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[1]殷夢媛,石瑛,陳元川,等.傳統(tǒng)膏藥膜韌膏貼敷治療內(nèi)側(cè)間室膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2018,30(09):22-29.
　YIN Mengyuan,Shi Ying,CHEN Yuanchuan,et al.A clinical study of external application of Moren Gao(膜韌膏)for treatment of medial compartment knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(09):22-29.
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傳統(tǒng)膏藥膜韌膏貼敷治療內(nèi)側(cè)間室膝骨關(guān)節(jié)炎的臨床研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期數(shù):
2018年09期
頁碼:
22-29
欄目:
骨關(guān)節(jié)炎
出版日期:
2018-09-20

文章信息/Info

Title:
A clinical study of external application of Moren Gao(膜韌膏)for treatment of medial compartment knee osteoarthritis
作者:
殷夢媛; 石瑛; 陳元川; 龐堅(jiān); 熊軼喆; 張旻
1.上海中醫(yī)藥大學(xué)附屬曙光醫(yī)院,上海市中醫(yī)藥研究院骨傷科研究所,上海 201203
Author(s):
YIN Mengyuan; Shi Ying; CHEN Yuanchuan; PANG Jian; XIONG Yizhe; ZHANG Min
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,The Institute of Traumatology and Orthopedics Affiliated to Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝;  膏藥療法;  膜韌膏;  復(fù)方紫荊消傷巴布膏
Keywords:
osteoarthritis; knee;  emplastrum therapy;  Moren Gao;  Fufang Zijing Xiaoshang Babugao
摘要:
觀察傳統(tǒng)膏藥膜韌膏貼敷治療內(nèi)側(cè)間室膝骨關(guān)節(jié)炎(knee osteoarthritis,KOA)的臨床療效和安全性。方法:將118例內(nèi)側(cè)間室KOA患者隨機(jī)分為2組,每組59例,分別采用傳統(tǒng)膏藥膜韌膏貼敷和復(fù)方紫荊消傷巴布膏貼敷治療。因步態(tài)檢測設(shè)備測試時(shí)間過長的限制,分別從每組中隨機(jī)抽取14例患者納入三維步態(tài)分析。膜韌膏和復(fù)方紫荊消傷巴布膏均貼敷于膝關(guān)節(jié)內(nèi)側(cè)疼痛處,每天貼1次,每次12 h,連用4周。分別于治療前、治療開始后2周、4周、6周,比較2組患者西安大略和麥克馬斯特大學(xué)(Western Ontario and McMaster universities,WOMAC)骨關(guān)節(jié)炎指數(shù)量表疼痛評(píng)分、僵硬評(píng)分、軀體功能評(píng)分及總評(píng)分; 于治療前及治療開始后2周、4周,采用三維步態(tài)分析比較2組患者膝關(guān)節(jié)屈曲范圍; 于治療開始后4周,比較2組患者的綜合療效,并比較2組患者并發(fā)癥發(fā)生情況。結(jié)果:①WOMAC疼痛評(píng)分:時(shí)間因素和分組因素不存在交互效應(yīng)(F=1.183,P=0.304); 2組患者WOMAC疼痛評(píng)分比較,組間差異無統(tǒng)計(jì)學(xué)意義,即不存在分組效應(yīng)(F=-0.540,P=0.590); 2組患者治療前后不同時(shí)間點(diǎn)WOMAC疼痛評(píng)分的差異有統(tǒng)計(jì)學(xué)意義,即存在時(shí)間效應(yīng)(F=184.478, P=0.000),2組患者WOMAC疼痛評(píng)分隨時(shí)間均呈下降趨勢,且2組的下降趨勢完全一致[(17.49±8.90)分,(11.64±6.01)分,(8.59±3.94)分,(7.80±3.48)分,F=13.460,P=0.000;(16.10±7.85)分,(11.68±5.93)分,(8.41±4.22)分,(7.69±4.10)分,F=23.720,P=0.000]。②WOMAC僵硬評(píng)分。時(shí)間因素和分組因素不存在交互效應(yīng)(F=0.163,P=0.875); 2組患者WOMAC僵硬評(píng)分比較,組間差異無統(tǒng)計(jì)學(xué)意義,即不存在分組效應(yīng)(F=0.480,P=0.663); 2組患者治療前后不同時(shí)間點(diǎn)WOMAC僵硬評(píng)分的差異有統(tǒng)計(jì)學(xué)意義,即存在時(shí)間效應(yīng)(F=36.914,P=0.000),2組患者WOMAC僵硬評(píng)分隨時(shí)間均呈下降趨勢,且2組的下降趨勢完全一致[(5.95±2.24)分,(4.98±2.47)分,(4.08±3.83)分,(3.66±1.74)分,F=3.710,P=0.012;(6.27±4.41)分,(5.31±2.06)分,(4.14±2.83)分,(3.76±1.69)分,F=3.200,P=0.024]。③WOMAC軀體功能評(píng)分。時(shí)間因素和分組因素不存在交互效應(yīng)(F=0.413,P=0.617); 2組患者WOMAC軀體功能評(píng)分比較,組間差異無統(tǒng)計(jì)學(xué)意義,即不存在分組效應(yīng)(F=1.510,P=0.132); 2組患者治療前后不同時(shí)間點(diǎn)WOMAC軀體功能評(píng)分的差異有統(tǒng)計(jì)學(xué)意義,即存在時(shí)間效應(yīng)(F=137.806,P=0.000),2組患者WOMAC軀體功能評(píng)分隨時(shí)間均呈下降趨勢,且2組的下降趨勢完全一致[(54.07±20.54)分,(45.41±27.21)分,(33.27±18.29)分,(30.34±18.72)分,F=6.960,P=0.000;(57.31±26.22)分,(48.98±22.76)分,(39.03±17.21)分,(33.83±24.05)分,F=12.120,P=0.000]。