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[1]張遼,鄧穎萍,金甬,等.基于數(shù)據(jù)挖掘法的葉海教授治療膝骨關(guān)節(jié)炎用藥規(guī)律研究[J].中醫(yī)正骨,2020,32(02):36-41.
　ZHANG Liao,DENG Yingping,JIN Yong,et al.A study of medication rule of Professor YE Hai in treatment of knee osteoarthritis based on data mining approach[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2020,32(02):36-41.
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基于數(shù)據(jù)挖掘法的葉海教授治療膝骨關(guān)節(jié)炎用藥規(guī)律研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第32卷
期數(shù):
2020年02期
頁碼:
36-41
欄目:
調(diào)查研究
出版日期:
2020-02-20

文章信息/Info

Title:
A study of medication rule of Professor YE Hai in treatment of knee osteoarthritis based on data mining approach
作者:
張遼; 鄧穎萍; 金甬; 許旻鳴
(寧波市中醫(yī)院,浙江 寧波 315010)
Author(s):
ZHANG Liao; DENG Yingping; JIN Yong; XU Minming
Ningbo Hospital of Traditional Chinese Medicine,Ningbo 315010,Zhejiang,China
關(guān)鍵詞:
數(shù)據(jù)挖掘;  骨關(guān)節(jié)炎; 膝;  名醫(yī)經(jīng)驗(yàn);  方劑分析; 計(jì)算機(jī)輔助
Keywords:
data mining;  osteoarthritis; knee;  famous doctor's experience;  formula anal; comput assist
摘要:
目的:分析葉海教授治療膝骨關(guān)節(jié)炎(knee osteoarthritis,KOA)的用藥規(guī)律。方法:收集2017年9月至2019年5月,葉海教授為首次到寧波市中醫(yī)院門診就診的211例KOA患者開具的211首中藥處方。所有患者后期均獲得定期復(fù)診,且療效肯定。將中藥處方信息錄入中國(guó)中醫(yī)科學(xué)院中藥研究所研制的中醫(yī)傳承輔助系統(tǒng)(V2.5),由2人負(fù)責(zé)數(shù)據(jù)審核,確保數(shù)據(jù)準(zhǔn)確。使用軟件進(jìn)行頻次統(tǒng)計(jì)分析,并基于關(guān)聯(lián)規(guī)則和熵聚類進(jìn)行組方規(guī)律分析,最終預(yù)測(cè)新的處方。結(jié)果:葉海教授開具的211首治療KOA的處方中,使用頻次居前6位的中藥分別為防風(fēng)(205次)、炒谷芽(205次)、延胡索(202次)、茯苓(200次)、制川烏(167次)、桑寄生(167次),使用頻次居前3位的藥物組合為防風(fēng)-炒谷芽(200次)、延胡索-防風(fēng)(197次)、延胡索-炒谷芽(197次)。挖掘出22個(gè)核心藥物組合,分別為仙茅-姜半夏-懷牛膝、雞內(nèi)金-荊芥-炒白術(shù)、雞內(nèi)金-炒白芍-炒白術(shù)、芡實(shí)-炒白芍-肉蓯蓉、芡實(shí)-炒白芍-炒白術(shù)、黃芩-蟬蛻-黨參、龍骨-浮小麥-牡蠣、桑寄生-蒼術(shù)-重樓、甘草-桂枝-酸棗仁、荊芥-姜半夏-細(xì)辛、酸棗仁-首烏藤-鉤藤、太子參-黨參-巴戟天、炒白芍-肉蓯蓉-薏苡仁、炒白芍-肉蓯蓉-火麻仁、懷牛膝-薏苡仁-通草、柴胡-熟地黃-陳皮、黃芩-甘草-桂枝、燈心草-甘草-酸棗仁-首烏藤、黃芩-甘草-桂枝-黨參、黃芩-桂枝-太子參-黨參、荊芥-柴胡-細(xì)辛-熟地黃、荊芥-細(xì)辛-熟地黃-炒白術(shù)。預(yù)測(cè)出6個(gè)新處方,處方1藥物組成包括仙茅、姜半夏、懷牛膝、薏苡仁、通草,處方2藥物組成包括雞內(nèi)金、荊芥、炒白術(shù)、炒白芍,處方3藥物組成包括芡實(shí)、炒白芍、肉蓯蓉、炒白術(shù),處方4藥物組成包括甘草、桂枝、酸棗仁、黃芩,處方5藥物組成包括黃芩、甘草、桂枝、黨參、太子參,處方6藥物組成包括荊芥、柴胡、細(xì)辛、熟地黃、炒白術(shù)。結(jié)論:葉海教授治療KOA用藥注重個(gè)體化差異和顧護(hù)中焦,常以健脾益腎、益氣養(yǎng)血、祛風(fēng)散寒、行氣化濕、疏肝和胃、豁痰化瘀立法。
Abstract:
Objective:To analyze the medication rule of Professor YE Hai in treatment of knee osteoarthritis(KOA).Methods:Two hundred and eleven traditional Chinese medicine(TCM)prescriptions issued by Professor YE Hai for 211 outpatients with KOA who were firstly treated in Ningbo Hospital of Traditional Chinese Medicine from September 2017 to May 2019 were collected.All patients were regularly followed up in the later period,and the positive curative effects were found.The information of TCM prescriptions were input into traditional Chinese medicine inheritance support system(TCMISS)(V2.5)developed by Institute of Chinese Materia Medica of China Academy of Chinese Medical Sciences,and the data was reviewed by 2 person for ensuring their accuracy.Frequency analysis was performed by using software and the prescription rules were analyzed based on association rules and entropy clustering for predicting new prescriptions.Results:In 211 TCM prescriptions issued by Professor YE Hai for KOA,the top 6 Chinese drugs with high occurrence frequency included saposhnikovia divaricata(205 times),parched fructus