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[1]任我行,丁立鵬,詹紅生.中醫(yī)體質(zhì)類型與腰椎間盤突出癥關(guān)系的Meta分析[J].中醫(yī)正骨,2023,35(05):20-24.
　REN Woxing,DING Lipeng,ZHAN Hongsheng.The relationship between TCM constitution types and lumbar disc herniation:a meta-analysis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(05):20-24.
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中醫(yī)體質(zhì)類型與腰椎間盤突出癥關(guān)系的Meta分析()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期數(shù):
2023年05期
頁(yè)碼:
20-24
欄目:
文獻(xiàn)研究
出版日期:
2023-05-20

文章信息/Info

Title:
The relationship between TCM constitution types and lumbar disc herniation:a meta-analysis
作者:
任我行; 丁立鵬; 詹紅生
(上海中醫(yī)藥大學(xué)附屬曙光醫(yī)院,上海 201203)
Author(s):
REN Woxing; DING Lipeng; ZHAN Hongsheng
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
關(guān)鍵詞:
椎間盤移位;  腰椎;  中醫(yī)體質(zhì);  專題Meta分析
Keywords:
intervertebral disc displacement;  lumbar vertebrae;  body constitution(TCM);  meta-analysis as topic
摘要:
目的:探討中醫(yī)體質(zhì)類型與腰椎間盤突出癥(lumbar disc herniation,LDH)的關(guān)系。方法:運(yùn)用計(jì)算機(jī)檢索中國(guó)知網(wǎng)、萬(wàn)方數(shù)據(jù)庫(kù)、維普網(wǎng)、中國(guó)生物醫(yī)學(xué)文獻(xiàn)服務(wù)系統(tǒng)、PubMed、Embase、Cochrane Library、Medline中有關(guān)中醫(yī)體質(zhì)類型與LDH關(guān)系的觀察性研究文獻(xiàn),檢索時(shí)限均為建庫(kù)至2022年11月17日。經(jīng)文獻(xiàn)篩選、數(shù)據(jù)提取及偏倚風(fēng)險(xiǎn)評(píng)價(jià)后,采用Stata17.0軟件分析LDH患者中不同中醫(yī)體質(zhì)類型所占比例及中醫(yī)體質(zhì)類型與LDH的關(guān)系,并用漏斗圖進(jìn)行發(fā)表偏倚分析。結(jié)果:共檢索到136篇文獻(xiàn),經(jīng)過(guò)逐層篩選最終納入10篇文獻(xiàn),其中橫斷面研究7項(xiàng)、病例對(duì)照研究3項(xiàng)。Meta分析結(jié)果顯示,LDH患者中血瘀質(zhì)、濕熱質(zhì)、陽(yáng)虛質(zhì)所占比例較高[21.71%,95%CI(0.19,0.26),P=0.000; 17.12%,95%CI(0.15,0.19),P=0.000; 15.17%,95%CI(0.11,0.21),P=0.000],平和質(zhì)、氣郁質(zhì)、氣虛質(zhì)、特稟質(zhì)所占比例較低[9.60%,95%CI(0.04,0.16),P=0.004; 6.47%,95%CI(0.04,0.08),P=0.000; 5.92%,95%CI(0.05,0.07),P=0.000; 1.53%,95%CI(0.01,0.03),P=0.000]; 血瘀質(zhì)和陽(yáng)虛質(zhì)是LDH的危險(xiǎn)因素[OR=1.01,95%CI(0.66,1.37),P=0.000; OR=0.89,95%CI(0.53,1.25),P=0.000],平和質(zhì)是LDH的保護(hù)因素[OR=-2.02,95%CI(-2.43,-1.62),P=0.000],其他中醫(yī)體質(zhì)類型與LDH的發(fā)生無(wú)明顯關(guān)系。以針對(duì)LDH患者中血瘀質(zhì)所占比例的7項(xiàng)橫斷面研究進(jìn)行發(fā)表偏倚分析,漏斗圖兩側(cè)不完全對(duì)稱,提示可能存在發(fā)表偏倚。結(jié)論:現(xiàn)有的證據(jù)表明,中醫(yī)體質(zhì)類型與LDH的發(fā)病有關(guān),血瘀質(zhì)、陽(yáng)虛質(zhì)是LDH的危險(xiǎn)因素,平和質(zhì)是LDH的保護(hù)因素。
Abstract:
Objective:To explore the relationship between TCM constitution types and lumbar disc herniation(LDH).Methods:All observational research articles about the relationship between TCM constitution types and LDH included from database establishing to November 17,2022 were retrieved from China National Knowledge Internet,Wanfang Database,Vip Database,Chinese Biomedical Literature Service System,PubMed,Embase,Cochrane Library and Medline through computer.The articles were screened,the information was extracted and the bias risk of the research in the articles was evaluated independently by two researchers according to the inclusion and exclusion criteria,and if any disagreement was found between them,another researcher was invited for making a final decision,and then a Meta-analysis on the proportion of different TCM constitution types in LDH patients and the relationship between TCM constitution types and LDH was conducted by using Stata17.0 software,furthermore,the publication bias was analyzed by using funnel plot.Results:One hundred and thirty-six articles were searched out.After screening,10 articles were included in the final analysis,including 7 cross-sectional study articles and 3 case-control study articles.The results of Meta-analysis revealed that the Stagnant-blood constitution,Damp-heat constitution and Yang-deficient constitution accounted for a high proportion(21.71%,95%CI(0.19,0.26),P=0.000; 17.12%,95%CI(0.15,0.19),P=0.000; 15.17%,95%CI(0.11,0.21),P=0.000),while the Balanced constitution(TCM),Stagnant-qi constitution(TCM),Qi-deficient constitution and Inherited-special constitution accounted for a low proportion in LDH patients(9.60%,95%CI(0.04,0.16),P=0.004; 6.47%,95%CI(0.04,0.08),P=0.000; 5.92%,95%CI(0.05,0.07),P=0.000; 1.53%,95%CI(0.01,0.03),P=0.000).The Stagnant-blood constitution and Yang-deficient constitution were the risk factors for LDH(OR=1.01,95%CI(0.66,1.37),P=0.000; OR=0.89,95%CI(0.53,1.25),P=0.000),while the Balanced constitution(TCM)was the protective factor for LDH(OR=-2.02,95%CI(-2.43,-1.62),P=0.000).No obvious relationship was found between the other TCM constitution types and the occurrence of LDH.Publication bias was analyzed according to Funnel plot drawned based on the proportion of Stagnant-blood constitution in LDH patients in the 7 cross-sectional studies,and the asymmetrical funnel plots demonstrated that there might be publication bias.Conclusion:Available evidences suggest that the occurrence of LDH is related to TCM constitution types.The Stagnant-blood constitution and Yang-deficient constitution are the risk factors,while the Balanced constitution(TCM)is the protective factor for LDH.

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備注/Memo

備注/Memo:
基金項(xiàng)目:上海市2020年度“科技創(chuàng)新行動(dòng)計(jì)劃”醫(yī)學(xué)創(chuàng)新研究專項(xiàng)(20MC1920600); 上海市臨床重點(diǎn)專科(中醫(yī)骨傷科)建設(shè)項(xiàng)目(shslczdzk03901) 通訊作者:詹紅生 E-mail:[email protected]
更新日期/Last Update: 1900-01-01