④WOMAC總評(píng)分。時(shí)間因素和分組因素不存在交互效應(yīng)(F=0.344,P=0.657); 2組患者WOMAC總評(píng)分比較,組間差異無統(tǒng)計(jì)學(xué)意義,即不存在分組效應(yīng)(F=1.070,P=0.286); 2組患者治療前后不同時(shí)間點(diǎn)WOMAC總評(píng)分的差異有統(tǒng)計(jì)學(xué)意義,即存在時(shí)間效應(yīng)(F=169.210 P=0.000),2組患者WOMAC總評(píng)分隨時(shí)間均呈下降趨勢,且2組的下降趨勢完全一致[(77.51±29.38)分,(62.03±24.39)分,(45.95±18.27)分,(41.80±25.57)分,F=8.810,P=0.000;(79.68±28.47)分,(65.97±26.18)分,(51.58±21.22)分,(45.29±20.66)分,F=14.670,P=0.000]。⑤三維步態(tài)分析中測量的膝關(guān)節(jié)屈曲范圍。時(shí)間因素和分組因素存在交互效應(yīng)(F=3.247,P=0.031); 2組患者膝關(guān)節(jié)屈曲范圍比較,組間差異有統(tǒng)計(jì)學(xué)意義,即存在分組效應(yīng)(F=5.116,P=0.043); 治療前后不同時(shí)間點(diǎn)膝關(guān)節(jié)屈曲范圍的差異有統(tǒng)計(jì)學(xué)意義,即存在時(shí)間效應(yīng)(F=2.376,P=0.048),2組患者膝關(guān)節(jié)屈曲范圍隨時(shí)間均呈上升趨勢,但2組的上升趨勢不完全一致[12.25°±9.68°,17.13°±9.44°,17.97°±4.25°,F=3.854,P=0.039; 11.57°±8.00°,12.94°±4.77°,13.39°±5.12°,F=2.036,P=0.043]; 治療前2組患者膝關(guān)節(jié)屈曲范圍比較,差異無統(tǒng)計(jì)學(xué)意義(t=0.991,P=0.331); 治療開始后2周、4周膜韌膏組膝關(guān)節(jié)屈曲范圍均大于復(fù)方紫荊消傷巴布膏組(t=7.468,P=0.003; t=5.213,P=0.041)。⑥綜合療效。治療開始后4周,膜韌膏組治愈1例、顯效1例、有效45例、無效12例,復(fù)方紫荊消傷巴布膏組顯效2例、有效42例、無效15例; 2組患者綜合療效比較,差異無統(tǒng)計(jì)學(xué)意義(Z=-0.651,P=0.515)。⑦安全性。膜韌膏組2例出現(xiàn)瘙癢、紅疹等皮膚過敏現(xiàn)象,復(fù)方紫荊消傷巴布膏組5例出現(xiàn)瘙癢、紅疹等皮膚過敏現(xiàn)象,囑患者暫停用藥后癥狀消失; 2組患者并發(fā)癥發(fā)生率比較,差異無統(tǒng)計(jì)學(xué)意義(P=0.439)。結(jié)論:采用膜韌膏貼敷與復(fù)方紫荊消傷巴布膏貼敷治療內(nèi)側(cè)間室KOA,均能緩解膝關(guān)節(jié)疼痛和僵硬,改善軀體功能,且并發(fā)癥少,但前者在改善膝關(guān)節(jié)屈曲范圍方面優(yōu)于后者。
Abstract:
To observe the clinical curative effects and safety of external application of Moren Gao(膜韌膏,MRG)for treatment of medial compartment knee osteoarthritis(KOA).Methods:One hundred and eighteen patients with medial compartment KOA were randomly divided into 2 groups,59 cases in each group.The patients were treated with external application of MRG(MRG group)and external application of Fufang Zijing Xiaoshang Babugao(復(fù)方紫荊消傷巴布膏,FFZJXSBBG)(FFZJXSBBG group)respectively.Fourteen patients were randomly selected from each group for three-dimensional gait analysis because the time of gait analysis was too long.MRG and FFZJXSBBG were applied to the pain spots of medial knee joint,once a day,12 hours at a time for consecutive 4 weeks.The Western Ontario and McMaster universities(WOMAC)osteoarthritis index pain scores,stiffness scores,physical function scores and total scores were compared between the 2 groups before treatment and at 2,4 and 6 weeks after the beginning of the treatment respectively.The knee flexion-extension range measured using three-dimensional gait analyser was compared between the 2 groups before treatment and at 2 and 4 weeks after the beginning of the treatment respectively.The total clinical curative effects and complications were compared between the 2 groups at 4 weeks after the beginning of the treatment.Results:There was no interaction between time factor and group factor in WOMAC pain scores(F=1.183,P=0.304).There was no