84年鼠女哪年财运最旺,857comvvv色九欧美激情|85PO_87国产精品欲av国产av资源

[1]王海生,顧新豐,劉婷,等.口服參蝎止痛膠囊治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2015,27(03):22-26.
　WANG Haisheng,GU Xinfeng,LIU Ting,et al.A clinical study on oral application of Shenxie Zhitong(參蝎止痛)capsule for treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):22-26.
點(diǎn)擊復(fù)制

口服參蝎止痛膠囊治療膝骨關(guān)節(jié)炎的臨床研究()
分享到：

《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第27卷
期數(shù):
2015年03期
頁(yè)碼:
22-26
欄目:
臨床研究
出版日期:
2015-03-30

文章信息/Info

Title:
A clinical study on oral application of Shenxie Zhitong(參蝎止痛)capsule for treatment of knee osteoarthritis
作者:
王海生; 顧新豐; 劉婷; 何杰; 王學(xué)宗; 曹月龍; 鄭昱新; 詹紅生
上海中醫(yī)藥大學(xué)附屬曙光醫(yī)院,上海 201203
Author(s):
WANG Haisheng; GU Xinfeng; LIU Ting; HE Jie; WANG Xuezong; CAO Yuelong; ZHENG Yuxin; ZHAN Hongsheng
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝;  中藥療法;  治療; 臨床研究性
Keywords:
osteoarthritis; knee;  drug therapy(TCD);  therapies; investigational
摘要:
目的:觀察口服參蝎止痛膠囊治療膝骨關(guān)節(jié)炎的臨床療效和安全性。方法:將120例膝骨關(guān)節(jié)炎患者按2:1:1的比例隨機(jī)分為3組,分別采用口服參蝎止痛膠囊、抗骨質(zhì)增生膠囊和參蝎止痛膠囊模擬劑治療。分別于治療前和治療3周后,記錄并比較3組患者膝關(guān)節(jié)西安大略和麥克馬斯特大學(xué)(Western Ontario and McMaster Universities,WOMAC)量表總積分及疼痛、僵硬、功能障礙積分,并比較3組患者不良反應(yīng)發(fā)生情況。結(jié)果:治療3周后,8例患者脫落。治療前3組患者膝關(guān)節(jié)WOMAC量表總積分[(1044.43±76.04)分,(1014.93±83.13)分,(1034.03±74.10)分]、疼痛積分[(220.12 ±21.21)分,(213.87 ±22.59)分,(216.17 ±19.83)分]、僵硬積分[(66.77±10.31)分,(63.90±9.72)分,(63.67±9.46)分]及功能障礙積分[(757.55±52.43)分,(737.71±58.83)分,(754.20±52.74)分]比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(F=1.453,P=0.238; F=0.953,P=0.388; F=1.450,P=0.243; F=1.462,P=0.236)。治療3周后3組患者膝關(guān)節(jié)WOMAC量表總積分[(763.02±85.42)分,(751.21±118.58)分,(964.08±70.15)分]、疼痛積分[(162.18±23.31)分,(176.54±23.62)分,(200.48±18.34)分]、僵硬積分[(43.49±8.72)分,(44.54±13.74)分,(60.93±9.66)分]及功能障礙積分[(524.00±87.48)分,(557.35±59.71)分,(699.85±51.39)分]比較,差異均有統(tǒng)計(jì)學(xué)意義(F=52.310,P=0.000; F=27.108,P=0.000; F=27.756,P=0.000; F=57.788,P=0.000)。進(jìn)一步兩兩比較,參蝎止痛膠囊組WOMAC量表總積分和僵硬積分與抗骨質(zhì)增生膠囊組比較,組間差異均無(wú)統(tǒng)計(jì)學(xué)意義(P=0.393,P=0.664); 參蝎止痛膠囊組疼痛積分及功能障礙積分均低于抗骨質(zhì)增生膠囊組(P=0.006,P=0.031); 參蝎止痛膠囊組和抗骨質(zhì)增生膠囊組的WOMAC量表總積分、疼痛積分、僵硬積分和功能障礙積分均低于參蝎止痛膠囊模擬劑組(P=0.000,P=0.000; P=0.000,P=0.000; P=0.000,P=0.000; P=0.000,P=0.000)。3組患者不良反應(yīng)發(fā)生率比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(χ2=0.386,P=1.000)。結(jié)論:采用口服參蝎止痛膠囊和抗骨質(zhì)增生膠囊治療膝骨關(guān)節(jié)炎,均能改善膝關(guān)節(jié)功能,緩解膝關(guān)節(jié)疼痛和僵硬,不良反應(yīng)小; 但在改善膝關(guān)節(jié)疼痛及功能障礙方面,參蝎止痛膠囊優(yōu)于抗骨質(zhì)增生膠囊,值得臨床推廣應(yīng)用。
Abstract:
Objective:To observe the clinical curative effect and safety of oral application of Shenxie Zhitong(參蝎止痛)capsule in the treatment of knee osteoarthritis(KOA).Methods:One hundred and twenty patients with KOA were randomly divided into 3 groups with a ratio of 2:1:1,and were treated with oral application of Shenxie Zhitong capsules,anti-hyperosteogeny capsules and mimetic Shenxie Zhitong capsules respectively.The total scores,pain scores,stiffness scores and dysfunction scores were assessed by using Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)scale and compared between the 3 groups before the treatment and after 3-week treatment,and the incidence rate of adverse reactions was also recorded.Results:Eight patients fell off after 3-week treatment.There was no statistical difference in WOMAC aggregate scores(1044.43+/-76.04,1014.93+/-83.13,1034.03+/-74.10 points),pain scores(220.12 +/-21.21,213.87 +/-22.59,216.17 +/-19.83 points),stiffness scores(66.77+/-10.31,63.90+/-9.72,63.67+/-9.46 points)and dysfunction scores(757.55+/-52.43,737.71+/-58.83,754.20+/-52.74 points)between the 3 groups before the treatment(F=1.453,P=0.238; F=0.953,P=0.388; F=1.450,P=0.243; F=1.462,P=0.236).There was statistical difference in WOMAC aggregate scores(763.02+/-85.42,751.21+/-118.58,964.08+/-70.15 points),pain scores(162.18+/-23.31,176.54+/-23.62, 200.48+/-18.34 points),stiffness scores(43.49+/-8.72,44.54+/-13.74,60.93+/-9.66 points)and dysfunction scores(524.00+/-87.48,557.35+/-59.71,699.85+/-51.39 points)between the 3 groups after 3-week treatment(F=52.310,P=0.000; F=27.108,P=0.000; F=27.756,P=0.000; F=57.788,P=0.000).Further pairwise comparison showed that there was no statistical difference in WOMAC aggregate scores and dysfunction scores between Shenxie Zhitong capsules group and anti-hyperosteogeny capsules group(P=0.393,P=0.664).The pain scores and dysfunction scores were lower in Shenxie Zhitong capsules group compared with anti-hyperosteogeny capsules group(P=0.006,P=0.031).The WOMAC aggregate scores,pain scores,stiffness scores and dysfunction scores were lower in Shenxie Zhitong capsules group and anti-hyperosteogeny capsules group compared with mimetic Shenxie Zhitong capsule group(P=0.000,P=0.000; P=0.000,P=0.000; P=0.000,P=0.000; P=0.000,P=0.000).There was no statistical difference in the incidence rate of adverse reactions between the 3 groups(χ2=0.386,P=1.000).Conclusion:Oral application of either Shenxie Zhitong capsules or anti-hyperosteogeny capsules can improve the knee function and relieve knee pain and stiffness with less adverse reactions in the treatment of KOA.However,the former surpasses the latter in improving knee pain and dysfunction,so it is worthy of popularizing in clinic.

