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[1]陳群群,崔俊英,霍少川,等.3種中醫(yī)證型股骨頭壞死患者的脂代謝特征對比研究[J].中醫(yī)正骨,2019,31(01):1-4.
　CHEN Qunqun,CUI Junying,HUO Shaochuan,et al.Lipid metabolism characteristics of patients with three types of TCM syndrome of femur head necrosis:a comparative study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(01):1-4.
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3種中醫(yī)證型股骨頭壞死患者的脂代謝特征對比研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期數(shù):
2019年01期
頁碼:
1-4
欄目:
臨床研究
出版日期:
2019-01-20

文章信息/Info

Title:
Lipid metabolism characteristics of patients with three types of TCM syndrome of femur head necrosis:a comparative study
作者:
陳群群1; 崔俊英2; 霍少川3; 何敏聰3
(1.廣州中醫(yī)藥大學(xué)第三附屬醫(yī)院,廣東 廣州 510378; 2.廣州市越秀區(qū)婦幼保健院,廣東 廣州 510030; 3.廣州中醫(yī)藥大學(xué),廣東 廣州 510405)
Author(s):
CHEN Qunqun1; CUI Junying2; HUO Shaochuan3; HE Mincong3
1.The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510378,Guangdong,China 2.Maternal and Child Health Hospital of Yuexiu District,Guangzhou 510030,Guangdong,China 3.Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong,China
關(guān)鍵詞:
股骨頭壞死;  證候;  血脂異常;  臨床試驗(yàn)
Keywords:
femur head necrosis;  symptom complex;  dyslipidemias;  clinical trial
摘要:
目的:比較3種中醫(yī)證型股骨頭壞死患者的脂代謝特征。方法:對符合要求的97例股骨頭壞死患者進(jìn)行中醫(yī)辨證分型,抽取外周靜脈血,測定并對比不同中醫(yī)證型股骨頭壞死患者的血清總膽固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白膽固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白膽固醇(low density lipoprotein cholesterol,LDL-C)、載脂蛋白(apolipoprotein,Apo)-A1、Apo -B含量。結(jié)果:納入研究的97例患者中,痰瘀蘊(yùn)結(jié)證32例、腎虛血瘀證45例、氣滯血瘀證20例。3種證候類型患者的血清HDL-C、Apo-A1、Apo-B含量比較,差異均無統(tǒng)計(jì)學(xué)意義[HDL-C:(0.99±0.42)mmol·L-1,(1.14±0.34)mmol·L-1,(0.88±0.41)mmol·L-1,F=0.182,P=0.834; Apo-A1:(1.18±0.27)g·L-1,(1.15±0.22)g·L-1,(1.08±0.23)g·L-1,F=0.919,P=0.402; Apo-B:(0.84±0.22)g·L-1,(0.82±0.21)g·L-1,(0.72±0.20)g·L-1,F=0.167,P=0.846]。3種證候類型患者的血清TC、TG、LDL-C含量比較,差異均有統(tǒng)計(jì)學(xué)意義[TC:(4.77±0.97)mmol·L-1,(4.34±0.81)mmol·L-1,(4.00±1.25)mmol·L-1,F=6.211,P=0.003; TG:(2.13±1.49)mmol·L-1,(1.54±0.98)mmol·L-1,(1.83±1.27)mmol·L-1,F=3.107,P=0.049; LDL-C:(2.95±1.01)mmol·L-1,(2.86±0.77)mmol·L-1,(2.39±1.14)mmol·L-1,F=3.589,P=0.031]; 痰瘀蘊(yùn)結(jié)證患者的血清TC、LDL-C含量均高于氣滯血瘀證患者(P=0.007; P=0.039),痰瘀蘊(yùn)結(jié)證患者和氣滯血瘀證患者的血清TC、LDL-C含量與腎虛血瘀證患者比較,組間差異均無統(tǒng)計(jì)學(xué)意義(TC:P=0.061,P=0.192; LDL-C:P=0.662,P=0.068); 痰瘀蘊(yùn)結(jié)證患者的血清TG含量高于腎虛血瘀證患者(P=0.040),痰瘀蘊(yùn)結(jié)證患者和腎虛血瘀證患者的血清TG含量與氣滯血瘀證患者比較,組間差異均無統(tǒng)計(jì)學(xué)意義(P=0.407,P=0.367)。結(jié)論:股骨頭壞死3種中醫(yī)證型中,痰瘀蘊(yùn)結(jié)證患者的脂代謝與其他2種證候類型患者的脂代謝存在較大差異。
Abstract:
Objective:To compare the lipid metabolism characteristics of patients with three types of TCM syndrome of femur head necrosis(FHN).Methods:Ninety-seven patients with FHN enrolled in the study were classified according to TCM syndrome differentiation,and their blood was drawn from peripheral vein.The serum contents of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein(Apo)-A1 and Apo-B were measured and compared between patients with different types of TCM syndrome of FHN.Results:Phlegm-stagnation syndrome(32 cases),kidney-deficiency-blood-stasis syndrome(45 cases)and qi-stagnation-blood-stasis syndrome(20 cases)were found in the 97 patients.There was no statistical difference in the serum contents of HDL-C,Apo-A1 and Apo-B between the patients with three types of TCM syndrome(HDL-C:0.99+/-0.42,1.14+/-0.34,0.88+/-0.41 mmol/L,F=0.182,P=0.834; Apo-A1:1.18+/-0.27,1.15+/-0.22,1.08+/0.23 g/L,F=0.919,P=0.402; Apo-B:0.84+/-0.22,0.82+/-0.21,0.72+/-0.20 g/L,F=0.167,P=0.846).There was statistical difference in the serum contents of TC,TG and LDL-C between the patients with three types of TCM syndrome(TC:4.77+/-0.97,4.34+/-0.81,4.00+/-1.25 mmol/L,F=6.211,P=0.003; TG:2.13+/-1.49,1.54+/-0.98,1.83+/-1.27 mmol/L,F=3.107,P=0.049; LDL-C:2.95+/-1.01,2.86+/-0.77,2.39+/-1.14 mmol/L,F=3.589,P=0.031).The serum contents of TC and LDL-C were higher in patients with phlegm-stagnation syndrome compared to patients with qi-stagnation-blood-stasis syndrome(P=0.007; P=0.039),and there was no statistical difference in the serum contents of TC and LDL-C between patients with phlegm-stagnation syndrome and patients with kidney-deficiency-blood-stasis syndrome and between patients with qi-stagnation-blood-stasis syndrome and patients with kidney-deficiency-blood-stasis syndrome(TC:P=0.061,P=0.192; LDL-C:P=0.662,P=0.068).The serum contents of TG were higher in patients with phlegm-stagnation syndrome compared to patients with kidney-deficiency-blood-stasis syndrome(P=0.040),and there was no statistical difference in the serum contents of TG between patients with phlegm-stagnation syndrome and patients with qi-stagnation-blood-stasis syndrome and between patients with kidney-deficiency-blood-stasis syndrome and patients with qi-stagnation-blood-stasis syndrome(P=0.407,P=0.367).Conclusion:Lipid metabolism of patients with phlegm-stagnation-type FHN is significantly different from that of patients with kidney-deficiency-blood-stasis-type FHN and patients with qi-stagnation-blood-stasis-type FHN.

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備注/Memo:
基金項(xiàng)目:廣東省中醫(yī)藥局科研項(xiàng)目(20161122)
通訊作者:陳群群 E-mail:[email protected]
更新日期/Last Update: 2019-07-11