84年鼠女哪年财运最旺,857comvvv色九欧美激情|85PO_87国产精品欲av国产av资源

[1]金鑫,譚勇海,張中禹,等.自體細(xì)胞生長因子注射聯(lián)合體外沖擊波治療下肢骨折不愈合的臨床研究[J].中醫(yī)正骨,2018,30(07):10-13.
　JIN Xin,TAN Yonghai,ZHANG Zhongyu,et al.A clinical study of injection of autologous cell growth factors combined with extracorporeal shock wave therapy for treatment of nonunion of lower limb fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(07):10-13.
點(diǎn)擊復(fù)制

自體細(xì)胞生長因子注射聯(lián)合體外沖擊波治療下肢骨折不愈合的臨床研究()
分享到：

《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期數(shù):
2018年07期
頁碼:
10-13
欄目:
臨床研究
出版日期:
2018-07-20

文章信息/Info

Title:
A clinical study of injection of autologous cell growth factors combined with extracorporeal shock wave therapy for treatment of nonunion of lower limb fractures
作者:
金鑫; 譚勇海; 張中禹; 鞠昌軍; 嚴(yán)偉; 姜紅江
(山東省文登整骨醫(yī)院,山東 威海 264400)
Author(s):
JIN Xin; TAN Yonghai; ZHANG Zhongyu; JU Changjun; YAN Wei; JIANG Hongjiang
The Wendeng Osteopath Hospital,Wendeng 264400,Shandong,China
關(guān)鍵詞:
骨折; 不愈合;  體外沖擊波治療;  血管內(nèi)皮生長因子類;  轉(zhuǎn)化生長因子β
Keywords:
fractures; ununited;  extracorporeal shockwave therapy;  vascular endothelial growth factors;  transforming growth factor beta
摘要:
目的:觀察自體細(xì)胞生長因子注射聯(lián)合體外沖擊波治療下肢骨折不愈合的臨床療效。方法:將48例下肢骨折不愈合患者隨機(jī)分為聯(lián)合治療組和沖擊波治療組,每組24例。聯(lián)合治療組先向骨折兩斷端注射以自體外周血制備的細(xì)胞生長因子,然后進(jìn)行體外沖擊波治療; 沖擊波治療組僅進(jìn)行沖擊波治療。自體細(xì)胞生長因子注射和體外沖擊波治療均每隔4 d治療1次,共治療3次。治療結(jié)束后定期拍攝X線片,觀察骨折愈合情況。結(jié)果:制備的細(xì)胞生長因子中主要包括血管內(nèi)皮生長因子、轉(zhuǎn)化生長因子-β,含量分別為(583.87±23.51)pg·mL-1和(195.73±26.08)pg·mL-1。48例患者均獲得隨訪,隨訪時(shí)間3～10個月,中位數(shù)4.5個月。治療后2個月時(shí),2組均有骨折開始愈合的病例,至治療后10個月時(shí),聯(lián)合治療組23例骨折愈合、沖擊波治療組18例骨折愈合,聯(lián)合治療組的骨折愈合率高于沖擊波治療組(χ2=4.181,P=0.041)。結(jié)論:自體細(xì)胞生長因子注射聯(lián)合體外沖擊波能有效治療下肢骨折不愈合,其效果優(yōu)于單純體外沖擊波治療。
Abstract:
Objective:To observe the clinical curative effects of injection of autologous cell growth factors combined with extracorporeal shock wave(ESW)therapy for treatment of nonunion of lower limb fractures.Methods:Forty-eight patients with nonunion of lower limb fractures were randomly divided into combination therapy group and ESW therapy group,24 cases in each group.The cell growth factors prepared by using autologous peripheral blood were injected into both broken ends of fractured bone and then ESW therapy was performed on patients in combination therapy group,while the patients in ESW therapy group were merely treated with ESW therapy.Both injection of autologous cell growth factors and ESW therapy were performed on patients for consecutive 3 times with a 4-day rest-insertion between times.The X-ray films of lower limbs were periodically taken after the end of the treatment,and the fracture healing was observed.Results:The prepared cell growth factors consisted mainly of vascular endothelial growth factor(VEGF)and transforming growth factor-β(TGF-β),which contents were 583.87+/-23.51 and 195.73+/-26.08 pg/mL respectively.All patients were followed up for 3-10 months with a median of 4.5 months.The fractures of some patients began to heal in both of the 2 groups at 2 months after the treatment.The fractures healed in 23 patients of combination therapy group and 18 patients of ESW therapy group at 10 months after the treatment,and the fracture healing rate was higher in combination therapy group compared to ESW therapy group(χ2=4.181,P=0.041).Conclusion:The combination therapy of injection of autologous cell growth factors and ESW therapy can effectively treat nonunion of lower limb fractures,and its curative effect is better than that of monotherapy of ESW.