statistical difference in WOMAC pain scores between the 2 groups,in other words,there was no group effect(F=-0.540,P=0.590).There was statistical difference in WOMAC pain scores between different timepoints before and after the treatment,in other words,there was time effect(F=184.478, P=0.000).The WOMAC pain scores presented a time-dependent decreasing trend in the 2 groups and the 2 groups were consistent with each other in the decreasing trend of WOMAC pain scores(17.49+/-8.90,11.64+/-6.01,8.59+/-3.94,7.80+/-3.48 points,F=13.460,P=0.000; 16.10+/-7.85,11.68+/-5.93,8.41+/-4.22,7.69+/-4.10 points,F=23.720,P=0.000).There was no interaction between time factor and group factor in WOMAC stiffness scores(F=0.163,P=0.875).There was no statistical difference in WOMAC stiffness scores between the 2 groups,in other words,there was no group effect(F=0.480,P=0.663).There was statistical difference in WOMAC stiffness scores between different timepoints before and after the treatment,in other words,there was time effect(F=36.914,P=0.000).The WOMAC stiffness scores presented a time-dependent decreasing trend in the 2 groups and the 2 groups were consistent with each other in the decreasing trend of WOMAC stiffness scores(5.95+/-2.24,4.98+/-2.47,4.08+/-3.83,3.66+/-1.74 points,F=3.710,P=0.012; 6.27+/-4.41,5.31+/-2.06,4.14+/-2.83,3.76+/-1.69 points,F=3.200,P=0.024).There was no interaction between time factor and group factor in WOMAC physical function scores(F=0.413,P=0.617).There was no statistical difference in WOMAC physical function scores between the 2 groups,in other words,there was no group effect(F=1.510,P=0.132).There was statistical difference in WOMAC physical function scores between different timepoints before and after the treatment,in other words,there was time effect(F=137.806,P=0.000).The WOMAC physical function scores presented a time-dependent decreasing trend in the 2 groups and the 2 groups were consistent with each other in the decreasing trend of WOMAC physical function scores(54.07+/-20.54,45.41+/-27.21,33.27+/-18.29,30.34+/-18.72 points,F=6.960,P=0.000; 57.31+/-26.22,48.98+/-22.76,39.03+/-17.21,33.83+/-24.05 points,F=12.120,P=0.000).There was no interaction between time factor and group factor in WOMAC total scores(F=0.344,P=0.657).There was no statistical difference in WOMAC total scores between the 2 groups,in other words,there was no group effect(F=1.070,P=0.286).There was statistical difference in WOMAC total scores between different timepoints before and after the treatment,in other words,there was time effect(F=169.210,P=0.000).The WOMAC total scores presented a time-dependent decreasing trend in the 2 groups and the 2 groups were consistent with each other in the decreasing trend of WOMAC total scores(77.51+/-29.38,62.03+/-24.39,45.95+/-18.27,41.80+/-25.57 points,F=8.810,P=0.000; 79.68+/-28.47,65.97+/-26.18,51.58+/-21.22,45.29+/-20.66 points,F=14.670,P=0.000).There was interaction between time factor and group factor in knee flexion-extension