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[1]吳鵬,王博,孔令成,等.強(qiáng)骨飲顆粒聯(lián)合阿侖膦酸鈉維D3片口服在原發(fā)性骨質(zhì)疏松性髖部骨折術(shù)后抗骨質(zhì)疏松治療中的應(yīng)用[J].中醫(yī)正骨,2016,28(05):16-19.
　WU Peng,WANG Bo,KONG Lingcheng,et al.Oral application of Qiangguyin Keli(強(qiáng)骨飲顆粒)and alendronate sodium Vitamin D3 tablets in postoperative anti-osteoporosis treatment in patients with primary osteoporotic hip fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(05):16-19.
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強(qiáng)骨飲顆粒聯(lián)合阿侖膦酸鈉維D3片口服在原發(fā)性骨質(zhì)疏松性髖部骨折術(shù)后抗骨質(zhì)疏松治療中的應(yīng)用()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第28卷
期數(shù):
2016年05期
頁(yè)碼:
16-19
欄目:
臨床研究
出版日期:
2016-05-20

文章信息/Info

Title:
Oral application of Qiangguyin Keli(強(qiáng)骨飲顆粒)and alendronate sodium Vitamin D3 tablets in postoperative anti-osteoporosis treatment in patients with primary osteoporotic hip fractures
作者:
吳鵬1; 王博1; 孔令成1; 劉康2; 史曉林2
1.浙江中醫(yī)藥大學(xué),浙江 杭州 310053;
2.浙江省新華醫(yī)院,浙江 杭州 310005
Author(s):
WU Peng1; WANG Bo1; KONG Lingcheng1; LIU Kang2; SHI Xiaolin2
1.Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China
2.Zhejiang Xinhua hospital,Hangzhou 310005,Zhejiang,China
關(guān)鍵詞:
骨質(zhì)疏松性骨折;  髖骨折;  骨折固定術(shù);  骨密度;  強(qiáng)骨飲
Keywords:
osteoporotic fractures;  hip fractures;  fracture fixation;  bone density;  Qianggu Yin
摘要:
目的:探討強(qiáng)骨飲顆粒聯(lián)合阿侖膦酸鈉維D3片口服用于原發(fā)性骨質(zhì)疏松性髖部骨折術(shù)后抗骨質(zhì)疏松治療的臨床療效及安全性。方法:原發(fā)性骨質(zhì)疏松性髖部骨折患者68例,隨機(jī)分為2組,每組34例。2組患者由同一組醫(yī)生行骨折固定術(shù)。術(shù)后第1天開(kāi)始,觀察組口服阿侖膦酸鈉維D3片,每次1粒,每周1次; 強(qiáng)骨飲顆粒,每次4 g,每日2次。對(duì)照組單純口服阿侖膦酸鈉維D3片。連續(xù)服用6個(gè)月。觀察骨折愈合情況,記錄骨折愈合時(shí)間。分別于術(shù)前和術(shù)后6個(gè)月檢測(cè)兩組患者腰椎及健側(cè)股骨頸骨密度,并采用視覺(jué)模擬量表(visual analogue scale,VAS)對(duì)患髖疼痛情況進(jìn)行評(píng)價(jià)。觀察2組患者的不良反應(yīng)和并發(fā)癥。結(jié)果:采用切開(kāi)復(fù)位動(dòng)力髖螺釘內(nèi)固定32例,采用切開(kāi)復(fù)位股骨近端髓內(nèi)釘內(nèi)固定33例,采用外固定架固定3例; 68例患者均獲隨訪,隨訪時(shí)間6～9個(gè)月,中位數(shù)7個(gè)月。觀察組骨折愈合34例,愈合時(shí)間(3.154±0.448)個(gè)月; 對(duì)照組骨折愈合33例,愈合時(shí)間(4.215±0.520)個(gè)月; 2組患者骨折愈合時(shí)間比較,差異有統(tǒng)計(jì)學(xué)意義(t=8.956,P=0.032)。術(shù)后6個(gè)月,2組患者腰椎和健側(cè)股骨頸骨密度均較術(shù)前增加[(0.687±0.036)g·cm-2,(0.697±0.028)g·cm-2,t=0.175,P=0.008;(0.685±0.037)g·cm-2,(0.690±0.026)g·cm-2,t=0.074,P=0.035;(0.577±0.104)g·cm-2,(0.734±0.102)g·cm-2,t=0.250,P=0.012;(0.578±0.106)g·cm-2,(0.658±0.099)g·cm-2,t=0.110,P=0.024]; 且觀察組高于對(duì)照組[(0.697±0.028)g·cm-2,(0.690±0.026)g·cm-2,t=2.031,P=0.023;(0.734±0.102)g·cm-2,(0.658±0.099)g·cm-2,t=3.117,P=0.027]; 2組患者患髖疼痛VAS評(píng)分均較術(shù)前降低[(5.541±0.732)分,(0.890±0.663)分,t=7.428,P=0.000;(5.494±0.895)分,(2.182±0.676)分,t=4.562,P=0.033],且觀察組VAS評(píng)分低于對(duì)照組[(0.890±0.663)分,(2.182±0.676)分,t=7.997,P=0.031]。服藥期間2組患者均未出現(xiàn)不良反應(yīng)。對(duì)照組并發(fā)骨折不愈合1例,術(shù)后7個(gè)月行人工全髖關(guān)節(jié)置換術(shù)。結(jié)論:對(duì)于原發(fā)性骨質(zhì)疏松性髖部骨折患者,術(shù)后應(yīng)用強(qiáng)骨飲顆粒聯(lián)合阿侖膦酸鈉維D3片口服進(jìn)行抗骨質(zhì)疏松治療,較單純口服阿侖膦酸鈉維D3片能更好地增加骨密度、緩解疼痛,更有利于骨折愈合,且安全可靠。
Abstract:
