84年鼠女哪年财运最旺,857comvvv色九欧美激情|85PO_87国产精品欲av国产av资源

[1]鄭春松,葉蕻芝,李西海,等.透骨消痛膠囊中補(bǔ)腎柔肝藥和活血祛風(fēng)藥治療 骨關(guān)節(jié)炎作用方式的計算機(jī)模擬比較[J].中醫(yī)正骨,2015,27(07):6-10.
　ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Comparison of the mode of action of Bushen Rougan(補(bǔ)腎柔肝)drugs versus Huoxue Qufeng(活血祛風(fēng))drugs contained in Tougu Xiaotong Jiaonang(透骨消痛膠囊)for the treatment of osteoarthritis:A computer simulation study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):6-10.
點(diǎn)擊復(fù)制

透骨消痛膠囊中補(bǔ)腎柔肝藥和活血祛風(fēng)藥治療 骨關(guān)節(jié)炎作用方式的計算機(jī)模擬比較()
分享到：

《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第27卷
期數(shù):
2015年07期
頁碼:
6-10
欄目:
膝骨關(guān)節(jié)炎
出版日期:
2015-07-31

文章信息/Info

Title:
Comparison of the mode of action of Bushen Rougan(補(bǔ)腎柔肝)drugs versus Huoxue Qufeng(活血祛風(fēng))drugs contained in Tougu Xiaotong Jiaonang(透骨消痛膠囊)for the treatment of osteoarthritis:A computer simulation study
作者:
鄭春松1; 葉蕻芝1; 李西海1; 葉錦霞2; 吳廣文1; 徐筱杰3; 劉獻(xiàn)祥1
1.福建中醫(yī)藥大學(xué)中西醫(yī)結(jié)合研究院,福建 福州 350122;
2.福建省中西醫(yī)結(jié)合老年性疾病重點(diǎn)實驗室,福建 福州 350122;
3.北京大學(xué)化學(xué)與分子工程學(xué)院,北京 100871
Author(s):
ZHENG Chunsong1; YE Hongzhi1; LI Xihai1; YE Jinxia2; WU Guangwen1; XU Xiaojie3; LIU Xianxiang1
1.Academy of Integrative Medicine affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350122,Fujian,China
2.Key laboratory of Integrated Traditional Chinese Medicine with Western Medicine of senile diseases,Fuzhou 350122,Fujian,China
3.College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China
關(guān)鍵詞:
骨關(guān)節(jié)炎;  透骨消痛膠囊;  計算機(jī)模擬;  補(bǔ)腎柔肝;  活血祛風(fēng)
Keywords:
osteoarthritis;  Tougu Xiaotong Jiaonang;  computer simulation;  Bushen Rougan;  Huoxue Qufeng
摘要:
從分子層面比較透骨消痛膠囊中補(bǔ)腎柔肝藥和活血祛風(fēng)藥治療骨關(guān)節(jié)炎(osteoarthritis,OA)的作用方式。方法:分別以透骨消痛膠囊中的補(bǔ)腎柔肝藥和活血祛風(fēng)藥所含化合物及OA靶點(diǎn)蛋白質(zhì)作為研究對象,利用描述符計算、分子對接、生物網(wǎng)絡(luò)等計算機(jī)模擬方法,分析二者的化合物化學(xué)空間特征及中藥-化合物-靶點(diǎn)網(wǎng)絡(luò)特征。結(jié)果:補(bǔ)腎柔肝藥和活血祛風(fēng)藥的化學(xué)成分在化學(xué)空間中有較大的重疊區(qū)域,但前者分布更廣; 在中藥-化合物-靶點(diǎn)網(wǎng)絡(luò)中,補(bǔ)腎柔肝藥和活血祛風(fēng)藥的作用網(wǎng)絡(luò)特征分布僅存在部分相似之處,其網(wǎng)絡(luò)中每個化合物的平均作用靶點(diǎn)數(shù)分別為4.3和1.9,平均每個靶點(diǎn)分別與2.7個和1.5個化合物相關(guān)聯(lián)。結(jié)論:在治療OA時,透骨消痛膠囊中補(bǔ)腎柔肝藥主要是通過混雜藥物的作用方式起作用,而活血祛風(fēng)藥主要是通過組合藥物的作用方式起作用。
Abstract:
Objective:To compare the mode of action of Bushen Rougan(補(bǔ)腎柔肝,BSRG)drugs versus Huoxue Qufeng(活血祛風(fēng),HXQF)drugs contained in Tougu Xiaotong Jiaonang(透骨消痛膠囊,TGXTJN)for the treatment of osteoarthritis(OA)at the molecular level.Methods:The compounds separated from BSRG drugs and HXQF drugs contained in TGXTJN and OA target proteins were taken as research objects.The chemical spatial features of the compounds and the features of Traditional Chinese drug(TCD)-compound-target network were analyzed through such computer simulation methods as descriptor calculation,molecular docking and biological networks.Results:The chemical composition of BSRG drugs and that of HXQF drugs had large overlap region in the chemical space,but the former was more widely distributed.BSRG drugs and HXQF drugs had partly similar features in the TCD-compound-target network.The average number of targets was 4.3 and 1.9 respectively for each compound in the network model,and each target was related to 2.7 and 1.5 compounds respectively on average.Conclusion:BSRG drugs contained in TGXTJN works mainly by means of mixture of drugs,while HXQF drugs contained in TGXTJN works mainly by means of combination of drugs in the treatment of OA.

