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[1]馬斌祥,屈紅,張云飛,等.基于國家專利數(shù)據(jù)庫的腰椎間盤突出癥內服中藥復方用藥規(guī)律研究[J].中醫(yī)正骨,2022,34(05):28-31.
　MA Binxiang,QU Hong,ZHANG Yunfei,et al.A study of clinical medication rules of oral TCM compounds for treatment of lumbar disc herniation based on national patent database[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2022,34(05):28-31.
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基于國家專利數(shù)據(jù)庫的腰椎間盤突出癥內服中藥復方用藥規(guī)律研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第34卷
期數(shù):
2022年05期
頁碼:
28-31
欄目:
數(shù)據(jù)庫研究
出版日期:
2022-05-20

文章信息/Info

Title:
A study of clinical medication rules of oral TCM compounds for treatment of lumbar disc herniation based on national patent database
作者:
馬斌祥1; 屈紅1; 張云飛1; 張洋2; 鄧夢2; 鄧強1
(1.甘肅省中醫(yī)院,甘肅 蘭州 730050; 2.甘肅中醫(yī)藥大學,甘肅 蘭州 730000)
Author(s):
MA Binxiang1; QU Hong1; ZHANG Yunfei1; ZHANG Yang2; DENG Meng2; DENG Qiang1
1.Gansu Provincial Hospital of TCM,Lanzhou 730050,Gansu,China 2.Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China
關鍵詞:
椎間盤移位;  腰椎;  方劑分析; 計算機輔助;  數(shù)據(jù)挖掘
Keywords:
intervertebral disc displacement;  lumbar vertebrae;  formula anal; comput assist;  data mining
摘要:
目的:基于國家專利數(shù)據(jù)庫探討治療腰椎間盤突出癥的內服中藥復方的用藥規(guī)律。方法:從國家專利數(shù)據(jù)庫篩選治療腰椎間盤突出癥的內服中藥復方專利。提取數(shù)據(jù)后,采用中醫(yī)傳承輔助系統(tǒng)(V2.5)中的“數(shù)據(jù)分析”模塊,進行用藥頻次統(tǒng)計和組方規(guī)律分析。結果:①用藥頻次統(tǒng)計結果。共篩選到207項治療腰椎間盤突出癥的內服中藥復方專利,專利發(fā)表時間為2002年7月至2021年4月。納入的207項中藥復方專利共涉及207首中藥復方、225味中藥。出現(xiàn)頻次≥30的中藥共34味,其中當歸、牛膝、杜仲出現(xiàn)頻次較高。藥性統(tǒng)計結果顯示,溫性藥、平性藥、寒性藥出現(xiàn)頻次較高。藥味統(tǒng)計結果顯示,辛味藥、苦味藥、甘味藥出現(xiàn)頻次較高。藥物歸經統(tǒng)計結果顯示,歸肝經、腎經、脾經、心經的藥物出現(xiàn)頻次較高。②組方規(guī)律分析結果。基于關聯(lián)規(guī)則的組方規(guī)律分析結果顯示,“牛膝-當歸”“牛膝-杜仲”“杜仲-當歸”等藥對出現(xiàn)頻次較高,“牛膝-杜仲-當歸”“沒藥-乳香-當歸”“牛膝-當歸-獨活”等角藥出現(xiàn)頻次較高; 共得到7條關聯(lián)規(guī)則,分別為“乳香、當歸→沒藥”“乳香→沒藥”“乳香、牛膝→沒藥”“沒藥、杜仲→乳香”“沒藥、牛膝→乳香”“牛膝、續(xù)斷→杜仲”“紅花、乳香→沒藥”。基于復雜網(wǎng)絡的組方規(guī)律分析結果顯示,牛膝、杜仲、當歸為核心藥物。結論:國家專利數(shù)據(jù)庫中治療腰椎間盤突出癥的內服中藥復方多以當歸、牛膝、杜仲、獨活、沒藥、乳香為核心進行加減,所用藥物多性溫、平、寒,味辛、苦、甘,歸肝、腎、脾、心經。
Abstract:
Objective:To explore the clinical medication rules of oral TCM compounds for treatment of lumbar disc herniation(LDH)based on national patent database.Methods:All authorized patents about oral TCM compounds for treatment of LDH were retrieved from the website of China Patent Announcement of China National Intellectual Property Administration through computer.The obtained patents were screened,and the oral TCM compounds involved in the patents were extracted and their names were standardized and input into Microsoft Office Excel 2019 software to build the database.The analysis on property,flavour,meridian distribution and usage frequency of the Chinese herbs(CHs)in compounds were conducted for excavating clinical medication rules by using data analysis module in TCM inheritance support system(TCMISS)software(V2.5).Results:①Two hundred and seven patents published from July 2002 to April 2021 were screened out,involving 207 TCM compounds and 225 CHs,among which 34 ones displayed a occurrence frequency of≥30,and the ones with high occurrence frequency included Angelica Sinensis,Achyranthes Bidentatae Radix(TCD)and Eucommiae Cortex.The results of statistics on medicinal property showed that the most frequently used CHs were those with a warm property,followed by the ones with a neutral property and a cold property.The results of statistics on medicinal flavor showed that the CHs with pungent,bitter and sweet flavors were more preferred.The results of statistics on meridian tropism showed that the CHs mainly acted on the liver meridians,kidney meridians,spleen meridians and heart meridians.②The results of analysis on association rules-based prescription rules showed that the paired-herbs with high occurrence frequency included Achyranthes Bidentatae Radix(TCD)-Angelica Sinensis,Achyranthes Bidentatae Radix(TCD)-Eucommiae Cortex and Eucommiae Cortex-Angelica Sinensis; and the triplet-herbs with high occurrence frequency included Achyranthes Bidentatae Radix(TCD)-Eucommiae Cortex-Angelica Sinensis,Myrrha-Frankincense-Angelica Sinensis and Achyranthes Bidentatae Radix(TCD)-Angelica Sinensis-Angelicae Pubescentis Radix(TCD).Furthermore,7 association rules were obtained,namely Frankincense+Angelica Sinensis→Myrrha,Frankincense→Myrrha,Frankincense+Achyranthes Bidentatae Radix(TCD)→Myrrha,Myrrha+Eucommiae Cortex→Frankincense,Myrrha+Achyranthes Bidentatae Radix(TCD)→Frankincense,Achyranthes Bidentatae Radix(TCD)+Dipsaci Radix→Eucommiae Cortex and Carthamus tinctorius+Frankincense→Myrrha.The results of analysis on complex network-based prescription rules showed that Achyranthes Bidentatae Radix(TCD),Eucommiae Cortex and Angelica Sinensis were used as the core CHs.Conclusion:The CHs are often the ones presented with warm,neutral and cold properties and pungent,bitter and sweet flavors and mainly act on liver meridians,kidney meridians,spleen meridians and heart meridians in oral TCM compounds for treatment of LDH in national patent database.Angelica Sinensis,Achyranthes Bidentatae Radix(TCD),Eucommiae Cortex,Angelicae Pubescentis Radix(TCD),Myrrha and Frankincense are usually used as the core of the oral TCM compounds.

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備注/Memo

備注/Memo:
基金項目:基于中醫(yī)臨床研究基地優(yōu)勢病種及擴展病種療效評價研究項目(國中醫(yī)藥科技中醫(yī)便函﹝2021﹞36號) 通訊作者:鄧強 E-mail:[email protected]
更新日期/Last Update: 1900-01-01