路防治骨質(zhì)疏松的研究進(jìn)展[J].中國(guó)骨質(zhì)疏松雜志,2022,28(11):1654-1658.
[11] 秦川,魏泓.實(shí)驗(yàn)動(dòng)物學(xué)[M].北京:人民衛(wèi)生出版社,2015:266-267.
[12] HOOIJMANS C R,ROVERS M M,DE VRIES R B M,et al.SYRCLE's risk of bias tool for animal studies[J].BMC Med Res Methodol,2014,14:43.
[13] 許兵,金紅婷,劉慧,等.補(bǔ)腎活血顆粒對(duì)去勢(shì)大鼠骨組織Wnt/β-Catenin通路的影響研究[J].中華中醫(yī)藥雜志,2013,28(11):3400-3405.
[14] 馬茍平.基于經(jīng)典Wnt-β-catenin通路六味地黃丸抗去勢(shì)大鼠骨質(zhì)疏松作用的機(jī)制研究[D].杭州:浙江中醫(yī)藥大學(xué),2015.
[15] 向璐.益骨膠囊對(duì)OVX大鼠Wnt/β-Catenin信號(hào)通路的影響[D].廣州:暨南大學(xué),2015.
[16] 徐敏敏,劉紹凡,萬銳杰,等.虎杖苷對(duì)去卵巢骨質(zhì)疏松大鼠β-Catenin及GSK-3β蛋白表達(dá)的影響[J].中國(guó)現(xiàn)代應(yīng)用藥學(xué),2018,35(1):103-106.
[17] 林曉芳,姚新苗,李威,等.益骨湯對(duì)去勢(shì)大鼠骨組織Wnt/β-catenin經(jīng)典信號(hào)通路的影響[J].浙江中醫(yī)藥大學(xué)學(xué)報(bào),2018,42(2):97-104.
[18] 成鵬,白銀亮,胡彩莉,等.黃芪甲苷通過調(diào)控FoxO3a/Wnt2/β-catenin通路抑制去卵巢大鼠骨質(zhì)疏松的作用[J].中國(guó)實(shí)驗(yàn)方劑學(xué)雜志,2018,24(15):161-166.
[19] 王大偉.基于Wnt3a/β-catenin信號(hào)通路探究補(bǔ)腎益氣活血方對(duì)絕經(jīng)后骨質(zhì)疏松癥療效機(jī)制研究[D].沈陽:遼寧中醫(yī)藥大學(xué),2019.
[20] 韓鵬勃,蔣鋒,劉柱,等.加味身痛逐瘀湯調(diào)控Wnt/β-catenin信號(hào)通路對(duì)大鼠骨質(zhì)疏松癥的防治作用[J].陜西中醫(yī),2020,41(6):715-719.
[21] 趙軍,董重陽,師建平,等.蒙藥藍(lán)刺頭調(diào)控FoxO/Wnt/β-catenin通路抗氧化應(yīng)激防治絕經(jīng)后骨質(zhì)疏松研究[J].中華中醫(yī)藥雜志,2021,36(1):116-121.
[22] 李耀洋,尚立芝,孫河龍,等.左歸丸對(duì)去勢(shì)骨質(zhì)疏松模型大鼠Wnt/β-catenin信號(hào)通路的影響[J].中國(guó)實(shí)驗(yàn)方劑學(xué)雜志,2021,27(6):15-22.
[23] 劉嵬,王文志,李志永,等.基于Wnt5a/β-catenin 信號(hào)通路探討杜仲健骨方對(duì)骨質(zhì)疏松癥大鼠的治療作用[J/OL].遼寧中醫(yī)雜志,2023[2023-03-18].https://kns.cnki.net/kcms/detail//21.1128.R.20230213.1118.081.html.
[24] 王慶諺.補(bǔ)腎益氣活血方對(duì)絕經(jīng)后骨質(zhì)疏松癥大鼠Wnt7b/β-catenin信號(hào)通路作用機(jī)制的研究[D].沈陽:遼寧中醫(yī)藥大學(xué),2019.
[25] 席永斌,顏春魯,孫仕華,等.從Wnt/β-catenin信號(hào)通路研究地黃飲子湯劑對(duì)去卵巢骨質(zhì)疏松模型大鼠的防治作用[J].中醫(yī)研究,2019,32(8):67-70.
[26] 柴爽,黃佳純,王吉利,等.補(bǔ)腎健脾活血方對(duì)大鼠絕經(jīng)后骨質(zhì)疏松癥的防治作用[J].中成藥,2019,41(9):2213-2216.
[27] 邢威,陳雁雁,王樹人,等.杜仲健骨方對(duì)大鼠骨質(zhì)疏松癥作用機(jī)制研究[J].廣東藥科大學(xué)學(xué)報(bào),2020,36(2):254-258.
[28] 任樹軍,梁彥林,王墉琦,等.生髓健骨膠囊對(duì)酒精性骨質(zhì)疏松大鼠Wnt信號(hào)通路的影響[J].時(shí)珍國(guó)醫(yī)國(guó)藥,2020,31(3):579-582.
