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[1]李新民,王玲,蔣雯,等.中老年女性腰椎椎后肌群退變與腰椎骨密度的關(guān)系研究[J].中醫(yī)正骨,2018,30(02):16-20.
 LI Xinmin,WANG Ling,JIANG Wen,et al.A clinical study on the relationship between lumbar vertebrae posterior muscle group degeneration and lumbar bone mineral density in middle-aged and elderly females[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(02):16-20.
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中老年女性腰椎椎后肌群退變與腰椎骨密度的關(guān)系研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期數(shù):
2018年02期
頁碼:
16-20
欄目:
臨床研究
出版日期:
2018-02-20

文章信息/Info

Title:
A clinical study on the relationship between lumbar vertebrae posterior muscle group degeneration and lumbar bone mineral density in middle-aged and elderly females
作者:
李新民1王玲1蔣雯1婁路馨1陳義忠2江艷芬2于愛紅1程曉光1
1.北京積水潭醫(yī)院,北京 100035; 2.四川省大邑縣人民醫(yī)院,四川 大邑 611300
Author(s):
LI Xinmin1WANG Ling1JIANG Wen1LOU Luxin1CHEN Yizhong2JIANG Yanfen2YU Aihong1CHENG Xiaoguang1
1.Beijing Jishuitan Hospital,Beijing 100035,China 2.The People's Hospital of Dayi county,Dayi 611300,Sichuan,China
關(guān)鍵詞:
腰椎 骨密度 定量CT 肌少癥 骨質(zhì)疏松 女性
Keywords:
Keywords lumbar vertebrae bone density quantitative computerized tomography sarcopenia osteoporosis femininity
摘要:
目的:研究中老年女性腰椎椎后肌群退變與腰椎骨密度的關(guān)系。方法:以一項前瞻性中國城鄉(xiāng)流行病學研究項目招募的社區(qū)健康志愿者中的中老年女性作為研究對象,共115例。45歲≤年齡<60歲者62例(中年組),年齡≥60歲者53例(老年組)。使用定量CT分別測量其腰椎骨密度,并測量L3椎體中部層面椎后肌群的肌肉面積及脂肪面積,計算腰椎椎后肌群內(nèi)的肌肉脂肪浸潤程度(muscle fat infiltration,MFI)[MFI=脂肪面積/(肌肉面積+脂肪面積)×100%]。采用直線相關(guān)分析和多元線性回歸分析探討腰椎骨密度與腰椎椎后肌群退變的關(guān)系。結(jié)果:中年組的腰椎骨密度、椎后肌群肌肉面積均高于老年組[(132.74±35.74)mg·cm-3,(91.43±28.40)mg·cm-3,t=6.779,P=0.000;(40.68±6.62)cm2,(38.01±6.41)cm2,t=2.182,P=0.031],椎后肌群脂肪面積、MFI均低于老年組[(1.89±0.99)cm2,(2.34±1.45)cm2,t=-1.997,P=0.048;(4.48±2.11)%,(5.85±3.44)%,t=-2.604,P=0.010]; 2組的體質(zhì)量指數(shù)比較,組間差異無統(tǒng)計學意義[(23.96±3.22)kg·m-2,(24.08±3.06)kg·m-2,t=-0.190,P=0.850]。中年組、老年組及總體研究對象的腰椎骨密度均與年齡呈負相關(guān)(r=-0.552,P=0.000; r=-0.599,P=0.000; r=-0.690,P=0.000)。中年組腰椎骨密度與椎后肌群脂肪面積及MFI均呈負相關(guān)(r=-0.267,P=0.037; r=-0.304,P=0.017),與椎后肌群肌肉面積不存在直線相關(guān)關(guān)系(r=0.081,P=0.581); 老年組腰椎骨密度與椎后肌群脂肪面積及MFI均呈負相關(guān)(r=-0.331,P=0.017; r=-0.371,P=0.007),與椎后肌群肌肉面積不存在直線相關(guān)關(guān)系(r=0.235,P=0.094); 總體研究對象的腰椎骨密度與椎后肌群脂肪面積及MFI均呈負相關(guān)(r=-0.191,P=0.042; r=-0.214,P=0.023),與椎后肌群肌肉面積不存在直線相關(guān)關(guān)系(r=0.132,P=0.163)。以腰椎骨密度為因變量,以年齡、體質(zhì)量指數(shù)、腰椎椎后肌群肌肉面積和脂肪面積作為自變量,進行多元線性回歸分析,得到的回歸方程分別為,腰椎骨密度(中年組)=379.695-3.929×年齡-7.609×腰椎椎后肌群脂肪面積、腰椎骨密度(老年組)=146.419-1.190×年齡-6.350×腰椎椎后肌群脂肪面積、腰椎骨密度(總體研究對象)=269.577-2.962×年齡-5.307×腰椎椎后肌群脂肪面積。結(jié)論:中老年女性腰椎椎后肌群脂肪含量的增加可能會導(dǎo)致腰椎骨密度的下降,是骨質(zhì)疏松的重要危險因素。
Abstract:
ABSTRACT Objective:To study the relationship between lumbar vertebrae posterior muscle group degeneration and lumbar bone mineral density(BMD)in middle-aged and elderly females.Methods:One hundred and fifteen middle-aged and elderly females were selected as the subjects from community healthy volunteers that were recruited for a prospective urban and rural epidemiologic study in China.Sixty-two females ranged in age from 45 to 60 years(middle-aged group),and 53 females were≥60 years old(elder group).Their lumbar BMD were measured by using quantitative computerized tomography(CT),and muscle area and fat area of posterior vertebral muscle group were measured at the level of middle-layer of L3 vertebrae.The degree of muscle fat infiltration(MFI)(MFI=fat area/(muscle area+fat area)×100%)of lumbar vertebrae posterior muscle group was calculated.The relationship between lumbar BMD and lumbar vertebrae posterior muscle group degeneration were analyzed by using linear correlation analysis and multiple linear regression

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備注/Memo

備注/Memo:
基金項目:北京市衛(wèi)生系統(tǒng)高層次衛(wèi)生技術(shù)人才培養(yǎng)項目(2009-2-03; 2013-3-033) 通訊作者:于愛紅 E-mail:[email protected]
更新日期/Last Update: 2018-07-02