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[1]王晶,許金海.骨質(zhì)疏松癥與中醫(yī)體質(zhì)類型關(guān)系的Meta分析[J].中醫(yī)正骨,2022,34(06):29-33.
　WANG Jing,XU Jinhai.The relationship between osteoporosis and TCM constitutional types:a meta-analysis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2022,34(06):29-33.
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骨質(zhì)疏松癥與中醫(yī)體質(zhì)類型關(guān)系的Meta分析()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第34卷
期數(shù):
2022年06期
頁碼:
29-33
欄目:
文獻(xiàn)研究
出版日期:
2022-06-20

文章信息/Info

Title:
The relationship between osteoporosis and TCM constitutional types:a meta-analysis
作者:
王晶1; 許金海2
(1.上海市中醫(yī)老年醫(yī)學(xué)研究所,上海 200031; 2.上海中醫(yī)藥大學(xué)附屬龍華醫(yī)院,上海 200032)
Author(s):
WANG Jing1; XU Jinhai2
1.Shanghai Geriatric Institute of Chinese Medicine,Shanghai 200031,China 2.Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China
關(guān)鍵詞:
骨質(zhì)疏松;  中醫(yī)體質(zhì)類型;  專題Meta分析
Keywords:
osteoporosis;  constitutional type(TCM);  meta-analysis as topic
摘要:
目的:探討骨質(zhì)疏松癥與中醫(yī)體質(zhì)類型的關(guān)系。方法:應(yīng)用計算機檢索Cochrane Library、PubMed、Embase、中國知網(wǎng)、萬方數(shù)據(jù)庫、維普網(wǎng)、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫中有關(guān)骨質(zhì)疏松癥與中醫(yī)體質(zhì)類型關(guān)系的觀察性研究文獻(xiàn),檢索時限均設(shè)定為建庫至2021年7月。經(jīng)文獻(xiàn)篩選、數(shù)據(jù)提取及偏倚風(fēng)險評價后,采用RevMan5.3軟件和R軟件(version3.5.2)對各中醫(yī)體質(zhì)類型在骨質(zhì)疏松癥患者中的分布情況、骨質(zhì)疏松癥患者中醫(yī)體質(zhì)類型和健康人群中醫(yī)體質(zhì)類型的對比情況、絕經(jīng)后骨質(zhì)疏松癥患者中醫(yī)體質(zhì)類型和健康人群中醫(yī)體質(zhì)類型的對比情況進(jìn)行Meta分析。結(jié)果:共檢索到208篇文獻(xiàn),經(jīng)過逐層篩選最終納入23篇文獻(xiàn),其中橫斷面研究4項、病例對照研究19項。Meta分析結(jié)果顯示,骨質(zhì)疏松癥患者中陰虛質(zhì)[27%,95%CI(21%,33%)]、陽虛質(zhì)[26%,95%CI(14%,40%)]、氣虛質(zhì)[17%,95%CI(10%,25%)]和血瘀質(zhì)[17%,95%CI(12%,24%)]所占比例較高; 陽虛質(zhì)、氣虛質(zhì)、血瘀質(zhì)、陰虛質(zhì)在骨質(zhì)疏松癥患者中的比例高于健康人群[OR=2.51,95%CI(1.94,3.25),P=0.000; OR=2.20,95%CI(1.64,2.96),P=0.000; OR=1.93,95%CI(1.34,2.78),P=0.000; OR=1.47,95%CI(1.06,2.05),P=0.020],濕熱質(zhì)、平和質(zhì)在骨質(zhì)疏松癥患者中的比例低于健康人群[OR=0.59,95%CI(0.39,0.90),P=0.010; OR=0.23,95%CI(0.14,0.38),P=0.000],氣郁質(zhì)、特稟質(zhì)、痰濕質(zhì)在骨質(zhì)疏松癥患者和健康人群中的比例相當(dāng)[OR=1.31,95%CI(0.81,2.11),P=0.260; OR=1.13,95%CI(0.68,1.90),P=0.630; OR=0.68,95%CI(0.45,1.02),P=0.060]; 陽虛質(zhì)、氣虛質(zhì)、血瘀質(zhì)、陰虛質(zhì)在絕經(jīng)后骨質(zhì)疏松癥患者中的比例高于健康人群[OR=2.52,95%CI(1.47,4.34),P=0.001; OR=2.22,95%CI(1.32,3.73),P=0.003; OR=2.18,95%CI(1.06,4.52),P=0.040; OR=1.70,95%CI(1.30,2.22),P=0.000],濕熱質(zhì)、痰濕質(zhì)、平和質(zhì)在絕經(jīng)后骨質(zhì)疏松癥患者中的比例低于健康人群[OR=0.69,95%CI(0.48,0.99),P=0.040; OR=0.48,95%CI(0.25,0.93),P=0.030; OR=0.21,95%CI(0.09,0.50),P=0.000],特稟質(zhì)、氣郁質(zhì)在絕經(jīng)后骨質(zhì)疏松癥患者和健康人群中的比例相當(dāng)[OR=0.89,95%CI(0.56,1.39),P=0.600; OR=0.75,95%CI(0.55,1.02),P=0.070]。結(jié)論:現(xiàn)有的證據(jù)表明,陽虛質(zhì)、氣虛質(zhì)、血瘀質(zhì)和陰虛質(zhì)是骨質(zhì)疏松癥患者的主要中醫(yī)體質(zhì)類型。
Abstract:
