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[1]李朝輝,孫忠義,張峻瑋,等.泛素-蛋白酶體系統(tǒng)在類風(fēng)濕關(guān)節(jié)炎研究中的應(yīng)用進(jìn)展[J].中醫(yī)正骨,2022,34(07):48-53.
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泛素-蛋白酶體系統(tǒng)在類風(fēng)濕關(guān)節(jié)炎研究中的應(yīng)用進(jìn)展()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第34卷
期數(shù):
2022年07期
頁(yè)碼:
48-53
欄目:
綜述
出版日期:
2022-07-20

文章信息/Info

作者:
李朝輝孫忠義張峻瑋聶偉志
(山東省文登整骨醫(yī)院,山東 威海 264400)
關(guān)鍵詞:
關(guān)節(jié)炎類風(fēng)濕 泛素蛋白連接酶復(fù)合物 蛋白酶體抑制劑 綜述
摘要:
類風(fēng)濕關(guān)節(jié)炎(rheumatoid arthritis,RA)是以反復(fù)發(fā)作的關(guān)節(jié)滑膜炎為特征的慢性系統(tǒng)性疾病,該病可能與蛋白酶對(duì)蛋白的作用失衡等有關(guān)。泛素-蛋白酶體系統(tǒng)是細(xì)胞內(nèi)蛋白質(zhì)降解的主要途徑,其主要通過(guò)降解錯(cuò)誤折疊的蛋白質(zhì)來(lái)維持細(xì)胞穩(wěn)態(tài),其功能異常會(huì)導(dǎo)致細(xì)胞穩(wěn)態(tài)失調(diào),從而引發(fā)包括RA在內(nèi)的多種疾病。本文對(duì)泛素-蛋白酶體系統(tǒng)進(jìn)行了概述,并對(duì)泛素-蛋白酶體系統(tǒng)在RA發(fā)生發(fā)展中的作用、泛素-蛋白酶體系統(tǒng)與RA相關(guān)的信號(hào)通路、泛素-蛋白酶體抑制劑在RA治療中的應(yīng)用進(jìn)行了綜述。

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更新日期/Last Update: 1900-01-01