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[1]許麗梅,賈良良,何曉娟,等.環(huán)狀RNA在骨關(guān)節(jié)炎發(fā)生發(fā)展中的作用[J].中醫(yī)正骨,2018,30(07):39-42.
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環(huán)狀RNA在骨關(guān)節(jié)炎發(fā)生發(fā)展中的作用()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期數(shù):
2018年07期
頁碼:
39-42
欄目:
綜 述
出版日期:
2018-07-20

文章信息/Info

作者:
許麗梅1賈良良1何曉娟1李慧1葉蕻芝2李西海1
(1.福建中醫(yī)藥大學(xué),福建 福州 350108; 2.福建省中西醫(yī)結(jié)合老年性疾病重點(diǎn)實(shí)驗(yàn)室,福建 福州 350108)
關(guān)鍵詞:
骨關(guān)節(jié)炎 RNA 綜述
摘要:
骨關(guān)節(jié)炎是一種常見的慢性、退行性、進(jìn)展性骨關(guān)節(jié)疾病,為力學(xué)因素與生物學(xué)因素共同作用下導(dǎo)致軟骨細(xì)胞、細(xì)胞外基質(zhì)和軟骨下骨三者降解-合成正常偶聯(lián)失衡的結(jié)果。環(huán)狀RNA(circular RNA,circRNA)是一類具有環(huán)形結(jié)構(gòu)的RNA分子,在多種生物體中廣泛存在,并在多種疾病中發(fā)揮特殊的生物學(xué)功能,但其在骨關(guān)節(jié)炎發(fā)生發(fā)展中的作用機(jī)制有待進(jìn)一步深入研究。本文從circRNA的生物學(xué)功能以及circRNA調(diào)控炎癥反應(yīng)、軟骨基質(zhì)代謝、軟骨下骨的改變與軟骨細(xì)胞增殖、分化、凋亡等方面對circRNA在骨關(guān)節(jié)炎發(fā)生發(fā)展中的作用進(jìn)行了綜述。

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備注/Memo

備注/Memo:
基金項(xiàng)目:國家自然科學(xué)基金面上項(xiàng)目(81573998); 福建省自然科學(xué)基金科技計(jì)劃項(xiàng)目(2016J01395); 中國博士后科學(xué)基金第60批面上資助項(xiàng)目(2016M600625); 中國博士后科學(xué)基金第10批特別資助項(xiàng)目(2017T100591) 通訊作者:李西海 E-mail:[email protected]
更新日期/Last Update: 2018-11-30