Objective:To explore the relationship between osteoporosis and TCM constitutional types.Methods:All observational research articles about the relationship between osteoporosis and TCM constitutional types included from database establishing to July 2021 were retrieved from Cochrane Library,PubMed,Embase,China National Knowledge Internet,Wanfang Database,Vip Database and Chinese Biomedical Literature Database through computer.The articles were screened and the information was extracted according to the inclusion and exclusion criteria.The bias risk of the research in the articles was evaluated by using the Newcastle-Ottawa scale(NOS)and the evaluation criterions recommended by agency for health care research and quality(AHRQ),and then a Meta-analysis on the distribution of TCM constitutional types in osteoporosis patients and the comparison of TCM constitutional types between osteoporosis patients and healthy people as well as between postmenopausal osteoporosis(PMOP)patients and healthy people was conducted by using RevMan5.3 software and R software(version3.5.2).Results:Two hundred and eight articles were searched out.After screening,23 articles were included in the final analysis,including 4 cross-sectional articles and 19 case-control articles.The results of Meta-analysis revealed that the Yin-deficiency constitution(27%,95%CI(21%,33%)),Yang-deficiency constitution(26%,95%CI(14%,40%)),Qi-deficiency constitution(17%,95%CI(10%,25%))and Stagnant-blood constitution(17%,95%CI(12%,24%))accounted for a high proportion in osteoporosis patients.The Yang-deficiency constitution,Qi-deficiency constitution,Stagnant-blood constitution and Yin-deficiency constitution accounted for a higher proportion in osteoporosis patients compared with healthy people(OR=2.51,95%CI(1.94,3.25),P=0.000; OR=2.20,95%CI(1.64,2.96),P=0.000; OR=1.93,95%CI(1.34,2.78),P=0.000; OR=1.47,95%CI(1.06,2.05),P=0.020),while the Damp-heat constitution and Balanced constitution(TCM)accounted for a lower proportion in osteoporosis patients compared with healthy people(OR=0.59,95%CI(0.39,0.90),P=0.010; OR=0.23,95%CI(0.14,0.38),P=0.000).Moreover,the Stagnant-qi constitution(TCM),Inherited-special constitution and Phlegm-dampness constitution accounted for a similar proportion in osteoporosis patients compared with healthy people(OR=1.31,95%CI(0.81,2.11),P=0.260; OR=1.13,95%CI(0.68,1.90),P=0.630; OR=0.68,95%%CI(0.45,1.02),P=0.060).The Yang-deficiency constitution,Qi-deficiency constitution,Stagnant-blood constitution and Yin-deficiency constitution accounted for a higher proportion in PMOP patients compared with healthy people(OR=2.52,95%CI(1.47,4.34),P=0.001; OR=2.22,95%CI(1.32,3.73),P=0.003; OR=2.18,95%CI(1.06,4.52),P=0.040; OR=1.70,95%CI(1.30,2.22),P=0.000),while the Damp-heat constitution,Phlegm-dampness constitution and Balanced constitution(TCM)accounted for a lower proportion in PMOP patients compared with healthy people(OR=0.69,95%CI(0.48,0.99),P=0.040; OR=0.48,95%CI(0.25,0.93),P=0.030; OR=0.21,95%CI(0.09,0.50),P=0.000).Moreover,the Inherited-special constitution and Stagnant-qi constitution(TCM)accounted for a similar proportion in PMOP patients compared with healthy people(OR=0.89,95%CI(0.56,1.39),P=0.600; OR=0.75,95%CI(0.55,1.02),P=0.070).Conclusion:Available evidences suggest that the Yang-deficiency constitution,Qi-deficiency constitution,Stagnant-blood constitution and Yin-deficiency constitution are the main TCM constitutional types of osteoporosis patients.

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備注/Memo

備注/Memo:
基金項目:國家重點研發(fā)計劃項目(2018YFC1704300) 通訊作者:許金海 E-mail:[email protected]
更新日期/Last Update: 1900-01-01