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[1]侯紅燕,黃凱,宋敏,等.從痰論治椎動(dòng)脈型頸椎病的 PI3K/Akt/mTOR信號(hào)調(diào)控機(jī)制研究進(jìn)展[J].中醫(yī)正骨,2018,30(08):42-45.
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從痰論治椎動(dòng)脈型頸椎病的 PI3K/Akt/mTOR信號(hào)調(diào)控機(jī)制研究進(jìn)展()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期數(shù):
2018年08期
頁(yè)碼:
42-45
欄目:
綜 述
出版日期:
2018-08-20

文章信息/Info

作者:
侯紅燕1黃凱1宋敏1董萬(wàn)濤2周靈通1鞏彥龍1
1.甘肅中醫(yī)藥大學(xué),甘肅 蘭州 730000; 2.甘肅中醫(yī)藥大學(xué)附屬醫(yī)院,甘肅 蘭州 730000
關(guān)鍵詞:
頸椎病 椎動(dòng)脈 磷酸肌醇3-激酶 蛋白激酶類 哺乳動(dòng)物雷帕霉素靶蛋白 痰證 祛痰 消痰 綜述
摘要:
近年來(lái)隨著人們生活及工作方式的改變,椎動(dòng)脈型頸椎病(cervical spondylosis of vertebral artery type,CSA)的發(fā)病率呈逐年增高趨勢(shì),且有明顯年輕化趨勢(shì),嚴(yán)重影響著人們的身心健康。中醫(yī)藥防治CSA的療效確切,但往往缺乏客觀的分子生物學(xué)依據(jù)解釋其作用機(jī)理。磷脂酰肌醇3-激酶(phosphoinositide 3-kinase,PI3K)/蛋白激酶B(protein kinase B,PKB/Akt)/哺乳動(dòng)物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信號(hào)通路在血管的生成及細(xì)胞的生長(zhǎng)代謝過(guò)程中發(fā)揮著關(guān)鍵作用,參與調(diào)控多種代謝疾病的病理形成過(guò)程。近年來(lái)PI3K/Akt/mTOR信號(hào)通路在CSA的發(fā)生發(fā)展中的作用日益受到重視。本文就從痰論治CSA的辨治機(jī)理和現(xiàn)代研究、PI3K/Akt/mTOR信號(hào)通路及其在CSA發(fā)病機(jī)制中的作用、從痰論治CSA對(duì)PI3K/Akt/mTOR信號(hào)通路的影響3個(gè)方面,對(duì)從痰論治CSA的PI3K/Akt/mTOR信號(hào)調(diào)控機(jī)制的研究進(jìn)展進(jìn)行了綜述。

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中醫(yī)正骨2018年8月第30卷第8期 J Trad Chin Orthop Trauma,2018,Vol.30,No.8(總605)
(總606)中醫(yī)正骨2018年8月第30卷第8期 J Trad Chin Orthop Trauma,2018,Vol.30,No.8
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備注/Memo

備注/Memo:
基金項(xiàng)目:甘肅省高等學(xué)校科研項(xiàng)目(2017A-053) 通訊作者:宋敏 E-mail:[email protected]
更新日期/Last Update: 2018-08-31