參考文獻(xiàn)/References:


[1] 陳劍,袁文,宋滇文.富血小板血漿在骨愈合治療中的作用[J].中國組織工程研究,2011,15(41):7755-7758.
[2] 譚勇海,姜紅江,秦立武,等.自體細(xì)胞生長因子治療中青年股骨頸骨折延遲愈合62例[J].中國中醫(yī)骨傷科雜志, 2014,22(4):61-62.
[3] 譚訓(xùn)香,金鑫,譚勇海,等.自體骨髓聯(lián)合細(xì)胞生長因子治療脛腓骨骨不連42例的體會[J].中國中醫(yī)骨傷科雜志,2016,24(1):44-45.
[4] 賈朗,黃榮忠,王愉樂,等.不同強(qiáng)度體外沖擊波聯(lián)合骨髓間充質(zhì)干細(xì)胞移植對大鼠骨缺損的修復(fù)效果[J].上海交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2016,36(12):1706-1712.
[5] 李恩.體外沖擊波治療骨不連臨床研究[D].太原:山西醫(yī)科大學(xué),2016.
[6] RODRIGUEZ-MERCHAN EC,FORRIOL F.Nonunion:general principles and experimental data[J].Clin Orthop Relat Res,2004,20(419):4-12.
[7] 葛站勇,白俊清.脛骨骨不連的常見原因及治療進(jìn)展[J].中國煤炭工業(yè)醫(yī)學(xué)雜志,2013,16(3):508-510.
[8] 潘治軍,楊濤,思玉樓,等.280例骨不連病例原因分析[J].中國骨傷,2013,26(4):284-286.
[9] 黃志明,熊濤,林川.18例肱骨干骨折術(shù)后骨不連原因分析[J].重慶醫(yī)學(xué),2008,37(21):2472-2474.
[10] MELNYK M,HENKE T,CLAES L,et al.Revascularisation during fracture healing with soft tissue injury[J].Arch Orthop Trauma Surg,2008,128(10):1159-1165.
[11] 彭國常,汪玉輝,李躍,等.脛骨內(nèi)固定術(shù)后非感染性骨不連的原因分析及治療[J].臨床醫(yī)學(xué)工程,2014,21(1):52-53.
[12] 蔣亮東,陶澄,何愛詠,等.75例股骨骨折不愈合發(fā)生的原因分析[J].重慶醫(yī)學(xué),2014,43(8):970-972.
[13] 崔博,鄭學(xué)清,舒暢,等.體外沖擊波誘導(dǎo)骨髓間充質(zhì)干細(xì)胞向成骨細(xì)胞分化[J].中國老年學(xué)雜志,2012,32(3):554-556.
[14] CHEN HS,CHEN LM,HUANG TW.Treatment of painful heel syndrome with shock waves[J].Clin Orthop Relat Res,2001,(387):41-46.
[15] MCCLURE SR,VAN SICKLE D,WHITE MR.Effects of extracorporeal shock wave therapy on bone[J].Vet Surg,2004,33(1):40-48.
[16] FRAIRIA R,BERTA L.Biological effects of extracorporeal shock waves on fibroblasts.A review[J].Muscles Ligaments Tendons J,2011,1(4):138-147.
[17] WANG CJ,HUANG KE,SUN YC,et al.VEGF modulates angiogenesis and osteogenesis in shockwave-promoted fracture healing in rabbits[J].J Surg Res,2011,171(1):114-119.
[18] VULPIANI MC,VETRANO M,CONFORTI F,et al.Effects of extracorporeal shock wave therapy on fracture nonun-ions[J].Am J Orthop(Belle Mead NJ),2012,41(9):122-127.
[19] 鮑小明.VEGF在骨質(zhì)疏松性骨折愈合中的作用[J].中國矯形外科雜志,2012,20(22):2054-2056.
[20] BROWN GA.AAOS clinical practice guideline:treatment of osteoarthritis of the knee:evidence-based guideline,2nd edition[J].J Am Acad Orthop Surg,2013,21(9):577-579.