Objective:To explore the clinical curative effect and safety of oral application of Qiangguyin Keli(強(qiáng)骨飲顆粒,QGYKL)and alendronate sodium Vitamin D3 tablets in postoperative anti-osteoporosis treatment in patients with primary osteoporotic hip fractures.Methods:Sixty-eight patients with primary osteoporotic hip fractures were randomly divided into 2 groups,34 cases in each group.The patients were treated with fracture fixation by the same group of surgeons.Since the 1st day after the surgery,the patients in observation group were treated with oral application of alendronate sodium Vitamin D3 tablets(one tablet at a time,once a week)and QGYKL(4 g at a time,twice a day),while the patients in control group were treated with oral application of only alendronate sodium Vitamin D3 tablets for 6 consecutive months.The fracture healing was observed and the fracture healing time was recorded.The BMD of lumbar vertebra and femoral neck of uninjured side were detected before the surgery and at 6 months after the surgery respectively,and the hip pain was evaluated by using visual analogue scale(VAS).Moreover,the adverse reactions and complications were observed and compared between the 2 groups. Results:The patients were treated with open reduction and dynamic hip screw(DHS)internal fixation(32),open reduction and proximal femoral nail(PFN)internal fixation(33)and external fixator fixation(3)respectively.All patients in the 2 groups were followed up for 6-9 months with a median of 7 months.The fracture healing was found in 34 cases and the healing time was 3.154+/-0.448 months in observation group,while the fracture healing was found in 33 cases and the healing time was 4.215+/-0.520 months in control group.There was statistical difference in the fracture healing time between the 2 groups(t=8.956,P=0.032).The BMD of lumbar vertebra and femoral neck of uninjured side increased in the 2 groups at 6 months after the surgery(0.687+/-0.036 vs 0.697+/-0.028 g/cm(2),t=0.175,P=0.008; 0.685+/-0.037 vs 0.690+/-0.026 g/cm(2),t=0.074,P=0.035; 0.577+/-0.104 vs 0.734+/-0.102 g/cm(2),t=0.250,P=0.012; 0.578+/-0.106 vs 0.658+/-0.099 g/cm(2),t=0.110,P=0.024),and the BMD were higher in observation group compared to control group(0.697+/-0.028 vs 0.690+/-0.026 g/cm(2),t=2.031,P=0.023; 0.734+/-0.102 vs 0.658+/-0.099 g/cm(2),t=3.117,P=0.027).The hip pain VAS scores decreased in the 2 groups at 6 months after the surgery(5.541+/-0.732 vs 0.890+/-0.663 points,t=7.428,P=0.000; 5.494+/-0.895 vs 2.182+/-0.676 points,t=4.562,P=0.033).The hip pain VAS scores were lower in observation group compared to control group(0.890+/-0.663 vs 2.182+/-0.676 points,t=7.997,P=0.031).No adverse reactions were found in the 2 groups during the treatment.One patient with fracture nonunion was found in control group and was treated with total hip arthroplasty at 7 months after the surgery.Conclusion:For postoperative treatment of osteoporosis in patients with primary osteoporotic hip fractures,oral application of QGYKL and alendronate sodium Vitamin D3 tablets can better increase bone density and relieve hip pain and is more conducive to fracture healing than the monotherapy of oral application of alendronate sodium Vitamin D3 tablets.Moreover,it is safe and reliable.

