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[1]林潔,范展彪,劉獻(xiàn)祥.基于數(shù)據(jù)挖掘技術(shù)探討陳可冀《清宮配方集成》中治療骨關(guān)節(jié)炎組方的用藥規(guī)律[J].中醫(yī)正骨,2017,29(11):15-19,25.
　LIN Jie,FAN Zhanbiao,LIU Xianxiang.Study on medication rule extracted from prescription for treatment of osteoarthritis in Royal Formulary of Qing Dynasty written by Chen Keji based on data mining techniques[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2017,29(11):15-19,25.
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基于數(shù)據(jù)挖掘技術(shù)探討陳可冀《清宮配方集成》中治療骨關(guān)節(jié)炎組方的用藥規(guī)律()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第29卷
期數(shù):
2017年11期
頁(yè)碼:
15-19,25
欄目:
基礎(chǔ)研究
出版日期:
2017-11-20

文章信息/Info

Title:
Study on medication rule extracted from prescription for treatment of osteoarthritis in Royal Formulary of Qing Dynasty written by Chen Keji based on data mining techniques
作者:
林潔; 范展彪; 劉獻(xiàn)祥
福建中醫(yī)藥大學(xué),福建 福州 350122
Author(s):
LIN Jie; FAN Zhanbiao; LIU Xianxiang
Fujian University of Traditional Chinese Medicine,Fuzhou 350122,Fujian,China
關(guān)鍵詞:
骨關(guān)節(jié)炎;  中醫(yī)藥學(xué)文獻(xiàn);  組方原則;  數(shù)據(jù)挖掘;  聚類分析
Keywords:
Key words osteoarthritis;  med pharmacol literature TCM;  formula composing principles;  data mining;  cluster analysis
摘要:
目的:探討陳可冀《清宮配方集成》中治療骨關(guān)節(jié)炎組方的用藥規(guī)律。方法:從《清宮配方集成》中篩選出124首治療骨關(guān)節(jié)炎的方劑,利用Access軟件建立數(shù)據(jù)庫(kù),分析每味藥物的出現(xiàn)頻次及按功效、性味、歸經(jīng)分類后藥物的累積出現(xiàn)頻次; 基于中醫(yī)傳承輔助平臺(tái)軟件(V2.5)對(duì)所選數(shù)據(jù)采用關(guān)聯(lián)分析中的Apriori算法分析常見組方規(guī)律,采用聚類分析法演化出核心組方及新方組合。結(jié)果:124首方劑中出現(xiàn)頻次居于前10位的中藥依次為當(dāng)歸、牛膝、防風(fēng)、獨(dú)活、羌活、杜仲、乳香、沒(méi)藥、熟地黃、木瓜,按功效分類后出現(xiàn)頻次居于前5位的依次為祛風(fēng)濕藥、活血化瘀藥、補(bǔ)肝腎藥、強(qiáng)筋骨藥、解表藥,藥性以溫、平多見,藥味以辛、苦、甘多見,歸經(jīng)以肝、腎、脾經(jīng)為主; 分析出常用中藥組合25個(gè),挖掘出24個(gè)核心組合、12個(gè)新方組合。結(jié)論:陳可冀《清宮配方集成》中治療骨關(guān)節(jié)炎的中藥組方,多用性溫、平,味辛、苦、甘,入肝、腎、脾經(jīng)的中藥; 其功效多以祛風(fēng)除濕、活血化瘀、補(bǔ)肝腎、強(qiáng)筋骨為主; 多以獨(dú)活寄生湯為核心進(jìn)行加減組方; 核心組方和新方組合可為臨床遣方用藥提供參考,但其療效有待進(jìn)一步研究。
Abstract:
ABSTRACT Objective:To explore the medication rule extracted from prescription for treatment of osteoarthritis in Royal Formulary of Qing Dynasty written by Chen Keji.Methods:One hundred and twenty-four prescriptions for treatment of OA were searched out from Royal Formulary of Qing Dynasty,and the database was established by using Access sorftware.The occurrence frequency of each drug and the accumulated frequency of drugs that were classificated according to function,property and flavour and meridian distribution were analyzed repectively.Based on the software of TCM inheritance auxiliary platform(V2.5),the common medication rules were searched out through analyzing the selected data by using Apriori algorithm in association analysis and the core prescription and combination of new prescription were obtained by using cluster analysis.Results:In 124 prescriptions,the top 10 Chinese drugs with high occurrence frequency included Chinese angelica,achyranthes bidentata,saposhnikovia divaricata,heracleum,notopterygium,eucommia ulmoides,frankincense,myrrh,prepared rehmannia root and pawpaw.According to the effect classification,the top 5 Chinese drugs with high occurrence frequency included antirheumatic Chinese drugs and Chinese drugs for blood-activating and stasis-resolving,reinforcing liver-kidney,strengthening bones and muscles and relieving exterior syndrome.The drug properties presented mainly with warm and normal; and the drug flavours presented mainly with pungent,bitter and sweet; and the meridian distributions presented mainly with liver meridian,kidney meridian and spleen meridian.Twenty five common traditional Chinese medicine(TCM)combination,24 core TCM combination and 12 new TCM combination were obtained.Conclusion:In TCM combination for treatment of osteoarthritis in Royal Formulary of Qing Dynasty written by Chen Keji,the drug properties presented mainly with warm and normal; and the drug flavours presented mainly with pungent,bitter and sweet; and the meridian distributions presented mainly with liver meridian,kidney meridian and spleen meridian; and the pharmacological actions presented mainly with antirheumatic,blood-activating and stasis-resolving,reinforcing liver-kidney,strengthening bones and muscles.Duhuo Jisheng Tang(獨(dú)活寄生湯)was usually used as the core of TCM combination.The core TCM combination and new TCM combination can provide reference for clinical medication,while their curative effects need to be further studied.

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省高等學(xué)校新世紀(jì)優(yōu)秀人才支持計(jì)劃項(xiàng)目(閩教科〔2017〕52號(hào)); 陳可冀中西醫(yī)結(jié)合發(fā)展基金項(xiàng)目(CKJ2017002) 通訊作者:劉獻(xiàn)祥 E-mail:[email protected]
更新日期/Last Update: 2018-04-02