相似文獻(xiàn)/References:

[1]茆軍,張惠法,嚴(yán)培軍,等.Ilizarov外固定支架結(jié)合克氏針固定治療Pilon骨折[J].中醫(yī)正骨,2015,27(10):32.
[2]伍輝國,江克羅,張文正,等.手法復(fù)位杉樹皮小夾板固定治療兒童閉合性指骨骨折[J].中醫(yī)正骨,2015,27(10):63.
[3]孫群周.組合式外固定器固定結(jié)合有限內(nèi)固定治療 GustiloⅢ型脛骨開放性骨折[J].中醫(yī)正骨,2015,27(09):25.
[4]劉昕,鄧志強(qiáng),葉家軍.大齡兒童肱骨外髁陳舊性骨折不愈合繼發(fā)肘外翻畸形的 分期手術(shù)治療[J].中醫(yī)正骨,2015,27(07):55.
[5]朱旭偉,萬春友,張濤,等.外固定架固定結(jié)合髓腔內(nèi)異體骨支撐治療四肢粉碎性骨折[J].中醫(yī)正骨,2015,27(12):68.
[6]楊少輝,許紅霞,邢健昆.正骨伸筋膠囊在膝關(guān)節(jié)周圍骨折術(shù)后康復(fù)中的應(yīng)用[J].中醫(yī)正骨,2015,27(02):43.
[7]譚新歡,畢宏政,聶偉志,等.SandersⅡ型跟骨骨折手法復(fù)位克氏針 內(nèi)固定術(shù)中植骨的臨床研究[J].中醫(yī)正骨,2015,27(06):6.
　TAN Xinhuan,BI Hongzheng,NIE Weizhi,et al.Clinical research on bone grafting after manipulative reduction and kirschner wire internal fixation for treatment of sandersⅡcalcaneal fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):6.
[8]張振南,王愛國,白玉,等.保留原釘?shù)膯纹べ|(zhì)鎖定加壓鋼板內(nèi)固定配合植骨治療 股骨干骨折髓內(nèi)釘固定術(shù)后骨折不愈合[J].中醫(yī)正骨,2015,27(05):40.
[9]倘艷鋒,李啟義,劉又文,等.富血小板血漿促進(jìn)骨修復(fù)的研究和應(yīng)用進(jìn)展[J].中醫(yī)正骨,2015,27(04):70.
[10]林全藝,丁振貝,陳慶運(yùn),等.彈性髓內(nèi)釘內(nèi)固定治療兒童四肢長骨干骨折[J].中醫(yī)正骨,2015,27(03):52.
[11]胡和軍,吳法強(qiáng),鄧雄偉,等.骨皮質(zhì)切剝術(shù)聯(lián)合生龍接骨膠囊口服治療四肢長骨干骨折不愈合[J].中醫(yī)正骨,2016,28(10):64.
[12]王沖,寧凡友.解剖鎖定加壓鋼板內(nèi)固定聯(lián)合自體髂骨板植骨治療肱骨干骨折不愈合[J].中醫(yī)正骨,2017,29(02):62.
[13]蘇虔,蘇波,褚東曉,等.應(yīng)用Ilizarov外固定支架治療股骨干骨折不愈合[J].中醫(yī)正骨,2017,29(11):55.
[14]陳弘林,涂來勇,趙疆,等.用于骨折延遲愈合和骨折不愈合的中藥湯劑的用藥規(guī)律研究[J].中醫(yī)正骨,2018,30(12):37.
　CHEN Honglin,TU Laiyong,ZHAO Jiang,et al.A study of medication rule of Traditional Chinese Medicine decoctions for treatment of delayed union and nonunion of fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(07):37.
[15]姜苗苗,譚勇海,金鑫,等.富血小板血漿聯(lián)合體外沖擊波治療骨不連的臨床研究[J].中醫(yī)正骨,2020,32(02):30.
　JIANG Miaomiao,TAN Yonghai,JIN Xin,et al.A clinical study of injection of platelet-rich plasma combined with extracorporeal shock wave therapy for treatment of nonunion of fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2020,32(07):30.
[16]唐洪濤,孫瑞波,田濤濤,等.體外沖擊波療法聯(lián)合自體骨髓血活性濃集物和富血小板血漿局部注射治療下肢骨折不愈合[J].中醫(yī)正骨,2024,36(06):61.

備注/Memo

備注/Memo:
基金項(xiàng)目:山東省威海市科技發(fā)展計(jì)劃項(xiàng)目(2017GNS13) 通訊作者:姜紅江 E-mail:[email protected]
更新日期/Last Update: 2018-11-30