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[1]曹嘉,周琦,錢齊榮.針灸聯(lián)合玻璃酸鈉關(guān)節(jié)腔注射與單純玻璃酸鈉關(guān)節(jié)腔注射治療膝骨關(guān)節(jié)炎的臨床療效系統(tǒng)評價[J].中醫(yī)正骨,2019,31(03):33-37.
　CAO Jia,ZHOU Qi,QIAN Qirong.Clinical curative effect of combination therapy of acupuncture and intra-articular injection of sodium hyaluronate versus monotherapy of intra-articular injection of sodium hyaluronate for treatment of knee osteoarthritis:a systematic review[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(03):33-37.
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針灸聯(lián)合玻璃酸鈉關(guān)節(jié)腔注射與單純玻璃酸鈉關(guān)節(jié)腔注射治療 膝骨關(guān)節(jié)炎的臨床療效系統(tǒng)評價()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期數(shù):
2019年03期
頁碼:
33-37
欄目:
文獻研究
出版日期:
2019-03-20

文章信息/Info

Title:
Clinical curative effect of combination therapy of acupuncture and intra-articular injection of sodium hyaluronate versus monotherapy of intra-articular injection of sodium hyaluronate for treatment of knee osteoarthritis:a systematic review
作者:
曹嘉; 周琦; 錢齊榮
(上海長征醫(yī)院,上海 200003)
Author(s):
CAO Jia; ZHOU Qi; QIAN Qirong
Shanghai Changzheng Hospital, Shanghai 200003,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝;  針刺療法;  注射; 關(guān)節(jié)內(nèi);  透明質(zhì)酸;  Meta分析
Keywords:
osteoarthritis; knee;  acupuncture therapy;  injections; intra-articular;  hyaluronic acid;  meta-analysis
摘要:
目的:系統(tǒng)評價針灸聯(lián)合玻璃酸鈉關(guān)節(jié)腔注射與單純玻璃酸鈉關(guān)節(jié)腔注射治療膝骨關(guān)節(jié)炎的臨床療效。方法:通過計算機檢索中國知網(wǎng)、萬方醫(yī)學(xué)網(wǎng)、重慶維普、美國醫(yī)學(xué)文摘和Cochrane臨床對照試驗中心注冊庫(2018年第1期)等數(shù)據(jù)庫從建庫至2018年3月15日,關(guān)于針灸聯(lián)合玻璃酸鈉關(guān)節(jié)腔注射與單純玻璃酸鈉關(guān)節(jié)腔注射治療膝骨關(guān)節(jié)炎臨床療效比較的文獻,進行Meta分析。結(jié)果:初檢共檢出相關(guān)文獻231篇,依據(jù)文獻納入和排除標準篩選后,最終納入9篇文獻進行分析,均為中文文獻。納入的9篇文獻均為單中心隨機對照臨床試驗; 8篇文獻描述了隨機分組方法,1篇文獻僅描述隨機分組,未提及隨機分組方法; 1篇文獻描述了在分組時采用了單盲的方法,均未提及患者盲法; 9篇文獻均未提及結(jié)果評估者盲法; 9篇文獻均有明確的診斷標準及療效評價標準。9篇文獻均計算了兩種療法的近期臨床治療有效率,并進行了比較,各項研究間異質(zhì)性較小(I2=0%),采用固定效應(yīng)模型分析,針灸聯(lián)合玻璃酸鈉關(guān)節(jié)腔注射治療膝骨關(guān)節(jié)炎近期臨床治療有效率高于單純玻璃酸鈉關(guān)節(jié)腔注射[RR=1.16,95%CI(1.10,1.22)]。9篇文獻的發(fā)表偏倚較小。結(jié)論:針灸聯(lián)合玻璃酸鈉關(guān)節(jié)腔注射治療膝骨關(guān)節(jié)炎的近期臨床療效優(yōu)于單純玻璃酸鈉關(guān)節(jié)腔注射。
Abstract:
Objective:To systematically review the clinical curative effect of combination therapy of acupuncture and intra-articular injection of sodium hyaluronate versus monotherapy of intra-articular injection of sodium hyaluronate for treatment of knee osteoarthritis(KOA).Methods:All the articles about clinical curative effects of combination therapy of acupuncture and intra-articular injection of sodium hyaluronate versus monotherapy of intra-articular injection of sodium hyaluronate for treatment of KOA included from database establishing to March 15,2018 were retrieved from China national knowledge internet,WanFang Data,VIP Database,Medline and Cochrane Central Register of Controlled Trials(2018,No.1)through computer,and a Meta-analysis was conducted.Results:Two hundred and thirty-one articles were searched out in the initial stage.After screening according to inclusion and exclusion criteria,9 Chinese single-center randomized controlled trial(RCT)articles were included in the final analysis,including 8 articles in which randomization method was described and 1 article in which only randomization was described and the method of randomization was not mentioned.Meanwhile,the single blind method used for grouping was described in 1 article while the blind method used for patients and outcome assessors was not mentioned in all of the 9 articles.Clear diagnostic criteria and curative effect evaluation criteria were described and the short-term clinical effective rate was evaluated and compared between the two therapies in all of the 9 articles.The minor heterogeneity was found between the studies(I2=0%),and a Meta-analysis was conducted by using fixed effect model.The result of Meta-analysis demonstrated that the short-term clinical curative effective rate of combination therapy of acupuncture and intra-articular injection of sodium hyaluronate was higher than that of monotherapy of intra-articular injection of sodium hyaluronate in treatment of KOA(RR=1.16,95%CI(1.10,1.22)),and the publication bias of the 9 articles was not obvious.Conclusion:Combination therapy of acupuncture and intra-articular injection of sodium hyaluronate surpasses monotherapy of intra-articular injection of sodium hyaluronate in short-term clinical curative effect in treatment of KOA.

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備注/Memo

備注/Memo:
基金項目:上海申康醫(yī)院發(fā)展中心臨床科技創(chuàng)新項目(SHDC12015320) 通訊作者:錢齊榮 E-mail:[email protected](收稿日期:2018-12-03 本文編輯:楊雅)
更新日期/Last Update: 2019-03-30