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[1]熊巍,吳忌,喻衫.祛風寒濕洗劑薰洗治療膝骨關節(jié)炎風寒濕痹證[J].中醫(yī)正骨,2019,31(02):74-76.
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祛風寒濕洗劑薰洗治療膝骨關節(jié)炎風寒濕痹證()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期數(shù):
2019年02期
頁碼:
74-76
欄目:
臨床報道
出版日期:
2019-02-20

文章信息/Info

作者:
熊巍; 吳忌; 喻衫
(四川省骨科醫(yī)院,四川 成都 610041)
關鍵詞:
骨關節(jié)炎; 膝;  痹證;  薰洗;  白細胞介素17
摘要:
目的:觀察祛風寒濕洗劑薰洗治療膝骨關節(jié)炎(knee osteoarthritis,KOA)風寒濕痹證的臨床療效和安全性,并探討其可能的作用機制。方法:2016年1—12月收治40例KOA風寒濕痹證患者,均采用祛風寒濕洗劑薰洗治療,每日2次,連續(xù)治療4周。分別于治療前、治療開始后1、3、6、12個月評定患者的膝關節(jié)疼痛視覺模擬量表(visual analogue scale,VAS)評分、美國膝關節(jié)學會評分(the Knee Society Score,KSS),測定血漿及關節(jié)液中白細胞介素(interleukin-17,IL-17)含量,觀察治療期間并發(fā)癥的發(fā)生情況。結果:治療過程中,患者均未出現(xiàn)皮膚過敏、燙傷等并發(fā)癥。患者治療前后不同時點的膝關節(jié)疼痛VAS評分、KSS、血漿及關節(jié)液 IL-17含量比較,差異均有統(tǒng)計學意義[VAS評分:(6.64±1.65)分,(3.26±1.43)分,(3.58±1.72)分,(3.74±1.54)分,(3.95±1.73)分,F=28.609,P=0.000; KSS:(56.41±8.75)分,(89.23±8.58)分,(87.69±8.65)分,(84.57±8.39)分,(80.53±9.72)分,F=95.529,P=0.000; 血漿IL-17含量:(6.61±1.78)pg·mL-1,(4.17±1.52)pg·mL-1,(4.57±1.65)pg·mL-1,(4.86±1.59)pg·mL-1,(5.15±1.76)pg·mL-1,F=12.592,P=0.000; 關節(jié)液 IL-17含量:(7.44±1.57)pg·mL-1,(5.23±1.86)pg·mL-1,(5.58±1.62)pg·mL-1,(5.77±1.81)pg·mL-1,(5.95±1.64)pg·mL-1,F=9.983,P=0.000]。治療開始后1、3、6、12個月時患者的膝關節(jié)疼痛VAS評分均低于治療前(P=0.000,P=0.000,P=0.000,P=0.000),KSS均高于治療前(P=0.000,P=0.000,P=0.000,P=0.000),血漿及關節(jié)液 IL-17含量均低于治療前(血漿IL-17含量:P=0.000,P=0.000,P=0.000,P=0.000; 關節(jié)液IL-17含量:P=0.000,P=0.000,P=0.000,P=0.000); 隨著時間延長,治療開始后各時點的VAS評分逐漸增高(P=0.000,P=0.000,P=0.000),KSS逐漸降低(P=0.000,P=0.000,P=0.000),血漿及關節(jié)液 IL-17含量均逐漸增高(血漿IL-17含量:P=0.000,P=0.000,P=0.000; 關節(jié)液IL-17含量:P=0.000,P=0.000,P=0.000)。結論:祛風寒濕洗劑薰洗治療KOA風寒濕痹證,可有效減輕患者的膝關節(jié)疼痛癥狀,改善膝關節(jié)功能,安全性較高,但隨著時間延長,療效逐漸減弱; 其作用機制可能與降低血漿及關節(jié)液中的IL-17含量有關。

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備注/Memo

備注/Memo:
通訊作者:熊巍 E-mail:[email protected](收稿日期:2018-10-10 本文編輯:李曉樂)
更新日期/Last Update: 2019-02-20