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[1]焦 鋒.益腎活血中藥對股骨轉(zhuǎn)子間骨折患者術(shù)后血清堿性磷酸酶和血清總鈣濃度的影響[J].中醫(yī)正骨,2016,28(04):16-18.
　JIAO Feng.Effect of Yishen Huoxue(益腎活血)traditional Chinese medicine on postoperative serum concentrations of alkaline phosphatase and total calcium in patients with intertrochanteric fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(04):16-18.
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益腎活血中藥對股骨轉(zhuǎn)子間骨折患者術(shù)后血清堿性磷酸酶和 血清總鈣濃度的影響()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第28卷
期數(shù):
2016年04期
頁碼:
16-18
欄目:
臨床研究
出版日期:
2016-04-20

文章信息/Info

Title:
Effect of Yishen Huoxue(益腎活血)traditional Chinese medicine on postoperative serum concentrations of alkaline phosphatase and total calcium in patients with intertrochanteric fractures
作者:
焦 鋒
廣東省廣州市中西醫(yī)結(jié)合醫(yī)院,廣東 廣州 510800
Author(s):
JIAO Feng
Guangzhou combinational hospital of traditional Chinese medicine and Western medicine,Guangzhou 510800,Guangdong,China
關(guān)鍵詞:
堿性磷酸酶;  鈣;  骨折愈合;  中藥療法;  益腎活血;  髖骨折;  治療; 臨床研究性
Keywords:
alkaline phosphatase;  calcium;  fracture healing;  drug therapy(TCD);  Yishen Huoxue;  hip fractures;  therapies; investigational
摘要:
目的:觀察益腎活血中藥對股骨轉(zhuǎn)子間骨折患者術(shù)后血清堿性磷酸酶和血清總鈣濃度的影響。方法:選取60例股骨轉(zhuǎn)子間骨折患者,隨機分為中藥組和常規(guī)組,每組30例。所有患者均由同一組醫(yī)師完成閉合復(fù)位股骨近端防旋髓內(nèi)釘內(nèi)固定手術(shù),術(shù)后常規(guī)進行抗感染、抗凝及營養(yǎng)支持治療。術(shù)后中藥組患者在常規(guī)治療的基礎(chǔ)上口服益腎活血中藥,連續(xù)服用14 d。分別于術(shù)后即刻和術(shù)后14 d抽靜脈血測定患者血清堿性磷酸酶和血清總鈣濃度。結(jié)果:術(shù)后即刻2組患者血清堿性磷酸酶和血清總鈣濃度比較,組間差異均無統(tǒng)計學(xué)意義(t=0.196,P=0.846; t=0.407,P=0.685)。術(shù)后14 d時中藥組的血清堿性磷酸酶濃度增高[(90.62±12.19)mmol·L-1,(105.40±11.63)mmol·L-1,t=4.805,P=0.000]; 常規(guī)組與術(shù)后即刻相比,差異無統(tǒng)計學(xué)意義[(91.27±13.52)mmol·L-1,(94.60±11.10)mmol·L-1,t=1.043,P=0.297]; 術(shù)后14 d時中藥組血清堿性磷酸酶濃度高于常規(guī)組(t=3.679,P=0.001)。術(shù)后14 d時2組患者的血清總鈣濃度均增高[(2.20±0.10)mmol·L-1,(2.29±0.10)mmol·L-1,t=3.486,P=0.000;(2.19±0.09)mmol·L-1,(2.27±0.12)mmol·L-1,t=2.292,P=0.005]; 術(shù)后14 d時2組患者的血清總鈣濃度比較,差異無統(tǒng)計學(xué)意義(t=0.701,P=0.486)。結(jié)論:口服益腎活血中藥可提高股骨轉(zhuǎn)子間骨折患者術(shù)后血清堿性磷酸酶濃度,但對血清總鈣濃度無明顯影響。
Abstract:
Objective:To observe the effect of Yishen Huoxue(益腎活血 YSHX)traditional Chinese medicine(TCM)on postoperative serum concentrations of alkaline phosphatase(AKP)and total calcium(TC)in patients with intertrochanteric fractures.Methods:Sixty patients with intertrochanteric fractures were selected and randomly divided into TCD group and conventional group,30 cases in each group.Closed reduction and proximal femoral nail anti-rotation internal fixation were performed in both of the 2 groups by the same group of surgeons.After the surgery,all of the patients were treated conventionally with anti-infective,anticoagulants and nutritional support.Moreover,the patients in TCD group were treated with oral application of YSHX TCM for consecutive 14 days.The serum concentrations of AKP and TC were measured after surgery immediately and at 14 days after surgery respectively.Results:There was no statistical difference in serum concentrations of AKP and TC between the 2 groups immediately post-operatively(t=0.196,P=0.846; t=0.407,P=0.685).The serum AKP concentrations increased in TCD group at 14 days after surgery(90.62+/-12.19 vs 105.40+/-11.63 mmol/l,t=4.805,P=0.000),and there was no statistical difference in serum AKP concentrations between the 2 timepoints in conventional group(91.27+/-13.52 vs 94.60+/-11.10 mmol/l,t=1.043,P=0.297).The serum AKP concentrations were higher in TCD group compared to conventional group at 14 days after surgery(t=3.679,P=0.001).The serum TC concentrations increased in both of the 2 groups at 14 days after surgery(2.20+/-0.10 vs 2.29+/-0.10 mmol/l,t=3.486,P=0.000; 2.19+/-0.09 vs 2.27+/-0.12 mmol/l,t=2.292,P=0.005).There was no statistical difference in serum TC concentrations between the 2 groups at 14 days after surgery(t=0.701,P=0.486).Conclusion:Oral application of YSHX TCM can raise postoperative serum AKP concentrations in patients with intertrochanteric fractures,while it has no obvious effect on serum TC concentrations.

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更新日期/Last Update: 2016-08-30