setariae germinatus(205 times),rhizoma corydalis(202 times),poria cocos(200 times),radix aconiti preparata(167 times),Chinese taxillus herb(167 times); and the top 3 drug combinations with high occurrence frequency included saposhnikovia divaricata-parched fructus setariae germinatus(200 times),rhizoma corydalis-saposhnikovia divaricata(197 times)and rhizoma corydalis-parched fructus setariae germinatus(197 times).Twenty-two core TCM combinations were found out,including curculigo orchioides-ginger processed pinellia-achyranthes bidentata,endothelium corneum gigeriae galli-schizonepeta tenuifolia-parched atractylodes macrocephala,endothelium corneum gigeriae galli-parched radix paeoniae alba-parched atractylodes macrocephala,euryale ferox-parched radix paeoniae alba-cistanche deserticola,euryale ferox-parched radix paeoniae alba-parched atractylodes macrocephala,scutellaria baicalensis-periostracum cicadae-codonopsis pilosula,os draconis-fructus tritici levis-concha ostreae,taxillus chinensis-atractylodes chinensis-paris polyphylla,glycyrrhiza uralensis-ramulus cinnamomi-semen ziziphi spinosae,schizonepeta tenuifolia-ginger processed pinellia-asarum heterotropoides,semen ziziphi spinosae-caulis polygoni multiflori-ramulus uncariae cum uncis,pseudostellaria heterophylla-codonopsis pilosula-morinda officinalis,parched radix paeoniae alba-cistanche deserticola-semen coicis,parched radix paeoniae alba-cistanche deserticola-fructus cannabis,achyranthes bidentata-semen coicis-medulla tetrapanacis,bupleurum chinense-radix rehmanniae praeparata-pericarpium citrus reticulata,scutellaria baicalensis-glycyrrhiza uralensis-ramulus cinnamomi,juncus effusus-glycyrrhiza uralensis-semen ziziphi spinosae-caulis polygoni multiflori,scutellaria baicalensis-glycyrrhiza uralensis-ramulus cinnamomi-codonopsis pilosula,scutellaria baicalensis-ramulus cinnamomi-pseudostellaria heterophylla-codonopsis pilosula,schizonepeta tenuifolia-bupleurum chinense-asarum heterotropoides-radix rehmanniae praeparata and schizonepeta tenuifolia-asarum heterotropoides-radix rehmanniae praeparata-parched atractylodes macrocephala.Six new predicted TCM prescriptions were obtained,and the drug combinations of the prescriptions were(1)curculigo orchioides,ginger processed pinellia,achyranthes bidentata,semen coicis and medulla tetrapanacis,(2)endothelium corneum gigeriae galli,schizonepeta tenuifolia,parched atractylodes macrocephala and parched radix paeoniae alba,(3)euryale ferox,parched radix paeoniae alba,cistanche deserticola and parched atractylodes macrocephala,(4)glycyrrhiza uralensis,ramulus cinnamomi,semen ziziphi spinosae and scutellaria baicalensis,(5)scutellaria baicalensis,glycyrrhiza uralensis,ramulus cinnamomi,codonopsis pilosula and pseudostellaria heterophylla,(6)schizonepeta tenuifolia,bupleurum chinense,asarum heterotropoides,radix rehmanniae praeparata and parched atractylodes macrocephala respectively.Conclusion:Professor YE Hai attaches importance to individual differences and middle-jiao protection and he often takes the medication rule as the policy in treatment of KOA,including invigorating spleen and replenishing kidney,reinforcing qi and nourishing blood,expelling wind and dispersing cold,activating qi-flowing and dissipating dampness,soothing liver and harmonizing stomach and resolving stasis and eliminating phlegm.

