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[1]童磊,賈鋒,范麗,等.膝關(guān)節(jié)滑液白細(xì)胞介素1β、白細(xì)胞介素17、前列腺素E2含量與老年膝骨關(guān)節(jié)炎預(yù)后的關(guān)系研究…[J].中醫(yī)正骨,2022,34(01):33-36.
　TONG Lei,JIA Feng,FAN Li,et al.The relationship between the prognosis of knee osteoarthritis and the contents of interleukin-1β,interleukin-17 and prostaglandin E2 in knee synovial fluid in the aged[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2022,34(01):33-36.
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膝關(guān)節(jié)滑液白細(xì)胞介素1β、白細(xì)胞介素17、前列腺素E2含量與老年膝骨關(guān)節(jié)炎預(yù)后的關(guān)系研究…()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第34卷
期數(shù):
2022年01期
頁(yè)碼:
33-36
欄目:
臨床研究
出版日期:
2022-01-20

文章信息/Info

Title:
The relationship between the prognosis of knee osteoarthritis and the contents of interleukin-1β,interleukin-17 and prostaglandin E2 in knee synovial fluid in the aged
作者:
童磊; 賈鋒; 范麗; 劉強(qiáng)
(南陽(yáng)市中心醫(yī)院,河南 南陽(yáng) 473003)
Author(s):
TONG Lei; JIA Feng; FAN Li; LIU Qiang
Nanyang Central Hospital,Nanyang 473003,Henan,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝;  預(yù)后;  老年人;  滑液;  白細(xì)胞介素1β;  白細(xì)胞介素17;  地諾前列酮
Keywords:
osteoarthritis; knee;  prognosis;  aged;  synovial fluid;  interleukin-1beta;  interleukin-17;  dinoprostone
摘要:
目的:探究膝關(guān)節(jié)滑液白細(xì)胞介素(interleukin,IL)-1β、IL-17、前列腺素E2(prostaglandin E2,PGE2)含量與老年膝骨關(guān)節(jié)炎(knee osteoarthritis,KOA)預(yù)后的關(guān)系。方法:選擇110例老年KOA患者和60例單純半月板損傷患者作為研究對(duì)象。入院后測(cè)定其膝關(guān)節(jié)滑液IL-1β、IL-17、PGE2含量。依據(jù)治療6個(gè)月后的Lysholm膝關(guān)節(jié)評(píng)分評(píng)價(jià)KOA患者的預(yù)后,Lysholm評(píng)分≥70分為預(yù)后良好、Lysholm評(píng)分<70分為預(yù)后不良。比較老年KOA患者與單純半月板損傷患者,以及老年KOA患者中預(yù)后良好者與預(yù)后不良者的膝關(guān)節(jié)滑液IL-1β、IL-17、PGE2含量。以老年KOA患者膝關(guān)節(jié)滑液IL-1β、IL-17、PGE2含量為自變量,以患者是否發(fā)生預(yù)后不良為因變量進(jìn)行Logistic回歸分析。采用受試者操作特征(receiver operating characteristic,ROC)曲線分析評(píng)價(jià)采用膝關(guān)節(jié)滑液IL-1β、IL-17、PGE2含量預(yù)測(cè)老年KOA預(yù)后的靈敏度、特異度、準(zhǔn)確度,并測(cè)定曲線下面積(area under curve,AUC)。結(jié)果:老年KOA患者的膝關(guān)節(jié)滑液IL-1β、IL-17、PGE2含量均高于單純半月板損傷者[(79.13±13.17)pg·mL-1,(24.89±4.15)pg·mL-1,t=34.018,P=0.000;(30.31±5.07)pg·mL-1,(11.05±1.85)pg·mL-1,t=30.906,P=0.000;(325.41±54.29)pg·mL-1,(207.96±34.71)pg·mL-1,t=15.785,P=0.000]。老年KOA患者中預(yù)后良好者的膝關(guān)節(jié)滑液IL-1β、IL-17、PGE2含量均低于預(yù)后不良者[(69.71±8.71)pg·mL-1,(86.32±10.79)pg·mL-1,t=8.183,P=0.000;(23.01±3.84)pg·mL-1,(39.63±6.61)pg·mL-1,t=16.195,P=0.000;(235.37±25.69)pg·mL-1,(366.31±38.73)pg·mL-1,t=20.282,P=0.000]。Logistic回歸分析結(jié)果顯示,膝關(guān)節(jié)滑液IL-1β、IL-17、PGE2含量均為老年KOA預(yù)后不良的危險(xiǎn)因素[OR=3.117,95%CI(1.545,4.690); OR=4.899,95%CI(1.749,8.049); OR=5.376,95%CI(1.845,8.908)]。ROC分析結(jié)果顯示,采用膝關(guān)節(jié)滑液IL-1β、IL-17、PGE2含量預(yù)測(cè)老年KOA預(yù)后的靈敏度分別為89.29%、82.14%、78.57%,特異度分別為85.37%、82.93%、76.83%,準(zhǔn)確度分別為87.27%、85.45%、81.82%,AUC分別為0.815、0.801、0.780。結(jié)論:膝關(guān)節(jié)滑液IL-1β、IL-17、PGE2含量均為老年KOA預(yù)后不良的危險(xiǎn)因素,也可作為預(yù)測(cè)老年KOA預(yù)后的指標(biāo)。
Abstract:
Objective:To explore the relationship between the prognosis of knee osteoarthritis(KOA)and the contents of interleukin(IL)-1β,IL-17 and prostaglandin E2(PGE2)in knee synovial fluid in the aged.Methods:One hundred and ten aged patients with KOA and 60 patients with simple meniscus injury were selected out as the subjects,and the contents of IL-1β,IL-17 and PGE2 in their knee synovial fluid were measured after hospital admission.The prognosis of KOA was evaluated according to the Lysholm knee scores measured after 6-month treatment.The Lysholm score of≥70 points was classified as favorable prognosis,while the Lysholm score of<70 points as unfavorable prognosis.The contents of IL-1β,IL-17 and PGE2 in knee synovial fluid were compared between aged patients with KOA and patients with simple meniscus injury as well as between aged KOA patients with favorable prognosis and aged KOA patients with unfavorable prognosis.The Logistic regression analysis was conducted by taking the contents of IL-1β,IL-17 and PGE2 in knee synovial fluid as independent variable and whether unfavourable prognosis was occurred as dependent variable respectively.The prognoses of aged KOA patients were predicted using the contents of IL-1β,IL-17 and PGE2 in knee synovial fluid and the sensitivity,specificity and accuracy of prediction were analyzed and evaluated by using receiver operating characteristic(ROC)curve,and the area under curve(AUC)was measured.Results:The contents of IL-1β,IL-17 and PGE2 in knee synovial fluid were higher in aged patients with KOA compared to patients with simple meniscus injury(79.13±13.17 vs 24.89±4.15 pg/mL,t=34.018,P=0.000; 30.31±5.07 vs 11.05±1.85 pg/mL,t=30.906,P=0.000; 325.41±54.29 vs 207.96±34.71 pg/mL,t=15.785,P=0.000),whereas they were lower in aged KOA patients with favorable prognosis compared to patients with unfavorable prognosis(69.71±8.71 vs 86.32±10.79 pg/mL,t=8.183,P=0.000; 23.01±3.84 vs 39.63±6.61 pg/mL,t=16.195,P=0.000; 235.37±25.69 vs 366.31±38.73 pg/mL,t=20.282,P=0.000).The results of logistic regression analysis revealed that the contents of IL-1β,IL-17 and PGE2 in knee synovial fluid were the risk factors for unfavorable prognosis of KOA in aged patients(OR=3.117,95%CI(1.545,4.690); OR=4.899,95%CI(1.749,8.049); OR=5.376,95%CI(1.845,8.908)).The results of ROC analysis showed that the sensitivities of prediction of prognosis in aged KOA patients using the contents of IL-1β,IL-17 and PGE2 in knee synovial fluid were 89.29%,82.14% and 78.57%; the specificities were 85.37%,82.93% and 76.83%; the accuracies were 87.27%,85.45% and 81.82% respectively; and their AUC were 0.815,0.801 and 0.780 respectively.Conclusion:The contents of IL-1β,IL-17 and PGE2 in knee synovial fluid are the risk factors for unfavorable prognosis of KOA in aged patients,and they can also be used as the indexes for predicting prognosis of KOA in aged patients.

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備注/Memo

備注/Memo:
基金項(xiàng)目:河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃項(xiàng)目(2018020579)
更新日期/Last Update: 1900-01-01