參考文獻(xiàn)/References:

[1] 孫國(guó)麗,倪力剛,史曉林.運(yùn)動(dòng)療法聯(lián)合強(qiáng)骨飲口服在股骨轉(zhuǎn)子間骨折術(shù)后康復(fù)中的應(yīng)用[J].中醫(yī)正骨,2012,24(10):29-32.
[2] 吳連國(guó),劉康,黃俊俊,等.強(qiáng)骨飲對(duì)股骨頸骨折患者人工股骨頭置換術(shù)后假體周圍骨密度的影響[J].中醫(yī)正骨,2014,26(4):15-18.
[3] 徐偉鋒,葉健,吳連國(guó).強(qiáng)骨飲對(duì)骨質(zhì)疏松性股骨頸骨折患者全髖關(guān)節(jié)置換術(shù)后血清骨代謝生化指標(biāo)和骨密度的影響[J].中醫(yī)正骨,2015,27(2):12-16.
[4] 何偉濤,毛應(yīng)德龍,孫金谞,等.強(qiáng)骨飲對(duì)骨吸收參數(shù)TRACP5b及Crosslaps的影響[J].中醫(yī)正骨,2009,21(12):1-3.
[5] 史曉林.自擬強(qiáng)骨飲治療骨質(zhì)疏松癥的32例臨床報(bào)告[J].中國(guó)中醫(yī)骨傷科雜志,2006,14(2):57-58.
[6] 中華醫(yī)學(xué)會(huì)骨質(zhì)疏松和骨礦鹽疾病分會(huì).原發(fā)性骨質(zhì)疏松癥診治指南(2011年)[J].中華骨質(zhì)疏松和骨礦鹽疾病雜志,2011,4(1):2-17.
[7] Tascioglu F,Colak O,Armagan O,et al.The treatment of osteoporosis in patients with rheumatoid arthritis receiving glucocorticoids:a comparison of alendronate and intranasal salmon calcitonin[J].Rheumatol Int,2005,26(1):21-29.
[8] 邱貴興.老年骨質(zhì)疏松性骨折的治療策略[J].中華老年骨科與康復(fù)電子雜志,2015,1(1):1-5.
[9] 李春雯.益氣溫經(jīng)法對(duì)絕經(jīng)后骨質(zhì)疏松性髖部骨折患者骨轉(zhuǎn)換指標(biāo)的影響[J].中醫(yī)正骨,2014,26(12):7-9.
[10] 邱貴興,裴福興,胡偵明,等.中國(guó)骨質(zhì)疏松性骨折診療指南(骨質(zhì)疏松性骨折診斷及治療原則)[J].中華骨與關(guān)節(jié)外科雜志,2015,5(5):371-374.
[11] 趙洪.阿侖膦酸鈉對(duì)骨質(zhì)疏松癥治療作用的臨床觀察[J].齊齊哈爾醫(yī)學(xué)院學(xué)報(bào),2014,35(22):3343.
[12] 龔建程,陳圣華,徐衛(wèi)國(guó),等.仙靈骨葆聯(lián)合阿倫膦酸鈉治療腎陽(yáng)虧虛型骨質(zhì)疏松癥的臨床研究[J].中醫(yī)正骨,2012,24(5):7-9.
[13] 張鋼.阿倫膦酸鈉對(duì)大鼠股骨骨質(zhì)疏松性骨折愈合過(guò)程的影響[D].重慶:重慶醫(yī)科大學(xué),2014.
[14] 陳明,鄭瓊,方真華,等.阿倫膦酸鈉對(duì)骨髓生成破骨細(xì)胞及骨吸收作用的影響[J].中國(guó)矯形外科雜志,2008,16(4):282-284.
[15] 吳宗鍵,王繼芳,盧世璧,等.阿倫膦酸鈉對(duì)破骨細(xì)胞凋亡的影響[J].中國(guó)骨質(zhì)疏松雜志,2002,8(1):58-60.
[16] 顧聯(lián)斌.福美加與福善美治療骨質(zhì)疏松癥的療效對(duì)比觀察[J].中國(guó)實(shí)用醫(yī)藥,2015,8(8):154.
[17] 吳連國(guó),王定,朱彥昭,等.強(qiáng)骨飲治療原發(fā)性骨質(zhì)疏松癥的臨床研究[J].中國(guó)中醫(yī)藥科技,2009,16(3):167-168.
[18] 史曉林,劉康,李勝利.自擬強(qiáng)骨飲治療骨質(zhì)疏松性骨痛的44例臨床報(bào)告[J].中國(guó)中醫(yī)骨傷科雜志,2007,15(2):9-10.

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[11]陳勍,劉鐘,陳文亮,等.股骨近端防旋髓內(nèi)釘固定聯(lián)合口服仙靈骨葆膠囊治療腎陽(yáng)虛型骨質(zhì)疏松性股骨轉(zhuǎn)子間骨折[J].中醫(yī)正骨,2017,29(07):69.

備注/Memo

備注/Memo:
通訊作者:史曉林 E-mail:[email protected]
更新日期/Last Update: 2016-10-30