range measured using three-dimensional gait analyser(F=3.247,P=0.031).There was statistical difference in knee flexion-extension range between the 2 groups,in other words,there was group effect(F=5.116,P=0.043).There was statistical difference in knee flexion-extension range between different timepoints before and after the treatment,in other words,there was time effect(F=2.376,P=0.048).The knee flexion-extension range presented a time-dependent increasing trend in the 2 groups and the 2 groups were inconsistent with each other in the increasing trend of knee flexion-extension range(12.25+/-9.68,17.13+/-9.44,17.97+/-4.25 degrees,F=3.854,P=0.039; 11.57+/-8.00,12.94+/-4.77,13.39+/-5.12 degrees,F=2.036,P=0.043).There was no statistical difference in knee flexion-extension range between the 2 groups before the treatment(t=0.991,P=0.331).The knee flexion-extension range was greater in MRG group compared to FFZJXSBBG group at 2 and 4 weeks after the beginning of the treatment(t=7.468,P=0.003; t=5.213,P=0.041).At 4 weeks after the beginning of the treatment,1 patient was cured,1 good,45 fair and 12 poor in MRG group; while 2 obtained a good result,42 fair and 15 poor in FFZJXSBBG group.There was no statistical difference in the total curative effects between the 2 groups(Z=-0.651,P=0.515).Skin allergic reactions such as pruritus and erythema were found in 2 patients in MRG group and 5 patients in FFZJXSBBG group,and the symptoms disappeared after the plaster was suspended according to doctor's advice.There was no statistical difference in complication incidences between the 2 groups(P=0.439).Conclusion:Both external application of MRG and external application of FFZJXSBBG can relieve knee pain and stiffness and improve physical function in treatment of medial compartment KOA,and both of them have less complications,however,the former surpasses the latter in improving the knee flexion-extension range.

參考文獻(xiàn)/References:

[1] BHATIA D,BEJARANO T,NOVO M.Current interventions in the management of knee osteoarthritis[J].J Pharm Bioallied Sci,2013,5(1):30-38.
[2] LIIKAVAINIO T,BRAGGE T,HAKKARAINEN MA,et al.Gait and muscle activation changes in men with knee osteoarthritis[J].Knee,2010,17(1):69-76.
[3] PANDY MG,ANDRIACCHI TP.Muscle and joint function in human locomotion[J].Annu Rev Biomed Eng,2010,12(1):401-433.
[4] THORP LE,WIMMER MA,BLOCK JA,et al.Bone mineral density in the proximal tibia varies as a function of static alignment and knee adduction angular momentum in individuals with medial knee osteoarthritis[J].Bone,2006,39(5):1116-1122.
[5] FELSON DT,HODGSON R.Identifying and treating preclinical and early osteoarthritis[J].Rheum Dis Clin North Am,2014,40(4):699-710.
[6] MCALINDON TE,BANNURU RR,SULLIVAN MC,et al.OARSI guidelines for the non-surgical management of knee osteoarthritis[J].Osteoarthritis and Cartilage,2014,22(3):363-388.
[7] 中華醫(yī)學(xué)會(huì)骨科學(xué)分會(huì).骨關(guān)節(jié)炎診治指南(2007年版)[J].中華關(guān)節(jié)外科雜志(電子版),2007,1(4):280-283.
