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[1]董一平,袁強(qiáng),張寧,等.外泌體在股骨頭壞死診治中的應(yīng)用[J].中醫(yī)正骨,2023,35(01):47-52.
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外泌體在股骨頭壞死診治中的應(yīng)用()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期數(shù):
2023年01期
頁(yè)碼:
47-52
欄目:
綜述
出版日期:
2023-01-20

文章信息/Info

作者:
董一平1; 袁強(qiáng)1; 張寧2; 張穎3
(1.河南中醫(yī)藥大學(xué)研究生院,河南 鄭州 450046; 2.湖南中醫(yī)藥大學(xué)研究生院,湖南 長(zhǎng)沙 410208; 3.河南省洛陽(yáng)正骨醫(yī)院/河南省骨科醫(yī)院,河南 洛陽(yáng) 471002)
關(guān)鍵詞:
股骨頭壞死;  外泌體;  綜述
摘要:
股骨頭壞死(osteonecrosis of the femoral head,ONFH)是一種常見(jiàn)的骨科疾病,發(fā)病機(jī)制復(fù)雜,目前臨床上的治療方法并不令人滿意。外泌體是細(xì)胞分泌的具有雙層膜的細(xì)胞外囊泡,內(nèi)含豐富的蛋白質(zhì)與核酸分子。外泌體在血清中的含量及外泌體內(nèi)miRNA的差異性能夠反映ONFH的發(fā)生階段; 而不同細(xì)胞來(lái)源的外泌體能夠通過(guò)調(diào)控信號(hào)傳導(dǎo)和相關(guān)基因表達(dá)影響骨細(xì)胞、血管細(xì)胞的增殖分化,進(jìn)而影響骨重塑。因此,外泌體在ONFH的診治方面具有重要的應(yīng)用價(jià)值。本文對(duì)外泌體進(jìn)行了概述,對(duì)外泌體在ONFH診斷和治療中的應(yīng)用價(jià)值進(jìn)行了綜述。

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中醫(yī)正骨2023年1月第35卷第1期 J Trad Chin Orthop Trauma,2023,Vol.35,No.1(總051)
(總052)中醫(yī)正骨2023年1月第35卷第1期 J Trad Chin Orthop Trauma,2023,Vol.35,No.1
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(收稿日期:2022-03-27 本文編輯:呂寧)

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備注/Memo

備注/Memo:
基金項(xiàng)目:國(guó)家自然科學(xué)基金項(xiàng)目(81774348)通訊作者:張穎 E-mail:[email protected]
更新日期/Last Update: 1900-01-01