參考文獻(xiàn)/References:

[1] 劉獻(xiàn)祥.中醫(yī)藥治療膝骨性關(guān)節(jié)炎的研究現(xiàn)狀[J].中醫(yī)正骨,2012,24(1):3-7.
[2] 林木南,劉獻(xiàn)祥.透骨消痛方治療膝骨性關(guān)節(jié)炎30例[J].福建中醫(yī)藥,2005,36(4):15-16
[3] 劉伯齡,梁珪清,高雪偉,等.透骨消痛膠囊干預(yù)膝骨性關(guān)節(jié)炎早期COX-2炎癥途徑的實驗研究[J].福建中醫(yī)藥大學(xué)學(xué)報,2011,21(4):13-15.
[4] 吳廣文,褚劍鋒,許惠鳳,等.透骨消痛膠囊含藥血清對退變關(guān)節(jié)軟骨細(xì)胞表達(dá)TNF-α、IL-1β的影響[J].世界中西醫(yī)結(jié)合雜志,2012,7(4):295-298.
[5] 鄭春松,徐筱杰,葉蕻芝,等.兩種治法方藥治療骨性關(guān)節(jié)炎的計算機(jī)模擬比較研究[J].中國中西醫(yī)結(jié)合雜志,2014,34(4):480-485.
[6] Zheng CS,Xu XJ,Ye HZ,et al.Computational approaches for exploring the potential synergy and polypharmacology of Duhuo Jisheng Decoction in the therapy of osteoarthritis[J].Mol Med Rep,2013,7(6):1812-1818.
[7] Zheng CS,Zhuang ZQ,Xu XJ,et al.In silico search for multi-target therapies for osteoarthritis based on 10 common Huoxue Huayu herbs and potential applications to other diseases[J].Mol Med Rep,2014,9(3):857-862.
[8] 鄭春松,徐筱杰,劉獻(xiàn)祥,等.精制透骨消痛顆粒防治骨性關(guān)節(jié)炎的計算機(jī)藥理學(xué)[J].物理化學(xué)學(xué)報,2010,26(3):775-783.
[9] Qin C,Zhang C,Zhu F,et al.Therapeutic target database update 2014: a resource for targeted therapeutics[J].Nucleic Acids Res,2014,42(Database issue):D1118-D1123.
[10] Deshpande N,Addess KJ,Bluhm WF,et al.The RCSB Protein Data Bank:a redesigned query system and relational database based on the mmCIF schema[J].Nucleic Acids Res,2005,33(Database issue):D233-D237.
[11] 薛森海,王治倫,楊浩杰.基質(zhì)金屬蛋白酶及細(xì)胞因子在骨關(guān)節(jié)炎發(fā)病機(jī)制中的研究[J].中國地方病防治雜志,2007,22(6):420-423.
[12] 袁琴,闞衛(wèi)兵,宋朋飛,等.補(bǔ)腎活血方對大鼠膝骨關(guān)節(jié)炎滑膜細(xì)胞β-catenin、MMP-7的影響[J].中國骨傷,2012,25(9):761-765.
[13] Dobson CM.Chemical space and biology[J].Nature,2004,432(719):824-828.
[14] 陳立武,鄭春松,杜建.用分子對接法探討清熱消癥飲的抑瘤作用機(jī)制[J].中國臨床藥理學(xué)與治療學(xué),2007,12(3):324-328.
[15] Smoot ME,Ono K,Ruscheinski J,et al.Cytoscape 2.8:new features for data integration and network visualization[J].Bioinformatics,2011,27(3):431-432.
[16] 李西海,陳文列,劉獻(xiàn)祥.補(bǔ)腎柔肝法防治骨性關(guān)節(jié)炎作用機(jī)制探討[J].福建中醫(yī)藥大學(xué)學(xué)報,2011,21(2):66-69.
[17] 朱孝芹,孫大勇.改善疾病的骨關(guān)節(jié)炎治療藥物研究進(jìn)展[J].承德醫(yī)學(xué)院學(xué)報,2010,27(4):421-424.
[18] Grabowski K,Baringhaus KH,Schneider G.Scaffold diversity of natural products:inspiration for combinatorial library design[J].Nat Prod Rep,2008,25(5):892-904.
[19] Yildirim MA,Goh KI,Cusick ME,et al.Drug-target network[J].Nat Biotechnol,2007,25(10):1119-1126.
[20] 王林,戴冠中,胡海波.無標(biāo)度網(wǎng)絡(luò)的一個新的拓?fù)鋮?shù)[J].系統(tǒng)工程理論與實踐,2006,26(6):49-53.