[8] KELLGREN JH,LAWRENCE JS.Radiological assessment of osteo-arthrosis[J].Ann Rheum Dis,1957,16(4):494-502.
[9] BELLAMY N,BUCHANAN WW,GOLDSMITH CH,et al.Validation study of WOMAC:a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee[J].J Rheumatol,1988,15(12):1833-1840.
[10] 鄭筱萸.中藥新藥臨床研究指導(dǎo)原則(試行)[M].北京:中國醫(yī)藥科技出版社,2002:156.
[11] RAMSEY DK,WRETENBERG PF.Biomechanics of the knee:methodological considerations in the in vivo kinematic analysis of the tibiofemoral and patellofemoral joint[J].Clin Biomech(Bristol, Avon),1999,14(9):595-611.
[12] FARROKHI S,TASHMAN S,GIL AB,et al.Are the kinematics of the knee joint altered during the loading response phase of gait in individuals with concurrent knee osteoarthritis and complaints of joint instability? A dynamic stereo X-ray study[J].Clin Biomech(Bristol, Avon),2012,27(4):384-389.
[13] 朱清廣,房敏,龔利.步態(tài)分析中運(yùn)動(dòng)學(xué)及動(dòng)力學(xué)參數(shù)在膝骨性關(guān)節(jié)炎中的應(yīng)用[J].北京中醫(yī)藥,2011,30(10):755-757.
[14] 龐堅(jiān),羅明江,曹月龍,等.芻論膝骨關(guān)節(jié)炎“本痿標(biāo)痹,痹痿并存”[J].上海中醫(yī)藥雜志,2013,47(3):25-26.
[15] 宋獻(xiàn)文,龐堅(jiān),石印玉.石氏方藥內(nèi)服外敷治療膝骨關(guān)節(jié)炎60例[J].上海中醫(yī)藥雜志,2013,47(5):62-63.
[16] 姜海瑩,季波,翟明智.膜韌膏外敷治療軟組織損傷1000例[J].中醫(yī)外治雜志,1998,7(5):31.
[17] 吳海.膜韌膏外敷治療急性軟組織損傷的臨床療效評(píng)估[J].世界最新醫(yī)學(xué)信息文摘,2015,15(34):29.

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[3]鄭春松,葉蕻芝,李西海,等.透骨消痛膠囊中補(bǔ)腎柔肝藥和活血祛風(fēng)藥治療 骨關(guān)節(jié)炎作用方式的計(jì)算機(jī)模擬比較[J].中醫(yī)正骨,2015,27(07):6.
　ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Comparison of the mode of action of Bushen Rougan(補(bǔ)腎柔肝)drugs versus Huoxue Qufeng(活血祛風(fēng))drugs contained in Tougu Xiaotong Jiaonang(透骨消痛膠囊)for the treatment of osteoarthritis:A computer simulation study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):6.
[4]宋兵華,孫俊英,倪增良,等.全膝關(guān)節(jié)置換術(shù)前CT測量股骨后髁角的臨床意義[J].中醫(yī)正骨,2015,27(07):38.
[5]鄭春松,葉蕻芝,李西海,等.獨(dú)活寄生湯含藥血清對(duì)白細(xì)胞介素1β誘導(dǎo)的 退變關(guān)節(jié)軟骨細(xì)胞中基質(zhì)金屬蛋白酶 和環(huán)氧化酶2表達(dá)的影響[J].中醫(yī)正骨,2015,27(12):1.
　ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Impact of Duhuo Jisheng Tang(獨(dú)活寄生湯)medicated serum on expression of matrix metalloproteinase and cyclooxygenase 2 in degenerative articular chondrocytes induced by interleukin-1 beta[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):1.
[6]王金良,孫京濤,李玲,等.骨水泥聯(lián)合螺釘修復(fù)全膝關(guān)節(jié)置換術(shù)中 脛骨平臺(tái)內(nèi)側(cè)骨缺損[J].中醫(yī)正骨,2015,27(12):55.
[7]馮榮,王平,李炳奇,等.鈹針刺絡(luò)拔罐結(jié)合中藥口服治療膝骨關(guān)節(jié)炎合并 原發(fā)性血小板增多癥1例[J].中醫(yī)正骨,2015,27(12):73.