[29] 喻琴云,蘇孝共,包琦瑛,等.白藜蘆醇對(duì)去卵巢骨質(zhì)疏松大鼠Wnt/β-Catenin通路的影響[J].中國(guó)臨床藥理學(xué)與治療學(xué),2017,22(6):645-649.
[30] 潘亞磊,張玉苗,楊易寧,等.基于Wnt/β-catenin信號(hào)通路探討太白楤木抗去卵巢大鼠骨質(zhì)疏松癥的作用和機(jī)制[J].中國(guó)骨質(zhì)疏松雜志,2022,28(5):648-652.
[31] 王一鳳,樊國(guó)峰,陳勝樂.西紅花苷對(duì)去卵巢骨質(zhì)疏松大鼠Wnt/β-Catenin信號(hào)通路的影響[J].臨床和實(shí)驗(yàn)醫(yī)學(xué)雜志,2022,21(1):8-13.
[32] 凌家艷,劉慶,馬威,等.補(bǔ)腎通絡(luò)方對(duì)去勢(shì)大鼠骨質(zhì)疏松癥模型子宮內(nèi)膜和骨量流失的影響[J].中醫(yī)藥導(dǎo)報(bào),2022,28(6):20-23.
[33] 羅潔,許輝,張信成.益腎健骨顆粒對(duì)絕經(jīng)后骨質(zhì)疏松大鼠骨組織Wnt/β-catenin通路的影響[J].湖南中醫(yī)雜志,2022,38(7):166-169.
[34] 王健,張馳.基于Wnt/β-連環(huán)素通路探討補(bǔ)骨脂素對(duì)骨質(zhì)疏松癥大鼠的影響[J].世界中醫(yī)藥,2022,17(12):1697-1702.
[35] 李沁園,代冬芳,吳佩鋒,等.二十五味鬼臼丸通過Wnt/β-catenin信號(hào)通路改善去卵巢大鼠骨質(zhì)疏松癥[J].中國(guó)實(shí)驗(yàn)方劑學(xué)雜志,2023,29(2):59-65.
[36] 張強(qiáng),張敏,黃志榮,等.續(xù)斷皂苷Ⅵ調(diào)控Wnt/β-Catenin通路對(duì)骨質(zhì)疏松的影響機(jī)制[J].世界科學(xué)技術(shù)-中醫(yī)藥現(xiàn)代化,2022,24(6):2245-2254.
[37] 王杰,李琰,石威,等.基于腸道菌群的骨碎補(bǔ)抗絕經(jīng)后骨質(zhì)疏松癥的機(jī)制研究[J].中國(guó)中醫(yī)骨傷科雜志,2022,30(12):7-14.
[38] 鐘建春,謝興文,李鼎鵬,等.Wnt/β-catenin信號(hào)通路探究羌活魚超微粉抗去卵巢大鼠骨質(zhì)疏松的作用機(jī)制[J].中國(guó)骨質(zhì)疏松雜志,2022,28(12):1750-1754.
[39] 余自層,郭楊,馬勇,等.蒙藥那仁滿都拉調(diào)控Wnt/β-catenin信號(hào)通路抗骨質(zhì)疏松的作用及機(jī)制[J].中國(guó)骨質(zhì)疏松雜志,2023,29(1):58-63.
[40] 任輝.龜板防治GIOP中miRNA調(diào)控Wnt/β-catenin通路的機(jī)理研究[D].廣州:廣州中醫(yī)藥大學(xué),2017.
[41] 徐紅余,姚麒.小檗堿調(diào)控Wnt/β-catenin信號(hào)對(duì)骨質(zhì)疏松大鼠的作用研究[J].現(xiàn)代實(shí)用醫(yī)學(xué),2020,32(11):1314-1317.
[42] 石曉征,李娜,李曉華,等.梅花鹿茸Ⅰ型膠原對(duì)骨質(zhì)疏松大鼠Wnt/β-catenin信號(hào)通路的影響[J].長(zhǎng)春中醫(yī)藥大學(xué)學(xué)報(bào),2018,34(5):832-835.
[43] 陳世海,謝興文,李建國(guó),等.Wnt/β-catenin信號(hào)通路在補(bǔ)腎中藥靶向治療骨質(zhì)疏松癥中應(yīng)用的研究進(jìn)展[J].中國(guó)骨質(zhì)疏松雜志,2019,25(4):559-563.
[44] MACDONALD B T,TAMAI K,HE X.Wnt/beta-catenin signaling:components,mechanisms,and diseases[J].Dev Cell,2009,17(1):9-26.
[45] WANG C G,HU Y H,SU S L,et al.LncRNA DANCR and miR-320a suppressed osteogenic differentiation in osteo-porosis by directly inhibiting the Wnt/β-catenin signaling pathway[J].Exp Mol Med,2020,52(8):1310-1325.