參考文獻(xiàn)/References:

[1] Neogi T.The epidemiology and impact of pain in osteoarthritis[J].Osteoarthritis Cartilage,2013,21(9):1145-1153.
[2] Konttinen YT,Sillat T,Barreto G,et al.Osteoarthritis as an autoinflammatory disease caused by chondrocyte-mediated inflammatory responses[J].Arthritis Rheum,2012,64(3):613-616.
[3] 劉獻(xiàn)祥.中醫(yī)藥治療膝骨性關(guān)節(jié)炎的研究現(xiàn)狀[J].中醫(yī)正骨,2012,24(1):3-7.
[4] 王學(xué)宗,鄭昱新,曹月龍,等.柔肝和化痰中藥復(fù)方對(duì)膝骨關(guān)節(jié)炎患者關(guān)節(jié)功能及關(guān)節(jié)液軟骨寡聚基質(zhì)蛋白濃度的影響[J].中醫(yī)正骨,2014,26(1):17-20.
[5] Moskowitz RW,Altman RD,Hochberg MC,et al.骨關(guān)節(jié)炎診斷與治療[M].謝利軍主譯.4版.北京:人民衛(wèi)生出版社,2008:264-265.
[6] Hochberg MC,AItman RD,Brandt KD,et al.Guidelines for the medical management of osteoarthritis.PartⅡ.Osteoarthritis of the knee.American College of Rheumatology[J].Arthritis Rheum,1995,38(11):1541-1546.
[7] 鄭筱萸.中藥新藥臨床研究指導(dǎo)原則[M].北京:中國(guó)醫(yī)藥科技出版社,2002:349-353.
[8] Wang X,Cao Y,Pang J,et al.Traditional chinese herbal patch for short-term management of knee osteoarthritis:a randomized,double-blind,placebo-controlled trial[J].Evid Based Complement Alternat Med,2012,20(17):1706.
[9] Zampelis V,Ornstein E,Franzen H,et al.A simple visual analog scale for pain is as responsive as the WOMAC,the SF-36,and the EQ-5D in measuring outcomes of revision hip arthroplasty[J].Acta Orthop,2014,85(2):128-132.
[10] Papathanasiou G,Stasi S,Oikonomou L,et al.Clinimetric properties of WOMAC index in Greek knee osteoarthritis patients:comparisons with both self-reported and physical performance measures[J].Rheumatol Int,2015,35(1):115-123.
[11] 田志清,吳官保.中醫(yī)藥治療膝骨性關(guān)節(jié)炎的臨床研究進(jìn)展[J].湖南中醫(yī)雜志,2008,24(2):106-108.
[12] 陳瑛,姚政,徐雋斐,等.糖神方聯(lián)合參蝎止痛膠囊治療肝腎虧虛型糖尿病周圍神經(jīng)病變的臨床療效觀察[J].時(shí)珍國(guó)醫(yī)國(guó)藥,2011,22(4):953-955.
[13] 潘峰,朱建華,郭建文.朱良春膏方運(yùn)用蟲(chóng)類藥經(jīng)驗(yàn)[J].中醫(yī)雜志,2012,53(11):912-913.
[14] 丘青中.石氏傷科蟲(chóng)類藥物的臨床應(yīng)用[J].現(xiàn)代中西醫(yī)結(jié)合雜志,2011,20(15):1883-1884.
[15] 陳小波,劉南海.三七總皂苷離子導(dǎo)入治療膝骨關(guān)節(jié)炎的臨床療效觀察[J].實(shí)用中西醫(yī)結(jié)合臨床,2010,10(6):10-11.
[16] 熊英瓊,程紹民,劉端勇,等.全蝎蜈蚣在痹病治療中的應(yīng)用思路[J].遼寧中醫(yī)雜志,2011,38(4):793-795.

相似文獻(xiàn)/References:

[1]樊慶陽(yáng),任凱晶.定制3D打印切模輔助全膝關(guān)節(jié)置換術(shù)治療 膝骨關(guān)節(jié)炎合并股骨干骨折畸形愈合[J].中醫(yī)正骨,2015,27(11):37.
[2]劉曉雅,孫永強(qiáng),劉國(guó)杰.主動(dòng)快速康復(fù)鍛煉對(duì)全膝關(guān)節(jié)置換術(shù)后關(guān)節(jié)活動(dòng)度的影響[J].中醫(yī)正骨,2015,27(09):73.
[3]鄭春松,葉蕻芝,李西海,等.透骨消痛膠囊中補(bǔ)腎柔肝藥和活血祛風(fēng)藥治療 骨關(guān)節(jié)炎作用方式的計(jì)算機(jī)模擬比較[J].中醫(yī)正骨,2015,27(07):6.
　ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Comparison of the mode of action of Bushen Rougan(補(bǔ)腎柔肝)drugs versus Huoxue Qufeng(活血祛風(fēng))drugs contained in Tougu Xiaotong Jiaonang(透骨消痛膠囊)for the treatment of osteoarthritis:A computer simulation study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):6.
[4]宋兵華,孫俊英,倪增良,等.全膝關(guān)節(jié)置換術(shù)前CT測(cè)量股骨后髁角的臨床意義[J].中醫(yī)正骨,2015,27(07):38.
[5]鄭春松,葉蕻芝,李西海,等.獨(dú)活寄生湯含藥血清對(duì)白細(xì)胞介素1β誘導(dǎo)的 退變關(guān)節(jié)軟骨細(xì)胞中基質(zhì)金屬蛋白酶 和環(huán)氧化酶2表達(dá)的影響[J].中醫(yī)正骨,2015,27(12):1.
　ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Impact of Duhuo Jisheng Tang(獨(dú)活寄生湯)medicated serum on expression of matrix metalloproteinase and cyclooxygenase 2 in degenerative articular chondrocytes induced by interleukin-1 beta[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):1.
[6]王金良,孫京濤,李玲,等.骨水泥聯(lián)合螺釘修復(fù)全膝關(guān)節(jié)置換術(shù)中 脛骨平臺(tái)內(nèi)側(cè)骨缺損[J].中醫(yī)正骨,2015,27(12):55.
[7]馮榮,王平,李炳奇,等.鈹針刺絡(luò)拔罐結(jié)合中藥口服治療膝骨關(guān)節(jié)炎合并 原發(fā)性血小板增多癥1例[J].中醫(yī)正骨,2015,27(12):73.
[8]蔡云仙.圍手術(shù)期耳穴按壓聯(lián)合平衡針療法 在全膝關(guān)節(jié)置換術(shù)后鎮(zhèn)痛中的應(yīng)用[J].中醫(yī)正骨,2015,27(06):41.
[9]張榮,王健.人工全膝關(guān)節(jié)置換術(shù)的圍手術(shù)期心理護(hù)理[J].中醫(yī)正骨,2015,27(05):77.
[10]喻長(zhǎng)純,楊明路,王戰(zhàn)朝.不同手術(shù)方式治療脛骨平臺(tái)骨折畸形愈合的體會(huì)[J].中醫(yī)正骨,2015,27(03):37.
[11]孟維娜,明立功,王新德,等.關(guān)節(jié)鏡下清理聯(lián)合腓骨近1/3段截骨治療膝骨關(guān)節(jié)炎[J].中醫(yī)正骨,2015,27(11):40.
[12]明立功,孟維娜,王新德,等.腓骨近端截骨治療內(nèi)側(cè)間室膝骨關(guān)節(jié)炎的近期療效觀察[J].中醫(yī)正骨,2015,27(10):25.
[13]張杰,王人彥,張玉柱.膝骨關(guān)節(jié)炎的治療進(jìn)展[J].中醫(yī)正骨,2015,27(10):68.
[14]梁朝,蔡靜怡,閆立,等.針刀療法改善膝骨關(guān)節(jié)炎早期疼痛癥狀的療效評(píng)價(jià)[J].中醫(yī)正骨,2015,27(09):9.
　LIANG Zhao,CAI Jingyi,YAN Li,et al.Evaluation of the curative effect of needle-knife therapy for relieving knee pain in patients with early knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):9.
[15]王建武,黨建軍,李強(qiáng),等.四聯(lián)療法治療膝骨關(guān)節(jié)炎[J].中醫(yī)正骨,2015,27(08):44.
[16]劉紅娟,郭會(huì)利,郭樹(shù)農(nóng).云克聯(lián)合中藥治療膝骨關(guān)節(jié)炎的護(hù)理[J].中醫(yī)正骨,2015,27(08):75.
[17]陳衛(wèi)衡.探索建立系統(tǒng)的膝骨關(guān)節(jié)炎中醫(yī)臨床科研范式 和理論體系[J].中醫(yī)正骨,2015,27(07):1.
[18]帥波,沈霖,楊艷萍,等.加味青娥丸治療膝骨關(guān)節(jié)炎的作用機(jī)制研究[J].中醫(yī)正骨,2015,27(07):15.
　SHUAI Bo,SHEN Lin,YANG Yanping,et al.Study on the mechanism of action of Jiawei Qing'e Wan(加味青娥丸)for the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):15.
[19]梅其杰,袁長(zhǎng)深,段戡,等.壯藥骨痹方燙熨聯(lián)合運(yùn)動(dòng)療法治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2015,27(07):27.
　MEI Qijie,YUAN Changshen,DUAN Kan,et al.Clinical study of the curative effect of hot compressing and rubbing with packet of Gubi Fang(骨痹方)combined with exercise therapy in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):27.
[20]王丹輝,張燕,劉麗娟,等.重組人Ⅱ型腫瘤壞死因子受體-抗體融合蛋白 關(guān)節(jié)腔注射聯(lián)合中藥薰洗治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2015,27(07):31.
　WANG Danhui,ZHANG Yan,LIU Lijuan,et al.Clinical study on intra-articular injection of TypeⅡrecombinant human tumor necrosis factor receptor-Fc fusion protein combined with Chinese herbal steaming and washing therapy for treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):31.

備注/Memo

備注/Memo:
2014-11-13收稿 2014-12-18修回
基金項(xiàng)目:國(guó)家自然科學(xué)基金(81373665,81302988,81173277); 上海市教育委員會(huì)科研創(chuàng)新項(xiàng)目(11YZ64,12YZ064); “海派中醫(yī)流派傳承研究基地”項(xiàng)目(ZYSNXD-CC-HPGC-JD-001); 上海領(lǐng)軍人才(041); 上海市科委重點(diǎn)科技攻關(guān)項(xiàng)目及科技支撐項(xiàng)目(11DZ1972902,13411950500,13401902502)
通訊作者:鄭昱新 E-mail:sg_zyx1728@126.com
更新日期/Last Update: 2015-03-30