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[1]雷騰飛,張玉民,熊軼喆,等.復(fù)方紫荊消傷巴布膏外用聯(lián)合益氣活血方內(nèi)服治療神經(jīng)根型頸椎病的臨床研究[J].中醫(yī)正骨,2018,30(03):13-16，21.
　LEI Tengfei,ZHANG Yumin,XIONG Yizhe,et al.A clinical study of external application of Fufang Zijing Xiaoshang Babugao(復(fù)方紫荊消傷巴布膏)combined with oral application of Yiqi Huoxue Fang(益氣活血方)for treatment of cervical spondylotic radiculopathy[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(03):13-16，21.
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復(fù)方紫荊消傷巴布膏外用聯(lián)合益氣活血方內(nèi)服治療神經(jīng)根型頸椎病的臨床研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期數(shù):
2018年03期
頁碼:
13-16，21
欄目:
頸椎疾患
出版日期:
2018-03-20

文章信息/Info

Title:
A clinical study of external application of Fufang Zijing Xiaoshang Babugao(復(fù)方紫荊消傷巴布膏)combined with oral application of Yiqi Huoxue Fang(益氣活血方)for treatment of cervical spondylotic radiculopathy
作者:
雷騰飛1; 張玉民1; 熊軼喆1; 陳博1; 胡零三1; 黃海生2; 詹紅生1
1.上海中醫(yī)藥大學(xué)附屬曙光醫(yī)院,上海市中醫(yī)藥研究院骨傷科研究所,上海 201203; 2.上海市中西醫(yī)結(jié)合醫(yī)院,上海 200082
Author(s):
LEI Tengfei1; ZHANG Yumin1; XIONG Yizhe1; CHEN Bo1; HU Lingsan1; HUANG Haisheng2; ZHAN Hongsheng1
1.Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China 2.Shanghai combinational hospital of traditional Chinese medicine and Western medicine,Shanghai 200082,China
關(guān)鍵詞:
頸椎病;  神經(jīng)根病;  益氣活血方;  復(fù)方紫荊消傷巴布膏;  臨床試驗
Keywords:
Keywords cervical spondylosis;  radiculopathy;  Yiqi Huoxue Fang;  Fufang Zijing Xiaoshang Babugao;  clinical trial
摘要:
目的:觀察復(fù)方紫荊消傷巴布膏外用聯(lián)合益氣活血方內(nèi)服治療神經(jīng)根型頸椎病的臨床療效。方法:將90例神經(jīng)根型頸椎病患者隨機分為3組,其中采用復(fù)方紫荊消傷巴布膏外用37例(復(fù)方紫荊消傷巴布膏組)、采用益氣活血方內(nèi)服29例(益氣活血方組)、采用復(fù)方紫荊消傷巴布膏外用聯(lián)合益氣活血方內(nèi)服24例(復(fù)方紫荊消傷巴布膏聯(lián)合益氣活血方組)。復(fù)方紫荊消傷巴布膏外貼每天1次,每次12 h,連用6周; 益氣活血方內(nèi)服每日1劑,早晚2次服用,連服6周。分別于治療前及治療開始后2周、4周、6周記錄并比較3組患者頸部疼痛視覺模擬量表(visual analogue scale,VAS)評分和頸椎功能障礙指數(shù)(neck disability index,NDI)。結(jié)果:①頸部疼痛VAS評分。時間因素和分組因素不存在交互效應(yīng)(F=2.250,P=0.058); 3組患者頸部疼痛VAS評分比較,組間差異無統(tǒng)計學(xué)意義,不存在分組效應(yīng)(F=1.528,P=0.218); 治療前后不同時間點之間頸部疼痛VAS評分的差異有統(tǒng)計學(xué)意義,存在時間效應(yīng)(F=57.080,P=0.000); 3組頸部疼痛VAS評分隨時間均呈降低趨勢,且3組的降低趨勢完全一致[(4.84±1.68)分,(3.62±1.69)分,(2.54±1.88)分,(1.74±1.24)分,F=85.491,P=0.000;(5.14±1.98)分,(4.17±2.19)分,(2.59±1.80)分,(1.84±1.52)分,F=42.705,P=0.000;(5.42±1.67)分,(3.46±1.96)分,(1.83±1.61)分,(1.06±0.63)分,F=42.863,P=0.000]。②NDI。時間因素和分組因素存在交互效應(yīng)(F=1.930,P=0.026); 3組患者NDI比較,組間差異有統(tǒng)計學(xué)意義,存在分組效應(yīng)(F=3.782,P=0.017); 治療前后不同時間點之間NDI的差異有統(tǒng)計學(xué)意義,存在時間效應(yīng)(F=40.546,P=0.000); 3組NDI隨時間均呈降低趨勢,但3組的降低趨勢不完全一致; 治療前和治療開始后2周,3組NDI比較,組間差異均無統(tǒng)計學(xué)意義[(22.54±8.39)%,(20.70±7.48)%,(24.65±8.45)%,F=1.632,P=0.195;(17.50±6.54)%,(17.60±6.41)%,(13.10±4.23)%,F=1.863,P=0.210]; 治療開始后4周和6周,3組NDI比較,組間差異均有統(tǒng)計學(xué)意義[(11.31±3.19)%,(13.56±4.45)%,(7.33±2.56)%,F=2.754,P=0.028;(7.82±4.32)%,(9.58±3.26)%,(4.73±2.10)%,F=7.458,P=0.013]; 復(fù)方紫荊消傷巴布膏組、益氣活血方組NDI均高于復(fù)方紫荊消傷巴布膏聯(lián)合益氣活血方組(P=0.008,P=0.039; P=0.011,P=0.006),復(fù)方紫荊消傷巴布膏組NDI與益氣活血方組比較差異均無統(tǒng)計學(xué)意義(P=0.148,P=0.174)。結(jié)論:復(fù)方紫荊消傷巴布膏外用聯(lián)合益氣活血方內(nèi)服治療神經(jīng)根型頸椎病,能夠緩解頸部疼痛,改善頸椎功能,且在改善頸椎功能方面優(yōu)于單純復(fù)方紫荊消傷巴布膏外用和單純益氣活血方內(nèi)服,值得臨床推廣應(yīng)用。
Abstract:
ABSTRACT Objective:To observe the clinical curative effects of external application of Fufang Zijing Xiaoshang Babugao(復(fù)方紫荊消傷巴布膏,FFZJXSBBG)combined with oral application of Yiqi Huoxue Fang(益氣活血方,YQHXF)for treatment of cervical spondylotic radiculopathy(CSR).Methods:Ninety patients with CSR were randomly divided into 3 groups,37 patients were treated with external application of FFZJXSBBG(FFZJXSBBG group),29 patients were treatd with oral application of YQHXF(YQHXF group),while the others were treated with external application of FFZJXSBBG combined with oral application of YQHXF(combination treatment group).FFZJXSBBG were applied once a day,12 hours at a time for consecutive 6 weeks; while YQHXF were taken one dose a day in the morning and evening respectively for consecutive 6 weeks.Neck pain visual analogue scale(VAS)scores and neck disability index(NDI)were recorded and compared between the 3 groups before treatment and at 2,4 and 6 weeks after the beginning of the treatment respectively.Results:The analytic results of neck pain VAS scores showed that(1)there was no interaction between time factor and group factor(F=2.250,P=0.058);(2)there was no statistical difference in neck pain VAS scores between the 3 groups,in other words,there was no group effect(F=1.528,P=0.218);(3)there was statistical difference in the neck pain VAS scores between different timepoints before and after the treatment,in other words,there was time effect(F=57.080,P=0.000); and(4)the neck pain VAS scores presented a time-dependent decreasing trend in the 3 groups and the 3 groups were consistent with each other in the decreasing trend of neck pain VAS scores(4.84+/-1.68,3.62+/-1.69,2.54+/-1.88,1.74+/-1.24 points,F=85.491,P=0.000; 5.14+/-1.98,4.17+/-2.19,2.59+/-1.80,1.84+/-1.52 points,F=42.705,P=0.000; 5.42+/-1.67,3.46+/-1.96,1.83+/-1.61,1.06+/-0.63 points,F=42.863,P=0.000).The analytic results of NDI showed that(1)there was interaction between time factor and group factor(F=1.930,P=0.026);(2)there was statistical difference in NDI between the 3 groups,in other words,there was group effect(F=3.782,P=0.017);(3)there was statistical difference in NDI between different timepoints before and after the treatment,in other words,there was time effect(F=40.546,P=0.000);(4)the NDI presented a time-dependent decreasing trend in the 3 groups while the 3 groups were inconsistent with each other in the decreasing trend of NDI;(5)there was no statistical difference in NDI between the 3 groups before treatment and at 2 weeks after the beginning of the treatment(22.54+/-8.39,20.70+/-7.48,24.65+/-8.45%,F=1.632,P=0.195; 17.50+/-6.54,17.60+/-6.41,13.10+/-4.23%,F=1.863,P=0.210);(6)there was statistical difference in NDI between the 3 groups at 4 and 6 weeks after the beginning of the treatment(11.31+/-3.19,13.56+/-4.45,7.33+/-2.56%,F=2.754,P=0.028; 7.82+/-4.32,9.58+/-3.26,4.73+/-2.10%,F=7.458,P=0.013); and(7)the NDI were higher in FFZJXSBBG group and YQHXF group compared to combination treatment group(P=0.008,P=0.039; P=0.011,P=0.006)and there was no statistical difference in NDI between FFZJXSBBG group and YQHXF group(P=0.148,P=0.174).Conclusion:Combination of external application of FFZJXSBBG with oral application of YQHXF can relieve neck pain and improve cervical vertebra function in treatment of CSR,and it is superior to the monotherapy of external application of FFZJXSBBG and the monotherapy of oral application of YQHXF in improving cervical vertebra function,so it is worthy of popularizing in clinic.

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備注/Memo

備注/Memo:
基金項目:國家自然科學(xué)基金面上項目(81473702); 國家自然科學(xué)基金青年科學(xué)基金項目(81503596); 上海市科學(xué)技術(shù)委員會科研計劃項目(14401970402,15401934100); 上海市進(jìn)一步加快中醫(yī)藥事業(yè)發(fā)展三年行動計劃建設(shè)(2014—2016年)項目(ZY3-LCPT-2-1005); 上海市市級醫(yī)院新興前沿技術(shù)聯(lián)合攻關(guān)項目(SHDC12014121) 通訊作者:詹紅生 E-mail:[email protected]
更新日期/Last Update: 2018-08-02