相似文獻(xiàn)/References:

[1]孟維娜,明立功,王新德,等.關(guān)節(jié)鏡下清理聯(lián)合腓骨近1/3段截骨治療膝骨關(guān)節(jié)炎[J].中醫(yī)正骨,2015,27(11):40.
[2]明立功,孟維娜,王新德,等.腓骨近端截骨治療內(nèi)側(cè)間室膝骨關(guān)節(jié)炎的近期療效觀察[J].中醫(yī)正骨,2015,27(10):25.
[3]張杰,王人彥,張玉柱.膝骨關(guān)節(jié)炎的治療進(jìn)展[J].中醫(yī)正骨,2015,27(10):68.
[4]梁朝,蔡靜怡,閆立,等.針刀療法改善膝骨關(guān)節(jié)炎早期疼痛癥狀的療效評價[J].中醫(yī)正骨,2015,27(09):9.
　LIANG Zhao,CAI Jingyi,YAN Li,et al.Evaluation of the curative effect of needle-knife therapy for relieving knee pain in patients with early knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):9.
[5]王建武,黨建軍,李強(qiáng),等.四聯(lián)療法治療膝骨關(guān)節(jié)炎[J].中醫(yī)正骨,2015,27(08):44.
[6]劉紅娟,郭會利,郭樹農(nóng).云克聯(lián)合中藥治療膝骨關(guān)節(jié)炎的護(hù)理[J].中醫(yī)正骨,2015,27(08):75.
[7]陳衛(wèi)衡.探索建立系統(tǒng)的膝骨關(guān)節(jié)炎中醫(yī)臨床科研范式 和理論體系[J].中醫(yī)正骨,2015,27(07):1.
[8]帥波,沈霖,楊艷萍,等.加味青娥丸治療膝骨關(guān)節(jié)炎的作用機(jī)制研究[J].中醫(yī)正骨,2015,27(07):15.
　SHUAI Bo,SHEN Lin,YANG Yanping,et al.Study on the mechanism of action of Jiawei Qing'e Wan(加味青娥丸)for the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):15.
[9]梅其杰,袁長深,段戡,等.壯藥骨痹方燙熨聯(lián)合運(yùn)動療法治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2015,27(07):27.
　MEI Qijie,YUAN Changshen,DUAN Kan,et al.Clinical study of the curative effect of hot compressing and rubbing with packet of Gubi Fang(骨痹方)combined with exercise therapy in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):27.
[10]王丹輝,張燕,劉麗娟,等.重組人Ⅱ型腫瘤壞死因子受體-抗體融合蛋白 關(guān)節(jié)腔注射聯(lián)合中藥薰洗治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2015,27(07):31.
　WANG Danhui,ZHANG Yan,LIU Lijuan,et al.Clinical study on intra-articular injection of TypeⅡrecombinant human tumor necrosis factor receptor-Fc fusion protein combined with Chinese herbal steaming and washing therapy for treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):31.
[11]葉錦霞,付長龍,林潔,等.透骨消痛膠囊對毒胡蘿卜素誘導(dǎo)的內(nèi)質(zhì)網(wǎng)應(yīng)激PEKR信號通路介導(dǎo)的大鼠體外培養(yǎng)關(guān)節(jié)軟骨細(xì)胞凋亡的影響[J].中醫(yī)正骨,2017,29(06):1.
　YE Jinxia,FU Changlong,LIN Jie,et al.Effect of Tougu Xiaotong Jiaonang(透骨消痛膠囊)on apoptosis mediated by endoplasmic reticulum stress(PEKR signaling pathway)and induced by thapsigargin in rat's articular chondrocytes cultured in vitro[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2017,29(07):1.

備注/Memo

備注/Memo:
2015-06-02收稿 2015-06-12修回
基金項目:國家自然科學(xué)基金項目(81202713); 陳可冀中西醫(yī)結(jié)合發(fā)展基金資助項目(CKJ2015010)
通訊作者:劉獻(xiàn)祥 E-mail:[email protected]
更新日期/Last Update: 2015-07-30