參考文獻(xiàn)/References:

[1] 方亮,董睿,金紅婷,等.富血小板血漿關(guān)節(jié)腔注射聯(lián)合補(bǔ)腎活血方口服治療膝骨關(guān)節(jié)炎肝腎虧虛證的臨床研究[J].中醫(yī)正骨,2018,30(11):1-5.
[2] WALLACE I J,WORTHINGTON S,FELSON DT,et al.Knee osteoarthritis has doubled in prevalence since the mid-20th century[J].Proc Natl Acad Sci U S A,2017,114(35):9332-9336.
[3] 吳權(quán),李啟運(yùn),王素英,等.活血、溫經(jīng)、補(bǔ)益肝腎類中藥對(duì)膝骨關(guān)節(jié)炎兔關(guān)節(jié)軟骨形態(tài)的影響[J].中醫(yī)正骨,2014,26(6):15-18.
[4] 柯高峰,盧建華,吳權(quán).活血、溫經(jīng)及補(bǔ)肝腎藥物對(duì)兔膝骨關(guān)節(jié)炎滑膜NO及TL-6濃度的影響[J].中國(guó)中醫(yī)骨傷科雜志,2013,21(11):11-13.
[5] 何海軍,王榮田,陳志偉,等.膝骨關(guān)節(jié)炎“從筋論治”的臨床研究[J].北京中醫(yī)藥,2016,35(5):451-455.
[6] 高歡歡,薛志鵬,李泰賢, 等.治療膝骨關(guān)節(jié)炎的中成藥的組方規(guī)律分析[J].中國(guó)藥房,2019,30(15):2096-2100.
[7] 張遼,韓晶晶,鄧穎萍,等.葉海教授基于“經(jīng)緯辨證”理論治療膝骨關(guān)節(jié)炎的臨證經(jīng)驗(yàn)[J].中國(guó)中醫(yī)骨傷科雜志,2019,27(4):69-70.
[8] 葉海,韓晶晶,許旻鳴.簡(jiǎn)析傷科“經(jīng)緯辨證”基本理論[J].中醫(yī)學(xué)報(bào),2018,33(9):1675-1678.
[9] 韓晶晶.葉海“經(jīng)緯辨證”法簡(jiǎn)介[J].浙江中醫(yī)雜志,2018,53(5):322.
[10] 張遼,金甬,王煥明,等.“經(jīng)緯辨證”理論指導(dǎo)下針刀配合手法及蚌式開合功能鍛煉治療髕股關(guān)節(jié)外側(cè)高壓綜合征的臨床研究[J].中醫(yī)正骨,2018,30(4):23-27.
[11] 鄭筱萸.中藥新藥臨床研究指導(dǎo)原則[M].北京:中國(guó)醫(yī)藥科技出版社,2002:349-353.
[12] 中國(guó)中醫(yī)藥研究促進(jìn)會(huì)骨科專業(yè)委員會(huì),中國(guó)中西醫(yī)結(jié)合學(xué)會(huì)骨傷科專業(yè)委員會(huì)關(guān)節(jié)工作委員會(huì).膝骨關(guān)節(jié)炎中醫(yī)診療專家共識(shí)(2015年版)[J].中醫(yī)正骨,2015,27(7):4-5.
[13] 季青青,張國(guó)梁,劉雨香,等.數(shù)據(jù)挖掘技術(shù)在名老中醫(yī)學(xué)術(shù)經(jīng)驗(yàn)研究的應(yīng)用[J].中醫(yī)藥臨床雜志,2018,30(4):587-590.
[14] 唐仕歡,申丹,盧朋,等.中醫(yī)傳承輔助平臺(tái)應(yīng)用評(píng)述[J].中華中醫(yī)藥雜志,2015,30(2):329-331.
[15] 吳嘉瑞,唐仕歡,郭位先,等.基于數(shù)據(jù)挖掘的名老中醫(yī)經(jīng)驗(yàn)傳承研究述評(píng)[J].中國(guó)中藥雜志,2014,39(4):614-617.
[16] 萬全慶,金甬.活血搜風(fēng)治療頸椎間盤突出癥[J].中國(guó)鄉(xiāng)村醫(yī)生,1999(9):40.
[17] 金甬,萬全慶.膝關(guān)節(jié)退行性骨關(guān)節(jié)病的治療[J].中國(guó)骨傷,1998,11(5):36-37.
[18] 韓晶晶.葉海治療傷科痰瘀證經(jīng)驗(yàn)淺析[J].浙江中醫(yī)雜志,2019,54(5):372-373.