[8]蔡云仙.圍手術(shù)期耳穴按壓聯(lián)合平衡針療法 在全膝關(guān)節(jié)置換術(shù)后鎮(zhèn)痛中的應(yīng)用[J].中醫(yī)正骨,2015,27(06):41.
[9]張榮,王健.人工全膝關(guān)節(jié)置換術(shù)的圍手術(shù)期心理護(hù)理[J].中醫(yī)正骨,2015,27(05):77.
[10]喻長純,楊明路,王戰(zhàn)朝.不同手術(shù)方式治療脛骨平臺(tái)骨折畸形愈合的體會(huì)[J].中醫(yī)正骨,2015,27(03):37.
[11]孟維娜,明立功,王新德,等.關(guān)節(jié)鏡下清理聯(lián)合腓骨近1/3段截骨治療膝骨關(guān)節(jié)炎[J].中醫(yī)正骨,2015,27(11):40.
[12]明立功,孟維娜,王新德,等.腓骨近端截骨治療內(nèi)側(cè)間室膝骨關(guān)節(jié)炎的近期療效觀察[J].中醫(yī)正骨,2015,27(10):25.
[13]張杰,王人彥,張玉柱.膝骨關(guān)節(jié)炎的治療進(jìn)展[J].中醫(yī)正骨,2015,27(10):68.
[14]梁朝,蔡靜怡,閆立,等.針刀療法改善膝骨關(guān)節(jié)炎早期疼痛癥狀的療效評(píng)價(jià)[J].中醫(yī)正骨,2015,27(09):9.
　LIANG Zhao,CAI Jingyi,YAN Li,et al.Evaluation of the curative effect of needle-knife therapy for relieving knee pain in patients with early knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):9.
[15]王建武,黨建軍,李強(qiáng),等.四聯(lián)療法治療膝骨關(guān)節(jié)炎[J].中醫(yī)正骨,2015,27(08):44.
[16]劉紅娟,郭會(huì)利,郭樹農(nóng).云克聯(lián)合中藥治療膝骨關(guān)節(jié)炎的護(hù)理[J].中醫(yī)正骨,2015,27(08):75.
[17]陳衛(wèi)衡.探索建立系統(tǒng)的膝骨關(guān)節(jié)炎中醫(yī)臨床科研范式 和理論體系[J].中醫(yī)正骨,2015,27(07):1.
[18]帥波,沈霖,楊艷萍,等.加味青娥丸治療膝骨關(guān)節(jié)炎的作用機(jī)制研究[J].中醫(yī)正骨,2015,27(07):15.
　SHUAI Bo,SHEN Lin,YANG Yanping,et al.Study on the mechanism of action of Jiawei Qing'e Wan(加味青娥丸)for the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):15.
[19]梅其杰,袁長深,段戡,等.壯藥骨痹方燙熨聯(lián)合運(yùn)動(dòng)療法治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2015,27(07):27.
　MEI Qijie,YUAN Changshen,DUAN Kan,et al.Clinical study of the curative effect of hot compressing and rubbing with packet of Gubi Fang(骨痹方)combined with exercise therapy in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):27.
[20]王丹輝,張燕,劉麗娟,等.重組人Ⅱ型腫瘤壞死因子受體-抗體融合蛋白 關(guān)節(jié)腔注射聯(lián)合中藥薰洗治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2015,27(07):31.
　WANG Danhui,ZHANG Yan,LIU Lijuan,et al.Clinical study on intra-articular injection of TypeⅡrecombinant human tumor necrosis factor receptor-Fc fusion protein combined with Chinese herbal steaming and washing therapy for treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):31.

備注/Memo

備注/Memo:
基金項(xiàng)目: 上海市進(jìn)一步加快中醫(yī)藥事業(yè)發(fā)展三年行動(dòng)計(jì)劃項(xiàng)目(ZY3-CCCX-1-1003); 上海市重中之重臨床醫(yī)學(xué)中心和重點(diǎn)學(xué)科建設(shè)項(xiàng)目(2017ZZ02024) 通訊作者:石瑛 E-mail:shiying1974@126.com
更新日期/Last Update: 2018-09-20