[46] SHEN G,REN H,SHANG Q,et al.Foxf1 knockdown promotes BMSC osteogenesis in part by activating the Wnt/β-catenin signalling pathway and prevents ovariectomy-induced bone loss[J].EBioMedicine,2020,52:102626.

相似文獻(xiàn)/References:

[1]張莉,秦丹霞,張細(xì)姣.Orem自理理論在前路手術(shù)治療脊髓型頸椎病 圍手術(shù)期護(hù)理中的應(yīng)用[J].中醫(yī)正骨,2015,27(09):75.
[2]徐西林,趙永蘭,張曉峰,等.活骨注射液髖關(guān)節(jié)腔灌注對(duì)兔股骨頭壞死模型 血管內(nèi)皮生長(zhǎng)因子表達(dá)的動(dòng)態(tài)影響[J].中醫(yī)正骨,2015,27(08):1.
　XU Xilin,ZHAO Yonglan,ZHANG Xiaofeng,et al.Dynamic effect of intra-articular hip injection of Huogu injection on the expression of vascular endothelial growth factor in rabbit models with femur head necrosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):1.
[3]李林軍.應(yīng)用膨脹式椎弓根螺釘內(nèi)固定治療合并骨質(zhì)疏松的 胸腰椎退行性疾病[J].中醫(yī)正骨,2015,27(08):49.
[4]韓艷,溫利平,劉娜,等.補(bǔ)腎活血方對(duì)去卵巢大鼠骨代謝及骨密度的影響[J].中醫(yī)正骨,2015,27(12):7.
　HAN Yan,WEN Liping,LIU Na,et al.Effect of Bushen Huoxue Fang(補(bǔ)腎活血方)on bone metabolism and bone mineral density in the ovariectomized rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):7.
[5]李學(xué)朋,朱立國(guó).骨疏康膠囊對(duì)去卵巢大鼠骨小梁的影響[J].中醫(yī)正骨,2015,27(12):12.
　LI Xuepeng,ZHU Liguo.Effect of Gushukang Jiaonang(骨疏康膠囊)on bone trabecula in the ovariectomized rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):12.
[6]陳冠軍,陳揚(yáng),莊汝杰.可灌注骨水泥椎弓根螺釘系統(tǒng) 在老年腰椎疾患手術(shù)中的應(yīng)用[J].中醫(yī)正骨,2015,27(02):40.
[7]王丹輝,賁越,韓梅.林蛙油治療絕經(jīng)后骨質(zhì)疏松癥的臨床研究[J].中醫(yī)正骨,2014,26(01):27.
　Wang Danhui*,Ben Yue,Han Mei..Clinical study of Rana temporaria oil in the treatment of postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(07):27.
[8]黃建華,黃建武,李慧輝,等.加味左歸丸對(duì)絕經(jīng)后骨質(zhì)疏松癥肝腎不足證 患者骨密度的影響[J].中醫(yī)正骨,2013,25(11):19.
　Huang Jianhua*,Huang Jianwu,Li Huihui,et al.Effect of JIAWEI ZUOGUI pill on bone mineral density in postmenopausal osteoporosis patients with deficiency of liver and kidney[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(07):19.
[9]項(xiàng)旻,楊虹,林愛菊,等.絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素的關(guān)系研究[J].中醫(yī)正骨,2013,25(12):20.
　Xiang Min*,Yang Hong,Lin Aiju,et al.Clinical study on the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(07):20.
[10]史曉林,李春雯,張志強(qiáng).弱陽離子磁珠分離技術(shù)和基質(zhì)輔助激光解吸電離飛行時(shí)間質(zhì)譜技術(shù)在原發(fā)性Ⅰ型骨質(zhì)疏松癥血清標(biāo)志蛋白篩選中的應(yīng)用[J].中醫(yī)正骨,2014,26(03):5.
　Shi Xiaolin*,Li Chunwen,Zhang Zhiqiang..Application of magnetic beads based weak cation exchange separation technology and matrix-assisted laser desorption-ionization time of flight mass spectrometry technology in screening serum protein markers of primary type-Ⅰ osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(07):5.
[11]朱國(guó)濤,陳錦成,劉洪文,等.活動(dòng)障礙綜合征的研究進(jìn)展[J].中醫(yī)正骨,2020,32(05):46.
[12]沈贊,王冠尹,張鎰,等.絕經(jīng)后骨質(zhì)疏松癥鼠模型的研究進(jìn)展[J].中醫(yī)正骨,2023,35(12):46.

備注/Memo

備注/Memo:
基金項(xiàng)目:國(guó)家自然科學(xué)基金項(xiàng)目(81973889); 中醫(yī)藥“雙鏈融合”中青年科研創(chuàng)新團(tuán)隊(duì)項(xiàng)目(2022-SLRH-LJ-001); 陜西省中醫(yī)藥重點(diǎn)研究室建設(shè)項(xiàng)目(陜中醫(yī)藥發(fā)〔2018〕32號(hào)) 通訊作者:袁普衛(wèi) E-mail:[email protected]
更新日期/Last Update: 1900-01-01