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[2]應(yīng)俊,張?jiān)?羅程,等.核轉(zhuǎn)錄因子-κB在骨關(guān)節(jié)炎炎癥反應(yīng)中的作用[J].中醫(yī)正骨,2015,27(07):40.
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[6]魏瑄,宋樹春,王金良.術(shù)前精確測(cè)量和評(píng)估在全髖關(guān)節(jié)置換治療 成人發(fā)育性髖關(guān)節(jié)發(fā)育不良繼發(fā)骨關(guān)節(jié)炎中的價(jià)值[J].中醫(yī)正骨,2015,27(01):30.
[7]李顯,顧敏琪.蜂毒與蜂針療法的作用機(jī)制及其在類風(fēng)濕關(guān)節(jié)炎 和骨關(guān)節(jié)炎治療中的應(yīng)用[J].中醫(yī)正骨,2016,28(02):69.
[8]劉飛,劉剛,郭浩山,等.化瘀滲濕湯對(duì)全膝關(guān)節(jié)置換術(shù)后血漿D-二聚體 和纖維蛋白原含量的影響[J].中醫(yī)正骨,2016,28(03):30.
　LIU Fei,LIU Gang,GUO Haoshan,et al.Effect of Huayu Shenshi Tang(化瘀滲濕湯)on plasma contents of D-dimer and fibrinogen after total knee arthroplasty[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(02):30.
[9]趙明明,蔡一強(qiáng),丁永利,等.無柄人工全髖關(guān)節(jié)置換術(shù)治療髖關(guān)節(jié)疾患的臨床研究[J].中醫(yī)正骨,2016,28(04):37.
[10]徐方琪,孫奇,朱星瑜,等.不同生理磁共振成像技術(shù)在早期膝骨關(guān)節(jié)炎診斷中的應(yīng)用進(jìn)展[J].中醫(yī)正骨,2016,28(04):64.

備注/Memo

備注/Memo:
(收稿日期:2019-08-29 本文編輯:李曉樂)基金項(xiàng)目:國(guó)家中醫(yī)藥管理局全國(guó)名老中醫(yī)藥專家傳承工作室建設(shè)項(xiàng)目(國(guó)中醫(yī)藥人教發(fā)[2016]42號(hào)); 浙江省中醫(yī)藥科技計(jì)劃項(xiàng)目(2018ZB119); 浙江省“十三五”中醫(yī)重點(diǎn)專科建設(shè)項(xiàng)目(浙衛(wèi)辦中醫(yī)[2019]1號(hào)) 通訊作者:張遼 E-mail:[email protected]
更新日期/Last Update: 2020-02-15